NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|392890049|ref|NP_495065|]
View 

BHLH domain-containing protein [Caenorhabditis elegans]

Protein Classification

helix-loop-helix domain-containing protein( domain architecture ID 10439830)

helix-loop-helix (HLH) domain-containing protein is a DNA-binding protein that may act as a transcription factor

CATH:  4.10.280.10
Gene Ontology:  GO:0003677|GO:0046983
PubMed:  1755826|8018712|15808743|30602438
SCOP:  4000913

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HLH pfam00010
Helix-loop-helix DNA-binding domain;
93-148 9.06e-09

Helix-loop-helix DNA-binding domain;


:

Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 50.54  E-value: 9.06e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392890049   93 RRKVKTEREKIRRKKQDDCYAELKFFILNKQMGSyeqrlKLERITILEIIIDYIKH 148
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTLPPDK-----KLSKAEILRLAIEYIKH 51
 
Name Accession Description Interval E-value
HLH pfam00010
Helix-loop-helix DNA-binding domain;
93-148 9.06e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 50.54  E-value: 9.06e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392890049   93 RRKVKTEREKIRRKKQDDCYAELKFFILNKQMGSyeqrlKLERITILEIIIDYIKH 148
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTLPPDK-----KLSKAEILRLAIEYIKH 51
HLH smart00353
helix loop helix domain;
98-153 1.13e-05

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 41.82  E-value: 1.13e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 392890049    98 TEREKIRRKKQDDCYAELKFFILNKQMGSyeqrlKLERITILEIIIDYIKHNSDLL 153
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPTLPKNK-----KLSKAEILRLAIEYIKSLQEEL 51
bHLH-O_HES5 cd11461
basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar ...
 101-152 2.06e-03

basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar proteins; HES-5, also termed Class B basic helix-loop-helix protein 38 (bHLHb38), or hairy and enhancer of split 5, is a bHLH-O transcription factor that is involved in cell differentiation and proliferation in a variety of tissues. HES-5 is an essential effector for Notch signaling. It acts as a transducer of Notch signals in brain vascular development. It also acts as a key mediator of Wnt-3a-induced neuronal differentiation and plays a crucial role in normal inner ear hair cell development. HES-5 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.


Pssm-ID: 381467 [Multi-domain]  Cd Length: 59  Bit Score: 35.78  E-value: 2.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 392890049 101 EKIRRKKQDDCYAELKFfILNKQMGSYEQRLKLERITILEIIIDYIKHNSDL 152
Cdd:cd11461    8 EKTRRDRINSSIEQLKT-LLEKEFQRHQPNSKLEKADILEMTVSFLKQSAKL 58
 
Name Accession Description Interval E-value
HLH pfam00010
Helix-loop-helix DNA-binding domain;
93-148 9.06e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 50.54  E-value: 9.06e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 392890049   93 RRKVKTEREKIRRKKQDDCYAELKFFILNKQMGSyeqrlKLERITILEIIIDYIKH 148
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTLPPDK-----KLSKAEILRLAIEYIKH 51
HLH smart00353
helix loop helix domain;
98-153 1.13e-05

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 41.82  E-value: 1.13e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 392890049    98 TEREKIRRKKQDDCYAELKFFILNKQMGSyeqrlKLERITILEIIIDYIKHNSDLL 153
Cdd:smart00353   1 NARERRRRRKINEAFDELRSLLPTLPKNK-----KLSKAEILRLAIEYIKSLQEEL 51
bHLH-O_HES5 cd11461
basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar ...
 101-152 2.06e-03

basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar proteins; HES-5, also termed Class B basic helix-loop-helix protein 38 (bHLHb38), or hairy and enhancer of split 5, is a bHLH-O transcription factor that is involved in cell differentiation and proliferation in a variety of tissues. HES-5 is an essential effector for Notch signaling. It acts as a transducer of Notch signals in brain vascular development. It also acts as a key mediator of Wnt-3a-induced neuronal differentiation and plays a crucial role in normal inner ear hair cell development. HES-5 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability.


Pssm-ID: 381467 [Multi-domain]  Cd Length: 59  Bit Score: 35.78  E-value: 2.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 392890049 101 EKIRRKKQDDCYAELKFfILNKQMGSYEQRLKLERITILEIIIDYIKHNSDL 152
Cdd:cd11461    8 EKTRRDRINSSIEQLKT-LLEKEFQRHQPNSKLEKADILEMTVSFLKQSAKL 58
bHLH_TS_taxi_Dei cd11431
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar ...
 93-153 7.48e-03

basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster protein taxi and similar proteins; Protein taxi, also termed protein delilah (Dei), is a bHLH transcription factor that is involved in regulation of cell adhesion and attachment that is expressed in specialized cells that provide anchoring sites to either muscles (tendon cells), or proprioceptors (chordotonal attachment cells) during embryonic development. It probably plays an important role in the differentiation of epidermal cells into the tendon cells that form the attachment sites for all muscles.


Pssm-ID: 381437 [Multi-domain]  Cd Length: 59  Bit Score: 33.94  E-value: 7.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392890049  93 RRKVKTEREKIRRKKQDDCYAELKFFIlnKQMGSYEQRLKLERITILEIIIDYIKHNSDLL 153
Cdd:cd11431    1 RRKTANARERDRMREINDAFEALRRAV--PEYPVAGKDGKLTKITTLRLAMNYIKALTDLL 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH