ABC transporter domain-containing protein [Caenorhabditis elegans]
Protein Classification
P-loop NTPase family protein( domain architecture ID 1562424)
P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| P-loop_NTPase super family | cl38936 | P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ... |
18-238 | 1.15e-30 | ||||
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families. The actual alignment was detected with superfamily member cd03234: Pssm-ID: 476819 [Multi-domain] Cd Length: 226 Bit Score: 119.68 E-value: 1.15e-30
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| Name | Accession | Description | Interval | E-value | |||||
| ABCG_White | cd03234 | White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ... |
18-238 | 1.15e-30 | |||||
White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors. The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red pigments, which are synthesized from guanine, and brown pigments, which are synthesized from tryptophan. The pigment precursors are encoded by the white, brown, and scarlet genes, respectively. Evidence from genetic and biochemical studies suggest that the White and Brown proteins function as heterodimers to import guanine, while the White and Scarlet proteins function to import tryptophan. However, a recent study also suggests that White may be involved in the transport of a metabolite, such as 3-hydroxykynurenine, across intracellular membranes. Mammalian ABC transporters belonging to the White subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1 (ABC8), the human homolog of the Drosophila white gene is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. It is possible that human ABCG1 forms heterodimers with several heterologous partners. Pssm-ID: 213201 [Multi-domain] Cd Length: 226 Bit Score: 119.68 E-value: 1.15e-30
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| 3a01204 | TIGR00955 | The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, ... |
20-305 | 2.47e-28 | |||||
The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, Other] Pssm-ID: 273361 [Multi-domain] Cd Length: 617 Bit Score: 119.77 E-value: 2.47e-28
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| NatA | COG4555 | ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, ... |
25-253 | 3.89e-18 | |||||
ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, Inorganic ion transport and metabolism]; Pssm-ID: 443618 [Multi-domain] Cd Length: 243 Bit Score: 84.14 E-value: 3.89e-18
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| ABC_tran | pfam00005 | ABC transporter; ABC transporters for a large family of proteins responsible for translocation ... |
37-183 | 1.47e-10 | |||||
ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains. Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 59.58 E-value: 1.47e-10
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| PLN03211 | PLN03211 | ABC transporter G-25; Provisional |
36-267 | 2.85e-10 | |||||
ABC transporter G-25; Provisional Pssm-ID: 215634 [Multi-domain] Cd Length: 659 Bit Score: 62.97 E-value: 2.85e-10
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| Name | Accession | Description | Interval | E-value | |||||
| ABCG_White | cd03234 | White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ... |
18-238 | 1.15e-30 | |||||
White pigment protein homolog of ABCG transporter subfamily; The White subfamily represents ABC transporters homologous to the Drosophila white gene, which acts as a dimeric importer for eye pigment precursors. The eye pigmentation of Drosophila is developed from the synthesis and deposition in the cells of red pigments, which are synthesized from guanine, and brown pigments, which are synthesized from tryptophan. The pigment precursors are encoded by the white, brown, and scarlet genes, respectively. Evidence from genetic and biochemical studies suggest that the White and Brown proteins function as heterodimers to import guanine, while the White and Scarlet proteins function to import tryptophan. However, a recent study also suggests that White may be involved in the transport of a metabolite, such as 3-hydroxykynurenine, across intracellular membranes. Mammalian ABC transporters belonging to the White subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1 (ABC8), the human homolog of the Drosophila white gene is induced in monocyte-derived macrophages during cholesterol influx mediated by acetylated low-density lipoprotein. It is possible that human ABCG1 forms heterodimers with several heterologous partners. Pssm-ID: 213201 [Multi-domain] Cd Length: 226 Bit Score: 119.68 E-value: 1.15e-30
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| 3a01204 | TIGR00955 | The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, ... |
20-305 | 2.47e-28 | |||||
The Eye Pigment Precursor Transporter (EPP) Family protein; [Transport and binding proteins, Other] Pssm-ID: 273361 [Multi-domain] Cd Length: 617 Bit Score: 119.77 E-value: 2.47e-28
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| NatA | COG4555 | ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, ... |
25-253 | 3.89e-18 | |||||
ABC-type Na+ transport system, ATPase component NatA [Energy production and conversion, Inorganic ion transport and metabolism]; Pssm-ID: 443618 [Multi-domain] Cd Length: 243 Bit Score: 84.14 E-value: 3.89e-18
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| CcmA | COG1131 | ABC-type multidrug transport system, ATPase component [Defense mechanisms]; |
25-223 | 3.91e-17 | |||||
ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Pssm-ID: 440746 [Multi-domain] Cd Length: 236 Bit Score: 80.88 E-value: 3.91e-17
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| ABCG_EPDR | cd03213 | Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette ... |
19-238 | 5.79e-17 | |||||
Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus. Pssm-ID: 213180 [Multi-domain] Cd Length: 194 Bit Score: 79.52 E-value: 5.79e-17
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| ABC_subfamily_A | cd03263 | ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily ... |
25-211 | 6.86e-13 | |||||
ATP-binding cassette domain of the lipid transporters, subfamily A; The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency, degenerative retinopathies, and congenital keratinization disorders. The ABCA1 protein is involved in disorders of cholesterol transport and high-density lipoprotein (HDL) biosynthesis. The ABCA4 (ABCR) protein transports vitamin A derivatives in the outer segments of photoreceptor cells, and therefore, performs a crucial step in the visual cycle. The ABCA genes are not present in yeast. However, evolutionary studies of ABCA genes indicate that they arose as transporters that subsequently duplicated and that certain sets of ABCA genes were lost in different eukaryotic lineages. Pssm-ID: 213230 [Multi-domain] Cd Length: 220 Bit Score: 68.30 E-value: 6.86e-13
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| ABC_drug_resistance_like | cd03264 | ABC-type multidrug transport system, ATPase component; The biological function of this family ... |
35-187 | 2.80e-11 | |||||
ABC-type multidrug transport system, ATPase component; The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213231 [Multi-domain] Cd Length: 211 Bit Score: 63.37 E-value: 2.80e-11
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| ABC_tran | pfam00005 | ABC transporter; ABC transporters for a large family of proteins responsible for translocation ... |
37-183 | 1.47e-10 | |||||
ABC transporter; ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain pfam00664. These four domains may belong to a single polypeptide or belong in different polypeptide chains. Pssm-ID: 394964 [Multi-domain] Cd Length: 150 Bit Score: 59.58 E-value: 1.47e-10
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| PLN03211 | PLN03211 | ABC transporter G-25; Provisional |
36-267 | 2.85e-10 | |||||
ABC transporter G-25; Provisional Pssm-ID: 215634 [Multi-domain] Cd Length: 659 Bit Score: 62.97 E-value: 2.85e-10
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| ABC_NatA_sodium_exporter | cd03266 | ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a ... |
25-238 | 4.18e-10 | |||||
ATP-binding cassette domain of the Na+ transporter; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of a single ATP-binding protein and a single integral membrane protein. Pssm-ID: 213233 [Multi-domain] Cd Length: 218 Bit Score: 60.07 E-value: 4.18e-10
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| ABC_cobalt_CbiO_domain1 | cd03225 | First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ... |
35-211 | 5.58e-10 | |||||
First domain of the ATP-binding cassette component of cobalt transport system; Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC transport system of the CbiMNQO family is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most of cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems. Pssm-ID: 213192 [Multi-domain] Cd Length: 211 Bit Score: 59.40 E-value: 5.58e-10
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| ABC_ATPase | cd00267 | ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ... |
35-211 | 1.01e-09 | |||||
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213179 [Multi-domain] Cd Length: 157 Bit Score: 57.64 E-value: 1.01e-09
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| ABC_Iron-Siderophores_B12_Hemin | cd03214 | ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related ... |
35-212 | 2.92e-09 | |||||
ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC transporter mediating vitamin B12 uptake. The two ATP-binding cassettes (BtuD) are in close contact with each other, as are the two membrane-spanning subunits (BtuC); this arrangement is distinct from that observed for the E. coli lipid flippase MsbA. The BtuC subunits provide 20 transmembrane helices grouped around a translocation pathway that is closed to the cytoplasm by a gate region, whereas the dimer arrangement of the BtuD subunits resembles the ATP-bound form of the Rad50 DNA repair enzyme. A prominent cytoplasmic loop of BtuC forms the contact region with the ATP-binding cassette and represent a conserved motif among the ABC transporters. Pssm-ID: 213181 [Multi-domain] Cd Length: 180 Bit Score: 56.67 E-value: 2.92e-09
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| ABC_putative_ATPase | cd03269 | ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the ... |
24-190 | 5.27e-09 | |||||
ATP-binding cassette domain of an uncharacterized transporter; This subgroup is related to the subfamily A transporters involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two integral membranes. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213236 [Multi-domain] Cd Length: 210 Bit Score: 56.52 E-value: 5.27e-09
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| ABC_BcrA_bacitracin_resist | cd03268 | ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily ... |
35-224 | 9.59e-09 | |||||
ATP-binding cassette domain of the bacitracin-resistance transporter; The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multi-enzyme complex BcrABC. Bacitracin has potent antibiotic activity against gram-positive bacteria. The inhibition of peptidoglycan biosynthesis is the best characterized bacterial effect of bacitracin. The bacitracin resistance of B. licheniformis is mediated by the ABC transporter Bcr which is composed of two identical BcrA ATP-binding subunits and one each of the integral membrane proteins, BcrB and BcrC. B. subtilis cells carrying bcr genes on high-copy number plasmids develop collateral detergent sensitivity, a similar phenomenon in human cells with overexpressed multi-drug resistance P-glycoprotein. Pssm-ID: 213235 [Multi-domain] Cd Length: 208 Bit Score: 55.69 E-value: 9.59e-09
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| ABC_DR_subfamily_A | cd03230 | ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily ... |
25-223 | 1.48e-08 | |||||
ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; This family of ATP-binding proteins belongs to a multi-subunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding protein and one or two integral membrane proteins. Eukaryotic systems of the ABCA subfamily display ABC domains that are quite similar to this family. The ATP-binding domain shows the highest similarity between all members of the ABC transporter family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213197 [Multi-domain] Cd Length: 173 Bit Score: 54.33 E-value: 1.48e-08
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| ABC_NatA_like | cd03267 | ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; ... |
37-238 | 1.67e-08 | |||||
ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative membrane spanning regions at its C-terminus. In B. subtilis, NatAB is inducible by agents such as ethanol and protonophores, which lower the proton-motive force across the membrane. The closest sequence similarity to NatA is exhibited by DrrA of the two-component daunorubicin- and doxorubicin-efflux system. Hence, the functional NatAB is presumably assembled with two copies of the single ATP-binding protein and the single integral membrane protein. Pssm-ID: 213234 [Multi-domain] Cd Length: 236 Bit Score: 55.42 E-value: 1.67e-08
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| fecE | PRK11231 | Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; |
36-185 | 9.96e-08 | |||||
Fe(3+) dicitrate ABC transporter ATP-binding protein FecE; Pssm-ID: 183044 [Multi-domain] Cd Length: 255 Bit Score: 53.48 E-value: 9.96e-08
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| ABC_DrrA | cd03265 | Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein ... |
34-211 | 1.29e-07 | |||||
Daunorubicin/doxorubicin resistance ATP-binding protein; DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin. In addition to DrrA, the complex includes an integral membrane protein called DrrB. DrrA belongs to the ABC family of transporters and shares sequence and functional similarities with a protein found in cancer cells called P-glycoprotein. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region in addition to the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213232 [Multi-domain] Cd Length: 220 Bit Score: 52.76 E-value: 1.29e-07
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
30-211 | 2.60e-07 | |||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 53.37 E-value: 2.60e-07
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| ABC_Metallic_Cations | cd03235 | ATP-binding cassette domain of the metal-type transporters; This family includes transporters ... |
36-238 | 9.65e-07 | |||||
ATP-binding cassette domain of the metal-type transporters; This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-siderophore uptake family suggesting that they share a common ancestor. The best characterized metal-type ABC transporters are the YfeABCD system of Y. pestis, the SitABCD system of Salmonella enterica serovar Typhimurium, and the SitABCD transporter of Shigella flexneri. Moreover other uncharacterized homologs of these metal-type transporters are mainly found in pathogens like Haemophilus or enteroinvasive E. coli isolates. Pssm-ID: 213202 [Multi-domain] Cd Length: 213 Bit Score: 49.84 E-value: 9.65e-07
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| EcfA2 | COG1122 | Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and ... |
28-211 | 1.28e-06 | |||||
Energy-coupling factor transporter ATP-binding protein EcfA2 [Inorganic ion transport and metabolism, General function prediction only]; Pssm-ID: 440739 [Multi-domain] Cd Length: 230 Bit Score: 49.64 E-value: 1.28e-06
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| ABC_MJ0796_LolCDE_FtsE | cd03255 | ATP-binding cassette domain of the transporters involved in export of lipoprotein and ... |
25-64 | 1.79e-06 | |||||
ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane. Pssm-ID: 213222 [Multi-domain] Cd Length: 218 Bit Score: 49.03 E-value: 1.79e-06
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| ABC_PhnC_transporter | cd03256 | ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; ... |
25-215 | 2.28e-06 | |||||
ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all kingdoms of wildlife, but only prokaryotic microorganisms are able to cleave this bond. Certain bacteria such as E. coli can use alkylphosphonates as a phosphorus source. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213223 [Multi-domain] Cd Length: 241 Bit Score: 49.10 E-value: 2.28e-06
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| CcmA | COG4133 | ABC-type transport system involved in cytochrome c biogenesis, ATPase component ... |
36-183 | 3.30e-06 | |||||
ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 443308 [Multi-domain] Cd Length: 206 Bit Score: 48.24 E-value: 3.30e-06
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| ABCC_cytochrome_bd | cd03247 | ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome ... |
30-213 | 1.05e-05 | |||||
ATP-binding cassette domain of CydCD, subfamily C; The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd quinol oxidase and for periplasmic c-type cytochromes. CydCD were proposed to determine a heterooligomeric complex important for heme export into the periplasm or to be involved in the maintenance of the proper redox state of the periplasmic space. In Bacillus subtilis, the absence of CydCD does not affect the presence of halo-cytochrome c in the membrane and this observation suggests that CydCD proteins are not involved in the export of heme in this organism. Pssm-ID: 213214 [Multi-domain] Cd Length: 178 Bit Score: 46.15 E-value: 1.05e-05
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| hmuV | PRK13548 | hemin importer ATP-binding subunit; Provisional |
35-68 | 1.46e-05 | |||||
hemin importer ATP-binding subunit; Provisional Pssm-ID: 237422 [Multi-domain] Cd Length: 258 Bit Score: 46.69 E-value: 1.46e-05
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| 3a01205 | TIGR00956 | Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other] |
35-265 | 2.12e-05 | |||||
Pleiotropic Drug Resistance (PDR) Family protein; [Transport and binding proteins, Other] Pssm-ID: 273362 [Multi-domain] Cd Length: 1394 Bit Score: 47.80 E-value: 2.12e-05
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| SufC | COG0396 | Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, ... |
35-67 | 2.72e-05 | |||||
Fe-S cluster assembly ATPase SufC [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440165 [Multi-domain] Cd Length: 245 Bit Score: 45.83 E-value: 2.72e-05
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| ABC_NikE_OppD_transporters | cd03257 | ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ... |
24-211 | 3.57e-05 | |||||
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF. Pssm-ID: 213224 [Multi-domain] Cd Length: 228 Bit Score: 45.19 E-value: 3.57e-05
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| YbbA | COG4181 | Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase ... |
36-64 | 3.91e-05 | |||||
Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 443338 [Multi-domain] Cd Length: 233 Bit Score: 45.12 E-value: 3.91e-05
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| LolD | COG1136 | ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis]; |
25-67 | 4.12e-05 | |||||
ABC-type lipoprotein export system, ATPase component [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440751 [Multi-domain] Cd Length: 227 Bit Score: 45.03 E-value: 4.12e-05
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| ABC_Org_Solvent_Resistant | cd03261 | ATP-binding cassette transport system involved in resistance to organic solvents; ABC ... |
35-211 | 4.60e-05 | |||||
ATP-binding cassette transport system involved in resistance to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213228 [Multi-domain] Cd Length: 235 Bit Score: 45.19 E-value: 4.60e-05
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| ABC_Carb_Monos_II | cd03215 | Second domain of the ATP-binding cassette component of monosaccharide transport system; This ... |
37-68 | 6.17e-05 | |||||
Second domain of the ATP-binding cassette component of monosaccharide transport system; This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. In members of Carb_Monos family the single hydrophobic gene product forms a homodimer, while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter. Pssm-ID: 213182 [Multi-domain] Cd Length: 182 Bit Score: 43.96 E-value: 6.17e-05
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| ccmA | TIGR01189 | heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein ... |
36-187 | 6.87e-05 | |||||
heme ABC exporter, ATP-binding protein CcmA; This model describes the cyt c biogenesis protein encoded by ccmA in bacteria. An exception is, an arabidopsis protein. Quite likely this is encoded by an organelle. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes: ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other] Pssm-ID: 273491 [Multi-domain] Cd Length: 198 Bit Score: 44.27 E-value: 6.87e-05
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| ABCG_PDR_domain1 | cd03233 | First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette ... |
21-238 | 6.92e-05 | |||||
First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213200 [Multi-domain] Cd Length: 202 Bit Score: 44.18 E-value: 6.92e-05
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| PRK13651 | PRK13651 | cobalt transporter ATP-binding subunit; Provisional |
25-67 | 7.23e-05 | |||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184210 [Multi-domain] Cd Length: 305 Bit Score: 45.08 E-value: 7.23e-05
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| ABC_CcmA_heme_exporter | cd03231 | Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the ... |
36-211 | 7.78e-05 | |||||
Cytochrome c biogenesis ATP-binding export protein; CcmA, the ATP-binding component of the bacterial CcmAB transporter. The CCM family is involved in bacterial cytochrome c biogenesis. Cytochrome c maturation in E. coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperon that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. The CcmAB proteins represent an ABC transporter and the CcmCD proteins participate in heme transfer to CcmE. Pssm-ID: 213198 [Multi-domain] Cd Length: 201 Bit Score: 44.02 E-value: 7.78e-05
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| ABC_cobalt_CbiO_domain2 | cd03226 | Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of ... |
36-211 | 8.32e-05 | |||||
Second domain of the ATP-binding cassette component of cobalt transport system; Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The CbiMNQO family ABC transport system is involved in cobalt transport in association with the cobalamin (vitamin B12) biosynthetic pathways. Most cobalt (Cbi) transport systems possess a separate CbiN component, the cobalt-binding periplasmic protein, and they are encoded by the conserved gene cluster cbiMNQO. Both the CbiM and CbiQ proteins are integral cytoplasmic membrane proteins, and the CbiO protein has the linker peptide and the Walker A and B motifs commonly found in the ATPase components of the ABC-type transport systems. Pssm-ID: 213193 [Multi-domain] Cd Length: 205 Bit Score: 44.17 E-value: 8.32e-05
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| cbiO | PRK13638 | energy-coupling factor ABC transporter ATP-binding protein; |
130-233 | 1.06e-04 | |||||
energy-coupling factor ABC transporter ATP-binding protein; Pssm-ID: 184198 [Multi-domain] Cd Length: 271 Bit Score: 44.23 E-value: 1.06e-04
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| ABC_KpsT_Wzt | cd03220 | ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC ... |
33-68 | 1.06e-04 | |||||
ATP-binding cassette component of polysaccharide transport system; The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and teichoic acids have been shown to be exported by ABC transporters. A typical system is made of a conserved integral membrane and an ABC. In addition to these proteins, capsular polysaccharide exporter systems require two 'accessory' proteins to perform their function: a periplasmic (E.coli) or a lipid-anchored outer membrane protein called OMA (Neisseria meningitidis and Haemophilus influenza) and a cytoplasmic membrane protein MPA2. Pssm-ID: 213187 [Multi-domain] Cd Length: 224 Bit Score: 44.06 E-value: 1.06e-04
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| GsiA | COG1123 | ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain ... |
25-68 | 1.10e-04 | |||||
ABC-type glutathione transport system ATPase component, contains duplicated ATPase domain [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440740 [Multi-domain] Cd Length: 514 Bit Score: 44.89 E-value: 1.10e-04
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| NupO | COG3845 | ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and ... |
37-68 | 1.10e-04 | |||||
ABC-type guanosine uptake system NupNOPQ, ATPase component NupO [Nucleotide transport and metabolism]; Pssm-ID: 443055 [Multi-domain] Cd Length: 504 Bit Score: 45.02 E-value: 1.10e-04
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| TagH | COG1134 | ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate ... |
24-68 | 1.28e-04 | |||||
ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism]; Pssm-ID: 440749 [Multi-domain] Cd Length: 245 Bit Score: 43.92 E-value: 1.28e-04
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| ZnuC | COG1121 | ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; ... |
36-67 | 1.49e-04 | |||||
ABC-type Mn2+/Zn2+ transport system, ATPase component [Inorganic ion transport and metabolism]; Pssm-ID: 440738 [Multi-domain] Cd Length: 245 Bit Score: 43.54 E-value: 1.49e-04
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| FepC | COG1120 | ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion ... |
35-212 | 1.50e-04 | |||||
ABC-type cobalamin/Fe3+-siderophores transport system, ATPase component [Inorganic ion transport and metabolism, Coenzyme transport and metabolism]; Pssm-ID: 440737 [Multi-domain] Cd Length: 254 Bit Score: 43.88 E-value: 1.50e-04
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| ycf16 | CHL00131 | sulfate ABC transporter protein; Validated |
34-67 | 2.35e-04 | |||||
sulfate ABC transporter protein; Validated Pssm-ID: 214372 [Multi-domain] Cd Length: 252 Bit Score: 43.09 E-value: 2.35e-04
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| cbiO | PRK13648 | cobalt transporter ATP-binding subunit; Provisional |
1-225 | 2.71e-04 | |||||
cobalt transporter ATP-binding subunit; Provisional Pssm-ID: 184207 [Multi-domain] Cd Length: 269 Bit Score: 43.20 E-value: 2.71e-04
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| AbcC | COG1135 | ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism]; |
25-64 | 3.25e-04 | |||||
ABC-type methionine transport system, ATPase component [Amino acid transport and metabolism]; Pssm-ID: 440750 [Multi-domain] Cd Length: 339 Bit Score: 43.14 E-value: 3.25e-04
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| ABC_MetN_methionine_transporter | cd03258 | ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ... |
25-64 | 3.36e-04 | |||||
ATP-binding cassette domain of methionine transporter; MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213225 [Multi-domain] Cd Length: 233 Bit Score: 42.57 E-value: 3.36e-04
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| PRK13536 | PRK13536 | nodulation factor ABC transporter ATP-binding protein NodI; |
36-195 | 3.91e-04 | |||||
nodulation factor ABC transporter ATP-binding protein NodI; Pssm-ID: 237419 [Multi-domain] Cd Length: 340 Bit Score: 42.90 E-value: 3.91e-04
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| SunT | COG2274 | ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase ... |
36-64 | 4.85e-04 | |||||
ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Pssm-ID: 441875 [Multi-domain] Cd Length: 711 Bit Score: 43.28 E-value: 4.85e-04
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| ABC_FeS_Assembly | cd03217 | ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of ... |
35-67 | 4.96e-04 | |||||
ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Biosynthesis of iron-sulfur clusters (Fe-S) depends on multi-protein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under stressful conditions. The SUF system is made of six proteins: SufC is an atypical cytoplasmic ABC-ATPase, which forms a complex with SufB and SufD; SufA plays the role of a scaffold protein for assembly of iron-sulfur clusters and delivery to target proteins; SufS is a cysteine desulfurase which mobilizes the sulfur atom from cysteine and provides it to the cluster; SufE has no associated function yet. Pssm-ID: 213184 [Multi-domain] Cd Length: 200 Bit Score: 41.74 E-value: 4.96e-04
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| ABCC_MRP_domain1 | cd03250 | ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ... |
36-67 | 6.22e-04 | |||||
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate. Pssm-ID: 213217 [Multi-domain] Cd Length: 204 Bit Score: 41.30 E-value: 6.22e-04
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| lolD | PRK11629 | lipoprotein-releasing ABC transporter ATP-binding protein LolD; |
36-67 | 7.83e-04 | |||||
lipoprotein-releasing ABC transporter ATP-binding protein LolD; Pssm-ID: 183244 [Multi-domain] Cd Length: 233 Bit Score: 41.34 E-value: 7.83e-04
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| araG | PRK11288 | L-arabinose ABC transporter ATP-binding protein AraG; |
31-186 | 8.49e-04 | |||||
L-arabinose ABC transporter ATP-binding protein AraG; Pssm-ID: 183077 [Multi-domain] Cd Length: 501 Bit Score: 42.21 E-value: 8.49e-04
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| MK0520 | COG2401 | ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction ... |
34-68 | 9.30e-04 | |||||
ABC-type ATPase fused to a predicted acetyltransferase domain [General function prediction only]; Pssm-ID: 441957 [Multi-domain] Cd Length: 222 Bit Score: 41.10 E-value: 9.30e-04
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| ABC_Carb_Monos_I | cd03216 | First domain of the ATP-binding cassette component of monosaccharide transport system; This ... |
25-68 | 1.01e-03 | |||||
First domain of the ATP-binding cassette component of monosaccharide transport system; This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (such as xylose, arabinose, and ribose), that cannot be broken down to simple sugars by hydrolysis. Pentoses include xylose, arabinose, and ribose. Important hexoses include glucose, galactose, and fructose. In members of the Carb_monos family, the single hydrophobic gene product forms a homodimer while the ABC protein represents a fusion of two nucleotide-binding domains. However, it is assumed that two copies of the ABC domains are present in the assembled transporter. Pssm-ID: 213183 [Multi-domain] Cd Length: 163 Bit Score: 40.10 E-value: 1.01e-03
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| ABCC_ATM1_transporter | cd03253 | ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC ... |
34-67 | 1.21e-03 | |||||
ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; ATM1 is an ABC transporter that is expressed in the mitochondria. Although the specific function of ATM1 is unknown, its disruption results in the accumulation of excess mitochondrial iron, loss of mitochondrial cytochromes, oxidative damage to mitochondrial DNA, and decreased levels of cytosolic heme proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213220 [Multi-domain] Cd Length: 236 Bit Score: 40.68 E-value: 1.21e-03
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| ABCG_PDR_domain2 | cd03232 | Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding ... |
35-197 | 1.33e-03 | |||||
Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters; The pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. This PDR subfamily represents domain I of its (ABC-IM)2 organization. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213199 [Multi-domain] Cd Length: 192 Bit Score: 40.30 E-value: 1.33e-03
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| ABC_FtsE | cd03292 | Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where ... |
24-187 | 1.36e-03 | |||||
Cell division ATP-binding protein FtsE; The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages Pssm-ID: 213259 [Multi-domain] Cd Length: 214 Bit Score: 40.47 E-value: 1.36e-03
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| ABCC_Glucan_exporter_like | cd03254 | ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan ... |
22-68 | 1.42e-03 | |||||
ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virulence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and lipid export. The MRP-like family, similar to all ABC proteins, have a common four-domain core structure constituted by two membrane-spanning domains each composed of six transmembrane (TM) helices and two nucleotide-binding domains (NBD). ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213221 [Multi-domain] Cd Length: 229 Bit Score: 40.67 E-value: 1.42e-03
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| MlaF | COG1127 | ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall ... |
35-64 | 1.63e-03 | |||||
ATPase subunit MlaF of the ABC-type intermembrane phospholipid transporter Mla [Cell wall/membrane/envelope biogenesis]; Pssm-ID: 440744 [Multi-domain] Cd Length: 241 Bit Score: 40.35 E-value: 1.63e-03
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| ABC_TM1139_LivF_branched | cd03224 | ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of ... |
34-67 | 1.85e-03 | |||||
ATP-binding cassette domain of branched-chain amino acid transporter; LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. Pssm-ID: 213191 [Multi-domain] Cd Length: 222 Bit Score: 40.11 E-value: 1.85e-03
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| ABCC_Protease_Secretion | cd03246 | ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of ... |
7-67 | 2.22e-03 | |||||
ATP-binding cassette domain of PrtD, subfamily C; This family represents the ABC component of the protease secretion system PrtD, a 60-kDa integral membrane protein sharing 37% identity with HlyB, the ABC component of the alpha-hemolysin secretion pathway, in the C-terminal domain. They export degradative enzymes by using a type I protein secretion system and lack an N-terminal signal peptide, but contain a C-terminal secretion signal. The Type I secretion apparatus is made up of three components, an ABC transporter, a membrane fusion protein (MFP), and an outer membrane protein (OMP). For the HlyA transporter complex, HlyB (ABC transporter) and HlyD (MFP) reside in the inner membrane of E. coli. The OMP component is TolC, which is thought to interact with the MFP to form a continuous channel across the periplasm from the cytoplasm to the exterior. HlyB belongs to the family of ABC transporters, which are ubiquitous, ATP-dependent transmembrane pumps or channels. The spectrum of transport substrates ranges from inorganic ions, nutrients such as amino acids, sugars, or peptides, hydrophobic drugs, to large polypeptides, such as HlyA. Pssm-ID: 213213 [Multi-domain] Cd Length: 173 Bit Score: 39.12 E-value: 2.22e-03
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| ABCF_EF-3 | cd03221 | ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is ... |
35-68 | 2.43e-03 | |||||
ATP-binding cassette domain of elongation factor 3, subfamily F; Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site. The reaction requires ATP hydrolysis. EF-3 contains two ATP nucleotide binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions. Pssm-ID: 213188 [Multi-domain] Cd Length: 144 Bit Score: 38.58 E-value: 2.43e-03
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| PRK09700 | PRK09700 | D-allose ABC transporter ATP-binding protein AlsA; |
26-186 | 2.44e-03 | |||||
D-allose ABC transporter ATP-binding protein AlsA; Pssm-ID: 182036 [Multi-domain] Cd Length: 510 Bit Score: 40.54 E-value: 2.44e-03
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| TauB | COG1116 | ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion ... |
25-64 | 3.08e-03 | |||||
ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Pssm-ID: 440733 [Multi-domain] Cd Length: 260 Bit Score: 39.69 E-value: 3.08e-03
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| ABC_HisP_GlnQ | cd03262 | ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ... |
34-67 | 3.18e-03 | |||||
ATP-binding cassette domain of the histidine and glutamine transporters; HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, respectively. Histidine permease is a multi-subunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP has properties intermediate between those of integral and peripheral membrane proteins and is accessible from both sides of the membrane, presumably by its interaction with HisQ and HisM. The two HisP subunits form a homodimer within the complex. The domain structure of the amino acid uptake systems is typical for prokaryotic extracellular solute binding protein-dependent uptake systems. All of the amino acid uptake systems also have at least one, and in a few cases, two extracellular solute binding proteins located in the periplasm of Gram-negative bacteria, or attached to the cell membrane of Gram-positive bacteria. The best-studied member of the PAAT (polar amino acid transport) family is the HisJQMP system of S. typhimurium, where HisJ is the extracellular solute binding proteins and HisP is the ABC protein. Pssm-ID: 213229 [Multi-domain] Cd Length: 213 Bit Score: 39.44 E-value: 3.18e-03
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| ABC_Class3 | cd03229 | ATP-binding cassette domain of the binding protein-dependent transport systems; This class is ... |
24-67 | 3.45e-03 | |||||
ATP-binding cassette domain of the binding protein-dependent transport systems; This class is comprised of all BPD (Binding Protein Dependent) systems that are largely represented in archaea and eubacteria and are primarily involved in scavenging solutes from the environment. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213196 [Multi-domain] Cd Length: 178 Bit Score: 38.71 E-value: 3.45e-03
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| ABC_NrtD_SsuB_transporters | cd03293 | ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ... |
25-64 | 3.48e-03 | |||||
ATP-binding cassette domain of the nitrate and sulfonate transporters; NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213260 [Multi-domain] Cd Length: 220 Bit Score: 39.38 E-value: 3.48e-03
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| ABC_Mj1267_LivG_branched | cd03219 | ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ... |
37-194 | 3.65e-03 | |||||
ATP-binding cassette component of branched chain amino acids transport system; The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E. coli branched-chain amino acid transporter. MJ1267 contains an insertion from residues 114 to 123 characteristic of LivG (Leucine-Isoleucine-Valine) homologs. The branched-chain amino acid transporter from E. coli comprises a heterodimer of ABCs (LivF and LivG), a heterodimer of six-helix TM domains (LivM and LivH), and one of two alternative soluble periplasmic substrate binding proteins (LivK or LivJ). Pssm-ID: 213186 [Multi-domain] Cd Length: 236 Bit Score: 39.34 E-value: 3.65e-03
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| phnK | PRK11701 | phosphonate C-P lyase system protein PhnK; Provisional |
39-67 | 3.98e-03 | |||||
phosphonate C-P lyase system protein PhnK; Provisional Pssm-ID: 183280 [Multi-domain] Cd Length: 258 Bit Score: 39.52 E-value: 3.98e-03
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| PRK10851 | PRK10851 | sulfate/thiosulfate ABC transporter ATP-binding protein CysA; |
35-64 | 4.82e-03 | |||||
sulfate/thiosulfate ABC transporter ATP-binding protein CysA; Pssm-ID: 182778 [Multi-domain] Cd Length: 353 Bit Score: 39.68 E-value: 4.82e-03
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| ABCC_TAP | cd03248 | ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; ... |
35-195 | 4.97e-03 | |||||
ATP-binding cassette domain of the Transporter Associated with Antigen Processing, subfamily C; TAP (Transporter Associated with Antigen Processing) is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum (ER), where these peptides are loaded on major histocompatibility complex (MHC) I molecules. Loaded MHC I leave the ER and display their antigenic cargo on the cell surface to cytotoxic T cells. Subsequently, virus-infected or malignantly transformed cells can be eliminated. TAP belongs to the large family of ATP-binding cassette (ABC) transporters, which translocate a vast variety of solutes across membranes. Pssm-ID: 213215 [Multi-domain] Cd Length: 226 Bit Score: 38.99 E-value: 4.97e-03
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| PRK15439 | PRK15439 | autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional |
27-64 | 5.06e-03 | |||||
autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional Pssm-ID: 185336 [Multi-domain] Cd Length: 510 Bit Score: 39.65 E-value: 5.06e-03
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| FtsE | COG2884 | Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning]; |
25-64 | 5.19e-03 | |||||
Cell division ATPase FtsE [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 442130 [Multi-domain] Cd Length: 223 Bit Score: 38.88 E-value: 5.19e-03
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| PRK13539 | PRK13539 | cytochrome c biogenesis protein CcmA; Provisional |
36-64 | 5.26e-03 | |||||
cytochrome c biogenesis protein CcmA; Provisional Pssm-ID: 237421 [Multi-domain] Cd Length: 207 Bit Score: 38.70 E-value: 5.26e-03
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| ABC_Carb_Solutes_like | cd03259 | ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is ... |
24-67 | 5.39e-03 | |||||
ATP-binding cassette domain of the carbohydrate and solute transporters-like; This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins. Pssm-ID: 213226 [Multi-domain] Cd Length: 213 Bit Score: 38.65 E-value: 5.39e-03
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| CydC | TIGR02868 | thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family ... |
36-68 | 5.40e-03 | |||||
thiol reductant ABC exporter, CydC subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Pssm-ID: 274331 [Multi-domain] Cd Length: 530 Bit Score: 39.65 E-value: 5.40e-03
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| PRK10895 | PRK10895 | lipopolysaccharide ABC transporter ATP-binding protein; Provisional |
24-219 | 6.85e-03 | |||||
lipopolysaccharide ABC transporter ATP-binding protein; Provisional Pssm-ID: 182817 [Multi-domain] Cd Length: 241 Bit Score: 38.72 E-value: 6.85e-03
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| CydD | TIGR02857 | thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family ... |
37-67 | 7.61e-03 | |||||
thiol reductant ABC exporter, CydD subunit; The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain (pfam00664) and a C-terminal ATP-binding domain (pfam00005). In E. coli these genes were discovered as mutants which caused the terminal heme-copper oxidase complex cytochrome bd to fail to assemble. Recent work has shown that the transporter is involved in export of redox-active thiol compounds such as cysteine and glutathione. The linkage to assembly of the cytochrome bd complex is further supported by the conserved operon structure found outside the gammaproteobacteria (cydABCD) containing both the transporter and oxidase genes components. The genes used as the seed members for this model are all either found in the gammproteobacterial context or the CydABCD context. All members of this family scoring above trusted at the time of its creation were from genomes which encode a cytochrome bd complex. Unfortunately, the gene symbol nomenclature adopted based on this operon in B. subtilis assigns cydC to the third gene in the operon where this gene is actually homologous to the E. coli cydD gene. We have chosen to name all homologs in this family in accordance with the precedence of publication of the E. coli name, CydD Pssm-ID: 274323 [Multi-domain] Cd Length: 529 Bit Score: 39.19 E-value: 7.61e-03
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| ATM1 | COG5265 | ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components ... |
35-63 | 7.61e-03 | |||||
ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 444078 [Multi-domain] Cd Length: 605 Bit Score: 39.03 E-value: 7.61e-03
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| MdlB | COG1132 | ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; |
35-64 | 8.63e-03 | |||||
ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; Pssm-ID: 440747 [Multi-domain] Cd Length: 579 Bit Score: 38.99 E-value: 8.63e-03
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| PRK10535 | PRK10535 | macrolide ABC transporter ATP-binding protein/permease MacB; |
35-67 | 9.20e-03 | |||||
macrolide ABC transporter ATP-binding protein/permease MacB; Pssm-ID: 182528 [Multi-domain] Cd Length: 648 Bit Score: 38.94 E-value: 9.20e-03
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| PotA | COG3842 | ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport ... |
34-67 | 9.49e-03 | |||||
ABC-type Fe3+/spermidine/putrescine transport systems, ATPase component [Amino acid transport and metabolism]; Pssm-ID: 443052 [Multi-domain] Cd Length: 353 Bit Score: 38.54 E-value: 9.49e-03
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