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Conserved domains on  [gi|71981157|ref|NP_495995|]
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Doublecortin domain-containing protein [Caenorhabditis elegans]

Protein Classification

ubiquitin family protein( domain architecture ID 10650207)

ubiquitin family protein belongs to an diverse class of protein modifier and gene expression regulatory proteins that participate in a number of cellular processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 13-98 4.70e-31

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


:

Pssm-ID: 214711  Cd Length: 89  Bit Score: 115.82  E-value: 4.70e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157     13 DFFPLRIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTD--LLRTATAVRRLFTTQGIPVHHFDDLETNGEYVAVETG 90
Cdd:smart00537   2 LVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81


                   ....*...
gi 71981157     91 PFVNVPYG 98
Cdd:smart00537  82 AFKKVDYG 89
PTZ00121 super family cl31754
MAEBL; Provisional
 194-556 8.72e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 8.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   194 KNEKWMMGERVKLETQSQTLAQKSEKDEQIPRLDIKEVDGGSTTSEFMRNGEKSKSTTKLPRLLNSNRSFRRepvsaqkp 273
Cdd:PTZ00121 1511 KADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK-------- 1582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   274 pSEEPRSTSENLPPIDLKSIQISQNSQSTSQKKDSDTiSIKTEEevisiLKPEKTTTESIVSSKISRKNAPKDDDEVRFH 353
Cdd:PTZ00121 1583 -AEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEA-KIKAEE-----LKKAEEEKKKVEQLKKKEAEEKKKAEELKKA 1655

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   354 RSYQVTETTYTTRNSDEtDRRKPENVEKTVESKNDRSVQDKSEKIEKKVPEKLSKPQKTETTKSKERAKWADQGNTT--- 430
Cdd:PTZ00121 1656 EEENKIKAAEEAKKAEE-DKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKaee 1734

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   431 LKREKSIEK-STRQGKIDKSIEKLIDKSIDNTEKLSSQKPKidmAKGELRKFDVDINEIPIRFEGPMVNKSRINTSRIVT 509
Cdd:PTZ00121 1735 AKKEAEEDKkKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK---EKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANII 1811

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 71981157   510 SRSTTNLFVDEIVNEDELDDVIERAQLWDLNRRRQNMRQQHTQTSGS 556
Cdd:PTZ00121 1812 EGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNN 1858
 
Name Accession Description Interval E-value
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 13-98 4.70e-31

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 115.82  E-value: 4.70e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157     13 DFFPLRIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTD--LLRTATAVRRLFTTQGIPVHHFDDLETNGEYVAVETG 90
Cdd:smart00537   2 LVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81


                   ....*...
gi 71981157     91 PFVNVPYG 98
Cdd:smart00537  82 AFKKVDYG 89
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 18-93 2.86e-18

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 79.57  E-value: 2.86e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71981157  18 RIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTDLLRTAT-AVRRLFT-TQGIPVHHFDDLETNGEYVAVETGPFV 93
Cdd:cd17071   2 IIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKAPFgAVRSIYTpTGGHRVKDLDSLQNGGVYVAAGSERFK 79
DCX pfam03607
Doublecortin;
35-92 5.04e-12

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 60.92  E-value: 5.04e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157    35 VVTRKQFKHWIVFLDALTDLLRTAT--AVRRLFTTQGIPVHHFDDLETNGEYVAVETGPF 92
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVVKLPfgAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
PTZ00121 PTZ00121
MAEBL; Provisional
 194-556 8.72e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 8.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   194 KNEKWMMGERVKLETQSQTLAQKSEKDEQIPRLDIKEVDGGSTTSEFMRNGEKSKSTTKLPRLLNSNRSFRRepvsaqkp 273
Cdd:PTZ00121 1511 KADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK-------- 1582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   274 pSEEPRSTSENLPPIDLKSIQISQNSQSTSQKKDSDTiSIKTEEevisiLKPEKTTTESIVSSKISRKNAPKDDDEVRFH 353
Cdd:PTZ00121 1583 -AEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEA-KIKAEE-----LKKAEEEKKKVEQLKKKEAEEKKKAEELKKA 1655

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   354 RSYQVTETTYTTRNSDEtDRRKPENVEKTVESKNDRSVQDKSEKIEKKVPEKLSKPQKTETTKSKERAKWADQGNTT--- 430
Cdd:PTZ00121 1656 EEENKIKAAEEAKKAEE-DKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKaee 1734

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   431 LKREKSIEK-STRQGKIDKSIEKLIDKSIDNTEKLSSQKPKidmAKGELRKFDVDINEIPIRFEGPMVNKSRINTSRIVT 509
Cdd:PTZ00121 1735 AKKEAEEDKkKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK---EKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANII 1811

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 71981157   510 SRSTTNLFVDEIVNEDELDDVIERAQLWDLNRRRQNMRQQHTQTSGS 556
Cdd:PTZ00121 1812 EGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNN 1858
 
Name Accession Description Interval E-value
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 13-98 4.70e-31

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 115.82  E-value: 4.70e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157     13 DFFPLRIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTD--LLRTATAVRRLFTTQGIPVHHFDDLETNGEYVAVETG 90
Cdd:smart00537   2 LVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEvvKLDLPHGVRKLYTLDGKKVTSLDELEDGGSYVASGTE 81


                   ....*...
gi 71981157     91 PFVNVPYG 98
Cdd:smart00537  82 AFKKVDYG 89
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 18-93 2.86e-18

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 79.57  E-value: 2.86e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71981157  18 RIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTDLLRTAT-AVRRLFT-TQGIPVHHFDDLETNGEYVAVETGPFV 93
Cdd:cd17071   2 IIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKAPFgAVRSIYTpTGGHRVKDLDSLQNGGVYVAAGSERFK 79
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 16-87 6.10e-16

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 72.61  E-value: 6.10e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71981157  16 PLRIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTDLLRTAT-AVRRLFTTQGIPVHHFDDLETNGEYVAV 87
Cdd:cd16113   1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVTEKVKLQTgAVRKLYTLDGKRISDPDELVNGGQYVAV 73
DCX1_DCDC2B cd17150
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 18-92 4.60e-12

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340670  Cd Length: 79  Bit Score: 61.74  E-value: 4.60e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 71981157  18 RIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTDLLRTATAVRRLFTT-QGIPVHHFDDLETNGEYVAVETGPF 92
Cdd:cd17150   2 NVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPVAVRNLYTPrEGHRVTELGDLQNGGHYVAAGFERF 77
DCX pfam03607
Doublecortin;
35-92 5.04e-12

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 60.92  E-value: 5.04e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157    35 VVTRKQFKHWIVFLDALTDLLRTAT--AVRRLFTTQGIPVHHFDDLETNGEYVAVETGPF 92
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVVKLPfgAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 18-87 3.27e-10

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 56.47  E-value: 3.27e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71981157  18 RIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTDLLRTAT-AVRRLFTTQGIPVHHFDDLETNGEYVAV 87
Cdd:cd01617   2 RITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLPTgGVRKLYTPSGKLVKSLSDLEDGESYVVC 72
DCX2_DCDC2B cd17153
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 16-87 9.81e-08

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340673  Cd Length: 80  Bit Score: 49.36  E-value: 9.81e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71981157  16 PLRIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTD--LLRTAtAVRRLFTTQGIPVHHFDDLETNGEYVAV 87
Cdd:cd17153   1 PCIIHVFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEkaNLRTG-AVRKLCTLDGVPLSSGKELVSGQYYVAV 73
DCX1_DCDC2C cd17151
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 18-86 1.72e-07

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340671  Cd Length: 79  Bit Score: 48.63  E-value: 1.72e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157  18 RIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTDLLRTATAVRRLFT-TQGIPVHHFDDLETNGEYVA 86
Cdd:cd17151   2 TILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTETVKVPFGVRCLYTpRNGHRVKGLDDLQGGGKYVA 71
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 16-87 6.21e-07

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 47.11  E-value: 6.21e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71981157  16 PLRIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTDLLRTAT-AVRRLFTTQGIPVHHFDDLETNGEYVAV 87
Cdd:cd17154   1 SRTINVFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLRTgGVFRLCTLNGHPVSDSTELEDNHYYVAV 73
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 16-87 1.55e-06

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 46.33  E-value: 1.55e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71981157  16 PLRIRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTDLLRTAT-AVRRLFTTQGIPVHHFDDLETNGEYVAV 87
Cdd:cd17152   1 PCTIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTgAVRRLYTLDGKLINDGSELENGQFYVAV 73
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 19-86 4.05e-06

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340669  Cd Length: 80  Bit Score: 45.15  E-value: 4.05e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157  19 IRVFRNGDMFDHGRILVVTRKQFKHWIVFLDALTDLLRTA-TAVRRLFTTQ-GIPVHHFDDLETNGEYVA 86
Cdd:cd17149   3 VLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPfGAVRNIYTPRgGHRVRSLEQLQSGEQYVA 72
DCX_DCDC5_like cd17072
Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar ...
 17-79 2.12e-04

Doublecortin-like domain found in doublecortin domain-containing protein 5 (DCDC5) and similar proteins; DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8 as well as with the Rab8 nucleotide exchange factor Rabin8. This family also includes DCDC1, which is a hydrophilic intracellular protein that contains only one DCX repeat. Therefore, DCDC1 might only bind to microtubules without microtubule polymerization properties. DCDC1 is mainly expressed in adult testis.


Pssm-ID: 340592  Cd Length: 71  Bit Score: 39.95  E-value: 2.12e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71981157  17 LRIRVFRNGD-MFDHGRILVVTRKQFKhwiVFLDALTDLLRTATAVRRLFTTQGIPVHHFDDLE 79
Cdd:cd17072   1 VRLRVLKNGErDLERAVYVVGPDLELQ---LFLDRCTERLNLPFAARRLFDENGKEIFTLRDLE 61
DCX1_DCDC5 cd17156
Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is ...
 17-81 7.93e-04

Doublecortin-like domain 1 found in doublecortin domain-containing protein 5 (DCDC5); DCDC5 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC5 is expressed during mitosis and is involved in coordinating late cytokinesis. DCDC5 interacts with cytoplasmic dynein and Rab8, as well as with the Rab8 nucleotide exchange factor Rabin8.


Pssm-ID: 340676  Cd Length: 76  Bit Score: 38.43  E-value: 7.93e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71981157  17 LRIRVFRNGDMFDHGRILVVTRKQfkhwiVFLDALTDLLRTATAVRRLFTTQGIPVHHFDDLETN 81
Cdd:cd17156   1 LRLRVLRNGEKDKNKAVTVVGEFQ-----LFLERCTTALNLPFAARRLFDEKGKEHFTLKDLKRD 60
PTZ00121 PTZ00121
MAEBL; Provisional
 194-556 8.72e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 8.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   194 KNEKWMMGERVKLETQSQTLAQKSEKDEQIPRLDIKEVDGGSTTSEFMRNGEKSKSTTKLPRLLNSNRSFRRepvsaqkp 273
Cdd:PTZ00121 1511 KADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK-------- 1582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   274 pSEEPRSTSENLPPIDLKSIQISQNSQSTSQKKDSDTiSIKTEEevisiLKPEKTTTESIVSSKISRKNAPKDDDEVRFH 353
Cdd:PTZ00121 1583 -AEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEA-KIKAEE-----LKKAEEEKKKVEQLKKKEAEEKKKAEELKKA 1655

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   354 RSYQVTETTYTTRNSDEtDRRKPENVEKTVESKNDRSVQDKSEKIEKKVPEKLSKPQKTETTKSKERAKWADQGNTT--- 430
Cdd:PTZ00121 1656 EEENKIKAAEEAKKAEE-DKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKaee 1734

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   431 LKREKSIEK-STRQGKIDKSIEKLIDKSIDNTEKLSSQKPKidmAKGELRKFDVDINEIPIRFEGPMVNKSRINTSRIVT 509
Cdd:PTZ00121 1735 AKKEAEEDKkKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRK---EKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANII 1811

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 71981157   510 SRSTTNLFVDEIVNEDELDDVIERAQLWDLNRRRQNMRQQHTQTSGS 556
Cdd:PTZ00121 1812 EGGKEGNLVINDSKEMEDSAIKEVADSKNMQLEEADAFEKHKFNKNN 1858
PTZ00121 PTZ00121
MAEBL; Provisional
 202-480 1.81e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   202 ERVKLETQSQTLAQKSEKDEQI-----PRLDIKEVDGGSTTSEFMRNGEKSKSTTKLPRLLNSNRSFRREPVSAQKPPSE 276
Cdd:PTZ00121 1233 EEAKKDAEEAKKAEEERNNEEIrkfeeARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAE 1312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   277 EPRSTSENLPPIDLKSIQISQNSQSTSQKKDSDTISIKTEEEVISILKPEKTTTESivsSKISRKNAPKDDDEVRfhrsy 356
Cdd:PTZ00121 1313 EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEA---AEKKKEEAKKKADAAK----- 1384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157   357 qvtETTYTTRNSDETDRRKPENVEKTVESKNDRSVQDKSEKIEKKVPEKlskpQKTETTKSK-ERAKWADQGNTTLKREK 435
Cdd:PTZ00121 1385 ---KKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEK----KKADEAKKKaEEAKKADEAKKKAEEAK 1457

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 71981157   436 SIEKSTRQGKIDKSIEKLiDKSIDNTEKLSSQKPKIDMAKG---ELRK 480
Cdd:PTZ00121 1458 KAEEAKKKAEEAKKADEA-KKKAEEAKKADEAKKKAEEAKKkadEAKK 1504
DCX1_DCLK1 cd17140
Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 18-97 5.12e-03

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340660  Cd Length: 89  Bit Score: 36.52  E-value: 5.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71981157  18 RIRVFRNGDMFDHGRILVVTRKQFKHwivFLDALTDLLRTAT-------AVRRLFTTQGI-PVHHFDDLETNGEYVAVET 89
Cdd:cd17140   4 KVRFYRNGDRYFKGIVYAISPDRFRS---FEALLADLTRTLSdnvnlpqGVRTIYTIDGLkKISSLDQLVEGESYVCGSI 80


                ....*...
gi 71981157  90 GPFVNVPY 97
Cdd:cd17140  81 EPFKKLEY 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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