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Conserved domains on  [gi|17509629|ref|NP_493346|]
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Protein CASC3 [Caenorhabditis elegans]

Protein Classification

Btz domain-containing protein( domain architecture ID 10660175)

Btz domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 55-165 1.09e-26

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


:

Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 104.45  E-value: 1.09e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509629     55 RSGGDSEEKEDEAAedGPEDGEEKSNLDDDQNVENPAYIPKTGRFYMHDDNRRGDVNNSQvQDDDSDDRRNLKKSraDCD 134
Cdd:smart01044   1 RGSGDGDEKSAPVA--NKETGKMRRRLEDDEYKKNPAYVPKRGAFFMHDDRFAEPEANGN-RPKGRGRRRLWQTD--EGR 75

                           90       100       110
                   ....*....|....*....|....*....|.
gi 17509629    135 WKHDRFDEKFQRPKTKKQIVTKYGFDIRHKD 165
Cdd:smart01044  76 WTHDRFEEDEQAPKSRPELVSTYGYDIRSKD 106
 
Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 55-165 1.09e-26

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 104.45  E-value: 1.09e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509629     55 RSGGDSEEKEDEAAedGPEDGEEKSNLDDDQNVENPAYIPKTGRFYMHDDNRRGDVNNSQvQDDDSDDRRNLKKSraDCD 134
Cdd:smart01044   1 RGSGDGDEKSAPVA--NKETGKMRRRLEDDEYKKNPAYVPKRGAFFMHDDRFAEPEANGN-RPKGRGRRRLWQTD--EGR 75

                           90       100       110
                   ....*....|....*....|....*....|.
gi 17509629    135 WKHDRFDEKFQRPKTKKQIVTKYGFDIRHKD 165
Cdd:smart01044  76 WTHDRFEEDEQAPKSRPELVSTYGYDIRSKD 106
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 55-166 6.88e-10

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 57.14  E-value: 6.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509629    55 RSGGDSEEKEDEAAEDGPEDGEEKSNLDDDQNVENPAYIPKTGRFYMHDDNRRGDVNNSQVQDDDSD--DRRNLKKSRAD 132
Cdd:pfam09405   6 SQSGRTPSAPPTEPKEDAERKRREHEKYEKERDENPAFVPTRGAFFLHDDRFAEPAANGFGKSKGRPygRRRRLWDDASE 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 17509629   133 CDWKHDRFDEKF--QRPKTKKQIVTKYGFDIRHKDG 166
Cdd:pfam09405  86 GKWTHDLFEEVAgeQAPKSKPERVPRSGYDIRNGPG 121
 
Name Accession Description Interval E-value
Btz smart01044
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 55-165 1.09e-26

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 214991 [Multi-domain]  Cd Length: 106  Bit Score: 104.45  E-value: 1.09e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509629     55 RSGGDSEEKEDEAAedGPEDGEEKSNLDDDQNVENPAYIPKTGRFYMHDDNRRGDVNNSQvQDDDSDDRRNLKKSraDCD 134
Cdd:smart01044   1 RGSGDGDEKSAPVA--NKETGKMRRRLEDDEYKKNPAYVPKRGAFFMHDDRFAEPEANGN-RPKGRGRRRLWQTD--EGR 75

                           90       100       110
                   ....*....|....*....|....*....|.
gi 17509629    135 WKHDRFDEKFQRPKTKKQIVTKYGFDIRHKD 165
Cdd:smart01044  76 WTHDRFEEDEQAPKSRPELVSTYGYDIRSKD 106
Btz pfam09405
CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility ...
 55-166 6.88e-10

CASC3/Barentsz eIF4AIII binding; This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide.


Pssm-ID: 430588 [Multi-domain]  Cd Length: 121  Bit Score: 57.14  E-value: 6.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509629    55 RSGGDSEEKEDEAAEDGPEDGEEKSNLDDDQNVENPAYIPKTGRFYMHDDNRRGDVNNSQVQDDDSD--DRRNLKKSRAD 132
Cdd:pfam09405   6 SQSGRTPSAPPTEPKEDAERKRREHEKYEKERDENPAFVPTRGAFFLHDDRFAEPAANGFGKSKGRPygRRRRLWDDASE 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 17509629   133 CDWKHDRFDEKF--QRPKTKKQIVTKYGFDIRHKDG 166
Cdd:pfam09405  86 GKWTHDLFEEVAgeQAPKSKPERVPRSGYDIRNGPG 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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