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Conserved domains on  [gi|17506829|ref|NP_492458|]
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Pyruvate kinase [Caenorhabditis elegans]

Protein Classification

pyruvate kinase( domain architecture ID 1562468)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase super family cl39076
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 78-561 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


The actual alignment was detected with superfamily member cd00288:

Pssm-ID: 453956 [Multi-domain]  Cd Length: 480  Bit Score: 665.55  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSdkRVIGIALDTKGPEIRTGLLAG 157
Cdd:cd00288   2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG--GPVAIALDTKGPEIRTGLFKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 158 GAsaEIELARGASIRLTTDPHFSEsGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDA-VICSVENGGMLGS 236
Cdd:cd00288  80 GK--DISLKAGDKFLVTTDPAAKK-GTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGS 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 237 RKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIIS 316
Cdd:cd00288 157 RKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILE 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 317 ESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGET 396
Cdd:cd00288 237 ASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 397 AKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYK 476
Cdd:cd00288 317 AKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYR 396

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 477 PAVPILTISRDVAVCRQLHLYRGVFPVHYPAERaADWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQGAGATNTL 556
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPK-PGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTM 475


                ....*
gi 17506829 557 RIITA 561
Cdd:cd00288 476 RILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 78-561 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 665.55  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSdkRVIGIALDTKGPEIRTGLLAG 157
Cdd:cd00288   2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG--GPVAIALDTKGPEIRTGLFKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 158 GAsaEIELARGASIRLTTDPHFSEsGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDA-VICSVENGGMLGS 236
Cdd:cd00288  80 GK--DISLKAGDKFLVTTDPAAKK-GTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGS 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 237 RKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIIS 316
Cdd:cd00288 157 RKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILE 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 317 ESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGET 396
Cdd:cd00288 237 ASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 397 AKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYK 476
Cdd:cd00288 317 AKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYR 396

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 477 PAVPILTISRDVAVCRQLHLYRGVFPVHYPAERaADWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQGAGATNTL 556
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPK-PGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTM 475


                ....*
gi 17506829 557 RIITA 561
Cdd:cd00288 476 RILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 78-558 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 607.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829    78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSdkRVIGIALDTKGPEIRTGLLAG 157
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG--RPVAILLDTKGPEIRTGEIKG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   158 GasaEIELARGASIRLTTDPHfSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSR 237
Cdd:TIGR01064  79 G---EVKLKKGDKVIITTDDI-KGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   238 KGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEK-GKKIKIIAKIENQEGVDNADEIIS 316
Cdd:TIGR01064 155 KGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKgAKDVKIIAKIENQEGVDNIDEIAE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   317 ESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGET 396
Cdd:TIGR01064 235 ASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGET 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   397 AKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYK 476
Cdd:TIGR01064 315 AKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYR 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   477 PAVPILTISRDVAVCRQLHLYRGVFPVHYPaeraaDWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTG-WRQGAGATNT 555
Cdd:TIGR01064 395 PNAPIIAVTPNERVARQLALYWGVFPFLVD-----EEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNT 469


                  ...
gi 17506829   556 LRI 558
Cdd:TIGR01064 470 IRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 78-560 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 584.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFsdKRVIGIALDTKGPEIRTGLLAG 157
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKEL--GRPVAILLDLQGPKIRTGKFKE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 158 GasaEIELARGASIRLTTDPhfsESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSR 237
Cdd:COG0469  81 G---PVELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSR 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 238 KGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIISE 317
Cdd:COG0469 155 KGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEA 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 318 SDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETA 397
Cdd:COG0469 235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 398 KGEYPVDALKIMHYICKEAEAAVYHRRLFDELlqNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKP 477
Cdd:COG0469 315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRL--RDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRP 392

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 478 AVPILTISRDVAVCRQLHLYRGVFPVHYPAeraadwPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQG-AGATNTL 556
Cdd:COG0469 393 KVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTL 466


                ....
gi 17506829 557 RIIT 560
Cdd:COG0469 467 KVHR 470
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 78-426 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 531.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829    78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKrvIGIALDTKGPEIRTGLLAG 157
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT--VAIALDTKGPEIRTGNTKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   158 GASaEIELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDA-VICSVENGGMLGS 236
Cdd:pfam00224  80 GKK-DIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   237 RKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIIS 316
Cdd:pfam00224 159 RKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   317 ESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGET 396
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318

                         330       340       350
                  ....*....|....*....|....*....|
gi 17506829   397 AKGEYPVDALKIMHYICKEAEAAVYHRRLF 426
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 78-545 9.89e-174

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 499.29  E-value: 9.89e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFsdKRVIGIALDTKGPEIRTGLLAG 157
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKL--GRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  158 GasaEIELARGASIRLTTDPhfSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSR 237
Cdd:PRK05826  82 G---KITLKTGDKFTLDTDQ--KEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  238 KGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAK-IENQEGVDNADEIIS 316
Cdd:PRK05826 157 KGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAkIERAEAVDNIDEIIE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  317 ESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGET 396
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  397 AKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTD---MShtiaiAATSAAASCHASAILLITTTGRSAIQCS 473
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEaiaMS-----AMYAANHLKGVKAIVALTESGRTARLIS 391

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17506829  474 RYKPAVPILTISRDVAVCRQLHLYRGVFPVHYpaeraaDWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTG 545
Cdd:PRK05826 392 RFRPGAPIFAVTRDEKTQRRLALYRGVYPVLF------DSAADTDDAAEEALRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 78-561 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 665.55  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSdkRVIGIALDTKGPEIRTGLLAG 157
Cdd:cd00288   2 RRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG--GPVAIALDTKGPEIRTGLFKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 158 GAsaEIELARGASIRLTTDPHFSEsGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDA-VICSVENGGMLGS 236
Cdd:cd00288  80 GK--DISLKAGDKFLVTTDPAAKK-GTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKtLVCEVLNGGVLGS 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 237 RKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIIS 316
Cdd:cd00288 157 RKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILE 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 317 ESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGET 396
Cdd:cd00288 237 ASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 397 AKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYK 476
Cdd:cd00288 317 AKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYR 396

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 477 PAVPILTISRDVAVCRQLHLYRGVFPVHYPAERaADWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQGAGATNTL 556
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPK-PGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTM 475


                ....*
gi 17506829 557 RIITA 561
Cdd:cd00288 476 RILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 78-558 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 607.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829    78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSdkRVIGIALDTKGPEIRTGLLAG 157
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG--RPVAILLDTKGPEIRTGEIKG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   158 GasaEIELARGASIRLTTDPHfSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSR 237
Cdd:TIGR01064  79 G---EVKLKKGDKVIITTDDI-KGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   238 KGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEK-GKKIKIIAKIENQEGVDNADEIIS 316
Cdd:TIGR01064 155 KGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKgAKDVKIIAKIENQEGVDNIDEIAE 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   317 ESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGET 396
Cdd:TIGR01064 235 ASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGET 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   397 AKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYK 476
Cdd:TIGR01064 315 AKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYR 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   477 PAVPILTISRDVAVCRQLHLYRGVFPVHYPaeraaDWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTG-WRQGAGATNT 555
Cdd:TIGR01064 395 PNAPIIAVTPNERVARQLALYWGVFPFLVD-----EEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNT 469


                  ...
gi 17506829   556 LRI 558
Cdd:TIGR01064 470 IRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 78-560 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 584.69  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFsdKRVIGIALDTKGPEIRTGLLAG 157
Cdd:COG0469   3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKEL--GRPVAILLDLQGPKIRTGKFKE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 158 GasaEIELARGASIRLTTDPhfsESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSR 237
Cdd:COG0469  81 G---PVELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSR 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 238 KGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIISE 317
Cdd:COG0469 155 KGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEA 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 318 SDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETA 397
Cdd:COG0469 235 SDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 398 KGEYPVDALKIMHYICKEAEAAVYHRRLFDELlqNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKP 477
Cdd:COG0469 315 VGKYPVEAVETMARIAEEAEKSLDYRRILDRL--RDEPERTITDAIARAAVELAEDLGAKAIVAFTESGSTARRISRYRP 392

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 478 AVPILTISRDVAVCRQLHLYRGVFPVHYPAeraadwPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQG-AGATNTL 556
Cdd:COG0469 393 KVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGTTNTL 466


                ....
gi 17506829 557 RIIT 560
Cdd:COG0469 467 KVHR 470
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 78-426 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 531.94  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829    78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKrvIGIALDTKGPEIRTGLLAG 157
Cdd:pfam00224   2 RRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT--VAIALDTKGPEIRTGNTKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   158 GASaEIELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDA-VICSVENGGMLGS 236
Cdd:pfam00224  80 GKK-DIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   237 RKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIIS 316
Cdd:pfam00224 159 RKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   317 ESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGET 396
Cdd:pfam00224 239 ATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGET 318

                         330       340       350
                  ....*....|....*....|....*....|
gi 17506829   397 AKGEYPVDALKIMHYICKEAEAAVYHRRLF 426
Cdd:pfam00224 319 AKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 78-545 9.89e-174

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 499.29  E-value: 9.89e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFsdKRVIGIALDTKGPEIRTGLLAG 157
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKL--GRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  158 GasaEIELARGASIRLTTDPhfSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSR 237
Cdd:PRK05826  82 G---KITLKTGDKFTLDTDQ--KEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  238 KGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAK-IENQEGVDNADEIIS 316
Cdd:PRK05826 157 KGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCPHAKIIAkIERAEAVDNIDEIIE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  317 ESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGET 396
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  397 AKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTD---MShtiaiAATSAAASCHASAILLITTTGRSAIQCS 473
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEaiaMS-----AMYAANHLKGVKAIVALTESGRTARLIS 391

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17506829  474 RYKPAVPILTISRDVAVCRQLHLYRGVFPVHYpaeraaDWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTG 545
Cdd:PRK05826 392 RFRPGAPIFAVTRDEKTQRRLALYRGVYPVLF------DSAADTDDAAEEALRLLLEKGLVESGDLVVVTSG 457
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 104-562 2.52e-168

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 485.32  E-value: 2.52e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  104 MNIARLNFSHGSHEYHAGTIANVREAADSFSDKrvIGIALDTKGPEIRTGLLAGGasaEIELARGASIRLTTDPHFSESG 183
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN--IAIALDTKGPEIRTGLFVGG---EAVMERGATCYVTTDPAFADKG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  184 TAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVI-CSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCKDLQF 262
Cdd:PTZ00300  76 TKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQTLkCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  263 GVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEGVDNADEIISESDGVMVARGDLGIEIPAEKVFLAQK 342
Cdd:PTZ00300 156 GVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  343 MLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYH 422
Cdd:PTZ00300 236 ILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNE 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  423 RRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFP 502
Cdd:PTZ00300 316 YVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVES 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  503 VHYPAERAADwPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQGAGATNTLRIITAE 562
Cdd:PTZ00300 396 VFFDAERLGH-DEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILVS 454
PLN02461 PLN02461
Probable pyruvate kinase
 58-543 8.74e-166

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 481.01  E-value: 8.74e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   58 ATTHMEHLcrLDIREAPHLVR-QTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSfsDK 136
Cdd:PLN02461   2 ANIDIEGI--LKGLPADGLRRpKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMAN--TG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  137 RVIGIALDTKGPEIRTGLLAGGASaeIELARGASIRLTTDphFSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIV 216
Cdd:PLN02461  78 ILCAVMLDTKGPEIRTGFLKDGKP--VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTV 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  217 eeLQTDA----VICSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCKD-LQFGVEQGVDIIFASFIRNAEGIRTIRKVLGE 291
Cdd:PLN02461 154 --LSCDVeagtVRCRCENSAMLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  292 KGKKIKIIAKIENQEGVDNADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRP 371
Cdd:PLN02461 232 HAKSILLISKVENQEGLDNFDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRP 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  372 TRAEGSDVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPtdMSHTIAIAATSAA 451
Cdd:PLN02461 312 TRAEATDVANAVLDGTDCVMLSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLP--MSPLESLASSAVR 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  452 ASCHASAILLI--TTTGRSAIQCSRYKPAVPILTI-------------SRDVAVCRQLHLYRGVFPVHYPAERAADWPTD 516
Cdd:PLN02461 390 TANKVKASLIVvlTRGGTTARLVAKYRPAVPILSVvvpeittdsfdwsCSDEAPARHSLIYRGLIPVLAEGSAKATDSES 469

                        490       500
                 ....*....|....*....|....*..
gi 17506829  517 VDNRINHAIAIGKDRGFIHKGDFLVVV 543
Cdd:PLN02461 470 TEEILEAAIEHAKKKGLCKPGDSVVAL 496
PRK09206 PRK09206
pyruvate kinase PykF;
78-558 4.57e-158

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 459.91  E-value: 4.57e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAAdSFSDKRViGIALDTKGPEIRTGLLAG 157
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVM-SKTGKKA-AILLDTKGPEIRTMKLEG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  158 GAsaEIELARGASIRLTTDphFSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSR 237
Cdd:PRK09206  80 GN--DVSLKAGQTFTFTTD--KSVVGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGEN 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  238 KGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVL----GEKGKKIKIIakiENQEGVDNADE 313
Cdd:PRK09206 156 KGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLkahgGENIQIISKI---ENQEGLNNFDE 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  314 IISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLS 393
Cdd:PRK09206 233 ILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLS 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  394 GETAKGEYPVDALKIMHYICKEAEaAVYHRRLFDELLQNtqkptDMSHTIAIAATSAAASCHASAILLI--TTTGRSAIQ 471
Cdd:PRK09206 313 GESAKGKYPLEAVSIMATICERTD-RVMNSRLESNNDNR-----KLRITEAVCRGAVETAEKLDAPLIVvaTQGGKSARS 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  472 CSRYKPAVPILTISRDVAVCRQLHLYRGVFPVhypaeraadwptdVDNRIN---HAIAIGKD----RGFIHKGDFLVVVT 544
Cdd:PRK09206 387 VRKYFPDATILALTTNEKTARQLVLSKGVVPQ-------------LVKEIAstdDFYRLGKElalqSGLAQKGDVVVMVS 453

                        490
                 ....*....|....
gi 17506829  545 GWRQGAGATNTLRI 558
Cdd:PRK09206 454 GALVPSGTTNTASV 467
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 51-562 2.11e-157

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 459.61  E-value: 2.11e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   51 QKLAAVPATTHMEHLCRLDIREaphlvRQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAA 130
Cdd:PTZ00066  16 GKATNISLDKILEPISDNDLRQ-----KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  131 DSFSDKRvIGIALDTKGPEIRTGLLAGGAsaEIELARGASIRLTTDphFSESGTAVNLFVDYKNIAKVLSVGSRVYIDDG 210
Cdd:PTZ00066  91 KARPNAN-LGILLDTKGPEIRTGFLKNHK--PITLKEGQTLKITTD--YTFLGDETCISCSYKKLPQSVKVGNIILIADG 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  211 LISLIVEELQTDAVICSVENGGMLGSRKGVNLPGTIVDLPAVSEKDCKD-LQFGVEQGVDIIFASFIRNAEGIRTIRKVL 289
Cdd:PTZ00066 166 SLSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLL 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  290 GEKGKKIKIIAKIENQEGVDNADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKP 369
Cdd:PTZ00066 246 GERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNP 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  370 RPTRAEGSDVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATS 449
Cdd:PTZ00066 326 RPTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVE 405

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  450 AAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVHYPAERaadwptDVDNRINHAIAIGK 529
Cdd:PTZ00066 406 TAEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQ------GTDVVIRNAIALAK 479

                        490       500       510
                 ....*....|....*....|....*....|....
gi 17506829  530 DRGFIHKGDFLVVVTGWRQG-AGATNTLRIITAE 562
Cdd:PTZ00066 480 ERGLVESGDSAIAVHGVKEEvAGSSNLMKVVKIP 513
PRK06354 PRK06354
pyruvate kinase; Provisional
 74-558 7.41e-155

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 455.92  E-value: 7.41e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   74 PHLVRQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAAdsFSDKRVIGIALDTKGPEIRTG 153
Cdd:PRK06354   4 RDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREAS--KKLGKTVGILQDLQGPKIRLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  154 LLAGGAsaeIELARGASIRLTTDPhfsESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDA--VICSVENG 231
Cdd:PRK06354  82 RFEDGP---IELKTGDEFILTSRE---VLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  232 GMLGSRKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKI-ENQEGVDN 310
Cdd:PRK06354 156 GVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHNGKHIPIIAKiEKQEAIDN 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  311 ADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCV 390
Cdd:PRK06354 236 IDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAV 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  391 MLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTD-----MSHTiaiaatsaAASCHASAILLITTT 465
Cdd:PRK06354 316 MLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEFTTTITNaisqaVSHI--------ALQLDAAAIVTLTKS 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  466 GRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVhypaeRAADWPTdVDNRINHAIAIGKDRGFIHKGDfLVVVT- 544
Cdd:PRK06354 388 GATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPL-----LVLDAPS-TDETFDAAINVAQESGLLKQGD-LVVITa 460

                        490
                 ....*....|....*
gi 17506829  545 GWRQG-AGATNTLRI 558
Cdd:PRK06354 461 GTLVGeSGSTDLMKV 475
PRK06247 PRK06247
pyruvate kinase; Provisional
 78-558 2.78e-140

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 414.71  E-value: 2.78e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   78 RQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSdkRVIGIALDTKGPEIRTGLLAG 157
Cdd:PRK06247   5 RRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETG--RPIGILADLQGPKLRLGRFAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  158 GAsaeIELARGASIRLTTDPhfsESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSR 237
Cdd:PRK06247  83 GK---VQLANGQTFRLDVDD---APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  238 KGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIakiENQEGVDNADEIISE 317
Cdd:PRK06247 157 KGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGRVPVMAKI---EKPQAIDRLEAIVEA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  318 SDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETA 397
Cdd:PRK06247 234 SDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETA 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  398 KGEYPVDALKIMHYICKEAEAAVYHRRLFDelLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKP 477
Cdd:PRK06247 314 SGKYPVEAVRTMARIIRQVERDPTYPPLIH--AQRPQPEATKRDAISYAARDIAERLDLAALVAYTSSGDTALRAARERP 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  478 AVPILTISRDVAVCRQLHLYRGVFPVhypaerAADWPTDVDNRINHAIAIGKDRGFIHKGDFLVVVTGWRQG-AGATNTL 556
Cdd:PRK06247 392 PLPILALTPNPETARRLALTWGVHCV------VVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGtPGSTNML 465


                 ..
gi 17506829  557 RI 558
Cdd:PRK06247 466 RI 467
PLN02765 PLN02765
pyruvate kinase
 80-562 2.85e-103

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 321.23  E-value: 2.85e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   80 TGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSfsDKRVIGIALDTKGPEIRtglLAGGA 159
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN--TKKLCAVMLDTVGPELQ---VINKT 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  160 SAEIELARGASIRLTTDPhfSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLIS--------LIVEELQTDAVICSVENG 231
Cdd:PLN02765 105 EKPISLKAGNTVTLTPDQ--SKEASSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVCTVKNS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  232 GML-GSRKGVNLPGTIVDLPAVSEKDCKDL-QFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKII-AKIENQEGV 308
Cdd:PLN02765 183 ATLaGSLFTLHVSQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLSQTQIfAKIENVEGL 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  309 DNADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVIcATQMLESMVHKPRPTRAEGSDVANAVLDGAD 388
Cdd:PLN02765 263 THFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAVLDGAD 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  389 CVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPtdMSHTIAIAATSAAASCHASAILLI--TTTG 466
Cdd:PLN02765 342 AILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEP--MSHLESIASSAVRAAIKVKASVIIvfTSSG 419

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  467 RSAIQCSRYKPAVPILTIsrdvaVC------------------RQLHLYRGVFPVHYPAERAADWPTDVDNRI-NHAIAI 527
Cdd:PLN02765 420 RAARLIAKYRPTMPVLSV-----VIprlktnqlkwsftgafqaRQCLIVRGLFPMLADPRHSAESTSATNESVlKVALDH 494

                        490       500       510
                 ....*....|....*....|....*....|....*
gi 17506829  528 GKDRGFIHKGDFLVVVtgwrQGAGATNTLRIITAE 562
Cdd:PLN02765 495 GKAAGVIKSHDRVVVC----QKVGDSSVVKIIELD 525
PLN02623 PLN02623
pyruvate kinase
 74-548 1.07e-102

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 321.49  E-value: 1.07e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   74 PHLVRQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSDKrVIGIALDTKGPEIRTG 153
Cdd:PLN02623 106 PSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDN-VIAIMLDTKGPEVRSG 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  154 ------LLAGGASAEIELARGAsirlttdphfsesGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICS 227
Cdd:PLN02623 185 dlpqpiMLEEGQEFTFTIKRGV-------------STEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCE 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  228 VENGGMLGSRKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKIENQEG 307
Cdd:PLN02623 252 VVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADS 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  308 VDNADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGA 387
Cdd:PLN02623 332 IPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGA 411

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  388 DCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLFDELLQNTQK---------PTDMSHTiaiaatsaaascHASA 458
Cdd:PLN02623 412 DAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNhmsemfafhATMMANT------------LGTS 479

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  459 ILLITTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVHypaeraADWPTDVDNRINHAIAIGKDRGFIHKGD 538
Cdd:PLN02623 480 IIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIY------MQFSDDAEETFARALSLLLNKGMVKEGE 553

                        490
                 ....*....|
gi 17506829  539 FLVVVTGWRQ 548
Cdd:PLN02623 554 EVALVQSGRQ 563
PRK06739 PRK06739
pyruvate kinase; Validated
 83-417 9.47e-102

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 311.49  E-value: 9.47e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   83 ICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSfsdkrvIGIALDTKGPEIRTGLLAGgasAE 162
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS------IKILGDVQGPKIRLGEIKG---EQ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  163 IELARGASIRLTTDPhfsESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSVENGGMLGSRKGVNL 242
Cdd:PRK06739  77 ITLQAGDSFILHTQP---VTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  243 PGTIVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKI-KIIAKIENQEGVDNADEIISESDGV 321
Cdd:PRK06739 154 PGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKEADGI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  322 MVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETAKGEY 401
Cdd:PRK06739 234 MIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEH 313

                        330
                 ....*....|....*.
gi 17506829  402 PVDALKIMHYICKEAE 417
Cdd:PRK06739 314 PIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 77-544 6.17e-83

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 267.77  E-value: 6.17e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   77 VRQTGIICTIGPACASVEMLQKLILNGMNIARLNFSHGSHEYHAGTIANVRE--AADSFSdkrvIGIALDTKGPEIRTGL 154
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRlnEEKGFA----VAVMMDTEGSEIHMGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  155 LAGGASAEIElarGASIRLTTDPHFSESGTAVNLFVDYKNIAKVLSVGSRVYIDDGLISL-IVEELQTDaVICSVENGGM 233
Cdd:PLN02762 100 LGGASSAKAE---DGEEWTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKIGPD-VKCKCTDPGL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  234 LGSRKGVNL--PGTIVD-----LPAVSEKDCKDLQFGVEQGVDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKI--EN 304
Cdd:PLN02762 176 LLPRANLTFwrDGSLVRernamLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDSDIGVIAkiES 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  305 QEGVDNADEIISESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVL 384
Cdd:PLN02762 256 LDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEAVR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  385 DGADCVMLSGETAKGEYPVDALKI-------MHYICKEAEaavYHRRLfdELLQNTQKPTD-MSHTIAIAATSAAASCHA 456
Cdd:PLN02762 336 QRADALMLSGESAMGLYPEKALSVlrsvslrMELWSREEK---RHEAL--ELPQLSSSLSDrISEEICNSAAKMANNLGV 410

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  457 SAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVHYpaeraaDWPTDVDNRINHAIAIGKDRGFIHK 536
Cdd:PLN02762 411 DAIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRL------DFSDDMESNLNKTFSLLKARGMIKS 484


                 ....*...
gi 17506829  537 GDFLVVVT 544
Cdd:PLN02762 485 GDLVIAVS 492
PRK08187 PRK08187
pyruvate kinase; Validated
 78-409 1.44e-45

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 167.50  E-value: 1.44e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   78 RQTGIICTIGPACASVE--MLQkLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSdkRVIGIALDTKGPEIRTGLL 155
Cdd:PRK08187 133 RRTRIMVTLPSEAADDPdfVLR-LAERGMDCARINCAHDDPAAWQAMIGHLRQAERATG--RRCKILMDLAGPKIRTGAV 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  156 AGGASAEiELARGASIRLTTDPHFS---ESGTAVNLFVdyKNIAKVLSVGSRVYIDDGLISLIVEELQTDAVICSV---- 228
Cdd:PRK08187 210 AGPLGKT-RLYTGDRLALVAQGPPRridEEHFQVTCTL--PEILARLAVGARVWIDDGKLGARVERVGPGGALLEVthar 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  229 ENGGMLGSRKGVNLPGTIVDLPAVSEKDCKDLQFGVEQGvDIIFASFIRNAEGIRTIRKVLGEKGKKIKIIAKI----EN 304
Cdd:PRK08187 287 PKGLKLKPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEALQAALAARRPDDWRKLGLvlkiET 365

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  305 QEGVDNADEIISESDG-----VMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDV 379
Cdd:PRK08187 366 PRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMTDA 445

                        330       340       350
                 ....*....|....*....|....*....|
gi 17506829  380 ANAvlDGADCVMLSgetaKGEYPVDALKIM 409
Cdd:PRK08187 446 AMA--ARAECVMLN----KGPYLVEAVTFL 469
PRK14725 PRK14725
pyruvate kinase; Provisional
 94-424 9.82e-38

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 147.40  E-value: 9.82e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   94 EMLQKLILNGMNIARLNFSHGSHEYHAGTIANVREAADSFSdkRVIGIALDTKGPEIRTGLLAGGA-------------- 159
Cdd:PRK14725 156 DLVRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELG--RRCRIAMDLAGPKLRTGPIAPGPrviklrptrdalgr 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  160 --------------------------------------SAEIEL--ARGASIRLT----TDPHFS---------ESGTA- 185
Cdd:PRK14725 234 vltparlwltasespppspppgpvglpvdpewlarlepGDELRFtdARGKKRKLTvtevDDEGVLaegsqtaylANGTLl 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  186 -------------------VNLFVDYK-----------------NIAKV----------LSVGSRVYIDDGLISLIVEEL 219
Cdd:PRK14725 314 rlgrhdstrvgglppveqkLRLKVGDRlvltrddapgdpaqgdaPPARIsctlpeafraARVGERVWFDDGKIGAVVVKV 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  220 QTDAVICSVENGGMLGSR----KGVNLPGTIVDLPAVSEKDCKDLQFGVEQGvDIIFASFIRNAEGIRTIRKVLGEKGKK 295
Cdd:PRK14725 394 EADEVELRITHARPGGSKlkagKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSFVRSPEDVRLLLDALEKLGAD 472

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829  296 IKIIAKI-ENQEGVDNADEII-----SESDGVMVARGDLGIEIPAEKVFLAQKMLISKCNRAGKPVICATQMLESMVHKP 369
Cdd:PRK14725 473 DLGVVLKiETRRAFENLPRILleamrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKG 552

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 17506829  370 RPTRAEGSDVANAVLdgADCVMLSgetaKGEYPVDALKIMHYICKEAEAAVYHRR 424
Cdd:PRK14725 553 LPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRVLDDILRRMEEHQRKKR 601
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
347-561 2.79e-31

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 123.86  E-value: 2.79e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 347 KCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDGADCVMLSGETAKGEYPVDALKIMHYICKEAEAAVYHRRLF 426
Cdd:COG3848   1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYREQR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829 427 DEllQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVHYP 506
Cdd:COG3848  81 VP--RAKESSTTITDAISHAVATTAADLGAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVE 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17506829 507 AeraadwPTDVDNRINHAIAIGKDRGFIHKGDfLVVVT-GWRQG-AGATNTLRIITA 561
Cdd:COG3848 159 E------SASTDEMFAVAVALALEAGLVKDGD-LVVITaGVPVGvSGTTNLLKVHVV 208
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 463-559 3.33e-28

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 108.72  E-value: 3.33e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506829   463 TTTGRSAIQCSRYKPAVPILTISRDVAVCRQLHLYRGVFPVHYPAeraadwPTDVDNRINHAIAIGKDRGFIHKGDFLVV 542
Cdd:pfam02887  23 TESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEMLRRAVKVAKEAGLVKKGDLVVI 96

                          90
                  ....*....|....*...
gi 17506829   543 VTGWRQG-AGATNTLRII 559
Cdd:pfam02887  97 TAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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