Uncharacterized protein CELE_F58D5.3 [Caenorhabditis elegans]
Protein Classification
O-fucosyltransferase family protein( domain architecture ID 94843)
O-fucosyltransferase family protein may be involved in glycan metabolism by O-fucosylation of protein substrates
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| O-FucT_like super family | cl16914 | GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ... |
80-354 | 9.20e-20 | |||||
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. The actual alignment was detected with superfamily member cd11301: Pssm-ID: 450121 Cd Length: 265 Bit Score: 87.90 E-value: 9.20e-20
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| Name | Accession | Description | Interval | E-value | |||||
| Fut1_Fut2_like | cd11301 | Alpha-1,2-fucosyltransferase; Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer ... |
80-354 | 9.20e-20 | |||||
Alpha-1,2-fucosyltransferase; Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer of alpha-L-fucose to the terminal beta-D-galactose residue of glycoconjugates via an alpha-1,2-linkage, generating carbohydrate structures that exhibit H-antigenicity for blood-group carbohydrates. These structures also act as ligands for morphogenesis, the adhesion of microbes, and metastasizing cancer cells. Fut1 is responsible for producing the H antigen on red blood cells. Fut2 is expressed in epithelia of secretory tissues, and individuals termed "secretors" have at least one functional copy of the gene; they secrete H antigen which is further processed into A and/or B antigens depending on the ABO genotype. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. Pssm-ID: 211387 Cd Length: 265 Bit Score: 87.90 E-value: 9.20e-20
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| Name | Accession | Description | Interval | E-value | |||||
| Fut1_Fut2_like | cd11301 | Alpha-1,2-fucosyltransferase; Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer ... |
80-354 | 9.20e-20 | |||||
Alpha-1,2-fucosyltransferase; Alpha-1,2-fucosyltransferases (Fut1, Fut2) catalyze the transfer of alpha-L-fucose to the terminal beta-D-galactose residue of glycoconjugates via an alpha-1,2-linkage, generating carbohydrate structures that exhibit H-antigenicity for blood-group carbohydrates. These structures also act as ligands for morphogenesis, the adhesion of microbes, and metastasizing cancer cells. Fut1 is responsible for producing the H antigen on red blood cells. Fut2 is expressed in epithelia of secretory tissues, and individuals termed "secretors" have at least one functional copy of the gene; they secrete H antigen which is further processed into A and/or B antigens depending on the ABO genotype. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes. Pssm-ID: 211387 Cd Length: 265 Bit Score: 87.90 E-value: 9.20e-20
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