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Conserved domains on  [gi|17535797|ref|NP_494589|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
19-319 1.14e-97

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 290.98  E-value: 1.14e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797    19 DSSDYLRNAYHVTAIFTVPLSILTFYIILKKTPSRMKTMKVPLLISHASSTNLDLMFTVYSAPYAFFPTASGKSLGVLGW 98
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797    99 LGVGVRWQAYWGHFSVMMLGVSFIILYENRQSQISTVKFKIQRKQTRILYFACRYLFSFVILLPFYIDGSDQVVLRKSVL 178
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797   179 KQIPCPTIEFFDSQTYVLLRPDEILPLFSNIIGFGGILAEIFFFLFHTVYHLTMVGNTSTSETTKKMQRKFLKIVSLQIS 258
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17535797   259 IPLIAIALPVLFTLYAGTMSYYNQAANNNAMIIMANHGLLSTCCTLFIYQPYRDFIMRKLT 319
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
19-319 1.14e-97

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 290.98  E-value: 1.14e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797    19 DSSDYLRNAYHVTAIFTVPLSILTFYIILKKTPSRMKTMKVPLLISHASSTNLDLMFTVYSAPYAFFPTASGKSLGVLGW 98
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797    99 LGVGVRWQAYWGHFSVMMLGVSFIILYENRQSQISTVKFKIQRKQTRILYFACRYLFSFVILLPFYIDGSDQVVLRKSVL 178
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797   179 KQIPCPTIEFFDSQTYVLLRPDEILPLFSNIIGFGGILAEIFFFLFHTVYHLTMVGNTSTSETTKKMQRKFLKIVSLQIS 258
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17535797   259 IPLIAIALPVLFTLYAGTMSYYNQAANNNAMIIMANHGLLSTCCTLFIYQPYRDFIMRKLT 319
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
19-319 1.14e-97

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 290.98  E-value: 1.14e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797    19 DSSDYLRNAYHVTAIFTVPLSILTFYIILKKTPSRMKTMKVPLLISHASSTNLDLMFTVYSAPYAFFPTASGKSLGVLGW 98
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797    99 LGVGVRWQAYWGHFSVMMLGVSFIILYENRQSQISTVKFKIQRKQTRILYFACRYLFSFVILLPFYIDGSDQVVLRKSVL 178
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797   179 KQIPCPTIEFFDSQTYVLLRPDEILPLFSNIIGFGGILAEIFFFLFHTVYHLTMVGNTSTSETTKKMQRKFLKIVSLQIS 258
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17535797   259 IPLIAIALPVLFTLYAGTMSYYNQAANNNAMIIMANHGLLSTCCTLFIYQPYRDFIMRKLT 319
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
18-314 3.45e-13

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 69.11  E-value: 3.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797    18 FDSSDYLRNAYHVTAIFTVPLSILTFYIILKKTPsRMKTMKVPLLISHASSTNLDLMFTVYSAPYAFFPTASGKSLGVLg 97
Cdd:pfam10327   5 FTVPFWLILYYHIIGTISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFL- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797    98 wlgvgVRWQAYWGHFSVMMLGVSFIILYEN-------RQSQISTV--KFKIQRKQTRILYFACrYLFSFVILLPFYIDGS 168
Cdd:pfam10327  83 -----ATVFGISSHYLMTIFVFLLSFQLESlllcfvrKHQAIAKIlsKHVIPKWLYIFLYILC-HIFPFLTAFLFYQSGL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797   169 DQVVLRKSVLKQIPCPTIEFFDSQTYVLLRPDEILPLFSNIIGFGGIL--AEIFFFLFHTVYHLTMVgNTSTSETTKKMQ 246
Cdd:pfam10327 157 SREEQLEYVKENYPEYLSQFSSLPNFAIYDYNPWLIVFGILAIFGGSLsfLILVYLTVDMFRMLKRL-RKKISAQTYQKH 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17535797   247 RKFLKIVSLQISIPLIAIALPVLFTLYAGTMSYYNQAANNNAMIIMANHGLLSTCCTLFIYQPYRDFI 314
Cdd:pfam10327 236 RAALRSLIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKFL 303
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
28-316 4.87e-06

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 47.55  E-value: 4.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797    28 YHVTAIFTVPLSILTFYIILKKTPSRMKTMKVplLISHASSTNLDLMFTVYSAPYAFFPtaSGKSL-----GVLGWLGvg 102
Cdd:pfam10317   5 YPIFFILGLILNLLLLYLIIFKSPKSLKTYRI--LLLNTAITQIISCILAFFTQQRIIP--NGVSMalisyGPCKYFG-- 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797   103 vRWQAYWGHF----SVMMLGVSFIILYENRQSQISTVKFKiqrKQTRILYFACRYLFSFVILLPFYIDGSDQVVLRKsvL 178
Cdd:pfam10317  79 -PWFCYSGYSllqhFLLHSGWSLLLTFYYRYYILKHVDPK---RKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEA--L 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535797   179 KQIPCPTIEFFDSQTYVLLRPDEILPLFSNIIGFGGILAE--IFFFLFHTVYHLTMVGNTSTSETTKKMQRKFLKIVSLQ 256
Cdd:pfam10317 153 TKELHPNYNLTDYTVTGFSDLQSFPALINTLIMTIPVFPIpiIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQ 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17535797   257 ISIPLIAIALPVLFTLYA---GTMSYYNQAANNNAMIIMAnhgLLSTCCTLFIYQPYRDFIMR 316
Cdd:pfam10317 233 ALLPLFSYIPGVTLYLLSqltGTEFLILEYFIFVLPALPP---LLDPLITIYFVTPYRRAILR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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