BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347     8 VKLNVGGSVFETWKSTLTKQ-DGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQELKKEA 86
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 17532347    87 EFYLLEHL-VDLC 98
Cdd:pfam02214  81 EFYGLDELaLELC 93

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347     8 VKLNVGGSVFETWKSTLTKQ-DGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQELKKEA 86
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 17532347    87 EFYLLEHL-VDLC 98
Cdd:pfam02214  81 EFYGLDELaLELC 93

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347      8 VKLNVGGSVFETWKSTLTKQDGFFKTLIETNvPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPdsEKELQELKKEAE 87
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSD-FKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP--EENVEELLELAD 78

                           90
                   ....*....|..
gi 17532347     88 FYLLEHLVDLCE 99
Cdd:smart00225  79 YLQIPGLVELCE 90

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347     8 VKLNVGGSVFETWKSTLTKQ-DGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQELKKEA 86
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTGGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 17532347    87 EFYLLEHL-VDLC 98
Cdd:pfam02214  81 EFYGLDELaLELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   8 VKLNVGGSVFETWKSTLTKQDGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQELKKEAE 87
Cdd:cd18369   1 VKLNVGGSLHYTTIGTLTKQDTMLRAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAELLAEAK 80

                        90
                ....*....|.
gi 17532347  88 FYLLEHLVDLC 98
Cdd:cd18369  81 YYLVQGLVEQC 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 10 (KCTD10); KCTD10, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (BACURD3), is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. Furthermore, KCTD10 may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD10 BTB domain forms a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   4 SETIVKLNVGGSVFETWKSTLTKQDGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQELK 83
Cdd:cd18399   5 SSKYVKLNVGGALYYTTMQTLTKQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLPESRREIEELL 84

                        90       100
                ....*....|....*....|....*
gi 17532347  84 KEAEFYLLEHLVDLCEPIKNKIRTY 108
Cdd:cd18399  85 AEAKYYLVQGLVEECQAALQNKDTY 109

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347      8 VKLNVGGSVFETWKSTLTKQDGFFKTLIETNvPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPdsEKELQELKKEAE 87
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSD-FKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLP--EENVEELLELAD 78

                           90
                   ....*....|..
gi 17532347     88 FYLLEHLVDLCE 99
Cdd:smart00225  79 YLQIPGLVELCE 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   7 IVKLNVGGSVFETWKSTLTK-QDGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQELKKE 85
Cdd:cd18365   2 IVNLNVGGVHYTTTLATLTRfPDSMLGAMFSGSMPTTRDDQGNYFIDRDGTLFRYILNFLRSSQLSLPEDFKEYDLLLRE 81

                        90
                ....*....|.
gi 17532347  86 AEFYLLEHLVD 96
Cdd:cd18365  82 ADFYQIEPLIE 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   7 IVKLNVGGSVFETWKSTLTKQ-DGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQELKKE 85
Cdd:cd18364   1 LVTLNVGGYLYITQRQTLTKYpDSFLEGMVNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLALE 80

                ....*.
gi 17532347  86 AEFYLL 91
Cdd:cd18364  81 ADFYQL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   8 VKLNVGGSVFETWKSTLTK-QDGFFKTLI--ETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLpDSEKELQELKK 84
Cdd:cd18362   2 VKLNVGGTYFLTTRTTLCRdPKSFLCRLCqeDPDLPSDKDETGAYLIDRDPTYFGPILNYLRHGKLII-DKDLAEEGVLE 80

                ....*
gi 17532347  85 EAEFY 89
Cdd:cd18362  81 EAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   8 VKLNVGGSVFETWKSTLTK-QDGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQELKKEA 86
Cdd:cd18395   3 ITLNVGGKLYTTSLATLTRyPDSMLGAMFSGKFPTKKDSQGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQEMGLLKREA 82

                        90
                ....*....|...
gi 17532347  87 EFYLLEHLVDLCE 99
Cdd:cd18395  83 DFYQIQPLIEALQ 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 17 (KCTD17); KCTD17 is a BTB/POZ domain-containing protein that functions as a substrate-adaptor for cullin3-RING ubiquitin ligases that polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD17 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   8 VKLNVGGSVFETWKSTLTK-QDGFFKTLIE-TNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLpdsEKELQE--LK 83
Cdd:cd18391   3 VRLNVGGTVFLTTRQTLCReQKSFLSRLCQgEELQSDRDETGAYLIDRDPTYFGPILNFLRHGKLVL---DKDMAEegVL 79

                        90       100
                ....*....|....*....|..
gi 17532347  84 KEAEFYLLEHLVDLcepIKNKI 105
Cdd:cd18391  80 EEAEFYNIGPLIRI---IKDRM 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   7 IVKLNVGGSVFETWKSTLTKQDG-----FFKTLIETNVPvkKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQE 81
Cdd:cd18367   4 IVELNVGGQVYTTSLSTLIKDPDsllgrMFSGKNRQELA--RDSKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERER 81

                        90
                ....*....|....
gi 17532347  82 LKKEAEFYLLEHLV 95
Cdd:cd18367  82 LKREAEYFQLPELV 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   8 VKLNVGGSVFETWKSTLTKQDGFFKTLIETNVP---VKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLpdsEKELQE--L 82
Cdd:cd18389   3 VRLNVGGTYFVSTKQTLCRDPKSFLYRLCQEDPdldSDKDETGAYLIDRDPTYFGPILNYLRHGKLII---NKELAEegV 79

                        90       100
                ....*....|....*....|....
gi 17532347  83 KKEAEFYLLEHLVDLcepIKNKIR 106
Cdd:cd18389  80 LEEAEFYNIASLVRL---VKERIR 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   7 IVKLNVGGSVFETWKSTLT-KQDGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSgvTVLPDSEKELQELKKE 85
Cdd:cd18393   3 VIHLNVGGKRFSTSRQTLTwIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRT--KELDPRGIHVSLLLHE 80

                        90
                ....*....|....*..
gi 17532347  86 AEFYLLEHLV---DLCE 99
Cdd:cd18393  81 AQFYGITPLVrrlQLCE 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   4 SETIVKLNVGGSVFETWKSTLTKQ-DGFFKTLIET--NVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLpdsEKELQ 80
Cdd:cd18390   3 VSKWVRLNVGGTYFLTTRQTLCRDpKSFLYRLCQAdpDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVI---NKDLA 79

                        90       100
                ....*....|....*....|....*...
gi 17532347  81 E--LKKEAEFYLLEHLVDLcepIKNKIR 106
Cdd:cd18390  80 EegVLEEAEFYNITSLIKL---VKDKIR 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   8 VKLNVGGSVFETWKSTLTKQDGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQeLKKEAE 87
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHAYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPAS-FKEELE 79

                ..
gi 17532347  88 FY 89
Cdd:cd18317  80 FW 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   3 FSEtIVKLNVGGSVFETWKSTLTK-QDGFFKTLIETNVP--VKKDTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKEL 79
Cdd:cd18397   1 FPE-IVELNVGGQVYVTRHTTLVSvPDSLLWHMFSQQKPgeLARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPER 79

                        90       100
                ....*....|....*....|.
gi 17532347  80 QELKKEAEFYLLEHLVDLCEP 100
Cdd:cd18397  80 SRLQREAEFFQLPELVKRLNP 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   8 VKLNVGGSVFETWKSTLTK-QDGFFKTLIETNVPVKK----DTSDCYFIDRSPKYFETVLNYMRSGVTVLPDSEKELQEL 82
Cdd:cd18370   1 VTLNVGGTLYSTTLETLTRfPDSMLGAMFRAGTPIPPnlnmQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALL 80

                ....*..
gi 17532347  83 KKEAEFY 89
Cdd:cd18370  81 RAEADFY 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   4 SETIVKLNVGGSVFETWKSTLtkqDGFFKTLI---ETNVPVKKDTSDcYFIDRSPKYFETVLNYMRSGVTVLPDSEKeLQ 80
Cdd:cd18417  33 NDEILVVNVSGRRFQTWKNTL---DRYPDTLLgssEKEFFYNEDTQE-YFFDRDPEMFRHILNFYRTGRLHYPRHEC-IQ 107

                ....*....
gi 17532347  81 ELKKEAEFY 89
Cdd:cd18417 108 AFDEELSFY 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   5 ETIVKLNVGGSVFETWKSTLTKQDGFFKTLIETNVPVKKDTSDcYFIDRSPKYFETVLNYMRSGVTVLPDSEKeLQELKK 84
Cdd:cd18419  34 DELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKE-YFFDRDPEVFRCVLNFYRTGKLHYPRYEC-ISAYDE 111

                        90       100
                ....*....|....*....|....*
gi 17532347  85 EAEFY--LLEHLVDLC-EPIKNKIR 106
Cdd:cd18419 112 ELAFYgiLPEIIGDCCyEEYKDRKR 136

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17532347   8 VKLNVGGSVFETWKSTLTKqdgFFKTLI---ETNVPVKKDTSDcYFIDRSPKYFETVLNYMRSG 68
Cdd:cd18380   2 IVINVSGRRFETWKNTLEK---YPDTLLgstEKEFFYDDDTKE-YFFDRDPEIFRHILNFYRTG 61

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17532347   8 VKLNVGGSVFETWKSTLTK-QDGFFKTLIETNV------PVKKDtsdcYFIDRSPKYFETVLNYMRSG 68
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNlPDTRLAWLTETEAsafdydPVTGE----FFFDRHPGVFAQILNYYRTG 64

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   7 IVKLNVGGSVFETWKSTLTK-QDGFFKTLIETNVPVKKDTSDCYFIDRSPKYFETVLNYMRsGVTVLPDSEKELQELKKE 85
Cdd:cd18372   2 VLRLNVGGCIYTARRESLCRfKDSMLSSMFSGRFPLKLDESGACVIDRDGRLFKYLLDYLH-GELQIPEDEQTRLALQEE 80

                        90       100
                ....*....|....*....|.
gi 17532347  86 AEFY-------LLEHLVDLCE 99
Cdd:cd18372  81 ADYFgipypysLTDHLANEME 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   4 SETIVkLNVGGSVFETWKSTL-----------TKQDGFFKTLIETNVPVKKDTSDC----YFIDRSPKYFETVLNYMRSG 68
Cdd:cd18415   1 NERII-LNVGGTRHETYRSTLktlpgtrlallASSDPQGDCLTQCSQVGGSDGSPGggneFFFDRHPGVFAYVLNYYRTG 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532347   8 VKLNVGGSVFETWKSTLTKQDGFFKTLIETNVPVKKD----TSDCYFIdrSPKYFETVLNYMRSGVTVLpdSEKELQELK 83
Cdd:cd18307   4 VVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDelsiTIDCDYL--SPETVEQLLDYFYTGKIVI--SEKNVEDLL 79

                        90
                ....*....|....*
gi 17532347  84 KEAEFYLLEHLVDLC 98
Cdd:cd18307  80 KGAKYFNIPRLKDHC 94