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Conserved domains on  [gi|71998326|ref|NP_494564|]
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Cyclin-H [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 3-154 1.09e-48

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410228  Cd Length: 150  Bit Score: 160.07  E-value: 1.09e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326   3 ATSTQKREWTYT-PEKLAAMRLEINIKFRQKYESVMQPDELEL-FVTPEEELRMQRSIEDAALKFADKFrpHIWPSVKWT 80
Cdd:cd20524   1 HTSTQRKHWIFSsEEELAELRAEANEKAREKLKESLKEEDAEPkFLTPEEELLLVRYYEKKLLEFCRAF--KLPDSVLAT 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71998326  81 ALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNVGEprQNAERILKLEPELMKILDYNL 154
Cdd:cd20524  79 ALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESE--KTAEIILEYELLLLQGLNFHL 150
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 157-305 1.36e-25

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410229  Cd Length: 126  Bit Score: 99.29  E-value: 1.36e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326 157 HCPYRPYEGHLMDMKTRM-LLLNFDLESIRRDSMRFFQNALQTDVLLLYPPSQIALAAInfgLHAQGKSDEILREFLRKL 235
Cdd:cd20525   1 HHPYRPLEGFLLDLKTRLpDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAAL---LLAASEAGIDVEEYLSEK 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326 236 IGIEEDSwahrdarpEDLEKLEKTVTRVNQIMREVDrnfvavteqerenHKSQLARIQALIPALDERRKE 305
Cdd:cd20525  78 LPGSEES--------EELEKLLEIIREIKKLVKKYE-------------GPPDKEEVKALDKKLKKCRNP 126
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 3-154 1.09e-48

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 160.07  E-value: 1.09e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326   3 ATSTQKREWTYT-PEKLAAMRLEINIKFRQKYESVMQPDELEL-FVTPEEELRMQRSIEDAALKFADKFrpHIWPSVKWT 80
Cdd:cd20524   1 HTSTQRKHWIFSsEEELAELRAEANEKAREKLKESLKEEDAEPkFLTPEEELLLVRYYEKKLLEFCRAF--KLPDSVLAT 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71998326  81 ALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNVGEprQNAERILKLEPELMKILDYNL 154
Cdd:cd20524  79 ALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESE--KTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 2-214 4.78e-47

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 161.16  E-value: 4.78e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326     2 YATSTQKREWTYTPE-KLAAMRLEINIKFRQKYESVMQP-DELELFVTPEEELRMQRSIEDAALKFADKFRPHIWPSVKW 79
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEeQLQEKRADANAKFREAHEEEEKVlEAKPIFLTPEEELDLVKYYEKRLLDFCSAFKPTMPTSVVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326    80 TALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNvGEPRQNAERILKLEPELMKILDYNLTVHCP 159
Cdd:TIGR00569  81 TAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLK-ETPLKALEQVLEYELLLIQQLNFHLIVHNP 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 71998326   160 YRPYEGHLMDMKTRMLLLNfDLESIRRDSMRFFQNALQTDVLLLYPPSQIALAAI 214
Cdd:TIGR00569 160 YRPLEGFLIDIKTRLPGLE-NPEYLRKHADKFLNRTLLTDAYLLYTPSQIALAAI 213
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 157-305 1.36e-25

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 99.29  E-value: 1.36e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326 157 HCPYRPYEGHLMDMKTRM-LLLNFDLESIRRDSMRFFQNALQTDVLLLYPPSQIALAAInfgLHAQGKSDEILREFLRKL 235
Cdd:cd20525   1 HHPYRPLEGFLLDLKTRLpDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAAL---LLAASEAGIDVEEYLSEK 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326 236 IGIEEDSwahrdarpEDLEKLEKTVTRVNQIMREVDrnfvavteqerenHKSQLARIQALIPALDERRKE 305
Cdd:cd20525  78 LPGSEES--------EELEKLLEIIREIKKLVKKYE-------------GPPDKEEVKALDKKLKKCRNP 126
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 158-268 1.29e-20

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 84.90  E-value: 1.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326   158 CPYRPYEGHLMDMKTRMLLLNFDLESIRRDSMRFFQNALQTDVLLLYPPSQIALAAInfgLHAQGKSDEilrEFLRKLIG 237
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRPPLLEDRIESLYKRAREILKSALLTDAYFLYTPSQIALAAL---LLADSPLAE---FYLTEKFG 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 71998326   238 IEEDswahrdaRPEDLEKLEKTVTRVNQIMR 268
Cdd:pfam16899  75 LPED-------RETKLEKLLDTIESCRNLLK 98
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 41-240 2.18e-17

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 80.93  E-value: 2.18e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326  41 ELELFVTPEEELRMQRSIEDAALKFADKFRPHiwpsVKWTALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEF--YI 118
Cdd:COG5333  33 EPELTLEKELNLVIYYLKLIMDLCTRLNLPQT----VLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTprDI 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326 119 TIEDFVKN-MNVGEPRQNAERILKLEPELMKILDYNLTVHCPYRPYEGHLMDMKtrmLLLNFDLESIrrdSMRFFQNALQ 197
Cdd:COG5333 109 SIESFEARdLWSEEPKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQ---EKDKYKLLQI---AWKIINDALR 182

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 71998326 198 TDVLLLYPPSQIALAAINFGLHAQGKsDEILREFLRKLIGIEE 240
Cdd:COG5333 183 TDLCLLYPPHIIALAALLIACEVLGM-PIIKLLDFVSYETKEE 224
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 80-148 6.21e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 35.26  E-value: 6.21e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71998326     80 TALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNVgeprQNAERILKLEPELMK 148
Cdd:smart00385  19 LAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY----FTEEEILRMERLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 3-154 1.09e-48

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 160.07  E-value: 1.09e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326   3 ATSTQKREWTYT-PEKLAAMRLEINIKFRQKYESVMQPDELEL-FVTPEEELRMQRSIEDAALKFADKFrpHIWPSVKWT 80
Cdd:cd20524   1 HTSTQRKHWIFSsEEELAELRAEANEKAREKLKESLKEEDAEPkFLTPEEELLLVRYYEKKLLEFCRAF--KLPDSVLAT 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71998326  81 ALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNVGEprQNAERILKLEPELMKILDYNL 154
Cdd:cd20524  79 ALTYFKRFYLKNSVMEYHPKEIMLTCLYLACKVEEFNISIDQFVGNIKESE--KTAEIILEYELLLLQGLNFHL 150
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 2-214 4.78e-47

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 161.16  E-value: 4.78e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326     2 YATSTQKREWTYTPE-KLAAMRLEINIKFRQKYESVMQP-DELELFVTPEEELRMQRSIEDAALKFADKFRPHIWPSVKW 79
Cdd:TIGR00569   1 YRNSSQKRHWTFTSEeQLQEKRADANAKFREAHEEEEKVlEAKPIFLTPEEELDLVKYYEKRLLDFCSAFKPTMPTSVVG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326    80 TALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNvGEPRQNAERILKLEPELMKILDYNLTVHCP 159
Cdd:TIGR00569  81 TAIMYFKRFYLNNSVMEYHPKIIMLTCVFLACKVEEFNVSIDQFVGNLK-ETPLKALEQVLEYELLLIQQLNFHLIVHNP 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 71998326   160 YRPYEGHLMDMKTRMLLLNfDLESIRRDSMRFFQNALQTDVLLLYPPSQIALAAI 214
Cdd:TIGR00569 160 YRPLEGFLIDIKTRLPGLE-NPEYLRKHADKFLNRTLLTDAYLLYTPSQIALAAI 213
CYCLIN_CCNH_rpt2 cd20525
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 157-305 1.36e-25

second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410229  Cd Length: 126  Bit Score: 99.29  E-value: 1.36e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326 157 HCPYRPYEGHLMDMKTRM-LLLNFDLESIRRDSMRFFQNALQTDVLLLYPPSQIALAAInfgLHAQGKSDEILREFLRKL 235
Cdd:cd20525   1 HHPYRPLEGFLLDLKTRLpDLKAENLEKLYKEAREFLNRSLLTDAPLLYPPSQIALAAL---LLAASEAGIDVEEYLSEK 77

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326 236 IGIEEDSwahrdarpEDLEKLEKTVTRVNQIMREVDrnfvavteqerenHKSQLARIQALIPALDERRKE 305
Cdd:cd20525  78 LPGSEES--------EELEKLLEIIREIKKLVKKYE-------------GPPDKEEVKALDKKLKKCRNP 126
Cyclin_C_2 pfam16899
Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family ...
 158-268 1.29e-20

Cyclin C-terminal domain; Cyclins contain two domains of similar all-alpha fold, this family corresponds with the C-terminal domain of some cyclins including cyclin C and cyclin H.


Pssm-ID: 465303  Cd Length: 98  Bit Score: 84.90  E-value: 1.29e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326   158 CPYRPYEGHLMDMKTRMLLLNFDLESIRRDSMRFFQNALQTDVLLLYPPSQIALAAInfgLHAQGKSDEilrEFLRKLIG 237
Cdd:pfam16899   1 HPFRPLEGFLLDLKTRPPLLEDRIESLYKRAREILKSALLTDAYFLYTPSQIALAAL---LLADSPLAE---FYLTEKFG 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 71998326   238 IEEDswahrdaRPEDLEKLEKTVTRVNQIMR 268
Cdd:pfam16899  75 LPED-------RETKLEKLLDTIESCRNLLK 98
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 41-240 2.18e-17

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 80.93  E-value: 2.18e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326  41 ELELFVTPEEELRMQRSIEDAALKFADKFRPHiwpsVKWTALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEF--YI 118
Cdd:COG5333  33 EPELTLEKELNLVIYYLKLIMDLCTRLNLPQT----VLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTprDI 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326 119 TIEDFVKN-MNVGEPRQNAERILKLEPELMKILDYNLTVHCPYRPYEGHLMDMKtrmLLLNFDLESIrrdSMRFFQNALQ 197
Cdd:COG5333 109 SIESFEARdLWSEEPKSSRERILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQ---EKDKYKLLQI---AWKIINDALR 182

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 71998326 198 TDVLLLYPPSQIALAAINFGLHAQGKsDEILREFLRKLIGIEE 240
Cdd:COG5333 183 TDLCLLYPPHIIALAALLIACEVLGM-PIIKLLDFVSYETKEE 224
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 2-154 1.87e-11

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 61.77  E-value: 1.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326   2 YATSTQKREWTYTPEKLAAMRLEINIKFRQKYE-----------------------SVMQPDELELFVTPEEELRMQRSI 58
Cdd:cd20585   2 FATSTHRQRWIFTPQDLTEKREAANQRAVDALQqcgatrveaqaagslgggaevggSNGKAAKLPEPLSADEELLMLKYY 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326  59 EDAALKFADKFR-PHiwpSVKWTALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNvgeprQNAE 137
Cdd:cd20585  82 EQKIQEVCRALRlPN---KIQATALLYFKRFYLQWSVMEHDPKRIMLTCIYLACKVEEYHVSAEELGKGIQ-----QDHQ 153

                       170
                ....*....|....*..
gi 71998326 138 RILKLEPELMKILDYNL 154
Cdd:cd20585 154 LILKNELALLQGLNFDL 170
CYCLIN_AcCycH_rpt2 cd20586
second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; ...
 157-272 1.58e-08

second cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410289 [Multi-domain]  Cd Length: 132  Bit Score: 52.43  E-value: 1.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71998326 157 HCPYRPYEGHLMDMKTRMLLLNFD----LESIRRDSMRFFQNALQTDVLLLYPPSQIALAAINFGLHAQGKSDeiLREFL 232
Cdd:cd20586   1 YAPYRALEGFVQDLEEFLAAGSGPdsqgLQELRKAALAAVDKLMLTDAPLLYPPGQLALAALRSANKAKGGVD--FDRYL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 71998326 233 -----RKLIGIEEDSWAHRDARPEDLEKLEKTVTRVNQ-IMREVDR 272
Cdd:cd20586  79 ervaaRAASKMPDDPAAALTAVLDEIEYLVSEGARPEVaEVKEIDR 124
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 72-139 1.06e-05

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 43.17  E-value: 1.06e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71998326  72 HIWPSVKWTALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNVGEPR-QNAERI 139
Cdd:cd00043  14 GLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSGVSEKElRKAEKE 82
CYCLIN_CCNC_rpt2 cd20514
second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 159-235 2.48e-04

second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410218 [Multi-domain]  Cd Length: 92  Bit Score: 39.53  E-value: 2.48e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71998326 159 PYRPYEGHLMDMK--TRMLLLNFdleSIRRDSMRffqnalqTDVLLLYPPSQIALAAINFGLHAQGKSdeiLREFLRKL 235
Cdd:cd20514   2 PYRPLTQYVQDAGldDELLPLAW---RIVNDSYR-------TDVCLLYPPYLIALACLHMACVLLQKD---ARQWFAEL 67
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 80-148 6.21e-03

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 35.26  E-value: 6.21e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71998326     80 TALAFFKRAFLVWVPSDTSIRMVMMACFYLAMKIDEFYITIEDFVKNMNVgeprQNAERILKLEPELMK 148
Cdd:smart00385  19 LAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY----FTEEEILRMERLLLE 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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