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Conserved domains on  [gi|17531555|ref|NP_495634|]
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U2A'/phosphoprotein 32 family A C-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1909296)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-218 6.78e-28

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 108.33  E-value: 6.78e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  66 IKKIENLDCLTTLTHLEFYDNQITKVENLDSLVNLESLDLSFNRITKIENLEKLTKLKTLFFVHNKITKIEGLDTLTELE 145
Cdd:cd21340  14 ITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 146 YLELGDNRIAK----------IENLDNNLKLdrLFLGANQIRLIENVDHLKKLTVLSLPANAITVVDNI----SGLHNLK 211
Cdd:cd21340  94 ELHIENQRLPPgekltfdprsLAALSNSLRV--LNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELldllSSWPSLR 171


                ....*..
gi 17531555 212 EIYLAQN 218
Cdd:cd21340 172 ELDLTGN 178
LRR_9 super family cl25994
Leucine-rich repeat;
147-310 6.26e-06

Leucine-rich repeat;


The actual alignment was detected with superfamily member pfam14580:

Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.91  E-value: 6.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555   147 LELGDNRIAKIENLDNNL-KLDRLFLGANQIRLIENVDHLKKLTVLSLPANAITVVDNisglhnlkeiylaqngikyvcG 225
Cdd:pfam14580  24 LDLRGYKIPIIENLGATLdQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGE---------------------G 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555   226 IDEHLPleildfnqnrlekveNIHQLkTLTdfwarGNKLDNWSIMDELVELPQLNSVYLDFNPIASVDTYRGKVIHLLQQ 305
Cdd:pfam14580  83 LGEALP---------------NLTEL-ILT-----NNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQ 141


                  ....*
gi 17531555   306 ITRLD 310
Cdd:pfam14580 142 LRLLD 146
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-218 6.78e-28

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 108.33  E-value: 6.78e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  66 IKKIENLDCLTTLTHLEFYDNQITKVENLDSLVNLESLDLSFNRITKIENLEKLTKLKTLFFVHNKITKIEGLDTLTELE 145
Cdd:cd21340  14 ITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 146 YLELGDNRIAK----------IENLDNNLKLdrLFLGANQIRLIENVDHLKKLTVLSLPANAITVVDNI----SGLHNLK 211
Cdd:cd21340  94 ELHIENQRLPPgekltfdprsLAALSNSLRV--LNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELldllSSWPSLR 171


                ....*..
gi 17531555 212 EIYLAQN 218
Cdd:cd21340 172 ELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-287 3.04e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 3.04e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  35 KNVDLTRHRIKEIGDY-SWLTHVEHFSFRWNLIKKI-ENLDCLTTLTHLEFYDNQITKV-ENLDSLVNLESLDLSFNRIT 111
Cdd:COG4886 116 ESLDLSGNQLTDLPEElANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQIT 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 112 KI-ENLEKLTKLKTLFFVHNKITKI-EGLDTLTELEYLELGDNRIAKIENLDNNLKLDRLFLGANQIRLIENVDHLKKLT 189
Cdd:COG4886 196 DLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLK 275

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 190 VLSLPANAITVVDnisgLHNLKEIYLAQNGIKYVCGIDEHLPLEILDFNQNRLEKVENIHQLKTLTDFWARGNKLDNWSI 269
Cdd:COG4886 276 TLDLSNNQLTDLK----LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                       250
                ....*....|....*...
gi 17531555 270 MDELVELPQLNSVYLDFN 287
Cdd:COG4886 352 LLLLLNLLSLLLTLLLTL 369
LRR_9 pfam14580
Leucine-rich repeat;
62-159 2.65e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 47.07  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555    62 RWNLIKKIENLDC-LTTLTHLEFYDNQITKVENLDSLVNLESLDLSFNRITKI-ENLEK-LTKLKTLFFVHNKITKIEGL 138
Cdd:pfam14580  27 RGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEaLPNLTELILTNNNLQELGDL 106

                          90       100
                  ....*....|....*....|....
gi 17531555   139 DTLTE---LEYLELGDNRIAKIEN 159
Cdd:pfam14580 107 DPLASlkkLTFLSLLRNPVTNKPH 130
LRR_9 pfam14580
Leucine-rich repeat;
147-310 6.26e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.91  E-value: 6.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555   147 LELGDNRIAKIENLDNNL-KLDRLFLGANQIRLIENVDHLKKLTVLSLPANAITVVDNisglhnlkeiylaqngikyvcG 225
Cdd:pfam14580  24 LDLRGYKIPIIENLGATLdQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGE---------------------G 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555   226 IDEHLPleildfnqnrlekveNIHQLkTLTdfwarGNKLDNWSIMDELVELPQLNSVYLDFNPIASVDTYRGKVIHLLQQ 305
Cdd:pfam14580  83 LGEALP---------------NLTEL-ILT-----NNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQ 141


                  ....*
gi 17531555   306 ITRLD 310
Cdd:pfam14580 142 LRLLD 146
LRR_SD22 smart00365
Leucine-rich repeat, SDS22-like subfamily;
97-118 1.26e-03

Leucine-rich repeat, SDS22-like subfamily;


Pssm-ID: 197684  Cd Length: 22  Bit Score: 35.71  E-value: 1.26e-03
                           10        20
                   ....*....|....*....|..
gi 17531555     97 LVNLESLDLSFNRITKIENLEK 118
Cdd:smart00365   1 LTNLEELDLGDNKIKKIENLDE 22
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 293-310 2.82e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.59  E-value: 2.82e-03
                           10
                   ....*....|....*...
gi 17531555    293 DTYRGKVIHLLQQITRLD 310
Cdd:smart00446   2 AHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-218 6.78e-28

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 108.33  E-value: 6.78e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  66 IKKIENLDCLTTLTHLEFYDNQITKVENLDSLVNLESLDLSFNRITKIENLEKLTKLKTLFFVHNKITKIEGLDTLTELE 145
Cdd:cd21340  14 ITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLE 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 146 YLELGDNRIAK----------IENLDNNLKLdrLFLGANQIRLIENVDHLKKLTVLSLPANAITVVDNI----SGLHNLK 211
Cdd:cd21340  94 ELHIENQRLPPgekltfdprsLAALSNSLRV--LNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELldllSSWPSLR 171


                ....*..
gi 17531555 212 EIYLAQN 218
Cdd:cd21340 172 ELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 119-311 3.23e-27

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 106.79  E-value: 3.23e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 119 LTKLKTLFFVHNKITKIEGLDTLTELEYLELGDNRIAKIENLDNNLKLDRLFLGANQIRLIENVDHLKKLTVLSLPANAI 198
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 199 TVVDNISGLHNLKEIYLA----QNGIKY------VCGIDEHlpLEILDFNQNRLEKVENIHQLKTLTDFWARGNKLDNWS 268
Cdd:cd21340  81 SVVEGLENLTNLEELHIEnqrlPPGEKLtfdprsLAALSNS--LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLE 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 17531555 269 IMDELVE-LPQLNSVYLDFNPIASVDTYRGKVIHLLQQITRLDG 311
Cdd:cd21340 159 ELLDLLSsWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDG 202
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 39-213 2.39e-22

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 93.31  E-value: 2.39e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  39 LTRHRIKEIGDYSWLTHVEHFSFRWNLIKKIENLDCLTTLTHLEFYDNQITKVENLDSLVNLESLDLSFNRITKIENLEK 118
Cdd:cd21340   9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLEN 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 119 LTKLKTLFFVHNKITKIEGL----DTLTE----LEYLELGDNRIAKIENLDNNLKLDRLFLGANQIRLIENVD----HLK 186
Cdd:cd21340  89 LTNLEELHIENQRLPPGEKLtfdpRSLAAlsnsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdllsSWP 168

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 17531555 187 KLTVLSLPANAIT--------VVDNISGLHNL--KEI 213
Cdd:cd21340 169 SLRELDLTGNPVCkkpkyrdkIILASKSLEVLdgKEI 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-287 3.04e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 3.04e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  35 KNVDLTRHRIKEIGDY-SWLTHVEHFSFRWNLIKKI-ENLDCLTTLTHLEFYDNQITKV-ENLDSLVNLESLDLSFNRIT 111
Cdd:COG4886 116 ESLDLSGNQLTDLPEElANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQIT 195

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 112 KI-ENLEKLTKLKTLFFVHNKITKI-EGLDTLTELEYLELGDNRIAKIENLDNNLKLDRLFLGANQIRLIENVDHLKKLT 189
Cdd:COG4886 196 DLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLK 275

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 190 VLSLPANAITVVDnisgLHNLKEIYLAQNGIKYVCGIDEHLPLEILDFNQNRLEKVENIHQLKTLTDFWARGNKLDNWSI 269
Cdd:COG4886 276 TLDLSNNQLTDLK----LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351

                       250
                ....*....|....*...
gi 17531555 270 MDELVELPQLNSVYLDFN 287
Cdd:COG4886 352 LLLLLNLLSLLLTLLLTL 369
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-344 3.29e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 3.29e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  63 WNLIKKIENLDCLTTLTHLEFYDNQITKVENLDSLVNLESLDLSFNritkiENLEKLTKLKTLFFVHNKITKI-EGLDTL 141
Cdd:COG4886  61 LLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANL 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 142 TELEYLELGDNRIAKI-ENLDNNLKLDRLFLGANQIRLI-ENVDHLKKLTVLSLPANAITVV-DNISGLHNLKEIYLAQN 218
Cdd:COG4886 136 TNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGN 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 219 GIKYvcgIDEHLP----LEILDFNQNRLEKVENIHQLKTLTDFWARGNKLDNwsiMDELVELPQLNSVYLDFNPIASVDT 294
Cdd:COG4886 216 QLTD---LPEPLAnltnLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTD---LPPLANLTNLKTLDLSNNQLTDLKL 289

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 17531555 295 YRGKVIHLLQQITRLDGTQCREHSMLRPPKEEKNETELSRVVLDNPSDDH 344
Cdd:COG4886 290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-281 6.60e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.21  E-value: 6.60e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  35 KNVDLTRHRIKEIGDY-SWLTHVEHFSFRWNLIKKI-ENLDCLTTLTHLEFYDNQITKV-ENLDSLVNLESLDLSFNRIT 111
Cdd:COG4886 139 KELDLSNNQLTDLPEPlGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLT 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 112 KI-ENLEKLTKLKTLFFVHNKITKIEGLDTLTELEYLELGDNRIAKIENLDNNLKLDRLFLGANQIRLIeNVDHLKKLTV 190
Cdd:COG4886 219 DLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL-KLKELELLLG 297

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 191 LSLPANAITVVDNISGLHNLKEIYLAQNGIKYVCGIDEHLPLEILDFNQNRLEKVENIHQLKTLTDFWARGNKLDNWSIM 270
Cdd:COG4886 298 LNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377

                       250
                ....*....|.
gi 17531555 271 DELVELPQLNS 281
Cdd:COG4886 378 TLLTLALLLLT 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-291 1.27e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 1.27e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  35 KNVDLTRHRIKEIGDY-SWLTHVEHFSFRWNLIKKI-ENLDCLTTLTHLEFYDNQITKV-ENLDSLVNLESLDLSFNRIT 111
Cdd:COG4886 162 KSLDLSNNQLTDLPEElGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLT 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 112 KIENLEKLTKLKTLFFVHNKITKIEGLDTLTELEYLELGDNRIakienldNNLKLDRLFLGANQIRLIENVDHLKKLTVL 191
Cdd:COG4886 242 DLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL-------TDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 192 SLPANAITVVDNISGLHNLKEIYLAQNGIKYVCGIDEHLPLEILDFNQNRLEKVENIHQLKTLTDFWARGNKLDNWSIMD 271
Cdd:COG4886 315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394

                       250       260
                ....*....|....*....|
gi 17531555 272 ELVELPQLNSVYLDFNPIAS 291
Cdd:COG4886 395 TTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-292 2.64e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 2.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  63 WNLIKKIENLDCLTTLTHLEFYDNQITKVENLDSLVNLESLDLSFNRITKIENLEKLTKLKTLFFVHNkitkiEGLDTLT 142
Cdd:COG4886  39 LLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLT 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 143 ELEYLELGDNRIAKI-ENLDNNLKLDRLFLGANQIR-LIENVDHLKKLTVLSLPANAITVVDN-ISGLHNLKEIYLAQNG 219
Cdd:COG4886 114 NLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTdLPEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQ 193

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17531555 220 IKYvcgIDEHLP----LEILDFNQNRLEKV-ENIHQLKTLTDFWARGNKLDNWSimdELVELPQLNSVYLDFNPIASV 292
Cdd:COG4886 194 ITD---LPEPLGnltnLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLP---ELGNLTNLEELDLSNNQLTDL 265
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-291 5.46e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 5.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  75 LTTLTHLEFYDNQITKVENLDSLVNLESLDLSFNRITKIENLEKLTKLKTLFFVHNKITKIEGLDTLTELEYLELGDNRI 154
Cdd:COG4886  10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 155 AKIENLDNNLKLDrlflganqIRLIENVDHLKKLTVLSLPANAITVV-DNISGLHNLKEIYLAQNGIKYVCGIDEHLP-L 232
Cdd:COG4886  90 TDLGDLTNLTELD--------LSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLTnL 161

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 233 EILDFNQNRLEKV-ENIHQLKTLTDFWARGNKLDNWSimDELVELPQLNSVYLDFNPIAS 291
Cdd:COG4886 162 KSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLP--EPLGNLTNLEELDLSGNQLTD 219
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 69-220 7.08e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.64  E-value: 7.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  69 IENLDCLTTLTHLEFYDNQITK------VENLDSLVNLESLDLSFNRITKiENLEKLtklktlffvhnkitkIEGLDTLT 142
Cdd:COG5238 229 AEALKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGA-EGAIAL---------------AKALQGNT 292

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 143 ELEYLELGDNRI------AKIENLDNNLKLDRLFLGANQIR------LIENVDHLKKLTVLSLPANAITV------VDNI 204
Cdd:COG5238 293 TLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGaqgaiaLAKALQENTTLHSLDLSDNQIGDegaialAKYL 372

                       170
                ....*....|....*.
gi 17531555 205 SGLHNLKEIYLAQNGI 220
Cdd:COG5238 373 EGNTTLRELNLGKNNI 388
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 69-199 7.47e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.64  E-value: 7.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  69 IENLDCLTTLTHLEFYDNQITK------VENLDSLVNLESLDLSFNRITK------IENLEKLTKLKTLFFVHNKITK-- 134
Cdd:COG5238 257 AEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqg 336

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 135 ----IEGLDTLTELEYLELGDNRI------AKIENLDNNLKLDRLFLGANQI---RLIENVDHLK--KLTVLSLPANAIT 199
Cdd:COG5238 337 aialAKALQENTTLHSLDLSDNQIgdegaiALAKYLEGNTTLRELNLGKNNIgkqGAEALIDALQtnRLHTLILDGNLIG 416
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 99-309 8.31e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.64  E-value: 8.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  99 NLESLDLSFNRITKI------ENLEKLTKLKTLFFVHNKITK------IEGLDTLTELEYLELGDNRI------AKIENL 160
Cdd:COG5238 181 SVETVYLGCNQIGDEgieelaEALTQNTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIgdegviALAEAL 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 161 DNNLKLDRLFLGANQI------RLIENVDHLKKLTVLSLPAN------AITVVDNISGLHNLKEIYLAQNGIKYVCGI-- 226
Cdd:COG5238 261 KNNTTVETLYLSGNQIgaegaiALAKALQGNTTLTSLDLSVNrigdegAIALAEGLQGNKTLHTLNLAYNGIGAQGAIal 340

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 227 ----DEHLPLEILDFNQNRL--EKVENIHQL----KTLTDFWARGNKLDNWSIMdELVELPQLNSV-YLDFNPIASVDTY 295
Cdd:COG5238 341 akalQENTTLHSLDLSDNQIgdEGAIALAKYlegnTTLRELNLGKNNIGKQGAE-ALIDALQTNRLhTLILDGNLIGAEA 419

                       250
                ....*....|....
gi 17531555 296 RGKVIHLLQQITRL 309
Cdd:COG5238 420 QQRLEQLLERIKSV 433
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-291 8.29e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.32  E-value: 8.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  93 NLDSLVNLESLDLSFNRITKIENLEKLTKLKTLFFVHNKITKIEGLDTLTELEYLELGDNRIAKIENLDNNLKLDRLFLG 172
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 173 ANQIRLIENVDHLKKLTVLSLPANaitvvDNISGLHNLKEIYLAQNGIKYVCGIDEHLP-LEILDFNQNRLEKV-ENIHQ 250
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTnLKELDLSNNQLTDLpEPLGN 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 17531555 251 LKTLTDFWARGNKLDnwSIMDELVELPQLNSVYLDFNPIAS 291
Cdd:COG4886 158 LTNLKSLDLSNNQLT--DLPEELGNLTNLKELDLSNNQITD 196
LRR_9 pfam14580
Leucine-rich repeat;
62-159 2.65e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 47.07  E-value: 2.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555    62 RWNLIKKIENLDC-LTTLTHLEFYDNQITKVENLDSLVNLESLDLSFNRITKI-ENLEK-LTKLKTLFFVHNKITKIEGL 138
Cdd:pfam14580  27 RGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEaLPNLTELILTNNNLQELGDL 106

                          90       100
                  ....*....|....*....|....
gi 17531555   139 DTLTE---LEYLELGDNRIAKIEN 159
Cdd:pfam14580 107 DPLASlkkLTFLSLLRNPVTNKPH 130
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-139 2.71e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.77  E-value: 2.71e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 17531555    99 NLESLDLSFNRITKIENLEKLTKLKTLFFVHN-KITKIEGLD 139
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
LRR_9 pfam14580
Leucine-rich repeat;
147-310 6.26e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.91  E-value: 6.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555   147 LELGDNRIAKIENLDNNL-KLDRLFLGANQIRLIENVDHLKKLTVLSLPANAITVVDNisglhnlkeiylaqngikyvcG 225
Cdd:pfam14580  24 LDLRGYKIPIIENLGATLdQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGE---------------------G 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555   226 IDEHLPleildfnqnrlekveNIHQLkTLTdfwarGNKLDNWSIMDELVELPQLNSVYLDFNPIASVDTYRGKVIHLLQQ 305
Cdd:pfam14580  83 LGEALP---------------NLTEL-ILT-----NNNLQELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQ 141


                  ....*
gi 17531555   306 ITRLD 310
Cdd:pfam14580 142 LRLLD 146
LRR_9 pfam14580
Leucine-rich repeat;
86-199 6.82e-06

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.91  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555    86 NQITKVENLD-SLVNLESLDLSFNRITKIENLEKLTKLKTLFFVHNKITKI-EGLD-TLTELEYLELGDNRIAKIENLDN 162
Cdd:pfam14580  29 YKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQELGDLDP 108

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 17531555   163 nlkldrlflganqirLIEnvdhLKKLTVLSLPANAIT 199
Cdd:pfam14580 109 ---------------LAS----LKKLTFLSLLRNPVT 126
LRR_8 pfam13855
Leucine rich repeat;
99-154 7.53e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 7.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555    99 NLESLDLSFNRITKI--ENLEKLTKLKTLFFVHNKITKIEG--LDTLTELEYLELGDNRI 154
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 76-118 1.93e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 1.93e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 17531555    76 TTLTHLEFYDNQITKVENLDSLVNLESLDLSFN-RITKIENLEK 118
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 120-162 1.86e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 1.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 17531555   120 TKLKTLFFVHNKITKIEGLDTLTELEYLEL-GDNRIAKIENLDN 162
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLAN 44
LRR_SD22 smart00365
Leucine-rich repeat, SDS22-like subfamily;
97-118 1.26e-03

Leucine-rich repeat, SDS22-like subfamily;


Pssm-ID: 197684  Cd Length: 22  Bit Score: 35.71  E-value: 1.26e-03
                           10        20
                   ....*....|....*....|..
gi 17531555     97 LVNLESLDLSFNRITKIENLEK 118
Cdd:smart00365   1 LTNLEELDLGDNKIKKIENLDE 22
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 293-310 2.82e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.59  E-value: 2.82e-03
                           10
                   ....*....|....*...
gi 17531555    293 DTYRGKVIHLLQQITRLD 310
Cdd:smart00446   2 AHYREKVIELLPQLRKLD 19
LRR_SD22 smart00365
Leucine-rich repeat, SDS22-like subfamily;
119-140 2.98e-03

Leucine-rich repeat, SDS22-like subfamily;


Pssm-ID: 197684  Cd Length: 22  Bit Score: 34.56  E-value: 2.98e-03
                           10        20
                   ....*....|....*....|..
gi 17531555    119 LTKLKTLFFVHNKITKIEGLDT 140
Cdd:smart00365   1 LTNLEELDLGDNKIKKIENLDE 22
LRR_SD22 smart00365
Leucine-rich repeat, SDS22-like subfamily;
141-162 5.75e-03

Leucine-rich repeat, SDS22-like subfamily;


Pssm-ID: 197684  Cd Length: 22  Bit Score: 33.79  E-value: 5.75e-03
                           10        20
                   ....*....|....*....|..
gi 17531555    141 LTELEYLELGDNRIAKIENLDN 162
Cdd:smart00365   1 LTNLEELDLGDNKIKKIENLDE 22
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 94-242 9.10e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 37.33  E-value: 9.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555  94 LDSLVNLESLDLSFNRITK------IENLEKLTKLKTLFFVHNKITKiEGLDTLTEleylELGDNRIAKIENLDNNLKLD 167
Cdd:cd00116 133 KDLPPALEKLVLGRNRLEGascealAKALRANRDLKELNLANNGIGD-AGIRALAE----GLKANCNLEVLDLNNNGLTD 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17531555 168 rlflgANQIRLIENVDHLKKLTVLSLPANAITVVD-------NISGLHNLKEIYLAQNGI-----KYVC-GIDEHLPLEI 234
Cdd:cd00116 208 -----EGASALAETLASLKSLEVLNLGDNNLTDAGaaalasaLLSPNISLLTLSLSCNDItddgaKDLAeVLAEKESLLE 282


                ....*...
gi 17531555 235 LDFNQNRL 242
Cdd:cd00116 283 LDLRGNKF 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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