BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  28 DRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW--NGDKFDLELVEDELCQKAFAPFLRFMY 105
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSEIELVEDPECAAVFEKFLRYLY 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 71997007 106 SNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFA 139
Cdd:cd18292  81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  28 DRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW--NGDKFDLELVEDELCQKAFAPFLRFMY 105
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSEIELVEDPECAAVFEKFLRYLY 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 71997007 106 SNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFA 139
Cdd:cd18292  81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007    37 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDlELVEDELCQKAFAPFLRFMYSNHVVlHKDNC 116
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS-EITLDDVSPEDFEALLEFMYTGKLI-SEENV 80

                          90       100
                  ....*....|....*....|..
gi 71997007   117 LPLLVLADKYNVTTLKKVCLDF 138
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEF 102

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007 156 WFSYATKAYHPSLIKSCMQAIALEFETLLTEEwekDWQELHRDQMIEILKCNNLKVASEFKLWEALQKWI 225
Cdd:cd18493   8 WLQYAKMCGHKELAEACLEFIAWNFEKVLKSP---DWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007   38 FYNNAQFSDVNM--KVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDelcqkAFAPFLRFMYSNHVVLHKDN 115
Cdd:PHA03098   3 SFELQKFCDESIiiVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNIDYD-----SFNEVIKYIYTGKINITSNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  116 CLPLLVLADKYNVTTLKKVCLDFaqseILPVIDLK---ELFSVWFSYATKAyhpsLIKSCMQAIALEFETLLTEEwekDW 192
Cdd:PHA03098  78 VKDILSIANYLIIDFLINLCINY----IIKIIDDNnciDIYRFSFFYGCKK----LYSAAYNYIRNNIELIYNDP---DF 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  193 QELHRDQMIEILKCNNLKVASEFKLWEALQKWIQAPNHSERRGntagplLAFLLPLIRFPFMNGDELNEVEKSAISEMHP 272
Cdd:PHA03098 147 IYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKD------ICLILKVLRITFLSEEGIKKLKRWKLRIKKK 220

                        250       260       270
                 ....*....|....*....|....*....|....
gi 71997007  273 KLFqpplllsykFNALPLSSRMSCKDFTKKQFLL 306
Cdd:PHA03098 221 KIV---------FNKRCIKIIYSKKYNLNKILPR 245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  28 DRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW--NGDKFDLELVEDELCQKAFAPFLRFMY 105
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSEIELVEDPECAAVFEKFLRYLY 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 71997007 106 SNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFA 139
Cdd:cd18292  81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  44 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW---NGDKFDLELVEDElcqkAFAPFLRFMYSNHVVLHKDNCLPLL 120
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMkesSSSEIELDDVSPE----AFEALLDYIYTGELELSEENVEELL 76

                ....*.
gi 71997007 121 VLADKY 126
Cdd:cd18186  77 AAADKL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007     46 DVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADK 125
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|...
gi 71997007    126 YNVTTLKKVCLDF 138
Cdd:smart00225  80 LQIPGLVELCEEF 92

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007    37 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDlELVEDELCQKAFAPFLRFMYSNHVVlHKDNC 116
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS-EITLDDVSPEDFEALLEFMYTGKLI-SEENV 80

                          90       100
                  ....*....|....*....|..
gi 71997007   117 LPLLVLADKYNVTTLKKVCLDF 138
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEF 102

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007 156 WFSYATKAYHPSLIKSCMQAIALEFETLLTEEwekDWQELHRDQMIEILKCNNLKVASEFKLWEALQKWI 225
Cdd:cd18493   8 WLQYAKMCGHKELAEACLEFIAWNFEKVLKSP---DWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  39 YNNAQFSDVNMKVG----EESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDElcQKAFAPFLRFMYSNHVVLHKD 114
Cdd:cd18349   3 FNNELMADVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVE--PAAFLILLKYMYSDEIDLEAD 80

                        90       100
                ....*....|....*....|....*....
gi 71997007 115 NCLPLLVLADKYNVTTLKKVCLDFAQSEI 143
Cdd:cd18349  81 TVLATLYAAKKYIVPALAKACVNFLETSL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  32 LCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMS---QKWNGDKFDLELVEDELcqkaFAPFLRFMYSNH 108
Cdd:cd18256   8 LAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAggmSESSKDVVQIHGVEPDI----FHILLDFIYTGV 83

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 71997007 109 VVLHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18256  84 VEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHP 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  41 NAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDK---FDLELVEDELCQKafapFLRFMYSNHVVLHKDNCL 117
Cdd:cd18240  14 EGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEkkvYKIPGVSPEMMEL----IIEYAYTRTVPITAENVE 89

                        90       100
                ....*....|....*....|....*...
gi 71997007 118 PLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18240  90 ELLPAADQFNIMGIVKACCDFLEDQLCP 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  36 AKFYNNAQFSDVNMKVGE----ESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDElcQKAFAPFLRFMYSNHVVL 111
Cdd:cd18347  14 AFLFNNEVLSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVE--PAAFLALLKFLYSDEVQI 91

                        90       100       110
                ....*....|....*....|....*....|..
gi 71997007 112 HKDNCLPLLVLADKYNVTTLKKVCLDFAQSEI 143
Cdd:cd18347  92 GPETVMTTLYTAKKYAVPALEAHCVEFLKKNL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  46 DVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDkFDLELVEdELCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADK 125
Cdd:cd18955   3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGD-LVITLPE-EVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                        90
                ....*....|...
gi 71997007 126 YNVTTLKKVCLDF 138
Cdd:cd18955  81 LGVHNIEKACFDF 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  44 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLA 123
Cdd:cd18265  23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQK-VSAAAMEVLLDYMYGGGLRIQEDNVESVLEAS 101

                        90       100
                ....*....|....*....|..
gi 71997007 124 DKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18265 102 DLLQVSKLREACVRFLEGQLHP 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  34 DMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDkfDLELVE-DELCQKAFAPFLRFMYSNHVVLH 112
Cdd:cd18298   2 SLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNED--DKNVIEiDQYSYPVYYAFLRYLYTDQVDLP 79

                        90       100
                ....*....|....*....|....*.
gi 71997007 113 KDNCLPLLVLADKYNVTTLKKVCLDF 138
Cdd:cd18298  80 PEDAIGLLDLANSYCEERLKKLCEDI 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  34 DMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHK 113
Cdd:cd18345   8 DLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITD-VDHEVMREMLRFIYTGKAPNLD 86

                        90       100
                ....*....|....*....|..
gi 71997007 114 DNCLPLLVLADKYNVTTLKKVC 135
Cdd:cd18345  87 KMADDLLAAADKYALERLKVMC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  34 DMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDK---FDLELVEDELcqkaFAPFLRFMYSN--- 107
Cdd:cd18343  11 DLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKknrVEINDVDPEV----FKEMMRFIYTGkap 86

                        90       100
                ....*....|....*....|....*...
gi 71997007 108 HVVLHKDNclpLLVLADKYNVTTLKKVC 135
Cdd:cd18343  87 NLDKMADN---LLAAADKYALERLKVMC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  40 NNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKfDLELVEDELCQKAFAPFLRFMYSNHVVLHKDNCLPL 119
Cdd:cd18341  23 DENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEK-KKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDI 101

                        90       100
                ....*....|....*....|....*.
gi 71997007 120 LVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18341 102 FALASRFQIPSVFTVCVTYLQKRLSP 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  36 AKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDvfdrmmsqKWN----GDKFDLELVEDElcQKAFAPFLRFMYSNHVVL 111
Cdd:cd18303  10 ASLFDKELYSDITIKLADKSIPAHKFVLAARSE--------KWSnenlASTNELDLSDIS--YEVVLALLRWLYTDELDL 79

                        90       100
                ....*....|....*....|....*.
gi 71997007 112 HKDN--CLPLLVLADKYNVTTLKKVC 135
Cdd:cd18303  80 TLDDefLLELMKAAKRFQLTDLVERC 105

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  37 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSqkwnGDKFDLELVEDELCQKAFAPFLRFM---YSNHV-VLH 112
Cdd:cd18300   2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFG----GNFRESSAKEVELPGVSKETFLALLeylYTDQApILE 77

                        90       100
                ....*....|....*....|...
gi 71997007 113 KDNCLPLLVLADKYNVTTLKKVC 135
Cdd:cd18300  78 DGDCVGLIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  44 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDELCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLA 123
Cdd:cd18254  22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPEVLELLLDFAYSSRIIINEENAESLLEAG 101

                        90       100
                ....*....|....*....|..
gi 71997007 124 DKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18254 102 DMLQFHDVRDAAAEFLEKNLYP 123

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007   38 FYNNAQFSDVNM--KVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDelcqkAFAPFLRFMYSNHVVLHKDN 115
Cdd:PHA03098   3 SFELQKFCDESIiiVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNIDYD-----SFNEVIKYIYTGKINITSNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  116 CLPLLVLADKYNVTTLKKVCLDFaqseILPVIDLK---ELFSVWFSYATKAyhpsLIKSCMQAIALEFETLLTEEwekDW 192
Cdd:PHA03098  78 VKDILSIANYLIIDFLINLCINY----IIKIIDDNnciDIYRFSFFYGCKK----LYSAAYNYIRNNIELIYNDP---DF 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  193 QELHRDQMIEILKCNNLKVASEFKLWEALQKWIQAPNHSERRGntagplLAFLLPLIRFPFMNGDELNEVEKSAISEMHP 272
Cdd:PHA03098 147 IYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKD------ICLILKVLRITFLSEEGIKKLKRWKLRIKKK 220

                        250       260       270
                 ....*....|....*....|....*....|....
gi 71997007  273 KLFqpplllsykFNALPLSSRMSCKDFTKKQFLL 306
Cdd:PHA03098 221 KIV---------FNKRCIKIIYSKKYNLNKILPR 245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  30 ETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMS---QKWNGDKFDLELVEDElcqkAFAPFLRFMYS 106
Cdd:cd18336   5 QTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTndvREAKQEEIKMEGVDPD----ALKALVHYAYT 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 71997007 107 NHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18336  81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHP 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  37 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSqkwNGDKFDLE-LVE-DELCQKAFAPFLRFMYSNHVVLHKD 114
Cdd:cd18253  11 EFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFC---NDHRESREmLVEiNGILAEAMDCFLQYVYTGKVKITTE 87

                        90       100       110
                ....*....|....*....|....*....|.
gi 71997007 115 NCLPLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18253  88 NVQYLFETSSLFQISPLRDACAKFLEEQLDP 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  35 MAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRM----MSQKwNGDKFDLELVEDelcqKAFAPFLRFMYSNHVV 110
Cdd:cd18235  12 MNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMftgdLSES-RANRVTLQDVDG----KALLLLIDYVYTAEIQ 86

                        90       100       110
                ....*....|....*....|....*....|....*
gi 71997007 111 LHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18235  87 VTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  45 SDVNMKVGEESYPAHRLILSKSSDVFDRMMSQkwngdkfDL-ELVEDELCQK-----AFAPFLRFMYSNHVVLHKDNCLP 118
Cdd:cd18234   2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTN-------DVrEATEEEIKLKdvdpdALWTLVQYCYTGRLELKEDNVES 74

                        90       100
                ....*....|....*....|
gi 71997007 119 LLVLADKYNVTTLKKVCLDF 138
Cdd:cd18234  75 LLATACLLQLSEVVEACCGF 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71997007  46 DVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEdelcQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADK 125
Cdd:cd18218  20 DTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCLGEGIS----PSTFKQLLDFVYGESVEVQPGELRPLLEAARA 95