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Conserved domains on  [gi|17532473|ref|NP_494681|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
12-308 8.81e-93

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 277.89  E-value: 8.81e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473    12 ASPSFLLLTTRIITCFEIPIWIFGAYCIQFKTPEKMKSVKGLMLNVHFWSTISDLTICCIGVPYLHLPCLAGYGLGLVQA 91
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473    92 PG----PLLYLGFTFLGAFAVSIIAVYENRLLTVINPTSR--WHKFRKAYLPLMCLFPPTYTIPIFASLPEQEHAREHVL 165
Cdd:pfam10318  81 LGvptpIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRitWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473   166 KSIPCLKVFSLNFQELFVLTLKPIVPAICGVFAASIAIFPIVIFFTLTFRQLLKRQKNyKYSYRTVRVQKNFLVSMSLQF 245
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKS-SLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17532473   246 VFIMTFMFIPCVLLLYIVIFKYHNQILNNFIIILFSCFGTGSTVVIILVYKPYREFAFLVLTC 308
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
12-308 8.81e-93

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 277.89  E-value: 8.81e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473    12 ASPSFLLLTTRIITCFEIPIWIFGAYCIQFKTPEKMKSVKGLMLNVHFWSTISDLTICCIGVPYLHLPCLAGYGLGLVQA 91
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473    92 PG----PLLYLGFTFLGAFAVSIIAVYENRLLTVINPTSR--WHKFRKAYLPLMCLFPPTYTIPIFASLPEQEHAREHVL 165
Cdd:pfam10318  81 LGvptpIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRitWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473   166 KSIPCLKVFSLNFQELFVLTLKPIVPAICGVFAASIAIFPIVIFFTLTFRQLLKRQKNyKYSYRTVRVQKNFLVSMSLQF 245
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKS-SLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17532473   246 VFIMTFMFIPCVLLLYIVIFKYHNQILNNFIIILFSCFGTGSTVVIILVYKPYREFAFLVLTC 308
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
12-308 8.81e-93

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 277.89  E-value: 8.81e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473    12 ASPSFLLLTTRIITCFEIPIWIFGAYCIQFKTPEKMKSVKGLMLNVHFWSTISDLTICCIGVPYLHLPCLAGYGLGLVQA 91
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473    92 PG----PLLYLGFTFLGAFAVSIIAVYENRLLTVINPTSR--WHKFRKAYLPLMCLFPPTYTIPIFASLPEQEHAREHVL 165
Cdd:pfam10318  81 LGvptpIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRitWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473   166 KSIPCLKVFSLNFQELFVLTLKPIVPAICGVFAASIAIFPIVIFFTLTFRQLLKRQKNyKYSYRTVRVQKNFLVSMSLQF 245
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKS-SLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17532473   246 VFIMTFMFIPCVLLLYIVIFKYHNQILNNFIIILFSCFGTGSTVVIILVYKPYREFAFLVLTC 308
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
11-301 1.21e-11

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 64.49  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473    11 FASPSFLLLTTRIITCFEIPIWIFGAYCIQFKTPeKMKSVKGLMLNVHFWSTISDLTICCIGVPYLHLPCLAGYGLG-LV 89
Cdd:pfam10327   5 FTVPFWLILYYHIIGTISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGfLA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473    90 QAPGPLLYLGFTFLGAFAVSIIA------VYENRLLTVINPTSRWHKFRKAYLPLMCL-FPPTYTIPIFASLPEQEHARE 162
Cdd:pfam10327  84 TVFGISSHYLMTIFVFLLSFQLEslllcfVRKHQAIAKILSKHVIPKWLYIFLYILCHiFPFLTAFLFYQSGLSREEQLE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473   163 HVLKSIPCLKvfsLNFQEL--FVLTLKPIVPAICGVFAASIAIFPIVIFFTLTFR--QLLKRQKNyKYSYRTVRVQKNFL 238
Cdd:pfam10327 164 YVKENYPEYL---SQFSSLpnFAIYDYNPWLIVFGILAIFGGSLSFLILVYLTVDmfRMLKRLRK-KISAQTYQKHRAAL 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17532473   239 VSMSLQFVfIMTFMFIPCVLLLYIVIFKY-HNQILNNFIIILFSCFGTGSTVVIILVYKPYREF 301
Cdd:pfam10327 240 RSLIAQFA-TSPVCILPPFAFVVVVLFPIeYSQEISEILLAIFSTHSSVNSIVLILTTPPYRKF 302
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
105-299 4.20e-04

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 41.29  E-value: 4.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473   105 AFAVSIIAV---YenRLLTVINPTsRWHKFRKAYLPLMCLFPP----TYTIPIFASLPEQEHAREHVLKSIpcLKVFSLN 177
Cdd:pfam10326  94 GVSISLLAVqfiY--RYLALCRPG-KLKYFDGKKLILWFLYPLifgaIWGLLVYFFLGPDEETDEYLREEL--LENYNLD 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17532473   178 FQEL---------------FVLTLKPIVPAICGVFAASIAIFPIVIFFTLTFRQLLKRQKNYkySYRTVRVQKNFLVSMS 242
Cdd:pfam10326 169 IDEVayvgpvyyptdengsKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG--SEKTRKLQKQLFKALV 246
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 17532473   243 LQFVFIMTFMFIPCVLLLYIVIFKYHNQILNNFIIILFSCFGTGSTVVIILVYKPYR 299
Cdd:pfam10326 247 IQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYR 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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