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Conserved domains on  [gi|17535693|ref|NP_495823|]
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Large ribosomal subunit protein uL24 [Caenorhabditis elegans]

Protein Classification

uL24 family ribosomal protein( domain architecture ID 11246010)

uL24 family ribosomal protein is required for the assembly of different ribosomal subunits and are widely distributed among all living organisms.

Gene Ontology:  GO:0006412|GO:0003735|GO:0003723
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 8-121 1.26e-62

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


:

Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 187.33  E-value: 1.26e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535693     8 SSDSGKSRKAHFNAPSHERRRIMSAPLTKELRTKHGIRAIPIRTDDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDKITRE 87
Cdd:pfam16906   1 SSSRRKQRKAHFNAPSHIRRKLMSAPLSKELREKYGVRSLPIRKGDEVKVVRGDFKGREGKVVQVYRKKYRIHVEGVTRE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 17535693    88 KANGSTVHIGIHPSKVAITKLKLDKDRRALVERK 121
Cdd:pfam16906  81 KANGTTVPVPIHPSKVVITKLKLDKDRKKILERK 114
 
Name Accession Description Interval E-value
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 8-121 1.26e-62

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 187.33  E-value: 1.26e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535693     8 SSDSGKSRKAHFNAPSHERRRIMSAPLTKELRTKHGIRAIPIRTDDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDKITRE 87
Cdd:pfam16906   1 SSSRRKQRKAHFNAPSHIRRKLMSAPLSKELREKYGVRSLPIRKGDEVKVVRGDFKGREGKVVQVYRKKYRIHVEGVTRE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 17535693    88 KANGSTVHIGIHPSKVAITKLKLDKDRRALVERK 121
Cdd:pfam16906  81 KANGTTVPVPIHPSKVVITKLKLDKDRKKILERK 114
PTZ00194 PTZ00194
60S ribosomal protein L26; Provisional
 4-141 4.83e-55

60S ribosomal protein L26; Provisional


Pssm-ID: 185508  Cd Length: 143  Bit Score: 169.16  E-value: 4.83e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535693    4 NPFVSSDSGKSRKAHFNAPSHERRRIMSAPLTKELRTKHGIRAIPIRTDDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDK 83
Cdd:PTZ00194   2 NSIVSSSRRKARKAHFTAPSHLRRKLMSAPLSKELRAKYNVRSMPVRKDDEVMVVRGHHKGREGKVTAVYRKKWVIHIEK 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 17535693   84 ITREKANGSTVHIGIHPSKVAITKLKLDKDRRALVERKAagRSRVTGILKGKHTDETV 141
Cdd:PTZ00194  82 ITREKANGEPVQIGIHPSNVIITKLKLNKDRKAILERKA--RSTKSDKGKGKYTAADK 137
rplX_A_E TIGR01080
ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and ...
 8-120 1.06e-44

ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and eukaryotic branch of the ribosomal protein L24p/L26e family. Bacterial and organellar forms are represented by related model TIGR01079. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273432  Cd Length: 114  Bit Score: 141.91  E-value: 1.06e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535693     8 SSDSGKSRKAHFNAPSHERRRIMSAPLTKELRTKHGIRAIPIRTDDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDKITRE 87
Cdd:TIGR01080   1 SKQPRKQRKALFTAPLHERRKLMSAPLSKELREKYGKRALPIRKGDEVRIVRGDFKGHEGKVSKVDRKRYRIYVEGVTKE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 17535693    88 KANGSTVHIGIHPSKVAITKLKLDKD-RRALVER 120
Cdd:TIGR01080  81 KVDGTEVPVPLHPSNVMITKLHLDDEkRKKLLER 114
KOW_RPL26 cd06089
KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at ...
 52-105 3.15e-13

KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at their N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. RPL26 makes a very minor contributions to the biogenesis, structure, and function of 60s ribosomal subunits. However, RPL24 is essential to generate the first intermediate during 50s ribosomal subunits assembly. RPL26 have an extra-ribosomal function to enhances p53 translation after DNA damage.


Pssm-ID: 240513  Cd Length: 65  Bit Score: 60.22  E-value: 3.15e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17535693  52 DDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDKITREKAN-----------GSTVHIGIHPSKVAI 105
Cdd:cd06089   1 GDEVQVIRGKDKGKQGKVLKVDRKKNRVIVEGVNVVKKHvkpsqenpqggIIEVEAPIHISNVML 65
RplX COG0198
Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 ...
 49-76 2.73e-04

Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439968 [Multi-domain]  Cd Length: 104  Bit Score: 37.74  E-value: 2.73e-04
                        10        20
                ....*....|....*....|....*...
gi 17535693  49 IRTDDEVVVMRGRHKGNTGRVLRCYRKK 76
Cdd:COG0198   5 IKKGDTVIVIAGKDKGKRGKVLKVLPKK 32
 
Name Accession Description Interval E-value
Ribosomal_L26 pfam16906
Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the ...
 8-121 1.26e-62

Ribosomal proteins L26 eukaryotic, L24P archaeal; Ribosomal_L26 is a family of the 50S and the 60S ribosomal proteins from eukaryotes - L26 - and archaea - L25.


Pssm-ID: 465307 [Multi-domain]  Cd Length: 114  Bit Score: 187.33  E-value: 1.26e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535693     8 SSDSGKSRKAHFNAPSHERRRIMSAPLTKELRTKHGIRAIPIRTDDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDKITRE 87
Cdd:pfam16906   1 SSSRRKQRKAHFNAPSHIRRKLMSAPLSKELREKYGVRSLPIRKGDEVKVVRGDFKGREGKVVQVYRKKYRIHVEGVTRE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 17535693    88 KANGSTVHIGIHPSKVAITKLKLDKDRRALVERK 121
Cdd:pfam16906  81 KANGTTVPVPIHPSKVVITKLKLDKDRKKILERK 114
PTZ00194 PTZ00194
60S ribosomal protein L26; Provisional
 4-141 4.83e-55

60S ribosomal protein L26; Provisional


Pssm-ID: 185508  Cd Length: 143  Bit Score: 169.16  E-value: 4.83e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535693    4 NPFVSSDSGKSRKAHFNAPSHERRRIMSAPLTKELRTKHGIRAIPIRTDDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDK 83
Cdd:PTZ00194   2 NSIVSSSRRKARKAHFTAPSHLRRKLMSAPLSKELRAKYNVRSMPVRKDDEVMVVRGHHKGREGKVTAVYRKKWVIHIEK 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 17535693   84 ITREKANGSTVHIGIHPSKVAITKLKLDKDRRALVERKAagRSRVTGILKGKHTDETV 141
Cdd:PTZ00194  82 ITREKANGEPVQIGIHPSNVIITKLKLNKDRKAILERKA--RSTKSDKGKGKYTAADK 137
rplX_A_E TIGR01080
ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and ...
 8-120 1.06e-44

ribosomal protein uL24, archaeal/eukaryotic form; This model represents the archaeal and eukaryotic branch of the ribosomal protein L24p/L26e family. Bacterial and organellar forms are represented by related model TIGR01079. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273432  Cd Length: 114  Bit Score: 141.91  E-value: 1.06e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535693     8 SSDSGKSRKAHFNAPSHERRRIMSAPLTKELRTKHGIRAIPIRTDDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDKITRE 87
Cdd:TIGR01080   1 SKQPRKQRKALFTAPLHERRKLMSAPLSKELREKYGKRALPIRKGDEVRIVRGDFKGHEGKVSKVDRKRYRIYVEGVTKE 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 17535693    88 KANGSTVHIGIHPSKVAITKLKLDKD-RRALVER 120
Cdd:TIGR01080  81 KVDGTEVPVPLHPSNVMITKLHLDDEkRKKLLER 114
KOW_RPL26 cd06089
KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at ...
 52-105 3.15e-13

KOW motif of Ribosomal Protein L26; RPL26 and its bacterial paralogs RPL24 have a KOW motif at their N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. RPL26 makes a very minor contributions to the biogenesis, structure, and function of 60s ribosomal subunits. However, RPL24 is essential to generate the first intermediate during 50s ribosomal subunits assembly. RPL26 have an extra-ribosomal function to enhances p53 translation after DNA damage.


Pssm-ID: 240513  Cd Length: 65  Bit Score: 60.22  E-value: 3.15e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17535693  52 DDEVVVMRGRHKGNTGRVLRCYRKKFVIHIDKITREKAN-----------GSTVHIGIHPSKVAI 105
Cdd:cd06089   1 GDEVQVIRGKDKGKQGKVLKVDRKKNRVIVEGVNVVKKHvkpsqenpqggIIEVEAPIHISNVML 65
RplX COG0198
Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 ...
 49-76 2.73e-04

Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L24 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439968 [Multi-domain]  Cd Length: 104  Bit Score: 37.74  E-value: 2.73e-04
                        10        20
                ....*....|....*....|....*...
gi 17535693  49 IRTDDEVVVMRGRHKGNTGRVLRCYRKK 76
Cdd:COG0198   5 IKKGDTVIVIAGKDKGKRGKVLKVLPKK 32
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 52-82 1.18e-03

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 34.67  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 17535693    52 DDEVVVMRGRHKGNTGRVLRCYRKKFVIHID 82
Cdd:pfam00467   2 GDVVRVIAGPFKGKVGKVVEVDDKKNRVLVE 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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