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Conserved domains on  [gi|17532979|ref|NP_494358|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 10459153)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515|GO:0006511
PubMed:  11178263|31898225
SCOP:  4001927

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FBA_2 pfam07735
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
228-273 1.68e-11

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


:

Pssm-ID: 429626  Cd Length: 67  Bit Score: 59.12  E-value: 1.68e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17532979   228 ITVNDLLVNNCTQLTISRSILTSKDMNIFLKHWINGSIKTLEFLEL 273
Cdd:pfam07735  22 ITLDDLLLINSKKIELDNSRLSLKDLNRFLKHWIKGSNPRLEYLEI 67
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
8-50 5.29e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 5.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17532979     8 LLRLPEKNLRIVLEQMGFLDLLAFSLCSKITKAHTTQLKRKID 50
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
FBA_2 pfam07735
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
228-273 1.68e-11

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 429626  Cd Length: 67  Bit Score: 59.12  E-value: 1.68e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17532979   228 ITVNDLLVNNCTQLTISRSILTSKDMNIFLKHWINGSIKTLEFLEL 273
Cdd:pfam07735  22 ITLDDLLLINSKKIELDNSRLSLKDLNRFLKHWIKGSNPRLEYLEI 67
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
8-50 5.29e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 5.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17532979     8 LLRLPEKNLRIVLEQMGFLDLLAFSLCSKITKAHTTQLKRKID 50
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
FBA_2 pfam07735
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
228-273 1.68e-11

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 429626  Cd Length: 67  Bit Score: 59.12  E-value: 1.68e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17532979   228 ITVNDLLVNNCTQLTISRSILTSKDMNIFLKHWINGSIKTLEFLEL 273
Cdd:pfam07735  22 ITLDDLLLINSKKIELDNSRLSLKDLNRFLKHWIKGSNPRLEYLEI 67
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
8-50 5.29e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 37.13  E-value: 5.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 17532979     8 LLRLPEKNLRIVLEQMGFLDLLAFSLCSKITKAHTTQLKRKID 50
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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