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Conserved domains on  [gi|392889146|ref|NP_494001|]
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MATH domain-containing protein [Caenorhabditis elegans]

Protein Classification

MATH domain-containing protein( domain architecture ID 10637326)

MATH (meprin and TRAF-C homology) domain-containing protein similar to Caenorhabditis elegans MATH domain-containing protein

Gene Ontology:  GO:0005515
PubMed:  12387856|17633013

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MATH smart00061
meprin and TRAF homology;
5-91 3.70e-14

meprin and TRAF homology;


:

Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 67.71  E-value: 3.70e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146     5 LLQHEFNNVGGLEENGGMTGTSETFGKFKWRLGIINSKGYLWLSLTCERLSKDVE--QVKTDFKLILISENGNRWaKNFD 82
Cdd:smart00061   1 VLSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSRkwSIEAEFTLKLVSQNGKSL-SKKD 79


                   ....*....
gi 392889146    83 GYCFKFNGT 91
Cdd:smart00061  80 KHVFEKPSG 88
MATH smart00061
meprin and TRAF homology;
139-233 5.64e-12

meprin and TRAF homology;


:

Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 61.55  E-value: 5.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146   139 QVFKNVQALMPGDDVYSERQSHLNLWWKLQIRRDATSLGVCVCC-KADDQKRRRKLRADLILALVSENGNRFAVKlKDAC 217
Cdd:smart00061   4 HTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCeKEECDSRKWSIEAEFTLKLVSQNGKSLSKK-DKHV 82

                           90
                   ....*....|....*.
gi 392889146   218 FDLISSETYncqGKFI 233
Cdd:smart00061  83 FEKPSGWGF---SKFI 95
 
Name Accession Description Interval E-value
MATH smart00061
meprin and TRAF homology;
5-91 3.70e-14

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 67.71  E-value: 3.70e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146     5 LLQHEFNNVGGLEENGGMTGTSETFGKFKWRLGIINSKGYLWLSLTCERLSKDVE--QVKTDFKLILISENGNRWaKNFD 82
Cdd:smart00061   1 VLSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSRkwSIEAEFTLKLVSQNGKSL-SKKD 79


                   ....*....
gi 392889146    83 GYCFKFNGT 91
Cdd:smart00061  80 KHVFEKPSG 88
MATH smart00061
meprin and TRAF homology;
139-233 5.64e-12

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 61.55  E-value: 5.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146   139 QVFKNVQALMPGDDVYSERQSHLNLWWKLQIRRDATSLGVCVCC-KADDQKRRRKLRADLILALVSENGNRFAVKlKDAC 217
Cdd:smart00061   4 HTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCeKEECDSRKWSIEAEFTLKLVSQNGKSLSKK-DKHV 82

                           90
                   ....*....|....*.
gi 392889146   218 FDLISSETYncqGKFI 233
Cdd:smart00061  83 FEKPSGWGF---SKFI 95
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 141-256 9.53e-07

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 47.25  E-value: 9.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146  141 FKNVQALMPGDDVYSERQSHLNLWWKLQIRRDATSLGVCVCC-KADDQKRRRKLRADLILALVSENGNRFAVKLKdACFD 219
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCdKEEELERGWSIETEFTLKLVSSNGKSVTKTDT-HVFE 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 392889146  220 LISSETYncqGKFIlEWRSI-GDFLNNGKMRVEAKVNV 256
Cdd:pfam00917  80 KPKGWGW---GKFI-SWDDLeKDYLVDDSITVEAHVKI 113
MATH cd00121
MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded ...
 140-254 4.72e-06

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.


Pssm-ID: 238068  Cd Length: 126  Bit Score: 45.83  E-value: 4.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146 140 VFKNV-QALMPGDDVYSERQSHLNLWWKLQIRR-----DATSLGVCVCC-KADDQKRRRKLRADLILALVSENGNRFAVK 212
Cdd:cd00121    4 TWKIVnFSELEGESIYSPPFEVGGYKWRIRIYPngdgeSGDYLSLYLELdKGESDLEKWSVRAEFTLKLVNQNGGKSLSK 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 392889146 213 LKDACFdliSSETYNCQG--KFIlEWRSIGD--FLNNGKMRVEAKV 254
Cdd:cd00121   84 SFTHVF---FSEKGSGWGfpKFI-SWDDLEDsyYLVDDSLTIEVEV 125
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 10-120 1.06e-05

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 44.17  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146   10 FNNVGGLEENGGMTGTSETFGKFKWRLGIINSKGYLWLSLTCERLSKD--VEQVKTDFKLILISENGNRWAKNFDGYCFK 87
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCDKEEELerGWSIETEFTLKLVSSNGKSVTKTDTHVFEK 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 392889146   88 FNGTGVHKkserIVGWGSLKNDFLVDGKIKVQA 120
Cdd:pfam00917  81 PKGWGWGK----FISWDDLEKDYLVDDSITVEA 109
 
Name Accession Description Interval E-value
MATH smart00061
meprin and TRAF homology;
5-91 3.70e-14

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 67.71  E-value: 3.70e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146     5 LLQHEFNNVGGLEENGGMTGTSETFGKFKWRLGIINSKGYLWLSLTCERLSKDVE--QVKTDFKLILISENGNRWaKNFD 82
Cdd:smart00061   1 VLSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSRkwSIEAEFTLKLVSQNGKSL-SKKD 79


                   ....*....
gi 392889146    83 GYCFKFNGT 91
Cdd:smart00061  80 KHVFEKPSG 88
MATH smart00061
meprin and TRAF homology;
139-233 5.64e-12

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 61.55  E-value: 5.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146   139 QVFKNVQALMPGDDVYSERQSHLNLWWKLQIRRDATSLGVCVCC-KADDQKRRRKLRADLILALVSENGNRFAVKlKDAC 217
Cdd:smart00061   4 HTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCeKEECDSRKWSIEAEFTLKLVSQNGKSLSKK-DKHV 82

                           90
                   ....*....|....*.
gi 392889146   218 FDLISSETYncqGKFI 233
Cdd:smart00061  83 FEKPSGWGF---SKFI 95
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 141-256 9.53e-07

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 47.25  E-value: 9.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146  141 FKNVQALMPGDDVYSERQSHLNLWWKLQIRRDATSLGVCVCC-KADDQKRRRKLRADLILALVSENGNRFAVKLKdACFD 219
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCdKEEELERGWSIETEFTLKLVSSNGKSVTKTDT-HVFE 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 392889146  220 LISSETYncqGKFIlEWRSI-GDFLNNGKMRVEAKVNV 256
Cdd:pfam00917  80 KPKGWGW---GKFI-SWDDLeKDYLVDDSITVEAHVKI 113
MATH cd00121
MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded ...
 140-254 4.72e-06

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.


Pssm-ID: 238068  Cd Length: 126  Bit Score: 45.83  E-value: 4.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146 140 VFKNV-QALMPGDDVYSERQSHLNLWWKLQIRR-----DATSLGVCVCC-KADDQKRRRKLRADLILALVSENGNRFAVK 212
Cdd:cd00121    4 TWKIVnFSELEGESIYSPPFEVGGYKWRIRIYPngdgeSGDYLSLYLELdKGESDLEKWSVRAEFTLKLVNQNGGKSLSK 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 392889146 213 LKDACFdliSSETYNCQG--KFIlEWRSIGD--FLNNGKMRVEAKV 254
Cdd:cd00121   84 SFTHVF---FSEKGSGWGfpKFI-SWDDLEDsyYLVDDSLTIEVEV 125
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 10-120 1.06e-05

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 44.17  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392889146   10 FNNVGGLEENGGMTGTSETFGKFKWRLGIINSKGYLWLSLTCERLSKD--VEQVKTDFKLILISENGNRWAKNFDGYCFK 87
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCDKEEELerGWSIETEFTLKLVSSNGKSVTKTDTHVFEK 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 392889146   88 FNGTGVHKkserIVGWGSLKNDFLVDGKIKVQA 120
Cdd:pfam00917  81 PKGWGWGK----FISWDDLEKDYLVDDSITVEA 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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