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Conserved domains on  [gi|17535609|ref|NP_495204|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

G-protein coupled receptor( domain architecture ID 11606548)

G-protein coupled receptor (GPCR) transmits physiological signals from the outside of the cell to the inside by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
13-301 3.08e-50

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


:

Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 169.35  E-value: 3.08e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  13 MYLPVIFIGLLGNFASFLVYRTAPMRKSTvgtlllILSLIDILLLILITPIFVLVFLPLWQDQWQKYSFHMSFFAYSTRY 92
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTRKSMRSST------NVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  93 VYPLCMMTKSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLSE------M 166
Cdd:cd14978  80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNnnsyyyV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 167 WMLDTEKHWWYFMFYFIILSVIFDYFLPFLIMTIANYHVIRALQESDEVITGLAV-------QKRKDQKTTVMLLVVTIF 239
Cdd:cd14978 160 IPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRrrrllsrSQRRERRTTIMLIAVVIV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17535609 240 FAFCHLFSMFLKVAESIFGGFltQTSFYWEVFAEFTIFLIIFHTSSTFFIYYGFSEKFRTIF 301
Cdd:cd14978 240 FLICNLPAGILNILEAIFGES--FLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
13-301 3.08e-50

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 169.35  E-value: 3.08e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  13 MYLPVIFIGLLGNFASFLVYRTAPMRKSTvgtlllILSLIDILLLILITPIFVLVFLPLWQDQWQKYSFHMSFFAYSTRY 92
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTRKSMRSST------NVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  93 VYPLCMMTKSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLSE------M 166
Cdd:cd14978  80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNnnsyyyV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 167 WMLDTEKHWWYFMFYFIILSVIFDYFLPFLIMTIANYHVIRALQESDEVITGLAV-------QKRKDQKTTVMLLVVTIF 239
Cdd:cd14978 160 IPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRrrrllsrSQRRERRTTIMLIAVVIV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17535609 240 FAFCHLFSMFLKVAESIFGGFltQTSFYWEVFAEFTIFLIIFHTSSTFFIYYGFSEKFRTIF 301
Cdd:cd14978 240 FLICNLPAGILNILEAIFGES--FLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
64-290 9.44e-09

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 55.38  E-value: 9.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609    64 FVLVFLPLW------QDQWQKYSFHMSFFAYstryVYPLCMmtkSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMK- 136
Cdd:pfam00001  33 FSLLTLPFWlvyylnHGDWPFGSALCKIVGA----LFVVNG---YASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVl 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609   137 -AGIFIIIFSIVFNFPRFFDYKIGDGYLSEMWMLDTEKHWWYFMFYFIILSVIFdYFLPFLIMTIANYHVIRALQESdEV 215
Cdd:pfam00001 106 iLVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLISVLG-FLLPLLVILVCYTLIIRTLRKS-AS 183
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17535609   216 ITGLAVQKRKDQKTTVMLLVVTIFFAFCHL-FSMFLkvaesIFGGFLTQTSFYWEVFAEFTIFLIIFHTSSTF--FIY 290
Cdd:pfam00001 184 KQKSSERTQRRRKALKTLAVVVVVFILCWLpYHIVN-----LLDSLALDCELSRLLDKALSVTLWLAYVNSCLnpIIY 256
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
13-301 3.08e-50

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 169.35  E-value: 3.08e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  13 MYLPVIFIGLLGNFASFLVYRTAPMRKSTvgtlllILSLIDILLLILITPIFVLVFLPLWQDQWQKYSFHMSFFAYSTRY 92
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTRKSMRSST------NVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFLPY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  93 VYPLCMMTKSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLSE------M 166
Cdd:cd14978  80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNnnsyyyV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 167 WMLDTEKHWWYFMFYFIILSVIFDYFLPFLIMTIANYHVIRALQESDEVITGLAV-------QKRKDQKTTVMLLVVTIF 239
Cdd:cd14978 160 IPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRRrrrllsrSQRRERRTTIMLIAVVIV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17535609 240 FAFCHLFSMFLKVAESIFGGFltQTSFYWEVFAEFTIFLIIFHTSSTFFIYYGFSEKFRTIF 301
Cdd:cd14978 240 FLICNLPAGILNILEAIFGES--FLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
91-294 4.21e-16

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 76.94  E-value: 4.21e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  91 RYVYPLCMMTKSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLSEMWMLD 170
Cdd:cd00637  72 KLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLC 151
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 171 TEkHWWYFMFYFIILSVIFdYFLPFLIMTIANYHVIRALQESDEVITGLAVQK------RKDQKTTVMLLVVTIFFAFCH 244
Cdd:cd00637 152 WP-DLTLSKAYTIFLFVLL-FLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSsrrrrrRRERKVTKTLLIVVVVFLLCW 229
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 17535609 245 LFSMFLKVAESIFGGFLTQTSFYWevfaEFTIFLIIFHTSSTFFIYYGFS 294
Cdd:cd00637 230 LPYFILLLLDVFGPDPSPLPRILY----FLALLLAYLNSAINPIIYAFFN 275
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
102-301 3.94e-13

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 68.78  E-value: 3.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 102 SCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLSEMWML----------DT 171
Cdd:cd14993  85 SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGTItiyictedwpSP 164
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 172 EKHWWYFMFYFIILsvifdYFLPFLIMTIANYHVIRAL-------QESDEVITGLAVQKRKDQKTTVMLLVVTIFFAFC- 243
Cdd:cd14993 165 ELRKAYNVALFVVL-----YVLPLLIISVAYSLIGRRLwrrkppgDRGSANSTSSRRILRSKKKVARMLIVVVVLFALSw 239
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17535609 244 ---HLFSMFLKvaesiFGGFLTQTSFYWeVFAEFTIFLIIFHTSSTF--FIYYGFSEKFRTIF 301
Cdd:cd14993 240 lpyYVLSILLD-----FGPLSSEESDEN-FLLILPFAQLLGYSNSAInpIIYCFMSKKFRRGF 296
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
64-290 9.44e-09

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 55.38  E-value: 9.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609    64 FVLVFLPLW------QDQWQKYSFHMSFFAYstryVYPLCMmtkSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMK- 136
Cdd:pfam00001  33 FSLLTLPFWlvyylnHGDWPFGSALCKIVGA----LFVVNG---YASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVl 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609   137 -AGIFIIIFSIVFNFPRFFDYKIGDGYLSEMWMLDTEKHWWYFMFYFIILSVIFdYFLPFLIMTIANYHVIRALQESdEV 215
Cdd:pfam00001 106 iLVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLISVLG-FLLPLLVILVCYTLIIRTLRKS-AS 183
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17535609   216 ITGLAVQKRKDQKTTVMLLVVTIFFAFCHL-FSMFLkvaesIFGGFLTQTSFYWEVFAEFTIFLIIFHTSSTF--FIY 290
Cdd:pfam00001 184 KQKSSERTQRRRKALKTLAVVVVVFILCWLpYHIVN-----LLDSLALDCELSRLLDKALSVTLWLAYVNSCLnpIIY 256
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
65-243 4.22e-08

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 53.43  E-value: 4.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  65 VLVFLPLWQDQWQKYSFHMSFFA-YSTRYVYPLCMmtkSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIII 143
Cdd:cd15001  49 LVFCVPLKTAEYFSPTWSLGAFLcKAVAYLQLLSF---ICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWI 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 144 FSIVFNFPRFFDYKI-GDGYLSEMWMLDTEKHWW---YFMFYFIILSVIFdYFLPFLIMTIanyhviralqesdevitgl 219
Cdd:cd15001 126 LSAILASPVLFGQGLvRYESENGVTVYHCQKAWPstlYSRLYVVYLAIVI-FFIPLIVMTF------------------- 185
                       170       180
                ....*....|....*....|....
gi 17535609 220 AVQKRKDQKTTVMLLVVTIFFAFC 243
Cdd:cd15001 186 AYARDTRKQVIKMLISVVVLFAVC 209
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
91-301 3.88e-06

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 47.56  E-value: 3.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  91 RYVYPLCMMTKSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLSEMWMLD 170
Cdd:cd14967  73 RFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECE 152
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 171 TEKHWWYfmfyfIILSVIFDYFLPFLIMTIANYHVIRALqesdevitglavqkRKDQKTTVMLLVVTIFFAFCHLFSMFL 250
Cdd:cd14967 153 FTPNKIY-----VLVSSVISFFIPLLIMIVLYARIFRVA--------------RRELKAAKTLAIIVGAFLLCWLPFFII 213
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 17535609 251 KVAESIFGGFLtqTSFYWevfaeFTIFLIIFHTSSTF--FIYYGFSEKFRTIF 301
Cdd:cd14967 214 YLVSAFCPPDC--VPPIL-----YAVFFWLGYLNSALnpIIYALFNRDFRRAF 259
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
14-298 1.49e-05

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 45.94  E-value: 1.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  14 YLPVIFIGLLGNFASFLV-YRTAPMRKSTvgtlllilslIDILLLILITPIFVLVFLPL-WQDQWQKYSFHMS-FFAYST 90
Cdd:cd15928   7 CSVLMLVGASGNLLTVLViGRSRDMRTTT----------NLYLSSLAVSDLLIFLVLPLdLYRLWRYRPWRFGdLLCRLM 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  91 RYVYPLCMMtksCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFF---------------- 154
Cdd:cd15928  77 YFFSETCTY---ASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVlvgvehiqgqqtprgf 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 155 ---DYKIGDGYLSEMWMLDTekhwwyfMFyfiilsvifdYFLPFLIMTIANYHVIRALQESDEVITGLAVQKR-KDQKTT 230
Cdd:cd15928 154 ectVVNVSSGLLSVMLWVST-------SF----------FFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRdNNHRQT 216
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17535609 231 V-MLLVVTIFFAFCHLfsmFLKVAESIFGGFLTQTSFYWEVFAEFTIF-LIIFHTSSTF--FIYYGFSEKFR 298
Cdd:cd15928 217 VrMLAVIVLAFVLCWL---PFHVGRVIFNHSRASTKHLHYVSQYFNLVsFVLFYLSAAInpILYNLMSKRYR 285
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
111-245 2.58e-05

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 45.36  E-value: 2.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 111 ITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFF-----DYKIGDGYLSEMWMLDTEKHWwyFMFYFIIL 185
Cdd:cd14997  95 ISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFitefkEEDFNDGTPVAVCRTPADTFW--KVAYILST 172
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17535609 186 SVIFdYFLPFLIMT-----IANYHVIRALQESDEVITGLAVQKRKDQKTTVMLLVVTIFFAFCHL 245
Cdd:cd14997 173 IVVF-FVVPLAILSglysvICRRLVGHPALESRRADAANRHTLRSRRQVVYMLITVVVLFFVCLL 236
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
69-250 3.04e-05

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 45.15  E-value: 3.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  69 LPLWQDQWQKYsFHMSFFAYSTRYVYPLCMMTKSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVF 148
Cdd:cd15189  53 LPFWAMNILNQ-FNWPFGELLCRVVNGVIKVNLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLL 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 149 NFPRFFDYKIGD--GYLSEMWMLDTEKHWWYFmfYFIILSVIFDYFLPFLIMTIANYHVIRALQESDEVItglAVQKRKD 226
Cdd:cd15189 132 SIPTFLLRKIKAipDLNITACVLLYPHEAWHF--AHIVLLNIVGFLLPLLVITFCNYNILQALRTREEST---RCEDRND 206
                       170       180
                ....*....|....*....|....*..
gi 17535609 227 QKTTVMLLVVTIFFAFCHL---FSMFL 250
Cdd:cd15189 207 SKATALVLAVTLLFLVCWGpyhFFTFL 233
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
103-298 3.13e-05

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 44.95  E-value: 3.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 103 CSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLSEMWMLDTEKHWWYFMFYF 182
Cdd:cd14982  86 GSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLASAAPI 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 183 IILSVIFDYFLPFLIMTIANYHVIRALQESDEVITGLAVQKRKDQKTTVMLLVVTIFFAFCHLFSMFLKVAESIFGGFLT 262
Cdd:cd14982 166 VLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRLSFIADCS 245
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 17535609 263 QTSFYwEVFAEFTIFLIIFHTSSTFFIYYGFSEKFR 298
Cdd:cd14982 246 ARNSL-YKAYRITLCLASLNSCLDPLIYYFLSKTFR 280
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
66-299 6.72e-05

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 43.91  E-value: 6.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  66 LVFLPLWQDqWQKYSFHMSFFAYSTRYVYPLCMMTKSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFS 145
Cdd:cd14985  50 VLTLPLWAT-YTANQYDWPFGAFLCKVSSYVISVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVA 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 146 IVFNFPRFFDYKIGDGYLSEMWMLDTEKHWWYFMFYFIILSVIFDYFLPFLIMTIANYHVIRALQESDEVItglAVQKRK 225
Cdd:cd14985 129 CLLSLPTFLLRSLQAIENLNKTACIMLYPHEAWHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERT---GKNGRK 205
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17535609 226 DQKTTVMLLVVTIFFAFCHLFSMFLKVAEsIFGGFLTQTSFYWEVFA----EFTIFLIIFHTSSTFFIYYGFSEKFRT 299
Cdd:cd14985 206 RRKSLKIIFALVVAFLVCWLPFHFFKFLD-FLAQLGAIRPCFWELFLdlglPIATCLAFTNSCLNPFIYVFVDRRFRQ 282
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
98-301 1.34e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 43.05  E-value: 1.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  98 MMTKSCSLYLMvliTIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFF---DYKIGDGYLSEMWMLDTEKH 174
Cdd:cd14970  83 MFTSIFCLTVM---SVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIfarTLQEEGGTISCNLQWPDPPD 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 175 WWYFMfyFIILSVIFDYFLPFLIMTIANYHVIRALQESDEVITGLAVQKRKD-QKTTVMLLVVTIFFAFCHL-FSMFLKV 252
Cdd:cd14970 160 YWGRV--FTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSGAREKRRArRKVTRLVLVVVAVFVVCWLpFHVFQIV 237
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 17535609 253 AESIfggfLTQTSFYWEVFAEFTIFLIIFHTSSTFFIYYGFSEKFRTIF 301
Cdd:cd14970 238 RLLI----DPPETLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
85-301 1.66e-04

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 42.79  E-value: 1.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  85 FFAYSTRYVYPLCMMTKSCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLS 164
Cdd:cd15098  70 FGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTA 149
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 165 EMWMLDTEkHWWYFMFY--FIILSVIFDYFLPFLIMTIANYHVIRALQESDEVITGLAvqKRKDQKTTVMLLVVTIFFAF 242
Cdd:cd15098 150 SNQTFCWE-NWPEKQQKpvYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLKNMSKKS--ERSKKKTAQTVLVVVVVFGI 226
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 243 C----HLFSMFLKvaesiFGGF-LTQTSFywevfaeftIFLIIFH-----TSSTFFIYYGF-SEKFRTIF 301
Cdd:cd15098 227 SwlphHIIHLWVE-----FGDFpLTQASF---------VLRITAHclayaNSCVNPIIYAFlSENFRKAY 282
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
104-298 8.78e-04

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 40.53  E-value: 8.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 104 SLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFfdykigdgYLSEMW-------MLDTEKHWw 176
Cdd:cd15129  89 SIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGIPFY--------WWSDMWrdshpptTLDKVLKW- 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 177 yfMFYFIIlsvifdYFLPFLIMTIANYHVIRALQESdeviTGLAVQKRKDQKTTVMLLVVTIFFAFCHLFSMFLkvaeSI 256
Cdd:cd15129 160 --THCFII------YFIPCTIFLVTNSVIIHKLRRR----KGRSGPQRRSGKTTAILLAITTVFAVLWAPRTVV----II 223
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 17535609 257 FGGFLTQTSFYWEVFAEFTI--FLIIFHTSSTFFIYYGFSEKFR 298
Cdd:cd15129 224 YHLYVSSVNRDWRVHLALDLanMLAMLNTAVNFFLYCFVSKRFR 267
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
104-301 9.52e-04

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 40.57  E-value: 9.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 104 SLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFP---RFFDYKIGDGYLSEMWMLDTEKHWWYFMF 180
Cdd:cd15202  87 SAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPHAicsKLETFKYSEDIVRSLCLEDWPERADLFWK 166
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 181 YFIILSVIFDYFLPFLIMTIANYHVIRALQES----DEVITGLAVQKRKDQKTTVMLLVVTIFFAFC----HLFSMFLKV 252
Cdd:cd15202 167 YYDLALFILQYFLPLLVISFAYARVGIKLWASnmpgDATTERYFALRRKKKKVIKMLMVVVVLFALCwlpfNIYVLLLSS 246
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 17535609 253 AESIFGGFLTQTSFYWEVFAeftifliIFHTSSTFFIYYGFSEKFRTIF 301
Cdd:cd15202 247 KPDYLIKTINAVYFAFHWLA-------MSSTCYNPFIYCWLNERFRIEF 288
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
103-242 1.72e-03

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 39.75  E-value: 1.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 103 CSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFF---DYKIGD-GYLSEMWMLDTEKHWWYF 178
Cdd:cd15369  86 CSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLseqTIQIPDlGITTCHDVLNEQLLMGYY 165
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17535609 179 MFYFIILSVIFdYFLPFLIMTIANYHVIRALQESDEVitglavqKRKDQKTTVMLLVVTIFFAF 242
Cdd:cd15369 166 VYYFSIFSCLF-FFVPLIITTVCYVSIIRCLSSSSDV-------ANSSKKTRALFMAVAVFCVF 221
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
92-301 2.45e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 38.99  E-value: 2.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609  92 YVYPLCMMTkscSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLSEMWMLDT 171
Cdd:cd14971  78 YFQQVSMHA---SIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSE 154
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 172 EKHWWYFMFYFIILSVIFDYFLPFLIMTIANYHVIRALQESDEVITGLAVQKRKDQKTTVMLLVVTIFFAFCHL-FSMFL 250
Cdd:cd14971 155 AWPSRAHRRAFALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGpIHAIL 234
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 17535609 251 KVAEsiFGGF-LTQTSFYWEVFAEftifLIIFHTSSTFFIYYGF-SEKFRTIF 301
Cdd:cd14971 235 LLVA--LGPFpLTYATYALRIWAH----CLAYSNSAVNPVLYAFlSEHFRKAF 281
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
102-245 3.57e-03

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 38.63  E-value: 3.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 102 SCSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFF------DYKIGDGYLSemWMLDTEKHW 175
Cdd:cd15132  85 YATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFlvgveqDNNIHPDDFS--RECKHTPYA 162
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17535609 176 WYFMFYFIILSVIFDYF-LPFLIMTIANYHVIRALQESDEVITG--LAVQKRKDQKTTVMLLVVTIFFAFCHL 245
Cdd:cd15132 163 VSSGLLGIMIWVTTTYFfLPMLCLSFLYGFIGRKLWKSKNDLRGpnAAARERSHRQTVRILAVVVLAFIICWL 235
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
103-243 6.07e-03

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 37.96  E-value: 6.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 103 CSLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRF----FDYKIGDGYLSEMWMLDTEKHWWYF 178
Cdd:cd14969  86 VSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIWLYGLFWALPPLFgwssYVPEGGGTSCSVDWYSKDPNSLSYI 165
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17535609 179 MFYFiilsvIFDYFLPFLIMTIANYHVIRALQESDEVITGLAVQ------KRKDQKTTVMLLVVTIFFAFC 243
Cdd:cd14969 166 VSLF-----VFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNSaitkrtKKAEKKVAKMVLVMIVAFLIA 231
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
102-301 8.25e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 37.37  E-value: 8.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 102 SCSLYLMVLITIERWIAVCRPLQAKvlCTNRNTMKAGIFIIIFSIVFNFPRFFDYK-IGDGYLSEMWMLDT--EKHWW-- 176
Cdd:cd15208  85 SVSVLTLSCIALDRWYAICHPLMFK--STAKRARVSILIIWIVSLLIMIPQAIVMEcSRVVPLANKTILLTvcDERWSds 162
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 177 -YFMFYFIILSVIFdYFLPFLIMTIANYHVIRAL-----------------QESDEVITGLAVQKRKDQKTTVMLLVVTI 238
Cdd:cd15208 163 iYQKVYHICFFLVT-YLLPLCLMILAYFQIFRKLwcrqipgtssvvqrkwnKPRKSAVAAEEKQLRSRRKTAKMLIVVVI 241
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17535609 239 FFAFCHLFSMFLKVAESIFGGFLTQTSFYWeVFAEFTIFLIIFHTSSTFFIYYGFSEKFRTIF 301
Cdd:cd15208 242 MFAICYLPVHLLNILRYVFGLFTVDRETIY-AWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
104-243 9.69e-03

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 37.28  E-value: 9.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 104 SLYLMVLITIERWIAVCRPLQAKVLCTNRNTMKAGIFIIIFSIVFNFPRFFDYKIGDGYLSEMWMLDTEKHWWYFMFYFI 183
Cdd:cd15090  86 SIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYWENLLK 165
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535609 184 ILSVIFDYFLPFLIMTIANYHVIRALQeSDEVITGLAVQKRKDQKTTVMLLVVTIFFAFC 243
Cdd:cd15090 166 ICVFIFAFIMPVLIITVCYGLMILRLK-SVRMLSGSKEKDRNLRRITRMVLVVVAVFIVC 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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