BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791     5 IKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRD-GDLPLPEdERELRELMAE 82
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPE-EVCLDEFLEE 79

                          90
                  ....*....|....
gi 17537791    83 AQFYWLDGLVLMCC 96
Cdd:pfam02214  80 AEFYGLDELALELC 93

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791     5 IKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRD-GDLPLPEdERELRELMAE 82
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPE-EVCLDEFLEE 79

                          90
                  ....*....|....
gi 17537791    83 AQFYWLDGLVLMCC 96
Cdd:pfam02214  80 AEFYGLDELALELC 93

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791      5 IKLDVGGTIFKTSKDTLTKFHSFFKTMLECKTGPKiEKTGCIFIDRSPKHFELILNLMRDGDLPLPEDerELRELMAEAQ 84
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKES-DKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE--NVEELLELAD 78

                           90
                   ....*....|....*
gi 17537791     85 FYWLDGLVLMCCDKL 99
Cdd:smart00225  79 YLQIPGLVELCEEFL 93

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791     5 IKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRD-GDLPLPEdERELRELMAE 82
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFpDTRLGRLLELECDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPE-EVCLDEFLEE 79

                          90
                  ....*....|....
gi 17537791    83 AQFYWLDGLVLMCC 96
Cdd:pfam02214  80 AEFYGLDELALELC 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2); This subfamily of KCTD proteins, also called the BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein (BACURD) subfamily, includes KCTD10 (BACURD3), KCTD13 (BACURD1), and TNFAIP1 (BACURD2). KCTD10 is a BTB/POZ domain-containing protein that interacts with proliferating cell nuclear antigen (PCNA) and polymerase delta, and participates in DNA repair, DNA replication, and cell-cycle control. Its down-regulation could inhibit cell proliferation. KCTD10 also plays crucial roles in embryonic angiogenesis and heart development in mammals by negatively regulating the Notch signaling pathway. KCTD13 is a BTB/POZ domain-containing protein that may function as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of RhoA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. TNFAIP1, also called protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair, cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD10 and KCTD13 BTB domains form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   5 IKLDVGGTIFKTSKDTLTKFHSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLPEDERELRELMAEAQ 84
Cdd:cd18369   1 VKLNVGGSLHYTTIGTLTKQDTMLRAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGSVPLPESRRELAELLAEAK 80

                        90
                ....*....|.
gi 17537791  85 FYWLDGLVLMC 95
Cdd:cd18369  81 YYLVQGLVEQC 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   5 IKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLP-EDERELRELMAE 82
Cdd:cd18376   1 VKLNVGGQKFTTTLDTLTKDpDSMLAAMFSGRHSLKKDEDGSYFIDRDGTHFRHILNYLRDGEVKIPtEDRSVLKELLEE 80

                ....*....
gi 17537791  83 AQFYWLDGL 91
Cdd:cd18376  81 AEYYQLRGL 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   5 IKLDVGGTIFKTSKDTLTKFHSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLPEDERELRELMAEAQ 84
Cdd:cd18401   5 VRLNVGGSLYYTTVQVLTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTVALPKSRQEIKELMAEAK 84

                        90
                ....*....|....*....
gi 17537791  85 FYWLDGLVLMCCDKLNSTK 103
Cdd:cd18401  85 YYLIQGLVDMCQAALQDKK 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   2 SEIIKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLPedERELRELM 80
Cdd:cd18363   1 GDIINLNVGGKRFSTSRQTLTWIpDSFFTSLLSGRISSLKDETGAIFIDRDPKLFSIILNYLRTKEIDLR--NVDISSLR 78

                ....*.
gi 17537791  81 AEAQFY 86
Cdd:cd18363  79 HEAEFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   4 IIKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLPEDERELRELMAE 82
Cdd:cd18364   1 LVTLNVGGYLYITQRQTLTKYpDSFLEGMVNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQENQLLALE 80

                ....*.
gi 17537791  83 AQFYWL 88
Cdd:cd18364  81 ADFYQL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   3 EIIKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLpeDERELRELMA 81
Cdd:cd18392   2 EIIQLNVGGTRFSTSRQTLMWIpDSFFSSLLSGRISSLKDETGAIFIDRDPTAFVPILNFLRTKELDL--RGVNINVLRH 79

                ....*
gi 17537791  82 EAQFY 86
Cdd:cd18392  80 EAEFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   5 IKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLPEDERELRELMAEA 83
Cdd:cd18395   3 ITLNVGGKLYTTSLATLTRYpDSMLGAMFSGKFPTKKDSQGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQEMGLLKREA 82

                ....*....
gi 17537791  84 QFYWLDGLV 92
Cdd:cd18395  83 DFYQIQPLI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 6 (KCTD6); KCTD6, also called KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3 (KCASH3), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5) as well as suppressing histone deacetylase and Hedgehog activity in medulloblastoma. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   1 MSEIIKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLPEDERELREL 79
Cdd:cd18394   1 MTDPVTLNVGGHLYTTSLSTLTRYpDSMLGAMFRGDFPTARDSQGNYFIDRDGPLFRYILNFLRTSELTLPVDFKEFDLL 80

                        90
                ....*....|...
gi 17537791  80 MAEAQFYWLDGLV 92
Cdd:cd18394  81 RKEADFYQIEPLI 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   1 MSEIIKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKIEK--TGCIFIDRSPKHFELILNLMRDGDLPLPEDERELR 77
Cdd:cd18367   1 FPEIVELNVGGQVYTTSLSTLIKDpDSLLGRMFSGKNRQELARdsKGRYFLDRDGVLFRYILDYLRNQKLVLPENFPERE 80

                        90
                ....*....|....*
gi 17537791  78 ELMAEAQFYWLDGLV 92
Cdd:cd18367  81 RLKREAEYFQLPELV 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17537791   5 IKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPkIEKTGCIFIDRSPKHFELILNLMRDGDLPLPED 72
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFpDTRLGKLAKESHAY-DESTNEYFFDRNPEVFEAILDYYRTGELHLPSN 68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   5 IKLDVGGTIFKTSKDTLTKFHSFFKTMLeCKTGPKI----EKTGCIFIDRSPKHFELILNLMRDGDLPLPEDERElRELM 80
Cdd:cd18389   3 VRLNVGGTYFVSTKQTLCRDPKSFLYRL-CQEDPDLdsdkDETGAYLIDRDPTYFGPILNYLRHGKLIINKELAE-EGVL 80

                        90
                ....*....|....*....
gi 17537791  81 AEAQFYWLDGLVLMCCDKL 99
Cdd:cd18389  81 EEAEFYNIASLVRLVKERI 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   2 SEIIKLDVGGTIFKTSKDTLTKFHSFFKTMLeCKTGPKIE----KTGCIFIDRSPKHFELILNLMRDGDLPLPEDERElR 77
Cdd:cd18390   4 SKWVRLNVGGTYFLTTRQTLCRDPKSFLYRL-CQADPDLDsdkdETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAE-E 81

                        90       100
                ....*....|....*....|..
gi 17537791  78 ELMAEAQFYWLDGLVLMCCDKL 99
Cdd:cd18390  82 GVLEEAEFYNITSLIKLVKDKI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   5 IKLDVGGTIFKTSKDTLTKFHSFFKTMLeCKTGPKI----EKTGCIFIDRSPKHFELILNLMRDGDLPLPEDERElRELM 80
Cdd:cd18362   2 VKLNVGGTYFLTTRTTLCRDPKSFLCRL-CQEDPDLpsdkDETGAYLIDRDPTYFGPILNYLRHGKLIIDKDLAE-EGVL 79

                ....*.
gi 17537791  81 AEAQFY 86
Cdd:cd18362  80 EEAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   5 IKLDVGGTIFKTSKDTLTKFHSFFKTMLECKTGPKIEKT--GCIFIDRSPKHFELILNLMRDGDLPLPEDERELRELMAE 82
Cdd:cd18388   4 VHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPIVLDSlkQHYFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLLYEE 83

                        90
                ....*....|
gi 17537791  83 AQFYWLDGLV 92
Cdd:cd18388  84 AKYYQLQPMV 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   3 EIIKLDVGGTIFKTSKDTLTKFH-SFFKTMLECKTGPKIEKTGCIFIDRSPKHFELILNLMRdGDLPLPEDERELRELMA 81
Cdd:cd18372   1 DVLRLNVGGCIYTARRESLCRFKdSMLSSMFSGRFPLKLDESGACVIDRDGRLFKYLLDYLH-GELQIPEDEQTRLALQE 79

                ....*
gi 17537791  82 EAQFY 86
Cdd:cd18372  80 EADYF 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   2 SEIIKLDVGGTIFKTSKDTLTKF-HSFFKTMLECKTGPKI--EKTGCIFIDRSPKHFELILNLMRDGDLPLPEDERELRE 78
Cdd:cd18397   2 PEIVELNVGGQVYVTRHTTLVSVpDSLLWHMFSQQKPGELarDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSR 81

                        90
                ....*....|....
gi 17537791  79 LMAEAQFYWLDGLV 92
Cdd:cd18397  82 LQREAEFFQLPELV 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17537791   5 IKLDVGGTIFKTSKDTLTKFHSffkTML--ECKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLPEDE 73
Cdd:cd18380   2 IVINVSGRRFETWKNTLEKYPD---TLLgsTEKEFFYDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHE 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   5 IKLDVGGTIFKTSKDTL-----TKFHSFFKTMLECKTGPKIekTGCIFIDRSPKHFELILNLMRDGDLPLPED------E 73
Cdd:cd18379   1 IVINVGGVRHETYKSTLrnlpdTRLAWLTETEASAFDYDPV--TGEFFFDRHPGVFAQILNYYRTGKLHCPADvcgplfE 78

                        90       100
                ....*....|....*....|....
gi 17537791  74 RELrelmaeaQFYWLDGLVL-MCC 96
Cdd:cd18379  79 EEL-------AFWGIDETQIePCC 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17537791   3 EIIKLDVGGTIFKTSKDTLTKFHSFFKTMLEcKTGPKIEKTGCIFIDRSPKHFELILNLMRDGDLPLPEDE 73
Cdd:cd18419  35 ELIVLNVSGRRFQTWRTTLERYPDTLLGSTE-KEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYE 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

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                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537791   9 VGGTIFKTSKDTLTKFHSFFKTmLECKTGPKIEKTGCIFID-RSPKHFELILNLMRDGDLPLpeDERELRELMAEAQFYW 87
Cdd:cd18230  28 VEGKIFKAHKNVLLGSSRYFKT-LYCQVQKTSDQATVTHLDiVTAQGFKAIIDFMYSAHLAL--TSKNVIEVMSAASYLQ 104

                        90       100
                ....*....|....*....|
gi 17537791  88 LDGLVLMCCDKLNSTKKVQI 107
Cdd:cd18230 105 MTDIVQACHNFIKAALDISI 124