NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17535591|ref|NP_496028|]
View 

GH18 domain-containing protein [Caenorhabditis elegans]

Protein Classification

glycoside hydrolase family 18 protein( domain architecture ID 12217520)

glycoside hydrolase family 18 protein similar to chitinase, which catalyzes the random endo-hydrolysis of the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins

CAZY:  GH18
EC:  3.2.1.-
Gene Ontology:  GO:0008061|GO:0005975|GO:0004568
PubMed:  32439576

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glyco_18 smart00636
Glyco_18 domain;
44-150 8.96e-33

Glyco_18 domain;


:

Pssm-ID: 214753 [Multi-domain]  Cd Length: 334  Bit Score: 118.16  E-value: 8.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591     44 RIIGYYFATQTS----VITSDQVSNLTHAVFAFVNITSDGQLQI-DGDLAKNRFTNLIEIAKQQtPQVKVMISIGGNDNS 118
Cdd:smart00636   1 RVVGYFTNWGVYgrnfPVDDIPASKLTHIIYAFANIDPDGTVTIgDEWADIGNFGQLKALKKKN-PGLKVLLSIGGWTES 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 17535591    119 NNFKPVLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:smart00636  80 DNFSSMLSDPASRKKFIDSIVSFLKKYGFDGI 111
 
Name Accession Description Interval E-value
Glyco_18 smart00636
Glyco_18 domain;
44-150 8.96e-33

Glyco_18 domain;


Pssm-ID: 214753 [Multi-domain]  Cd Length: 334  Bit Score: 118.16  E-value: 8.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591     44 RIIGYYFATQTS----VITSDQVSNLTHAVFAFVNITSDGQLQI-DGDLAKNRFTNLIEIAKQQtPQVKVMISIGGNDNS 118
Cdd:smart00636   1 RVVGYFTNWGVYgrnfPVDDIPASKLTHIIYAFANIDPDGTVTIgDEWADIGNFGQLKALKKKN-PGLKVLLSIGGWTES 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 17535591    119 NNFKPVLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:smart00636  80 DNFSSMLSDPASRKKFIDSIVSFLKKYGFDGI 111
Glyco_hydro_18 pfam00704
Glycosyl hydrolases family 18;
44-150 1.03e-29

Glycosyl hydrolases family 18;


Pssm-ID: 425828 [Multi-domain]  Cd Length: 311  Bit Score: 109.47  E-value: 1.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591    44 RIIGYYFATQTSVIT-SDQVSNLTHAVFAFVNITS-DGQLQIdGDLAKNRFTNLIEIAKQQTPQVKVMISIGGNDNSNNF 121
Cdd:pfam00704   1 RIVGYYTSWGVYRNGnFLPSDKLTHIIYAFANIDGsDGTLFI-GDWDLGNFEQLKKLKKQKNPGVKVLLSIGGWTDSTGF 79

                          90       100
                  ....*....|....*....|....*....
gi 17535591   122 KPVLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:pfam00704  80 SLMASNPASRKKFADSIVSFLRKYGFDGI 108
ChiA COG3325
Chitinase, GH18 family [Carbohydrate transport and metabolism];
25-150 4.88e-22

Chitinase, GH18 family [Carbohydrate transport and metabolism];


Pssm-ID: 442554 [Multi-domain]  Cd Length: 391  Bit Score: 89.97  E-value: 4.88e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  25 SISSTVAASTYPATPGCNKRIIGYYfaTQTSVITSD------QVSNLTHAVFAFVNITSDGQLQIDGDLAKNRFT----- 93
Cdd:COG3325   1 SATASVSDTAAAATATSGKRVVGYF--TQWGIYGRNylvkdiPASKLTHINYAFANVDPDGKCSVGDAWAKPSVDgaadd 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17535591  94 ---------NLIEIAKQQTPQVKVMISIGGNDNSNNFKPVLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:COG3325  79 wdqplkgnfNQLKKLKAKNPNLKVLISIGGWTWSKGFSDAAATPASRAAFVDSCVDLLRKYNFDGI 144
GH18_chitinase-like cd00598
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant ...
 45-150 1.05e-21

The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model.


Pssm-ID: 119349 [Multi-domain]  Cd Length: 210  Bit Score: 86.28  E-value: 1.05e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  45 IIGYYF---ATQTSVITSDQVSNLTHAVFAFVNITSDGQLQIDGDLAKNRFTNLIEIAKQQTPQVKVMISIGGNDNSNNF 121
Cdd:cd00598   1 VICYYDgwsSGRGPDPTDIPLSLCTHIIYAFAEISSDGSLNLFGDKSEEPLKGALEELASKKPGLKVLISIGGWTDSSPF 80

                        90       100
                ....*....|....*....|....*....
gi 17535591 122 KPVlSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:cd00598  81 TLA-SDPASRAAFANSLVSFLKTYGFDGV 108
 
Name Accession Description Interval E-value
Glyco_18 smart00636
Glyco_18 domain;
44-150 8.96e-33

Glyco_18 domain;


Pssm-ID: 214753 [Multi-domain]  Cd Length: 334  Bit Score: 118.16  E-value: 8.96e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591     44 RIIGYYFATQTS----VITSDQVSNLTHAVFAFVNITSDGQLQI-DGDLAKNRFTNLIEIAKQQtPQVKVMISIGGNDNS 118
Cdd:smart00636   1 RVVGYFTNWGVYgrnfPVDDIPASKLTHIIYAFANIDPDGTVTIgDEWADIGNFGQLKALKKKN-PGLKVLLSIGGWTES 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 17535591    119 NNFKPVLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:smart00636  80 DNFSSMLSDPASRKKFIDSIVSFLKKYGFDGI 111
Glyco_hydro_18 pfam00704
Glycosyl hydrolases family 18;
44-150 1.03e-29

Glycosyl hydrolases family 18;


Pssm-ID: 425828 [Multi-domain]  Cd Length: 311  Bit Score: 109.47  E-value: 1.03e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591    44 RIIGYYFATQTSVIT-SDQVSNLTHAVFAFVNITS-DGQLQIdGDLAKNRFTNLIEIAKQQTPQVKVMISIGGNDNSNNF 121
Cdd:pfam00704   1 RIVGYYTSWGVYRNGnFLPSDKLTHIIYAFANIDGsDGTLFI-GDWDLGNFEQLKKLKKQKNPGVKVLLSIGGWTDSTGF 79

                          90       100
                  ....*....|....*....|....*....
gi 17535591   122 KPVLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:pfam00704  80 SLMASNPASRKKFADSIVSFLRKYGFDGI 108
ChiA COG3325
Chitinase, GH18 family [Carbohydrate transport and metabolism];
25-150 4.88e-22

Chitinase, GH18 family [Carbohydrate transport and metabolism];


Pssm-ID: 442554 [Multi-domain]  Cd Length: 391  Bit Score: 89.97  E-value: 4.88e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  25 SISSTVAASTYPATPGCNKRIIGYYfaTQTSVITSD------QVSNLTHAVFAFVNITSDGQLQIDGDLAKNRFT----- 93
Cdd:COG3325   1 SATASVSDTAAAATATSGKRVVGYF--TQWGIYGRNylvkdiPASKLTHINYAFANVDPDGKCSVGDAWAKPSVDgaadd 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17535591  94 ---------NLIEIAKQQTPQVKVMISIGGNDNSNNFKPVLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:COG3325  79 wdqplkgnfNQLKKLKAKNPNLKVLISIGGWTWSKGFSDAAATPASRAAFVDSCVDLLRKYNFDGI 144
GH18_chitinase-like cd00598
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant ...
 45-150 1.05e-21

The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model.


Pssm-ID: 119349 [Multi-domain]  Cd Length: 210  Bit Score: 86.28  E-value: 1.05e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  45 IIGYYF---ATQTSVITSDQVSNLTHAVFAFVNITSDGQLQIDGDLAKNRFTNLIEIAKQQTPQVKVMISIGGNDNSNNF 121
Cdd:cd00598   1 VICYYDgwsSGRGPDPTDIPLSLCTHIIYAFAEISSDGSLNLFGDKSEEPLKGALEELASKKPGLKVLISIGGWTDSSPF 80

                        90       100
                ....*....|....*....|....*....
gi 17535591 122 KPVlSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:cd00598  81 TLA-SDPASRAAFANSLVSFLKTYGFDGV 108
GH18_chitolectin_chitotriosidase cd02872
This conserved domain family includes a large number of catalytically inactive chitinase-like ...
 66-149 2.38e-18

This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active chitotriosidases. The conserved domain is an eight-stranded alpha/beta barrel fold belonging to the family 18 glycosyl hydrolases. The fold has a pronounced active-site cleft at the C-terminal end of the beta-barrel. The chitolectins lack a key active site glutamate (the proton donor required for hydrolytic activity) but retain highly conserved residues involved in oligosaccharide binding. Chitotriosidase is a chitinolytic enzyme expressed in maturing macrophages, which suggests that it plays a part in antimicrobial defense. Chitotriosidase hydrolyzes chitotriose, as well as colloidal chitin to yield chitobiose and is therefore considered an exochitinase. Chitotriosidase occurs in two major forms, the large form being converted to the small form by either RNA or post-translational processing. Although the small form, containing the chitinase domain alone, is sufficient for the chitinolytic activity, the additional C-terminal chitin-binding domain of the large form plays a role in processing colloidal chitin. The chitotriosidase gene is nonessential in humans, as about 35% of the population are heterozygous and 6% homozygous for an inactivated form of the gene. HCGP39 is a 39-kDa human cartilage glycoprotein thought to play a role in connective tissue remodeling and defense against pathogens.


Pssm-ID: 119351 [Multi-domain]  Cd Length: 362  Bit Score: 79.91  E-value: 2.38e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  66 THAVFAFVNITSDGQLQI-----DGDL-AKNRFTNLieiaKQQTPQVKVMISIGG-NDNSNNFKPVLSSPDRKKLFINST 138
Cdd:cd02872  29 THIIYAFAGLNPDGNIIIldewnDIDLgLYERFNAL----KEKNPNLKTLLAIGGwNFGSAKFSAMAASPENRKTFIKSA 104

                        90
                ....*....|.
gi 17535591 139 VSFLQTYDIDG 149
Cdd:cd02872 105 IAFLRKYGFDG 115
GH18_chitinase cd06548
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant ...
 45-150 6.84e-18

The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.


Pssm-ID: 119365 [Multi-domain]  Cd Length: 322  Bit Score: 78.06  E-value: 6.84e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  45 IIGYY-----FATQTSVITSDQVSNLTHAVFAFVNITSDGQLQIDGDLAKNRFT------------------NLIEIAKQ 101
Cdd:cd06548   1 VVGYFtnwgiYGRNYFVTDDIPADKLTHINYAFADIDGDGGVVTSDDEAADEAAqsvdggadtddqplkgnfGQLRKLKQ 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 17535591 102 QTPQVKVMISIGGNDNSNNFKPVLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:cd06548  81 KNPHLKILLSIGGWTWSGGFSDAAATEASRAKFADSAVDFIRKYGFDGI 129
GH18_plant_chitinase_class_V cd02879
The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the ...
 47-149 4.45e-12

The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the chitin-binding domain present in other GH18 enzymes. The GH18 domain of the class V chitinases has endochitinase activity in some cases and no catalytic activity in others. Included in this family is a lectin found in black locust (Robinia pseudoacacia) bark, which binds chitin but lacks chitinase activity. Also included is a chitinase-related receptor-like kinase (CHRK1) from tobacco (Nicotiana tabacum), with an N-terminal GH18 domain and a C-terminal kinase domain, which is thought to be part of a plant signaling pathway. The GH18 domain of CHRK1 is expressed extracellularly where it binds chitin but lacks chitinase activity.


Pssm-ID: 119358 [Multi-domain]  Cd Length: 299  Bit Score: 62.00  E-value: 4.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  47 GYYFATQTSVITSDQVSNL-THAVFAFVNI-TSDGQLQIDGDLAKnRFTNLIEIAKQQTPQVKVMISIGG-NDNSNNFKP 123
Cdd:cd02879   7 GYWPAWSEEFPPSNIDSSLfTHLFYAFADLdPSTYEVVISPSDES-EFSTFTETVKRKNPSVKTLLSIGGgGSDSSAFAA 85

                        90       100
                ....*....|....*....|....*.
gi 17535591 124 VLSSPDRKKLFINSTVSFLQTYDIDG 149
Cdd:cd02879  86 MASDPTARKAFINSSIKVARKYGFDG 111
GH18_IDGF cd02873
The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects ...
 66-150 2.92e-10

The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are related to the glycosyl hydrolase family 18 (GH18) chitinases, but they have an amino acid substitution known to abolish chitinase catalytic activity. IDGFs may have evolved from chitinases to gain new functions as growth factors, interacting with cell surface glycoproteins involved in growth-promoting processes.


Pssm-ID: 119352 [Multi-domain]  Cd Length: 413  Bit Score: 56.94  E-value: 2.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  66 THAVFAFVNITSDG----QLQIDGDLAKNRF---TNLieiaKQQTPQVKVMISIGGN------DNSNNFKPVLSSPDRKK 132
Cdd:cd02873  32 THLVYGYAGIDADTykikSLNEDLDLDKSHYraiTSL----KRKYPHLKVLLSVGGDrdtdeeGENEKYLLLLESSESRN 107

                        90
                ....*....|....*...
gi 17535591 133 LFINSTVSFLQTYDIDGV 150
Cdd:cd02873 108 AFINSAHSLLKTYGFDGL 125
GH18_3CO4_chitinase cd06545
The Bacteroides thetaiotaomicron protein represented by pdb structure 3CO4 is an ...
 45-150 3.30e-09

The Bacteroides thetaiotaomicron protein represented by pdb structure 3CO4 is an uncharacterized bacterial member of the family 18 glycosyl hydrolases with homologs found in Flavobacterium, Stigmatella, and Pseudomonas.


Pssm-ID: 119362 [Multi-domain]  Cd Length: 253  Bit Score: 53.61  E-value: 3.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  45 IIGYYFATQTSVITSDQV--SNLTHAVFAFVNITSDGQLQIDGDLAknRFTNLIEIAKQQtpQVKVMISIGGNDNSNNFK 122
Cdd:cd06545   1 VVGYLPNYDDLNALSPTIdfSKLTHINLAFANPDANGTLNANPVRS--ELNSVVNAAHAH--NVKILISLAGGSPPEFTA 76

                        90       100
                ....*....|....*....|....*...
gi 17535591 123 PVLSsPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:cd06545  77 ALND-PAKRKALVDKIINYVVSYNLDGI 103
GH18_zymocin_alpha cd02878
Zymocin, alpha subunit. Zymocin is a heterotrimeric enzyme that inhibits yeast cell cycle ...
 46-150 7.15e-08

Zymocin, alpha subunit. Zymocin is a heterotrimeric enzyme that inhibits yeast cell cycle progression. The zymocin alpha subunit has a chitinase activity that is essential for holoenzyme action from the cell exterior while the gamma subunit contains the intracellular toxin responsible for G1 phase cell cycle arrest. The zymocin alpha and beta subunits are thought to act from the cell's exterior by docking to the cell wall-associated chitin, thus mediating gamma-toxin translocation. The alpha subunit has an eight-stranded TIM barrel fold similar to that of family 18 glycosyl hydrolases such as hevamine, chitolectin, and chitobiase.


Pssm-ID: 119357 [Multi-domain]  Cd Length: 345  Bit Score: 50.00  E-value: 7.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  46 IGYYFATQT------SVITSDQVSNLTHAVFAFVNITSDgqLQIDGDLAKNRFTNLIEIAKqqtpqVKVMISIGGNDNSN 119
Cdd:cd02878   3 IAYFEAYNLdrpclnMDVTQIDTSKYTHIHFAFANITSD--FSVDVSSVQEQFSDFKKLKG-----VKKILSFGGWDFST 75

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 17535591 120 N------FKPVLSSPDRKKlFINSTVSFLQTYDIDGV 150
Cdd:cd02878  76 SpstyqiFRDAVKPANRDT-FANNVVNFVNKYNLDGV 111
GH18_CFLE_spore_hydrolase cd02874
Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial ...
 45-150 4.51e-06

Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the forespore inner membrane and is deposited as a mature enzyme in the cortex layer of the spore. As part of a sensory mechanism capable of initiating germination, CFLE degrades a spore-specific peptidoglycan constituent called muramic-acid delta-lactam that comprises the outer cortex. CFLE has a C-terminal glycosyl hydrolase family 18 (GH18) catalytic domain as well as two N-terminal LysM peptidoglycan-binding domains. In addition to SleB, this family includes YaaH, YdhD, and YvbX from Bacillus subtilis.


Pssm-ID: 119353 [Multi-domain]  Cd Length: 313  Bit Score: 44.95  E-value: 4.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  45 IIGYYFATQTSVITSdqVSNLTH-----AVFAFvNITSDGQLQIDGDlaknrfTNLIEIAKQQtpQVKVMISIGgNDNSN 119
Cdd:cd02874   4 VLGYYTPRNGSDYES--LRANAPyltyiAPFWY-GVDADGTLTGLPD------ERLIEAAKRR--GVKPLLVIT-NLTNG 71

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 17535591 120 NFKP-----VLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:cd02874  72 NFDSelahaVLSNPEARQRLINNILALAKKYGYDGV 107
GH18_chitinase_D-like cd02871
GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes ...
 71-150 2.43e-03

GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (GH18) domain, a chitin-binding domain, and a fibronectin type III domain. The chitin-binding and fibronectin type III domains are located either N-terminal or C-terminal to the catalytic domain. This family includes exochitinase Chi36 from Bacillus cereus.


Pssm-ID: 119350 [Multi-domain]  Cd Length: 312  Bit Score: 36.93  E-value: 2.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  71 AFVNITSDGqlqiDGDLAKNRFTNLIEIAKQQTPQ---------VKVMISIGGNDNSNNfkpvLSSPDRKKLFINSTVSF 141
Cdd:cd02871  34 AFAEPTSDG----GGEVTFNNGSSPGGYSPAEFKAdikalqakgKKVLISIGGANGHVD----LNHTAQEDNFVDSIVAI 105


                ....*....
gi 17535591 142 LQTYDIDGV 150
Cdd:cd02871 106 IKEYGFDGL 114
GH18_narbonin cd06544
Narbonin is a plant 2S protein from the globulin fraction of narbon bean (Vicia narbonensis L.) ...
 96-150 2.95e-03

Narbonin is a plant 2S protein from the globulin fraction of narbon bean (Vicia narbonensis L.) cotyledons with unknown function. Narbonin has a glycosyl hydrolase family 18 (GH18) domain without the conserved catalytic residues and with no known enzymatic activity. Narbonin amounts to up to 3% of the total seed globulins of mature seeds and was thought to be a storage protein but was found to degrade too slowly during germination. This family also includes the VfNOD32 nodulin from Vicia faba.


Pssm-ID: 119361  Cd Length: 253  Bit Score: 36.58  E-value: 2.95e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17535591  96 IEIAKQQTPQVKVMISIGGNDNSNNFKPVlsSPDRKKLFINSTVSFL----QTYDIDGV 150
Cdd:cd06544  61 VKSIKAQHPNVKVVISIGGRGVQNNPTPF--DPSNVDSWVSNAVSSLtsiiQTYNLDGI 117
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
16-150 6.75e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 35.88  E-value: 6.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535591  16 NVSGTPTVTSISSTVAASTYPATPGCNKRIIGYY--FATQTSVITSDQVS---NLTHAVFAFVNITSDGQLQIDGDLAKN 90
Cdd:COG3469 188 TTASGATTPSATTTATTTGPPTPGLPKHVLVGYWhnFDNGSGYIRLSDVPdkyDVINVAFAEPTGATNGTVTFTLDPGSS 267

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17535591  91 RFTNLIE------IAKQQTPQVKVMISIGGNDNSnnfkPVLSSPDRKKLFINSTVSFLQTYDIDGV 150
Cdd:COG3469 268 SPGGYTDaqfkadIAALQAQGKKVLLSIGGANGT----VQLNTAAAADNFVNSVIALIDEYGFDGL 329
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH