NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17537311|ref|NP_494523|]
View 

BTB and MATH domain containing [Caenorhabditis elegans]

Protein Classification

BTB/POZ and MATH domain-containing protein( domain architecture ID 11110254)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and MATH (meprin and TRAF-C homology) domain-containing protein, similar to Caenorhabditis elegans BTB and MATH domain-containing proteins, bath-15 and bath-45, probable substrate-specific adaptors of an E3 ubiquitin-protein ligase complex

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 11-127 2.25e-28

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


:

Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 105.80  E-value: 2.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311    11 FKKVSEFKDGECRCGPLEEHFNVEWLLYINRKDDELAVFLGCNSlQGTEETTLSIYVELKFTLKNSIGTRVTkiaKCLLS 90
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCDK-EEELERGWSIETEFTLKLVSSNGKSVT---KTDTH 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 17537311    91 NKSTESDFGLNKFIGWETLLKDYLIDDSIIIEAKIKI 127
Cdd:pfam00917  77 VFEKPKGWGWGKFISWDDLEKDYLVDDSITVEAHVKI 113
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 144-248 1.10e-25

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


:

Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 98.48  E-value: 1.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311   144 SSEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLYGEPAMDDENVEG 223
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESS---VSEITLDDVSPEDFEALLEFMYTGKLISEENVDD 82

                          90       100
                  ....*....|....*....|....*
gi 17537311   224 ILHSAHMYKMTKVIRNCEEFLSNKS 248
Cdd:pfam00651  83 LLAAADKLQIPSLVDKCEEFLIKSL 107
 
Name Accession Description Interval E-value
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 11-127 2.25e-28

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 105.80  E-value: 2.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311    11 FKKVSEFKDGECRCGPLEEHFNVEWLLYINRKDDELAVFLGCNSlQGTEETTLSIYVELKFTLKNSIGTRVTkiaKCLLS 90
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCDK-EEELERGWSIETEFTLKLVSSNGKSVT---KTDTH 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 17537311    91 NKSTESDFGLNKFIGWETLLKDYLIDDSIIIEAKIKI 127
Cdd:pfam00917  77 VFEKPKGWGWGKFISWDDLEKDYLVDDSITVEAHVKI 113
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 144-248 1.10e-25

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 98.48  E-value: 1.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311   144 SSEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLYGEPAMDDENVEG 223
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESS---VSEITLDDVSPEDFEALLEFMYTGKLISEENVDD 82

                          90       100
                  ....*....|....*....|....*
gi 17537311   224 ILHSAHMYKMTKVIRNCEEFLSNKS 248
Cdd:pfam00651  83 LLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 150-248 1.90e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 86.98  E-value: 1.90e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311    150 DMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHSA 228
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD---KSEIYLDDVSPEDFRALLNFLYtGKLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 17537311    229 HMYKMTKVIRNCEEFLSNKS 248
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
MATH smart00061
meprin and TRAF homology;
7-104 1.82e-20

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 84.27  E-value: 1.82e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311      7 LTHIFKKVSEFKDGECRCGPLEEHFNVEWLLYINRKDDELAVFLGCNSLQGTEETTlSIYVELKFTLKNSIGTRVTKIAK 86
Cdd:smart00061   2 LSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSRKW-SIEAEFTLKLVSQNGKSLSKKDK 80

                           90
                   ....*....|....*...
gi 17537311     87 CLLSNkstESDFGLNKFI 104
Cdd:smart00061  81 HVFEK---PSGWGFSKFI 95
MATH cd00121
MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded ...
 7-126 9.62e-19

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.


Pssm-ID: 238068  Cd Length: 126  Bit Score: 80.50  E-value: 9.62e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311   7 LTHIFKKVSEFK-DGECRCGPLEEHFNVEWLLYINRKDDE-----LAVFLGCNSLQGTEETTlSIYVELKFTLKNSIGTR 80
Cdd:cd00121   1 GKHTWKIVNFSElEGESIYSPPFEVGGYKWRIRIYPNGDGesgdyLSLYLELDKGESDLEKW-SVRAEFTLKLVNQNGGK 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17537311  81 VTKIAKCLLSNKSTESDFGLNKFIGWETLLKDY-LIDDSIIIEAKIK 126
Cdd:cd00121  80 SLSKSFTHVFFSEKGSGWGFPKFISWDDLEDSYyLVDDSLTIEVEVK 126
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 151-231 5.40e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 71.54  E-value: 5.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 151 MIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMdceGKSEITLPDINPSDFQCLLEVLYGEPA-MDDENVEGILHSAH 229
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRES---GQAEINLRDISPEDFRALLEFLYGGKRdLDASNLLELLEAAN 77


                ..
gi 17537311 230 MY 231
Cdd:cd01165  78 FL 79
 
Name Accession Description Interval E-value
MATH pfam00917
MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This ...
 11-127 2.25e-28

MATH domain; This motif has been called the Meprin And TRAF-Homology (MATH) domain. This domain is hugely expanded in the nematode C. elegans.


Pssm-ID: 425944 [Multi-domain]  Cd Length: 113  Bit Score: 105.80  E-value: 2.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311    11 FKKVSEFKDGECRCGPLEEHFNVEWLLYINRKDDELAVFLGCNSlQGTEETTLSIYVELKFTLKNSIGTRVTkiaKCLLS 90
Cdd:pfam00917   1 IKNFSKIKEGESYYSPVEERFNIPWRLQIYRKGGFLGLYLHCDK-EEELERGWSIETEFTLKLVSSNGKSVT---KTDTH 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 17537311    91 NKSTESDFGLNKFIGWETLLKDYLIDDSIIIEAKIKI 127
Cdd:pfam00917  77 VFEKPKGWGWGKFISWDDLEKDYLVDDSITVEAHVKI 113
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 144-248 1.10e-25

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 98.48  E-value: 1.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311   144 SSEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLYGEPAMDDENVEG 223
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESS---VSEITLDDVSPEDFEALLEFMYTGKLISEENVDD 82

                          90       100
                  ....*....|....*....|....*
gi 17537311   224 ILHSAHMYKMTKVIRNCEEFLSNKS 248
Cdd:pfam00651  83 LLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 150-248 1.90e-21

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 86.98  E-value: 1.90e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311    150 DMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHSA 228
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD---KSEIYLDDVSPEDFRALLNFLYtGKLDLPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 17537311    229 HMYKMTKVIRNCEEFLSNKS 248
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
MATH smart00061
meprin and TRAF homology;
7-104 1.82e-20

meprin and TRAF homology;


Pssm-ID: 214496 [Multi-domain]  Cd Length: 95  Bit Score: 84.27  E-value: 1.82e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311      7 LTHIFKKVSEFKDGECRCGPLEEHFNVEWLLYINRKDDELAVFLGCNSLQGTEETTlSIYVELKFTLKNSIGTRVTKIAK 86
Cdd:smart00061   2 LSHTFKNVSRLEEGESYFSPSEEHFNIPWRLKIYRKNGFLSLYLHCEKEECDSRKW-SIEAEFTLKLVSQNGKSLSKKDK 80

                           90
                   ....*....|....*...
gi 17537311     87 CLLSNkstESDFGLNKFI 104
Cdd:smart00061  81 HVFEK---PSGWGFSKFI 95
MATH cd00121
MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded ...
 7-126 9.62e-19

MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane and are capable of cleaving growth factors, extracellular matrix proteins, and biologically active peptides. TRAF molecules serve as adapter proteins that link cell surface receptors of the Tumor Necrosis Factor and 1nterleukin-1/Toll-like families to downstream kinase cascades, which results in the activation of transcription factors and the regulation of cell survival, proliferation and stress responses in the immune and inflammatory systems. Other members include the ubiquitin ligases, TRIM37 and SPOP, and the ubiquitin-specific proteases, HAUSP and Ubp21p. A large number of uncharacterized members mostly from lineage-specific expansions in C. elegans and rice contain MATH and BTB domains, similar to SPOP. The MATH domain has been shown to bind peptide/protein substrates in TRAFs and HAUSP. It is possible that the MATH domain in other members of this superfamily also interacts with various protein substrates. The TRAF domain may also be involved in the trimerization of TRAFs. Based on homology, it is postulated that the MATH domain in meprins may be involved in its tetramer assembly and that the MATH domain, in general, may take part in diverse modular arrangements defined by adjacent multimerization domains.


Pssm-ID: 238068  Cd Length: 126  Bit Score: 80.50  E-value: 9.62e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311   7 LTHIFKKVSEFK-DGECRCGPLEEHFNVEWLLYINRKDDE-----LAVFLGCNSLQGTEETTlSIYVELKFTLKNSIGTR 80
Cdd:cd00121   1 GKHTWKIVNFSElEGESIYSPPFEVGGYKWRIRIYPNGDGesgdyLSLYLELDKGESDLEKW-SVRAEFTLKLVNQNGGK 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17537311  81 VTKIAKCLLSNKSTESDFGLNKFIGWETLLKDY-LIDDSIIIEAKIK 126
Cdd:cd00121  80 SLSKSFTHVFFSEKGSGWGFPKFISWDDLEDSYyLVDDSLTIEVEVK 126
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 151-231 5.40e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 71.54  E-value: 5.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 151 MIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMdceGKSEITLPDINPSDFQCLLEVLYGEPA-MDDENVEGILHSAH 229
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRES---GQAEINLRDISPEDFRALLEFLYGGKRdLDASNLLELLEAAN 77


                ..
gi 17537311 230 MY 231
Cdd:cd01165  78 FL 79
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-231 5.88e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 66.04  E-value: 5.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 148 YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIpldFEEMDCEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILH 226
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMF---SSGMKESSSSEIELDDVSPEAFEALLDYIYtGELELSEENVEELLA 77


                ....*
gi 17537311 227 SAHMY 231
Cdd:cd18186  78 AADKL 82
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-244 1.98e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 57.55  E-value: 1.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 146 EEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGI 224
Cdd:cd18257  16 HELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKE---NSEVEFQCIDETALQAIVEYAYtGTVFISQATVESL 92

                        90       100
                ....*....|....*....|
gi 17537311 225 LHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18257  93 LPAANLLQIKLVLKECCDFL 112
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 145-240 2.83e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 56.20  E-value: 2.83e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 145 SEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEG 223
Cdd:cd18314   3 DSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESN---LKEVTLEDVEPEIFETVLKYMYtGQVTLSEENVLD 79

                        90
                ....*....|....*..
gi 17537311 224 ILHSAHMYKMTKVIRNC 240
Cdd:cd18314  80 LLMLASKYQVPDLEKLC 96
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-244 4.01e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 56.64  E-value: 4.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 147 EYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPldfEEMDCEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGIL 225
Cdd:cd18256  19 EFCDVQLQVGMELFSVHRLVLAASSPYFAALFA---GGMSESSKDVVQIHGVEPDIFHILLDFIYtGVVEVTVSNVQELL 95

                        90
                ....*....|....*....
gi 17537311 226 HSAHMYKMTKVIRNCEEFL 244
Cdd:cd18256  96 VAADMLQLTEVVEICCEFL 114
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 130-247 4.03e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 53.82  E-value: 4.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 130 MTGFPR-KELRSFDEsseeYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFeeMDCEGKsEITLPDINPSDFQCLLE 208
Cdd:cd18247   4 SSGFPVmEEIRRQGK----LCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDM--VESKQD-EITMQGIEPSALEALIN 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 17537311 209 VLY-GEPAMDDENVEGILHSAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18247  77 FAYsGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-231 5.62e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 53.39  E-value: 5.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 145 SEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDCegkSEITLPDINPSDFQCLLEVLY-GE---PAMDDEN 220
Cdd:cd18287  19 NEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQ---SEIELKDTNAEAFKALLKYIYtGRltlTDLKEDV 95

                        90
                ....*....|.
gi 17537311 221 VEGILHSAHMY 231
Cdd:cd18287  96 LLDVLGLAHQY 106
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 130-244 1.26e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 52.38  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 130 MTGFPRKELRSFDE--SSEEYSDMIIAVG----DRKFYVLKQLLASNSTHFQSLIPLDFEEmdCeGKSEITLPDINPSDF 203
Cdd:cd18248   1 LEDHTKEAFQIMNElrLSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRE--C-GMEVVPIEGVHPCVM 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 17537311 204 QCLLEVLY-GEPAMDDENVEGILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18248  78 SRLIEFAYtASISVGEKCVLHVLPGAVMYQMDSVVKACCDFL 119
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 134-247 8.43e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 50.36  E-value: 8.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 134 PRKELRSFDES--SEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDCEGKSEITLPDINPSDFQCLLEVLY 211
Cdd:cd18258   1 PKEMLKELNQQrrAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEKLELTMSNINADVLELLLEFVY 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 17537311 212 -GEPAMDDENVEGILHSAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18258  81 tGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQ 117
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 138-244 1.07e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 49.65  E-value: 1.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 138 LRSFDESSEE--YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDCEGKSeITLPDINPSDFQCLLEVLY-GEP 214
Cdd:cd18245   2 LRALNSFREEphLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYK-IELEGISVEVMEEILDYIYtGQI 80

                        90       100       110
                ....*....|....*....|....*....|
gi 17537311 215 AMDDENVEGILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18245  81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFL 110
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-247 1.76e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 49.45  E-value: 1.76e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 145 SEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEG 223
Cdd:cd18340  24 HNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEE---SKKREIVLEDVDPDVMGKILHYIYtSEIEITEQNVQD 100

                        90       100
                ....*....|....*....|....
gi 17537311 224 ILHSAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18340 101 IFAAANMFQIPSIFTVCVSFLQKR 124
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-245 3.56e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 48.04  E-value: 3.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 145 SEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLY----GEPAMDDEN 220
Cdd:cd18297   9 NPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQ---TPVIEIPDIRYDIFQLMMQYLYtggvESLDVAQDD 85

                        90       100
                ....*....|....*....|....*
gi 17537311 221 VEGILHSAHMYKMTKVIRNCEEFLS 245
Cdd:cd18297  86 ALELLRAASFFQLDGLKRHCEILLS 110
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-247 8.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 47.46  E-value: 8.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 148 YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLYGEP-AMDDENVEGILH 226
Cdd:cd18265  23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKE---SRQAVVEIQKVSAAAMEVLLDYMYGGGlRIQEDNVESVLE 99

                        90       100
                ....*....|....*....|.
gi 17537311 227 SAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18265 100 ASDLLQVSKLREACVRFLEGQ 120
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-244 1.30e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 46.75  E-value: 1.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 148 YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcEGKSEITlpDINPSDFQCLLEVLY-GEPAMDDENVEGILH 226
Cdd:cd18253  18 FTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESR-EMLVEIN--GILAEAMDCFLQYVYtGKVKITTENVQYLFE 94

                        90
                ....*....|....*...
gi 17537311 227 SAHMYKMTKVIRNCEEFL 244
Cdd:cd18253  95 TSSLFQISPLRDACAKFL 112
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 144-244 1.57e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 46.75  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 144 SSEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVE 222
Cdd:cd18259  28 SNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVE---SISARVEIKDVDPAVMESLIDFAYtGKLTINQGNVE 104

                        90       100
                ....*....|....*....|..
gi 17537311 223 GILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18259 105 ALIRTSNRLQFPTVRKVCSRYL 126
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 144-247 1.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 46.51  E-value: 1.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 144 SSEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLipldFEEMDCEGKSE-ITLPDINPSDFQCLLEVLY-GEPAMDDENV 221
Cdd:cd18238  11 ENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAM----FTSEMAESKQDsITIKDIDEEAVELLVDFAYtGKLTLTVDNV 86

                        90       100
                ....*....|....*....|....*.
gi 17537311 222 EGILHSAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18238  87 QSLLYAASLLQVEEVAKACCEFMKDH 112
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-244 2.45e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 45.78  E-value: 2.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 150 DMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHSA 228
Cdd:cd18240  19 DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETE---KKVYKIPGVSPEMMELIIEYAYtRTVPITAENVEELLPAA 95

                        90
                ....*....|....*.
gi 17537311 229 HMYKMTKVIRNCEEFL 244
Cdd:cd18240  96 DQFNIMGIVKACCDFL 111
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-247 3.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 45.86  E-value: 3.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 150 DMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHSA 228
Cdd:cd18269  29 DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEE---SKKKEVVLEDVDPDVMGMILKYLYtSEIDLNDQNVQDIFALA 105

                        90
                ....*....|....*....
gi 17537311 229 HMYKMTKVIRNCEEFLSNK 247
Cdd:cd18269 106 SRFQIPSIFTVCVSYLQKR 124
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 136-249 5.54e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 44.98  E-value: 5.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 136 KELRSFDESSEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDF-EEMDCEGK-SEITLPDINPSDFQCLLEVLYGE 213
Cdd:cd18296   5 DELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFaESEENNGSiPVVTLHDVSPEVFAIVLYYIYTD 84

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 17537311 214 PA-MDDENVEGILHSAHMYKMTKVIRNCEEFLSNKSE 249
Cdd:cd18296  85 DTdLPPENAYDVLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-247 6.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 44.31  E-value: 6.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 164 KQLLASNSTHFQSLIPLDFeemdCEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHSAHMYKMTKVIRNCEE 242
Cdd:cd18282  27 KYVLATGSSVFYAMFYGGL----AENKNEIEIPDVEPAAFLNLLRYLYcDEIDLEPDTVLATLYAAKKYLVPHLARACVQ 102


                ....*
gi 17537311 243 FLSNK 247
Cdd:cd18282 103 FLETS 107
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-247 7.66e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 44.78  E-value: 7.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 136 KELRSFDESSEeYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLY-GEP 214
Cdd:cd18268  12 RQLNSLRQERI-LTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRE---SSQAKVDLKGIDSDVLDQIVDYVYtGEI 87

                        90       100       110
                ....*....|....*....|....*....|...
gi 17537311 215 AMDDENVEGILHSAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18268  88 LITRDNVLPLMEAASMLQYPKLFEACSLYLQDQ 120
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 138-247 1.40e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 44.11  E-value: 1.40e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 138 LRSFDESSEE--YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLY-GEP 214
Cdd:cd18266  13 LQGLNEQRQRglFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMRE---AHQKEVELVGASYIGLKAVIDFLYsSEL 89

                        90       100       110
                ....*....|....*....|....*....|...
gi 17537311 215 AMDDENVEGILHSAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18266  90 PLDGGNIDYVLETAHLLQIWKVVDFCCEYLENE 122
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 144-244 1.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 43.43  E-value: 1.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 144 SSEEYSDMIIAVG----DRKFYVLKQLLASNSTHFQSLIPLDFeemdCEGKSEITLPDINPSDFQCLLEVLYG-EPAMDD 218
Cdd:cd18349   4 NNELMADVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDL----AEVKSEIHIPDVEPAAFLILLKYMYSdEIDLEA 79

                        90       100
                ....*....|....*....|....*.
gi 17537311 219 ENVEGILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18349  80 DTVLATLYAAKKYIVPALAKACVNFL 105
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 123-247 2.09e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 43.20  E-value: 2.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 123 AKIKITKMTGFpRKElrsfdessEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPldfEEMDCEGKSEITLPDINPSD 202
Cdd:cd18242   5 AKSILNTMNSL-RKS--------NTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFT---SEMSEKGKSEVELQGLTAST 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 17537311 203 FQCLLEVLYGEPA-MDDENVEGILHSAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18242  73 MEILLDFVYTETVhVTVENVQELLPAACLLQLKGVKQACCEFLESQ 118
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 148-232 2.66e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 41.77  E-value: 2.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 148 YSDMIIAVGDRKFYVLKQLLASNSTHFQSLipldFEEMDCEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILH 226
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAAL----LKETPPDEHPVIILPDVPYSELKALLDFIYtGEVNVSQEQLESLLK 76


                ....*.
gi 17537311 227 SAHMYK 232
Cdd:cd18315  77 LAELLQ 82
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 138-244 2.98e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 42.83  E-value: 2.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 138 LRSFDESSEE--YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDCEgksEITLPDINPSDFQCLLEVLY-GEP 214
Cdd:cd18250   9 LRGLSELRAErkFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRAD---RVVLHGVSAEILGLLLDFSYtGRV 85

                        90       100       110
                ....*....|....*....|....*....|
gi 17537311 215 AMDDENVEGILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18250  86 TVTQDNVEALLRAADLFQFPSVKEACCAYL 115
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-247 3.07e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 43.02  E-value: 3.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 150 DMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHSA 228
Cdd:cd18244  32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERD---QDKIHLKGLTATGFSHVLQFMYyGTIELSMLTVHEILQAA 108

                        90
                ....*....|....*....
gi 17537311 229 HMYKMTKVIRNCEEFLSNK 247
Cdd:cd18244 109 MYVQLTEVVKFCCSFLLAK 127
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-245 3.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 42.96  E-value: 3.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 146 EEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGI 224
Cdd:cd18272  30 GLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEAR---NRVIELKDVSESVFQLLVDYIYhGTVKLRVEELQET 106

                        90       100
                ....*....|....*....|.
gi 17537311 225 LHSAHMYKMTKVIRNCEEFLS 245
Cdd:cd18272 107 YEVADMYQLTALFEECSRFLA 127
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-244 3.98e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 42.47  E-value: 3.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 146 EEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGI 224
Cdd:cd18237  19 KTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTE---SKSSEVELKDAEPDIIELLVEFAYtARISVNSNNVQSL 95

                        90       100
                ....*....|....*....|
gi 17537311 225 LHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18237  96 LDAANQYQIEPVKKMCVDFL 115
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-244 4.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 42.41  E-value: 4.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 150 DMIIAVGDRKFYVLKQLLASNSTHFQSLipldFEEMDCEGKSE-ITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHS 227
Cdd:cd18235  23 DVILVADGVEIPAHRVVLASCSPYFHAM----FTGDLSESRANrVTLQDVDGKALLLLIDYVYtAEIQVTEENVQVLLPA 98

                        90
                ....*....|....*..
gi 17537311 228 AHMYKMTKVIRNCEEFL 244
Cdd:cd18235  99 ANLLQLTDVRDACCDFL 115
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-244 8.66e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 41.38  E-value: 8.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 149 SDMIIAVGDRKFYVLKQLLASNSTHFQSLIPldfEEMDCEgKSEITL-PDINPSDFQCLLEVLY-GEPAMDDENVEGILH 226
Cdd:cd18331  25 TDVVIVVSREQFRAHKTVLMACSGLFYSIFT---DQLKCN-LSVINLdPEINPEGFNILLDFMYtSRLNLREGNIMAVMA 100

                        90
                ....*....|....*...
gi 17537311 227 SAHMYKMTKVIRNCEEFL 244
Cdd:cd18331 101 TAMYLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-211 9.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 41.40  E-value: 9.01e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17537311 146 EEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLipldFEEMDCEGKSEITLPDINPSDFQCLLEVLY 211
Cdd:cd18209  16 GQLCDVLLIVGDQKFRAHKNVLAASSEYFQSL----FTEKENESQSVFQLDFCEPDAFENVLNYIY 77
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-246 9.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 41.90  E-value: 9.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 148 YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPD-INPSDFQCLLEVLYGEPAM-DDENVEGIL 225
Cdd:cd18267  40 FTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKE---SQDSEVNFHDsIHPEVLELLLDYAYSSRVIiNEENAESLL 116

                        90       100
                ....*....|....*....|.
gi 17537311 226 HSAHMYKMTKVIRNCEEFLSN 246
Cdd:cd18267 117 EAGDMLEFQDIRDACAEFLEK 137
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-244 9.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 41.57  E-value: 9.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 146 EEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFeemdCEGKS-EITLPDINPSDFQCLLEVLY-GEPAMDDENVEG 223
Cdd:cd18335  17 QQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDV----CEAKQeEIKMEGIDPNALWDLVQFAYtGCLELKEDTIEN 92

                        90       100
                ....*....|....*....|.
gi 17537311 224 ILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18335  93 LLAAACLLQLSQVVEVCCHFL 113
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-247 1.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 41.37  E-value: 1.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 136 KELrsFDESseEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIpldFEEMDCEGKSEITLPDINPSDFQCLLEVLY-GEP 214
Cdd:cd18341  19 KEL--LDEN--KFVDCTLKAGDKSLPCHRLILAACSPYFREYF---LSEESEEKKKEVVLDNVDPNIMDMILKYLYsAEI 91

                        90       100       110
                ....*....|....*....|....*....|...
gi 17537311 215 AMDDENVEGILHSAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18341  92 DLNDGNVQDIFALASRFQIPSVFTVCVTYLQKR 124
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-248 1.24e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 41.19  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 150 DMIIAVGDRKFYVLKQLLASNSTHFQSLIPLdfEEMDcEGKSEITLPD--INPSDFQCLLEVLYGEPAMDDE-NVEGILH 226
Cdd:cd18196  23 DCVIVVGNRHFKAHRSVLAACSTHFRALFTV--AEGD-QTMNMIQLDSevVTAEAFAALIDMMYTSTLMLGEsNVMDVLL 99

                        90       100
                ....*....|....*....|..
gi 17537311 227 SAHMYKMTKVIRNCEEFLSNKS 248
Cdd:cd18196 100 AASHLHLNSVVKACKHYLTTRT 121
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 144-246 1.24e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 40.69  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 144 SSEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLYGE--PAMDDENV 221
Cdd:cd18300   5 NKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRE---SSAKEVELPGVSKETFLALLEYLYTDqaPILEDGDC 81

                        90       100
                ....*....|....*....|....*
gi 17537311 222 EGILHSAHMYKMTKVIRNCEEFLSN 246
Cdd:cd18300  82 VGLIVLANRLCLPRLVALCEQYIVK 106
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-247 1.46e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 40.77  E-value: 1.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 145 SEEYSDMIIAVGDRKFYVLKQLLASNSTHFqsliplDFEemDCEGKSEITLPDINPSDFQCLLEVLYG---EPAMDDENV 221
Cdd:cd18303  15 KELYSDITIKLADKSIPAHKFVLAARSEKW------SNE--NLASTNELDLSDISYEVVLALLRWLYTdelDLTLDDEFL 86

                        90       100
                ....*....|....*....|....*.
gi 17537311 222 EGILHSAHMYKMTKVIRNCEEFLSNK 247
Cdd:cd18303  87 LELMKAAKRFQLTDLVERCERALMSS 112
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 191-244 2.36e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 40.50  E-value: 2.36e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17537311 191 SEITLPDINPSDFQCLLEVLYG-EPAMDDENVEGILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18281  65 AEIELPDVEPAAFLALLRFLYSdEVQIGPETVMTTLYTAKKYAVPALESACVEFL 119
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 145-245 2.38e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 39.89  E-value: 2.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 145 SEEYSDMIIAVGDR-KFYVLKQLLASNSTHFQSLIPLdfeemdcegKSEITL-PDINPSDFQCLLEVLY-GEPAMDDENV 221
Cdd:cd18299   9 SPSCADVVFILQGGvRIFAHRIVLAAASSVFADLFLM---------MTVVTLdSDITPEAFRRVLEFLYtGVLDENEDDL 79

                        90       100
                ....*....|....*....|....
gi 17537311 222 EGILHSAHMYKMTKVIRNCEEFLS 245
Cdd:cd18299  80 KELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 144-241 2.54e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 40.22  E-value: 2.54e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 144 SSEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIpLDFEEMDCEGKSEITLPDINPSDFQCLLEVLY--GEPAMD--DE 219
Cdd:cd18350  20 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLL-TNKSEQESQGSKTIEISDIKYHIFQMLMQYLYygGTESMEipIA 98

                        90       100
                ....*....|....*....|..
gi 17537311 220 NVEGILHSAHMYKMTKVIRNCE 241
Cdd:cd18350  99 DVLELLSAASLFQLDALQRHCE 120
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 160-244 2.84e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 40.19  E-value: 2.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 160 FYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHSAHMYKMTKVIR 238
Cdd:cd18252  34 FHCHKAALAACSSYFKVMFTADMKE---KSNNVIKLSGIDHDILEALVNYVYtSQICITERNVQSLLEAADLLQFISVKK 110


                ....*.
gi 17537311 239 NCEEFL 244
Cdd:cd18252 111 ACEQFL 116
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-245 3.42e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 40.04  E-value: 3.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 136 KELRSFDESSEEYSDMIIAVGD----------RKFYVLKQLLASNSTHFQSLipldFEEMDCEGKSEITLPDINPSDFQC 205
Cdd:cd18346  10 KERFAFLFNNELLSDVRFVVGKgrprgpgpgaQRIPAHRFVLAAGSAVFDAM----FNGGMATTSAEIELPDVEPAAFLA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 17537311 206 LLEVLYG-EPAMDDENVEGILHSAHMYKMTKVIRNCEEFLS 245
Cdd:cd18346  86 LLRFLYSdEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLT 126
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 144-244 3.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 39.54  E-value: 3.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 144 SSEEYSDMIIAVGDRKFYVL--KQLLASNSTHFQSLipLDFEEMDCEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDEN 220
Cdd:cd18294  10 NNPEFSDVKFLVGPERQEIFahKCILAARCEVFRAM--FLTGPQKESTQSPLVLSDIEPEVFRAVLEFIYtNCVTLSNHT 87

                        90       100
                ....*....|....*....|....
gi 17537311 221 VEGILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18294  88 VIEVLAAAVEYGLDELRKLCERFI 111
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-243 3.84e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 39.02  E-value: 3.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 148 YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDCEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILH 226
Cdd:cd18307   1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDYLSPETVEQLLDYFYtGKIVISEKNVEDLLK 80

                        90
                ....*....|....*..
gi 17537311 227 SAHMYKMTKVIRNCEEF 243
Cdd:cd18307  81 GAKYFNIPRLKDHCVDF 97
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 149-231 3.97e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 39.55  E-value: 3.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 149 SDMIIAVGDRKFYVLKQLLASNSTHFQSLipLDFEEMDCEgKSEITLPDINPSDFQCLLEVLYG----EPamDDENVEGI 224
Cdd:cd18286  18 SDITIKVDGKTFKAHRCILCARSSYFAAM--LSGSWAESN-SSEITLTGVSHAAVSFVLLFIYGgvldLP--DDVNLGEL 92


                ....*..
gi 17537311 225 LHSAHMY 231
Cdd:cd18286  93 LSLADMY 99
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-244 5.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 39.06  E-value: 5.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 145 SEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcEGKSEITlpDINPSDFQCLLEVLY-GEPAMDDENVEG 223
Cdd:cd18345  15 RSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERK-QNRVEIT--DVDHEVMREMLRFIYtGKAPNLDKMADD 91

                        90       100
                ....*....|....*....|.
gi 17537311 224 ILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18345  92 LLAAADKYALERLKVMCEEAL 112
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-244 5.59e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 39.36  E-value: 5.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 147 EYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEmdcEGKSEITLPDINPSDFQCLLEVLYGEPAMDDE-NVEGIL 225
Cdd:cd18249  22 ELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAE---SRQTEVTIRDIDERAMELLIDFAYTSQITVEEgNVQTLL 98

                        90
                ....*....|....*....
gi 17537311 226 HSAHMYKMTKVIRNCEEFL 244
Cdd:cd18249  99 PAACLLQLAEIQEVCCEFL 117
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 139-246 5.83e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 38.77  E-value: 5.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 139 RSFDESSEeySDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDcegKSEITLPDINPSDFQCLLEVLY-GEPAMD 217
Cdd:cd18298   5 KAFNDPRT--SDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDD---KNVIEIDQYSYPVYYAFLRYLYtDQVDLP 79

                        90       100
                ....*....|....*....|....*....
gi 17537311 218 DENVEGILHSAHMYKMTKVIRNCEEFLSN 246
Cdd:cd18298  80 PEDAIGLLDLANSYCEERLKKLCEDIIKQ 108
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-240 1.03e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 38.27  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 145 SEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIpldfeeMDCEGKSEIT--LPDINPSDFQCLLEVLY-GEPAMDDENV 221
Cdd:cd18224  23 SETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLF------LSTELDVARTyvVDFITPANFEKVLSFIYtSELFTDLINV 96

                        90
                ....*....|....*....
gi 17537311 222 EGILHSAHMYKMTKVIRNC 240
Cdd:cd18224  97 GVIYEVAEKLGMEDLLKAC 115
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 148-244 1.03e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 38.45  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 148 YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEE-MDcegkSEITLPD-INPSDFQCLLEVLYGEP-AMDDENVEGI 224
Cdd:cd18254  22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLREsLD----STVNFHDsLHPEVLELLLDFAYSSRiIINEENAESL 97

                        90       100
                ....*....|....*....|
gi 17537311 225 LHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18254  98 LEAGDMLQFHDVRDAAAEFL 117
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 136-243 1.04e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 38.20  E-value: 1.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 136 KELRSFDESSEE--YSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPldfeemdcEGKS-EITLPDINPSDFQCLLEVLY- 211
Cdd:cd18232   4 KVLQALNKQREEgqYCDATLDVGGRVFKAHWSVLACCSHFFQSLYG--------DGTSgSVVLPESFAEVFGLLLDFFYt 75

                        90       100       110
                ....*....|....*....|....*....|..
gi 17537311 212 GEPAMDDENVEGILHSAHMYKMTKVIRNCEEF 243
Cdd:cd18232  76 GELALTRENRDRVLLAAKELRVPEAVELCQRF 107
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 157-245 1.12e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 38.65  E-value: 1.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 157 DRKFYVLKQLLASNSTHFQSLipldFEEMDCEGKSE-ITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHSAHMYKMT 234
Cdd:cd18273  43 GRLFPCNRNVLAAASPYFKSM----FTGGLYESKQEtVTIHDVDSESMALIIDYCYtGRVTLSEANVQRLYAAANMLQLE 118

                        90
                ....*....|.
gi 17537311 235 KVIRNCEEFLS 245
Cdd:cd18273 119 YVREACASFLA 129
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-242 2.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 37.43  E-value: 2.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 150 DMIIAVGDRKFYVLKQLLASNSTHFQSLipldFEEMDcegkSEITLPD---INPSDFQCLLEVLY-GEPAMDDENVEGIL 225
Cdd:cd18217  20 DCTIVIGQFQFKAHRNVLAAFSEYFGAQ----YKDTE----DNIVFLDqsqVSADGFQKLLEFIYtGNLNLDSWNVAEIH 91

                        90
                ....*....|....*..
gi 17537311 226 HSAHMYKMTKVIRNCEE 242
Cdd:cd18217  92 QAASYLGMEEVVAKCKI 108
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 191-244 3.05e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 37.36  E-value: 3.05e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17537311 191 SEITLPDINPSDFQCLLEVLYG-EPAMDDENVEGILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18347  65 TEIELPDVEPAAFLALLKFLYSdEVQIGPETVMTTLYTAKKYAVPALEAHCVEFL 119
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-244 3.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 36.74  E-value: 3.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 146 EEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLipldFE-EMDCEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEG 223
Cdd:cd18279  16 SRFTDCCLCVGGQEFQAHKAILAARSPVFSAM----FEhEMEESKKNRVEINDVDPEVFKEMMRFIYtGKAPNLDKMADD 91

                        90       100
                ....*....|....*....|.
gi 17537311 224 ILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18279  92 LLAAADKYALERLKVMCEDAL 112
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-248 4.52e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 36.44  E-value: 4.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 150 DMIIAVGDRKFYVLKQLLASNSTHFQSLipldFEEMDCEGKSEITLPDINPSDFQCLLEVLYGEPAM-DDENVEGILHSA 228
Cdd:cd18231  18 DIVLVRQRSTFPAHKGVLAAYSQFFHSL----FTQNKQLQRVELSLEALTSQGLQQILNFIYTSKLLvNSCNVQDVLNAA 93

                        90       100
                ....*....|....*....|
gi 17537311 229 HMYKMTKVIRNCEEFLSNKS 248
Cdd:cd18231  94 AVLQMNDIAASCQELIDSRS 113
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-244 4.77e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 36.73  E-value: 4.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 150 DMIIAVGDRKFYVLKQLLASNSTHFQSLIP--LDFEEMDCEGKSEITlpdinPSDFQCLLEVLY-GEPAMDDENVEGILH 226
Cdd:cd18323  25 DCTVLVGSTQFLAHRAVLASCSPFFHMFYKeqLDKRDLVCINNEIVT-----APAFSLLLEFMYeGRLSFNDTPVEDVLA 99

                        90
                ....*....|....*...
gi 17537311 227 SAHMYKMTKVIRNCEEFL 244
Cdd:cd18323 100 AASYLHMNDIVKVCKKRL 117
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 150-244 4.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 36.38  E-value: 4.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 150 DMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDC----EGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGI 224
Cdd:cd18228  21 DVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVlvspAGKCVLDLHHVTVTGFAPLLEYAYtSTLSINTENIIDV 100

                        90       100
                ....*....|....*....|
gi 17537311 225 LHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18228 101 LAAASYMQMFNVANTCSEFM 120
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 145-244 6.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 36.32  E-value: 6.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 145 SEEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFeeMDCEgKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEG 223
Cdd:cd18276  18 LAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGL--MECS-QREVVLHDITAESVSIILNYMYsSDLHLTNSNVQG 94

                        90       100
                ....*....|....*....|.
gi 17537311 224 ILHSAHMYKMTKVIRNCEEFL 244
Cdd:cd18276  95 VATAAFFLQMEDIFSVCQKYM 115
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-252 7.55e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 35.98  E-value: 7.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 149 SDMIIAVGDRKFYVLKQLLASNSTHFQSLIPLDFEEMDCEgksEITLPDINPSDFQCLLEVLYGEPAM-DDENVEGILHS 227
Cdd:cd18236  25 TDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEE---KIIIKGVDAETMQILLDYTYTSKVLiTKQNVQRVLEA 101

                        90       100
                ....*....|....*....|....*
gi 17537311 228 AHMYKMTKVIRNCEEFLSnKSEKPM 252
Cdd:cd18236 102 ASLFQFLRMVDACASFLT-EALHPE 125
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 164-244 8.06e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 36.15  E-value: 8.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 164 KQLLASNSTHFQSLIpldFEEMdCEGKSEITLPDINPSDFQCLLEVLY-GEPAMDDENVEGILHSAHMYKMTKVIRNCEE 242
Cdd:cd18348  41 KYVLAVGSSVFHAMF---YGEL-AEDKDEIRIPDVEPAAFLAMLKYIYcDEIDLAADTVLATLYAAKKYIVPHLARACVN 116


                ..
gi 17537311 243 FL 244
Cdd:cd18348 117 FL 118
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 146-246 9.11e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 35.57  E-value: 9.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17537311 146 EEYSDMIIAVGDRKFYVLKQLLASNSTHFQSLIpldfeemdcEGKSEITLPD--INPSDFQCLLEVLY-GEPAMDDENVE 222
Cdd:cd18225  21 QQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLL---------DSTDTISIDAsvVSPEEFALLLEMVYtGKLPPGKHNFT 91

                        90       100
                ....*....|....*....|....
gi 17537311 223 GILHSAHMYKMTKVIRNCEEFLSN 246
Cdd:cd18225  92 KIISVADSLQMFDVAVSCKNLLTS 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH