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Conserved domains on  [gi|32565552|ref|NP_495605|]
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Chondroitin proteoglycan 4 domain-containing protein [Caenorhabditis elegans]

Protein Classification

CPG4 domain-containing protein( domain architecture ID 10634585)

CPG4 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CPG4 pfam15481
Chondroitin proteoglycan 4; CPG4 is a domain family found in nematodes of one of nine core ...
 54-148 9.96e-33

Chondroitin proteoglycan 4; CPG4 is a domain family found in nematodes of one of nine core chondroitin proteoglycans. Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. CPG4 has the largest predicted mass of the C. elegans CPGs at 84 kDa. The majority of its 35 predicted glycosaminoglycan attachment sites reside in the COOH-terminal half of the protein, of which four sites were confirmed by DTT modification. The family is rich in conserved cysteines.


:

Pssm-ID: 406043  Cd Length: 94  Bit Score: 115.24  E-value: 9.96e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565552    54 YCMRKCIDPFINSTTSLWNMKNVVHQARKVCGHHAQAITCLKKeQYCDHNKLFAKASSSVEYMCATKHVLFERMESCLNP 133
Cdd:pfam15481   1 ECLRKCMPPLANSLISLDNMKNVVERFVKVCEQLEEASTCADK-TKCDDATLFSQATSGYEYMCIDKEEAFEDHIKCIQD 79

                          90
                  ....*....|....*
gi 32565552   134 VVDDIMSGCDKECYA 148
Cdd:pfam15481  80 AAGDVQSECEQKCAV 94
 
Name Accession Description Interval E-value
CPG4 pfam15481
Chondroitin proteoglycan 4; CPG4 is a domain family found in nematodes of one of nine core ...
 54-148 9.96e-33

Chondroitin proteoglycan 4; CPG4 is a domain family found in nematodes of one of nine core chondroitin proteoglycans. Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. CPG4 has the largest predicted mass of the C. elegans CPGs at 84 kDa. The majority of its 35 predicted glycosaminoglycan attachment sites reside in the COOH-terminal half of the protein, of which four sites were confirmed by DTT modification. The family is rich in conserved cysteines.


Pssm-ID: 406043  Cd Length: 94  Bit Score: 115.24  E-value: 9.96e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565552    54 YCMRKCIDPFINSTTSLWNMKNVVHQARKVCGHHAQAITCLKKeQYCDHNKLFAKASSSVEYMCATKHVLFERMESCLNP 133
Cdd:pfam15481   1 ECLRKCMPPLANSLISLDNMKNVVERFVKVCEQLEEASTCADK-TKCDDATLFSQATSGYEYMCIDKEEAFEDHIKCIQD 79

                          90
                  ....*....|....*
gi 32565552   134 VVDDIMSGCDKECYA 148
Cdd:pfam15481  80 AAGDVQSECEQKCAV 94
 
Name Accession Description Interval E-value
CPG4 pfam15481
Chondroitin proteoglycan 4; CPG4 is a domain family found in nematodes of one of nine core ...
 54-148 9.96e-33

Chondroitin proteoglycan 4; CPG4 is a domain family found in nematodes of one of nine core chondroitin proteoglycans. Vertebrates produce multiple chondroitin sulfate proteoglycans that play important roles in development and tissue mechanics. In the nematode Caenorhabditis elegans, the chondroitin chains lack sulfate but nevertheless play essential roles in embryonic development and vulval morphogenesis. CPG4 has the largest predicted mass of the C. elegans CPGs at 84 kDa. The majority of its 35 predicted glycosaminoglycan attachment sites reside in the COOH-terminal half of the protein, of which four sites were confirmed by DTT modification. The family is rich in conserved cysteines.


Pssm-ID: 406043  Cd Length: 94  Bit Score: 115.24  E-value: 9.96e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565552    54 YCMRKCIDPFINSTTSLWNMKNVVHQARKVCGHHAQAITCLKKeQYCDHNKLFAKASSSVEYMCATKHVLFERMESCLNP 133
Cdd:pfam15481   1 ECLRKCMPPLANSLISLDNMKNVVERFVKVCEQLEEASTCADK-TKCDDATLFSQATSGYEYMCIDKEEAFEDHIKCIQD 79

                          90
                  ....*....|....*
gi 32565552   134 VVDDIMSGCDKECYA 148
Cdd:pfam15481  80 AAGDVQSECEQKCAV 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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