NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17536349|ref|NP_496035|]
View 

GH18 domain-containing protein [Caenorhabditis elegans]

Protein Classification

glycoside hydrolase family 18 protein( domain architecture ID 12008696)

glycoside hydrolase family 18 protein similar to chitinase, which catalyzes the random endo-hydrolysis of the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glyco_hydro_18 pfam00704
Glycosyl hydrolases family 18;
97-229 2.19e-20

Glycosyl hydrolases family 18;


:

Pssm-ID: 425828 [Multi-domain]  Cd Length: 311  Bit Score: 90.98  E-value: 2.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349    97 PPDKVTFVLFA-ADRIGFDGSVEV-DHSSRTFSKLKEKSKIESSHFKKLLSIGGRSNTQFLPLVIADPRRKRRFFKSIIS 174
Cdd:pfam00704  19 PSDKLTHIIYAfANIDGSDGTLFIgDWDLGNFEQLKKLKKQKNPGVKVLLSIGGWTDSTGFSLMASNPASRKKFADSIVS 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17536349   175 ILEEYQLDGVDLLWKWAKNSNTKKC--SRFLCELKQKLKE--RKKNYVLSVQILPDEPS 229
Cdd:pfam00704  99 FLRKYGFDGIDIDWEYPGGNPEDKEnyDLLLRELRAALDEakGGKKYLLSAAVPASYPD 157
Glyco_hydro_18 pfam00704
Glycosyl hydrolases family 18;
272-402 9.00e-12

Glycosyl hydrolases family 18;


:

Pssm-ID: 425828 [Multi-domain]  Cd Length: 311  Bit Score: 65.55  E-value: 9.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349   272 SKKLTVDIFKFCYITS-DGNLQFEDEiAMKLFLKLKEQARSENLKLELIFKIDGRTNTFLFSSVILAHDKKRKFINSVIS 350
Cdd:pfam00704  20 SDKLTHIIYAFANIDGsDGTLFIGDW-DLGNFEQLKKLKKQKNPGVKVLLSIGGWTDSTGFSLMASNPASRKKFADSIVS 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17536349   351 FLKEYRLGNSDLIWKSTRSSFRVE--YFRFLDEFKSEIKE--RKRNYILSKVVRPP 402
Cdd:pfam00704  99 FLRKYGFDGIDIDWEYPGGNPEDKenYDLLLRELRAALDEakGGKKYLLSAAVPAS 154
 
Name Accession Description Interval E-value
Glyco_hydro_18 pfam00704
Glycosyl hydrolases family 18;
97-229 2.19e-20

Glycosyl hydrolases family 18;


Pssm-ID: 425828 [Multi-domain]  Cd Length: 311  Bit Score: 90.98  E-value: 2.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349    97 PPDKVTFVLFA-ADRIGFDGSVEV-DHSSRTFSKLKEKSKIESSHFKKLLSIGGRSNTQFLPLVIADPRRKRRFFKSIIS 174
Cdd:pfam00704  19 PSDKLTHIIYAfANIDGSDGTLFIgDWDLGNFEQLKKLKKQKNPGVKVLLSIGGWTDSTGFSLMASNPASRKKFADSIVS 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17536349   175 ILEEYQLDGVDLLWKWAKNSNTKKC--SRFLCELKQKLKE--RKKNYVLSVQILPDEPS 229
Cdd:pfam00704  99 FLRKYGFDGIDIDWEYPGGNPEDKEnyDLLLRELRAALDEakGGKKYLLSAAVPASYPD 157
Glyco_18 smart00636
Glyco_18 domain;
94-221 1.36e-17

Glyco_18 domain;


Pssm-ID: 214753 [Multi-domain]  Cd Length: 334  Bit Score: 83.11  E-value: 1.36e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349     94 SEKPPDKVTFVLFAADRIGFDGSVEVDHSS---RTFSKLKEKSKiESSHFKKLLSIGGRSNTQFLPLVIADPRRKRRFFK 170
Cdd:smart00636  19 DDIPASKLTHIIYAFANIDPDGTVTIGDEWadiGNFGQLKALKK-KNPGLKVLLSIGGWTESDNFSSMLSDPASRKKFID 97

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17536349    171 SIISILEEYQLDGVDLLWKWAKNSNTKK--CSRFLCELKQKLKE---RKKNYVLSV 221
Cdd:smart00636  98 SIVSFLKKYGFDGIDIDWEYPGGRGDDRenYTALLKELREALDKegaEGKGYLLTI 153
GH18_chitinase-like cd00598
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant ...
 97-235 3.58e-12

The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model.


Pssm-ID: 119349 [Multi-domain]  Cd Length: 210  Bit Score: 65.09  E-value: 3.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349  97 PPDKVTFVLFAADRIGFDGS--VEVDHSSRT-FSKLKEKSKIESSHfKKLLSIGGRSNTQFlPLVIADPRRKRRFFKSII 173
Cdd:cd00598  20 PLSLCTHIIYAFAEISSDGSlnLFGDKSEEPlKGALEELASKKPGL-KVLISIGGWTDSSP-FTLASDPASRAAFANSLV 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536349 174 SILEEYQLDGVDLLWKW---AKNSNTKKCSRFLCELKQKLKerKKNYVLSVQILPDEPSSWELFN 235
Cdd:cd00598  98 SFLKTYGFDGVDIDWEYpgaADNSDRENFITLLRELRSALG--AANYLLTIAVPASYFDLGYAYD 160
Glyco_hydro_18 pfam00704
Glycosyl hydrolases family 18;
272-402 9.00e-12

Glycosyl hydrolases family 18;


Pssm-ID: 425828 [Multi-domain]  Cd Length: 311  Bit Score: 65.55  E-value: 9.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349   272 SKKLTVDIFKFCYITS-DGNLQFEDEiAMKLFLKLKEQARSENLKLELIFKIDGRTNTFLFSSVILAHDKKRKFINSVIS 350
Cdd:pfam00704  20 SDKLTHIIYAFANIDGsDGTLFIGDW-DLGNFEQLKKLKKQKNPGVKVLLSIGGWTDSTGFSLMASNPASRKKFADSIVS 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17536349   351 FLKEYRLGNSDLIWKSTRSSFRVE--YFRFLDEFKSEIKE--RKRNYILSKVVRPP 402
Cdd:pfam00704  99 FLRKYGFDGIDIDWEYPGGNPEDKenYDLLLRELRAALDEakGGKKYLLSAAVPAS 154
Glyco_18 smart00636
Glyco_18 domain;
272-401 2.79e-11

Glyco_18 domain;


Pssm-ID: 214753 [Multi-domain]  Cd Length: 334  Bit Score: 64.24  E-value: 2.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349    272 SKKLTVDIFKFCYITSDGNLQFEDE-IAMKLFLKLKEqARSENLKLELIFKIDGRTNTFLFSSVILAHDKKRKFINSVIS 350
Cdd:smart00636  23 ASKLTHIIYAFANIDPDGTVTIGDEwADIGNFGQLKA-LKKKNPGLKVLLSIGGWTESDNFSSMLSDPASRKKFIDSIVS 101

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17536349    351 FLKEYRLGNSDLIWKSTRSSFRVE--YFRFLDEFKSEIKE---RKRNYILSKVVRP 401
Cdd:smart00636 102 FLKKYGFDGIDIDWEYPGGRGDDRenYTALLKELREALDKegaEGKGYLLTIAVPA 157
GH18_chitinase-like cd00598
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant ...
 268-407 7.15e-08

The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model.


Pssm-ID: 119349 [Multi-domain]  Cd Length: 210  Bit Score: 52.38  E-value: 7.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349 268 TENNSKKLTVDIFKFCYITSDGNLQFE-DEIAMKLFLKLKEQARSENlKLELIFKIDGRTNTFLFSSVILAhDKKRKFIN 346
Cdd:cd00598  17 TDIPLSLCTHIIYAFAEISSDGSLNLFgDKSEEPLKGALEELASKKP-GLKVLISIGGWTDSSPFTLASDP-ASRAAFAN 94

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17536349 347 SVISFLKEYRLGNSDLIWKSTRSSFRVEYF---RFLDEFKSEIKerKRNYILSKVVrPPLGFSL 407
Cdd:cd00598  95 SLVSFLKTYGFDGVDIDWEYPGAADNSDREnfiTLLRELRSALG--AANYLLTIAV-PASYFDL 155
ChiA COG3325
Chitinase, GH18 family [Carbohydrate transport and metabolism];
97-221 3.74e-07

Chitinase, GH18 family [Carbohydrate transport and metabolism];


Pssm-ID: 442554 [Multi-domain]  Cd Length: 391  Bit Score: 51.84  E-value: 3.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349  97 PPDKVTFVLFAADRIGFDGSVEVDHSS--------------------RTFSKLKEKSKiessHFKKLLSIGGRSNTQFLP 156
Cdd:COG3325  41 PASKLTHINYAFANVDPDGKCSVGDAWakpsvdgaaddwdqplkgnfNQLKKLKAKNP----NLKVLISIGGWTWSKGFS 116

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17536349 157 LVIADPRRKRRFFKSIISILEEYQLDGVDLLWKW----------AKNSNTKKCSRFLCELKQKL----KERKKNYVLSV 221
Cdd:COG3325 117 DAAATPASRAAFVDSCVDLLRKYNFDGIDIDWEYpgsggapgnvYRPEDKANFTALLKELRAQLdalgAETGKHYLLTA 195
 
Name Accession Description Interval E-value
Glyco_hydro_18 pfam00704
Glycosyl hydrolases family 18;
97-229 2.19e-20

Glycosyl hydrolases family 18;


Pssm-ID: 425828 [Multi-domain]  Cd Length: 311  Bit Score: 90.98  E-value: 2.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349    97 PPDKVTFVLFA-ADRIGFDGSVEV-DHSSRTFSKLKEKSKIESSHFKKLLSIGGRSNTQFLPLVIADPRRKRRFFKSIIS 174
Cdd:pfam00704  19 PSDKLTHIIYAfANIDGSDGTLFIgDWDLGNFEQLKKLKKQKNPGVKVLLSIGGWTDSTGFSLMASNPASRKKFADSIVS 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 17536349   175 ILEEYQLDGVDLLWKWAKNSNTKKC--SRFLCELKQKLKE--RKKNYVLSVQILPDEPS 229
Cdd:pfam00704  99 FLRKYGFDGIDIDWEYPGGNPEDKEnyDLLLRELRAALDEakGGKKYLLSAAVPASYPD 157
Glyco_18 smart00636
Glyco_18 domain;
94-221 1.36e-17

Glyco_18 domain;


Pssm-ID: 214753 [Multi-domain]  Cd Length: 334  Bit Score: 83.11  E-value: 1.36e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349     94 SEKPPDKVTFVLFAADRIGFDGSVEVDHSS---RTFSKLKEKSKiESSHFKKLLSIGGRSNTQFLPLVIADPRRKRRFFK 170
Cdd:smart00636  19 DDIPASKLTHIIYAFANIDPDGTVTIGDEWadiGNFGQLKALKK-KNPGLKVLLSIGGWTESDNFSSMLSDPASRKKFID 97

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17536349    171 SIISILEEYQLDGVDLLWKWAKNSNTKK--CSRFLCELKQKLKE---RKKNYVLSV 221
Cdd:smart00636  98 SIVSFLKKYGFDGIDIDWEYPGGRGDDRenYTALLKELREALDKegaEGKGYLLTI 153
GH18_chitinase-like cd00598
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant ...
 97-235 3.58e-12

The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model.


Pssm-ID: 119349 [Multi-domain]  Cd Length: 210  Bit Score: 65.09  E-value: 3.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349  97 PPDKVTFVLFAADRIGFDGS--VEVDHSSRT-FSKLKEKSKIESSHfKKLLSIGGRSNTQFlPLVIADPRRKRRFFKSII 173
Cdd:cd00598  20 PLSLCTHIIYAFAEISSDGSlnLFGDKSEEPlKGALEELASKKPGL-KVLISIGGWTDSSP-FTLASDPASRAAFANSLV 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536349 174 SILEEYQLDGVDLLWKW---AKNSNTKKCSRFLCELKQKLKerKKNYVLSVQILPDEPSSWELFN 235
Cdd:cd00598  98 SFLKTYGFDGVDIDWEYpgaADNSDRENFITLLRELRSALG--AANYLLTIAVPASYFDLGYAYD 160
Glyco_hydro_18 pfam00704
Glycosyl hydrolases family 18;
272-402 9.00e-12

Glycosyl hydrolases family 18;


Pssm-ID: 425828 [Multi-domain]  Cd Length: 311  Bit Score: 65.55  E-value: 9.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349   272 SKKLTVDIFKFCYITS-DGNLQFEDEiAMKLFLKLKEQARSENLKLELIFKIDGRTNTFLFSSVILAHDKKRKFINSVIS 350
Cdd:pfam00704  20 SDKLTHIIYAFANIDGsDGTLFIGDW-DLGNFEQLKKLKKQKNPGVKVLLSIGGWTDSTGFSLMASNPASRKKFADSIVS 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17536349   351 FLKEYRLGNSDLIWKSTRSSFRVE--YFRFLDEFKSEIKE--RKRNYILSKVVRPP 402
Cdd:pfam00704  99 FLRKYGFDGIDIDWEYPGGNPEDKenYDLLLRELRAALDEakGGKKYLLSAAVPAS 154
Glyco_18 smart00636
Glyco_18 domain;
272-401 2.79e-11

Glyco_18 domain;


Pssm-ID: 214753 [Multi-domain]  Cd Length: 334  Bit Score: 64.24  E-value: 2.79e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349    272 SKKLTVDIFKFCYITSDGNLQFEDE-IAMKLFLKLKEqARSENLKLELIFKIDGRTNTFLFSSVILAHDKKRKFINSVIS 350
Cdd:smart00636  23 ASKLTHIIYAFANIDPDGTVTIGDEwADIGNFGQLKA-LKKKNPGLKVLLSIGGWTESDNFSSMLSDPASRKKFIDSIVS 101

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 17536349    351 FLKEYRLGNSDLIWKSTRSSFRVE--YFRFLDEFKSEIKE---RKRNYILSKVVRP 401
Cdd:smart00636 102 FLKKYGFDGIDIDWEYPGGRGDDRenYTALLKELREALDKegaEGKGYLLTIAVPA 157
GH18_chitinase-like cd00598
The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant ...
 268-407 7.15e-08

The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have been identified in viruses, bacteria, fungi, protozoan parasites, insects, and plants. The structure of the GH18 domain is an eight-stranded beta/alpha barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel. The GH18 family includes chitotriosidase, chitobiase, hevamine, zymocin-alpha, narbonin, SI-CLP (stabilin-1 interacting chitinase-like protein), IDGF (imaginal disc growth factor), CFLE (cortical fragment-lytic enzyme) spore hydrolase, the type III and type V plant chitinases, the endo-beta-N-acetylglucosaminidases, and the chitolectins. The GH85 (glycosyl hydrolase, family 85) ENGases (endo-beta-N-acetylglucosaminidases) are closely related to the GH18 chitinases and are included in this alignment model.


Pssm-ID: 119349 [Multi-domain]  Cd Length: 210  Bit Score: 52.38  E-value: 7.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349 268 TENNSKKLTVDIFKFCYITSDGNLQFE-DEIAMKLFLKLKEQARSENlKLELIFKIDGRTNTFLFSSVILAhDKKRKFIN 346
Cdd:cd00598  17 TDIPLSLCTHIIYAFAEISSDGSLNLFgDKSEEPLKGALEELASKKP-GLKVLISIGGWTDSSPFTLASDP-ASRAAFAN 94

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17536349 347 SVISFLKEYRLGNSDLIWKSTRSSFRVEYF---RFLDEFKSEIKerKRNYILSKVVrPPLGFSL 407
Cdd:cd00598  95 SLVSFLKTYGFDGVDIDWEYPGAADNSDREnfiTLLRELRSALG--AANYLLTIAV-PASYFDL 155
ChiA COG3325
Chitinase, GH18 family [Carbohydrate transport and metabolism];
97-221 3.74e-07

Chitinase, GH18 family [Carbohydrate transport and metabolism];


Pssm-ID: 442554 [Multi-domain]  Cd Length: 391  Bit Score: 51.84  E-value: 3.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349  97 PPDKVTFVLFAADRIGFDGSVEVDHSS--------------------RTFSKLKEKSKiessHFKKLLSIGGRSNTQFLP 156
Cdd:COG3325  41 PASKLTHINYAFANVDPDGKCSVGDAWakpsvdgaaddwdqplkgnfNQLKKLKAKNP----NLKVLISIGGWTWSKGFS 116

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17536349 157 LVIADPRRKRRFFKSIISILEEYQLDGVDLLWKW----------AKNSNTKKCSRFLCELKQKL----KERKKNYVLSV 221
Cdd:COG3325 117 DAAATPASRAAFVDSCVDLLRKYNFDGIDIDWEYpgsggapgnvYRPEDKANFTALLKELRAQLdalgAETGKHYLLTA 195
GH18_chitinase cd06548
The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant ...
 128-221 6.49e-07

The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an eight-stranded alpha/beta barrel with a pronounced active-site cleft at the C-terminal end of the beta-barrel.


Pssm-ID: 119365 [Multi-domain]  Cd Length: 322  Bit Score: 50.71  E-value: 6.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349 128 KLKEKSKiessHFKKLLSIGGRSNTQFLPLVIADPRRKRRFFKSIISILEEYQLDGVDLLWKWAKNSNTKKCSR------ 201
Cdd:cd06548  77 KLKQKNP----HLKILLSIGGWTWSGGFSDAAATEASRAKFADSAVDFIRKYGFDGIDIDWEYPGSGGAPGNVArpedke 152

                        90       100
                ....*....|....*....|....*...
gi 17536349 202 ----FLCELKQKL----KERKKNYVLSV 221
Cdd:cd06548 153 nftlLLKELREALdalgAETGRKYLLTI 180
GH18_IDGF cd02873
The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects ...
 124-231 1.90e-06

The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are related to the glycosyl hydrolase family 18 (GH18) chitinases, but they have an amino acid substitution known to abolish chitinase catalytic activity. IDGFs may have evolved from chitinases to gain new functions as growth factors, interacting with cell surface glycoproteins involved in growth-promoting processes.


Pssm-ID: 119352 [Multi-domain]  Cd Length: 413  Bit Score: 49.62  E-value: 1.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349 124 RTFSKLKEKSkiesSHFKKLLSIGG-RSNTQFLP-----LVIADPRRKRRFFKSIISILEEYQLDGVDLLWKWAKNSNTK 197
Cdd:cd02873  63 RAITSLKRKY----PHLKVLLSVGGdRDTDEEGEnekylLLLESSESRNAFINSAHSLLKTYGFDGLDLAWQFPKNKPKK 138

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17536349 198 KCSRF-------------------------------LCELKQKLkeRKKNYVLSVQILPDEPSSW 231
Cdd:cd02873 139 VRGTFgsawhsfkklftgdsvvdekaaehkeqftalVRELKNAL--RPDGLLLTLTVLPHVNSTW 201
GH18_plant_chitinase_class_V cd02879
The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the ...
 90-193 4.17e-06

The class V plant chitinases have a glycosyl hydrolase family 18 (GH18) domain, but lack the chitin-binding domain present in other GH18 enzymes. The GH18 domain of the class V chitinases has endochitinase activity in some cases and no catalytic activity in others. Included in this family is a lectin found in black locust (Robinia pseudoacacia) bark, which binds chitin but lacks chitinase activity. Also included is a chitinase-related receptor-like kinase (CHRK1) from tobacco (Nicotiana tabacum), with an N-terminal GH18 domain and a C-terminal kinase domain, which is thought to be part of a plant signaling pathway. The GH18 domain of CHRK1 is expressed extracellularly where it binds chitin but lacks chitinase activity.


Pssm-ID: 119358 [Multi-domain]  Cd Length: 299  Bit Score: 48.13  E-value: 4.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349  90 DSSGSEKPPDKVTFVLFAADRIGFdgsVEVDHSSRT----------FSKLKEKSKIESSHFKKLLSIGG-RSNTQFLPLV 158
Cdd:cd02879  10 PAWSEEFPPSNIDSSLFTHLFYAF---ADLDPSTYEvvispsdeseFSTFTETVKRKNPSVKTLLSIGGgGSDSSAFAAM 86

                        90       100       110
                ....*....|....*....|....*....|....*
gi 17536349 159 IADPRRKRRFFKSIISILEEYQLDGVDLLWKWAKN 193
Cdd:cd02879  87 ASDPTARKAFINSSIKVARKYGFDGLDLDWEFPSS 121
GH18_zymocin_alpha cd02878
Zymocin, alpha subunit. Zymocin is a heterotrimeric enzyme that inhibits yeast cell cycle ...
 99-233 7.33e-05

Zymocin, alpha subunit. Zymocin is a heterotrimeric enzyme that inhibits yeast cell cycle progression. The zymocin alpha subunit has a chitinase activity that is essential for holoenzyme action from the cell exterior while the gamma subunit contains the intracellular toxin responsible for G1 phase cell cycle arrest. The zymocin alpha and beta subunits are thought to act from the cell's exterior by docking to the cell wall-associated chitin, thus mediating gamma-toxin translocation. The alpha subunit has an eight-stranded TIM barrel fold similar to that of family 18 glycosyl hydrolases such as hevamine, chitolectin, and chitobiase.


Pssm-ID: 119357 [Multi-domain]  Cd Length: 345  Bit Score: 44.61  E-value: 7.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349  99 DKVTFVLFAADRIGFDGSVEVDHSSRTFSKLKEKSKiesshFKKLLSIGGRS-----NT-QFLPLVIADPRRKRrFFKSI 172
Cdd:cd02878  26 SKYTHIHFAFANITSDFSVDVSSVQEQFSDFKKLKG-----VKKILSFGGWDfstspSTyQIFRDAVKPANRDT-FANNV 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17536349 173 ISILEEYQLDGVDLLWKW-----------AKNSNTKKCSRFLCELKQKLKERKKnyvLSVQIlpdePSS-WEL 233
Cdd:cd02878 100 VNFVNKYNLDGVDFDWEYpgapdipgipaGDPDDGKNYLEFLKLLKSKLPSGKS---LSIAA----PASyWYL 165
GH18_trifunctional cd06549
GH18 domain of an uncharacterized family of bacterial proteins, which share a common ...
 147-233 7.89e-04

GH18 domain of an uncharacterized family of bacterial proteins, which share a common three-domain architecture: an N-terminal glycosyl hydrolase family 18 (GH18) domain, a glycosyl transferase family 2 domain, and a C-terminal polysaccharide deacetylase domain.


Pssm-ID: 119366 [Multi-domain]  Cd Length: 298  Bit Score: 41.24  E-value: 7.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17536349 147 GGRSNTQFLPLVIADPRRKRRFFKSIISILEEYQLDGVDLLWKWAKNSNTKKCSRFLCELKQKLKERKKNYVLSVqilPD 226
Cdd:cd06549  71 GGAWDGKNIARLLADPSARAKFIANIAAYLERNQADGIVLDFEELPADDLPKYVAFLSELRRRLPAQGKQLTVTV---PA 147


                ....*..
gi 17536349 227 EPSSWEL 233
Cdd:cd06549 148 DEADWNL 154
GH18_chitinase_D-like cd02871
GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes ...
 141-217 1.40e-03

GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (GH18) domain, a chitin-binding domain, and a fibronectin type III domain. The chitin-binding and fibronectin type III domains are located either N-terminal or C-terminal to the catalytic domain. This family includes exochitinase Chi36 from Bacillus cereus.


Pssm-ID: 119350 [Multi-domain]  Cd Length: 312  Bit Score: 40.40  E-value: 1.40e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17536349 141 KKLLSIGGRSNTQFLPlviaDPRRKRRFFKSIISILEEYQLDGVDLlwKWAKNSNTKKCSRFLCELKQKLKERKKNY 217
Cdd:cd02871  75 KVLISIGGANGHVDLN----HTAQEDNFVDSIVAIIKEYGFDGLDI--DLESGSNPLNATPVITNLISALKQLKDHY 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH