MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627    11 VKNIAAMKEGDSQSTTSEQHFGLPWYFKVFCKDKHLQLCVYYGAQLIAE-EQSIEVECDFKMITPTGKIfVEKTGVRKYG 89
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCDKEEELErGWSIETEFTLKLVSSNGKS-VTKTDTHVFE 79

                          90       100
                  ....*....|....*....|...
gi 17531627    90 GETqyiGIGFPKFMLWEKMMKEF 112
Cdd:pfam00917  80 KPK---GWGWGKFISWDDLEKDY 99

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627    11 VKNIAAMKEGDSQSTTSEQHFGLPWYFKVFCKDKHLQLCVYYGAQLIAE-EQSIEVECDFKMITPTGKIfVEKTGVRKYG 89
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCDKEEELErGWSIETEFTLKLVSSNGKS-VTKTDTHVFE 79

                          90       100
                  ....*....|....*....|...
gi 17531627    90 GETqyiGIGFPKFMLWEKMMKEF 112
Cdd:pfam00917  80 KPK---GWGWGKFISWDDLEKDY 99

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627    150 DVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIADMY 229
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|...
gi 17531627    230 NAKLVTQNCENFL 242
Cdd:smart00225  81 QIPGLVELCEEFL 93

meprin and TRAF homology;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627      6 VMTRKVKNIAAMKEGDSQSTTSEQHFGLPWYFKVFCKDKHLQLCVYYGAQLI-AEEQSIEVECDFKMITPTGKIFVEKTG 84
Cdd:smart00061   1 VLSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECdSRKWSIEAEFTLKLVSQNGKSLSKKDK 80

                           90
                   ....*....|....*....
gi 17531627     85 VRKyggeTQYIGIGFPKFM 103
Cdd:smart00061  81 HVF----EKPSGWGFSKFI 95

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627    11 VKNIAAMKEGDSQSTTSEQHFGLPWYFKVFCKDKHLQLCVYYGAQLIAE-EQSIEVECDFKMITPTGKIfVEKTGVRKYG 89
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCDKEEELErGWSIETEFTLKLVSSNGKS-VTKTDTHVFE 79

                          90       100
                  ....*....|....*....|...
gi 17531627    90 GETqyiGIGFPKFMLWEKMMKEF 112
Cdd:pfam00917  80 KPK---GWGWGKFISWDDLEKDY 99

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627    150 DVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIADMY 229
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|...
gi 17531627    230 NAKLVTQNCENFL 242
Cdd:smart00225  81 QIPGLVELCEEFL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 148 FSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIAD 227
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                ..
gi 17531627 228 MY 229
Cdd:cd18186  81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 147 EFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIA 226
Cdd:cd18257  17 ELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAA 96

                        90
                ....*....|....*.
gi 17531627 227 DMYNAKLVTQNCENFL 242
Cdd:cd18257  97 NLLQIKLVLKECCDFL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17531627 151 VVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIADMY 229
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 150 DVVLVVK----ETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLI 225
Cdd:cd18248  23 DVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCVLHVLPG 102

                        90
                ....*....|....*..
gi 17531627 226 ADMYNAKLVTQNCENFL 242
Cdd:cd18248 103 AVMYQMDSVVKACCDFL 119

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 140 NFDEAMKEFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKE-----GNSSEVTLSSIDPNDFQNFLEVLYGHQEAI 214
Cdd:cd18296   9 FPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAEseennGSIPVVTLHDVSPEVFAIVLYYIYTDDTDL 88

                        90
                ....*....|....*
gi 17531627 215 TDESVEGVLLIADMY 229
Cdd:cd18296  89 PPENAYDVLYVADMY 103

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 147 EFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITD-ESVEGVLLI 225
Cdd:cd18286  16 EDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLPDdVNLGELLSL 95

                ....*
gi 17531627 226 ADMYN 230
Cdd:cd18286  96 ADMYG 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 148 FSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIAD 227
Cdd:cd18265  23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASD 102

                        90
                ....*....|....*
gi 17531627 228 MYNAKLVTQNCENFL 242
Cdd:cd18265 103 LLQVSKLREACVRFL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 140 NFDEAMKEF------SDVVLVVKETR-FHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQE 212
Cdd:cd18252   7 DFLDAFRTFyldglfTDITLQCASGQiFHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQI 86

                        90       100       110
                ....*....|....*....|....*....|..
gi 17531627 213 AITDESVEGVLLIADMYNAKLVTQNCENFLFR 244
Cdd:cd18252  87 CITERNVQSLLEAADLLQFISVKKACEQFLVR 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 148 FSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIAD 227
Cdd:cd18340  27 FVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAAN 106

                        90
                ....*....|....*
gi 17531627 228 MYNAKLVTQNCENFL 242
Cdd:cd18340 107 MFQIPSIFTVCVSFL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 148 FSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIAD 227
Cdd:cd18270  26 LTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYETAC 105

                        90
                ....*....|....*..
gi 17531627 228 MYNAKLVTQNCENFLFR 244
Cdd:cd18270 106 FLQVEDVLQRCREYLIK 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 150 DVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIADMY 229
Cdd:cd18247  21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGASFL 100

                        90
                ....*....|...
gi 17531627 230 NAKLVTQNCENFL 242
Cdd:cd18247 101 QLQSVKDACCEFL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 150 DVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIADMY 229
Cdd:cd18242  23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLL 102

                        90
                ....*....|...
gi 17531627 230 NAKLVTQNCENFL 242
Cdd:cd18242 103 QLKGVKQACCEFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 147 EFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYghqeaiTDEsvegvlLIA 226
Cdd:cd18280  13 EGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIY------KDE------LPD 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 17531627 227 DMYNAKLVTQncenflfrgAGSKMMLKKQLQLAYRYNLENLKRSCYSNL 275
Cdd:cd18280  81 DVEPAGSDSS---------SLDTTMAQHLLAAADRYALERLRLLCESRL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 148 FSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIAD 227
Cdd:cd18272  32 FADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVAD 111

                        90
                ....*....|....*..
gi 17531627 228 MYNAKLVTQNCENFLFR 244
Cdd:cd18272 112 MYQLTALFEECSRFLAR 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 146 KEFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLI 225
Cdd:cd18269  25 NKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFAL 104

                        90
                ....*....|....*..
gi 17531627 226 ADMYNAKLVTQNCENFL 242
Cdd:cd18269 105 ASRFQIPSIFTVCVSYL 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 147 EFSDVVLVVKETRFHVAKLFLAaQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEV----LYGHQEAITDESVEGV 222
Cdd:cd18305  14 ENSDITICALGREWKLHKIYLC-QSGYFASMFSGSWKESKETVINLEIPDDNITVEALNVvfgsLYRDEIEIKPSRVVSI 92

                        90       100
                ....*....|....*....|
gi 17531627 223 LLIADMYNAKLVTQNCENFL 242
Cdd:cd18305  93 LAAATLLQLDGLIQQCSEVM 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 138 VRNFDEaMKEFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDE 217
Cdd:cd18271  15 LQNFRE-QNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDD 93

                        90       100
                ....*....|....*....|....*..
gi 17531627 218 SVEGVLLIADMYNAKLVTQNCENFLFR 244
Cdd:cd18271  94 NVEMFFQMSSFLQVSLLSKACSDFLIK 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 150 DVVLVV--KETRFHVAKLF------LAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEG 221
Cdd:cd18273  28 DVTIEVngPGSGPGSGRLFpcnrnvLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGRVTLSEANVQR 107

                        90       100
                ....*....|....*....|...
gi 17531627 222 VLLIADMYNAKLVTQNCENFLFR 244
Cdd:cd18273 108 LYAAANMLQLEYVREACASFLAR 130

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 140 NFDEAMKE--FSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDE 217
Cdd:cd18332   9 NLNELRKRdiLTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTSRLPLTPR 88

                        90       100
                ....*....|....*....|....*
gi 17531627 218 SVEGVLLIADMYNAKLVTQNCENFL 242
Cdd:cd18332  89 TVPAVLAAATYLQMEHVVETCRRFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 130 WGFEKKVKVRNFDEAMKEFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYG 209
Cdd:cd18338   3 RHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYT 82

                        90       100       110
                ....*....|....*....|....*....|...
gi 17531627 210 HQEAITDESVEGVLLIADMYNAKLVTQNCENFL 242
Cdd:cd18338  83 AEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17531627 146 KEFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLY-GHQEAITD 216
Cdd:cd18297  10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYtGGVESLDV 81

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 146 KEFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLY-GHQEAITDESVEGVLL 224
Cdd:cd18300   7 GLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYtDQAPILEDGDCVGLIV 86

                ....*
gi 17531627 225 IADMY 229
Cdd:cd18300  87 LANRL 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 146 KEFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLI 225
Cdd:cd18249  21 RELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPA 100

                        90
                ....*....|....*....
gi 17531627 226 ADMYNAKLVTQNCENFLFR 244
Cdd:cd18249 101 ACLLQLAEIQEVCCEFLKR 119

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 150 DVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLIADMY 229
Cdd:cd18263  15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQL 94

                        90
                ....*....|....*.
gi 17531627 230 NAKLVTQNCENFLFRG 245
Cdd:cd18263  95 QISGALALCLDFLQRE 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531627 146 KEFSDVVLVVKETRFHVAKLFLAAQSGYFKALPIGNFKEGNSSEVTLSSIDPNDFQNFLEVLYGHQEAITDESVEGVLLI 225
Cdd:cd18335  17 QQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAA 96