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Conserved domains on  [gi|17509953|ref|NP_493365|]
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Eukaryotic translation initiation factor 3 30 kDa subunit [Caenorhabditis elegans]

Protein Classification

eukaryotic translation initiation factor 3 subunit J( domain architecture ID 5326)

eukaryotic translation initiation factor 3 (eIF3) subunit J is a component of the eIF3 complex that is required for several steps in the initiation of protein synthesis

CATH:  1.10.246.60
Gene Ontology:  GO:0003743|GO:0005852|GO:0006413|GO:0001732|GO:0042802

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eIF3_subunit super family cl07276
Translation initiation factor eIF3 subunit; This is a family of proteins which are subunits of ...
 1-151 2.51e-03

Translation initiation factor eIF3 subunit; This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3). In yeast it is called Hcr1. The Saccharomyces cerevisiae protein Swiss:Q05775 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p.


The actual alignment was detected with superfamily member pfam08597:

Pssm-ID: 462530  Cd Length: 239  Bit Score: 37.66  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509953     1 MSDWEDDDFEPEVSTFKRAEPAPEPVKIVDAPPPPQKAAPAAPKTLKAAPTFAMESLGRELTSAEKE-AIQKKNDLALAR 79
Cdd:pfam08597  34 KDSWDAEEEEEEEKEKAAKAAAAKAKKKKKSKKQKIAEKEAERKAEEEAEEEEELTPEDEAARKLRLrKAEEESDLENAA 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17509953    80 DLFGDDDSAEATDEAKTY--ANIMSKADFEYWGERVGGFLASRSKAS-CYGDMIGKLLTSVTDEMTPAEILKMVT 151
Cdd:pfam08597 114 DLFGGAGDPTKDTDLSSLdlFNPKTKEDFEELRKALAPKLTKYEKKSpHYSAFLEELIRDLAKPLSSEDIKKIAS 188
 
Name Accession Description Interval E-value
eIF3_subunit pfam08597
Translation initiation factor eIF3 subunit; This is a family of proteins which are subunits of ...
 1-151 2.51e-03

Translation initiation factor eIF3 subunit; This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3). In yeast it is called Hcr1. The Saccharomyces cerevisiae protein Swiss:Q05775 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p.


Pssm-ID: 462530  Cd Length: 239  Bit Score: 37.66  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509953     1 MSDWEDDDFEPEVSTFKRAEPAPEPVKIVDAPPPPQKAAPAAPKTLKAAPTFAMESLGRELTSAEKE-AIQKKNDLALAR 79
Cdd:pfam08597  34 KDSWDAEEEEEEEKEKAAKAAAAKAKKKKKSKKQKIAEKEAERKAEEEAEEEEELTPEDEAARKLRLrKAEEESDLENAA 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17509953    80 DLFGDDDSAEATDEAKTY--ANIMSKADFEYWGERVGGFLASRSKAS-CYGDMIGKLLTSVTDEMTPAEILKMVT 151
Cdd:pfam08597 114 DLFGGAGDPTKDTDLSSLdlFNPKTKEDFEELRKALAPKLTKYEKKSpHYSAFLEELIRDLAKPLSSEDIKKIAS 188
 
Name Accession Description Interval E-value
eIF3_subunit pfam08597
Translation initiation factor eIF3 subunit; This is a family of proteins which are subunits of ...
 1-151 2.51e-03

Translation initiation factor eIF3 subunit; This is a family of proteins which are subunits of the eukaryotic translation initiation factor 3 (eIF3). In yeast it is called Hcr1. The Saccharomyces cerevisiae protein Swiss:Q05775 has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p.


Pssm-ID: 462530  Cd Length: 239  Bit Score: 37.66  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17509953     1 MSDWEDDDFEPEVSTFKRAEPAPEPVKIVDAPPPPQKAAPAAPKTLKAAPTFAMESLGRELTSAEKE-AIQKKNDLALAR 79
Cdd:pfam08597  34 KDSWDAEEEEEEEKEKAAKAAAAKAKKKKKSKKQKIAEKEAERKAEEEAEEEEELTPEDEAARKLRLrKAEEESDLENAA 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17509953    80 DLFGDDDSAEATDEAKTY--ANIMSKADFEYWGERVGGFLASRSKAS-CYGDMIGKLLTSVTDEMTPAEILKMVT 151
Cdd:pfam08597 114 DLFGGAGDPTKDTDLSSLdlFNPKTKEDFEELRKALAPKLTKYEKKSpHYSAFLEELIRDLAKPLSSEDIKKIAS 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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