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Conserved domains on  [gi|17538129|ref|NP_496075|]
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Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 400-679 1.32e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 169.82  E-value: 1.32e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 400 VDWSSQNQlsvglaacvYLWSATTSQVIKLCDL-------GQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKK 472
Cdd:cd00200  15 VAFSPDGK---------LLATGSGDGTIKVWDLetgellrTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 473 TRELTGHSSRVGCLAWNADT--ICSGSRDRTIMHRDIRcdDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 551 LRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSGGgtaDRCLRFWNTLTAqpmQCVDT----GSQVCNVAWSKHSSELVST 626
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTG---KCLGTlrghENGVNSVAFSPDGYLLASG 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 17538129 627 HGYsfNHVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFW 679
Cdd:cd00200 238 SED--GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 400-679 1.32e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 169.82  E-value: 1.32e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 400 VDWSSQNQlsvglaacvYLWSATTSQVIKLCDL-------GQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKK 472
Cdd:cd00200  15 VAFSPDGK---------LLATGSGDGTIKVWDLetgellrTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 473 TRELTGHSSRVGCLAWNADT--ICSGSRDRTIMHRDIRcdDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 551 LRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSGGgtaDRCLRFWNTLTAqpmQCVDT----GSQVCNVAWSKHSSELVST 626
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTG---KCLGTlrghENGVNSVAFSPDGYLLASG 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 17538129 627 HGYsfNHVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFW 679
Cdd:cd00200 238 SED--GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
348-691 1.65e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 1.65e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 348 ATTTATSPFGGPFGVDSQRLLRTPRKPIRKVPKNPYKVLDAPELQDDFYLNLVDWSSQNQ--LSVGLAACVYLWSATTSQ 425
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRllASASADGTVRLWDLATGL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 426 VIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWNAD--TICSGSRDRTIM 503
Cdd:COG2319 112 LLRT----LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 504 HRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHgLLVSG 583
Cdd:COG2319 188 LWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASG 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 584 GgtADRCLRFWNTLTAQPMQCVDT-GSQVCNVAWSKHSSELVSthGYSFNHVIIWKYPSLQPVTKLVGHQYRVLYLAMSP 662
Cdd:COG2319 265 S--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340

                       330       340
                ....*....|....*....|....*....
gi 17538129 663 DGESIVTGAGDETLRFWHVFNKGNPPTIT 691
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLRTLT 369
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 522-679 6.24e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 6.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129  522 RQEVCGLKW-SPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSggGTADRCLRFWNTLTAQ 600
Cdd:PLN00181 532 RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS--GSDDGSVKLWSINQGV 609

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129  601 PMQCVDTGSQVCNVAWSKHSSElvSTHGYSFNHVIIW---KYPSLqPVTKLVGHQYRVLYLAMSpDGESIVTGAGDETLR 677
Cdd:PLN00181 610 SIGTIKTKANICCVQFPSESGR--SLAFGSADHKVYYydlRNPKL-PLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLK 685


                 ..
gi 17538129  678 FW 679
Cdd:PLN00181 686 LW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 516-550 1.99e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.99e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 17538129    516 RKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 444-573 1.87e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.81  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129   444 VQWCDKGDLLAVGTSRGvtQIWdvttqkkTRELTGHssRVgclaWnadticsgsrdrtimhrdircddndmGRKLTNHRQ 523
Cdd:pfam12894   1 MSWCPTMDLIALATEDG--ELL-------LHRLNWQ--RV----W--------------------------TLSPDKEDL 39

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 17538129   524 EVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWS 573
Cdd:pfam12894  40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 400-679 1.32e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 169.82  E-value: 1.32e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 400 VDWSSQNQlsvglaacvYLWSATTSQVIKLCDL-------GQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKK 472
Cdd:cd00200  15 VAFSPDGK---------LLATGSGDGTIKVWDLetgellrTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 473 TRELTGHSSRVGCLAWNADT--ICSGSRDRTIMHRDIRcdDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 551 LRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSGGgtaDRCLRFWNTLTAqpmQCVDT----GSQVCNVAWSKHSSELVST 626
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTG---KCLGTlrghENGVNSVAFSPDGYLLASG 237

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 17538129 627 HGYsfNHVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFW 679
Cdd:cd00200 238 SED--GTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
348-691 1.65e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.17  E-value: 1.65e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 348 ATTTATSPFGGPFGVDSQRLLRTPRKPIRKVPKNPYKVLDAPELQDDFYLNLVDWSSQNQ--LSVGLAACVYLWSATTSQ 425
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRllASASADGTVRLWDLATGL 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 426 VIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWNAD--TICSGSRDRTIM 503
Cdd:COG2319 112 LLRT----LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 504 HRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHgLLVSG 583
Cdd:COG2319 188 LWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASG 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 584 GgtADRCLRFWNTLTAQPMQCVDT-GSQVCNVAWSKHSSELVSthGYSFNHVIIWKYPSLQPVTKLVGHQYRVLYLAMSP 662
Cdd:COG2319 265 S--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 340

                       330       340
                ....*....|....*....|....*....
gi 17538129 663 DGESIVTGAGDETLRFWHVFNKGNPPTIT 691
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
416-681 3.42e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.63  E-value: 3.42e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 416 VYLWSATTSQVIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWNAD--TI 493
Cdd:COG2319 144 VRLWDLATGKLLRT----LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLL 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 494 CSGSRDRTIMHRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWS 573
Cdd:COG2319 220 ASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 574 PHHHgLLVSGGgtADRCLRFWNTLTAQPMQCVD-TGSQVCNVAWSKHSSELVSthGYSFNHVIIWKYPSLQPVTKLVGHQ 652
Cdd:COG2319 298 PDGK-LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHT 372

                       250       260
                ....*....|....*....|....*....
gi 17538129 653 YRVLYLAMSPDGESIVTGAGDETLRFWHV 681
Cdd:COG2319 373 GAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 439-681 1.82e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.87  E-value: 1.82e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 439 DQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWNADT--ICSGSRDRTimhrdIRC---DDND 513
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGtyLASGSSDKT-----IRLwdlETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 514 MGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPhhHGLLVSGGGtADRCLRF 593
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFVASSS-QDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 594 WNTLTAQPMQcVDTG--SQVCNVAWSKHSSELVSthGYSFNHVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGA 671
Cdd:cd00200 162 WDLRTGKCVA-TLTGhtGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS 238

                       250
                ....*....|
gi 17538129 672 GDETLRFWHV 681
Cdd:cd00200 239 EDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 473-679 1.69e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.10  E-value: 1.69e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 473 TRELTGHSSRVGCLAWNAD--TICSGSRDRTImhRDIRCDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDgkLLATGSGDGTI--KVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 551 LRRNEPIQTYTQHNAAVKALAWSPHHHgLLVSGGgtADRCLRFWNTLTAQPMQCVDT-GSQVCNVAWSkHSSELVSThGY 629
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSS--RDKTIKVWDVETGKCLTTLRGhTDWVNSVAFS-PDGTFVAS-SS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 17538129 630 SFNHVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFW 679
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
407-681 8.76e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.96  E-value: 8.76e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 407 QLSVGLAACVYLWSATTSQVIKLCDLGQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCL 486
Cdd:COG2319   5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 487 AWNAD--TICSGSRDRTImhRDIRCDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHN 564
Cdd:COG2319  85 AFSPDgrLLASASADGTV--RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 565 AAVKALAWSPHHHgLLVSGGGtaDRCLRFWNTLTAQPMQCVD-TGSQVCNVAWSKHSSELVSTHGYsfNHVIIWKYPSLQ 643
Cdd:COG2319 163 GAVTSVAFSPDGK-LLASGSD--DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSAD--GTVRLWDLATGK 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 17538129 644 PVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFWHV 681
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
400-596 8.10e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.11  E-value: 8.10e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 400 VDWSSQNQLsvgLAAC-----VYLWSATTSQVIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTR 474
Cdd:COG2319 210 VAFSPDGKL---LASGsadgtVRLWDLATGKLLRT----LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 475 ELTGHSSRVGCLAWNAD--TICSGSRDRTIMHRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLR 552
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 17538129 553 RNEPIQTYTQHNAAVKALAWSPHHHgLLVSGGgtADRCLRFWNT 596
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGR-TLASGS--ADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 400-595 7.18e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 7.18e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 400 VDWSSQNQL--SVGLAACVYLWSATTSQVIKLCDlGQTneqDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELT 477
Cdd:cd00200  99 VAFSPDGRIlsSSSRDKTIKVWDVETGKCLTTLR-GHT---DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 478 GHSSRVGCLAWNAD--TICSGSRDRTIMHRDIRCDDNDMGrkLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNE 555
Cdd:cd00200 175 GHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 17538129 556 PIQTYTQHNAAVKALAWSPhHHGLLVSGGgtADRCLRFWN 595
Cdd:cd00200 253 CVQTLSGHTNSVTSLAWSP-DGKRLASGS--ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
400-552 3.35e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 3.35e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 400 VDWSSQNQL--SVGLAACVYLWSATTSQVIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELT 477
Cdd:COG2319 252 VAFSPDGRLlaSGSADGTVRLWDLATGELLRT----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17538129 478 GHSSRVGCLAWNAD--TICSGSRDRTIMHRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLR 552
Cdd:COG2319 328 GHTGAVRSVAFSPDgkTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 556-681 1.49e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 1.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129 556 PIQTYTQHNAAVKALAWSPHHHgLLVSGGGtaDRCLRFWNTLTAQPMQCvDTG--SQVCNVAWSKHSSELVSthGYSFNH 633
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSG--DGTIKVWDLETGELLRT-LKGhtGPVRDVAASADGTYLAS--GSSDKT 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 17538129 634 VIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFWHV 681
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 522-679 6.24e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 6.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129  522 RQEVCGLKW-SPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSggGTADRCLRFWNTLTAQ 600
Cdd:PLN00181 532 RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS--GSDDGSVKLWSINQGV 609

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129  601 PMQCVDTGSQVCNVAWSKHSSElvSTHGYSFNHVIIW---KYPSLqPVTKLVGHQYRVLYLAMSpDGESIVTGAGDETLR 677
Cdd:PLN00181 610 SIGTIKTKANICCVQFPSESGR--SLAFGSADHKVYYydlRNPKL-PLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLK 685


                 ..
gi 17538129  678 FW 679
Cdd:PLN00181 686 LW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 516-550 1.99e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.99e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 17538129    516 RKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 444-573 1.87e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.81  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129   444 VQWCDKGDLLAVGTSRGvtQIWdvttqkkTRELTGHssRVgclaWnadticsgsrdrtimhrdircddndmGRKLTNHRQ 523
Cdd:pfam12894   1 MSWCPTMDLIALATEDG--ELL-------LHRLNWQ--RV----W--------------------------TLSPDKEDL 39

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 17538129   524 EVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWS 573
Cdd:pfam12894  40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-595 2.82e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.82e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17538129    555 EPIQTYTQHNAAVKALAWSPHHHgLLVSGGgtADRCLRFWN 595
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGS--DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
516-550 2.98e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.98e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 17538129   516 RKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 641-680 5.30e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 5.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17538129    641 SLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFWH 680
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
643-679 2.19e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.19e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 17538129   643 QPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFW 679
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
554-595 4.11e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 17538129   554 NEPIQTYTQHNAAVKALAWSPHHHgLLVSGGgtADRCLRFWN 595
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGS--DDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 469-502 6.44e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.44e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 17538129    469 TQKKTRELTGHSSRVGCLAWNAD--TICSGSRDRTI 502
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTI 36
WD40 pfam00400
WD domain, G-beta repeat;
471-503 1.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 17538129   471 KKTRELTGHSSRVGCLAWNAD--TICSGSRDRTIM 503
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDgkLLASGSDDGTVK 36
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 428-489 2.98e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 2.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17538129   428 KLCDLGQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWN 489
Cdd:pfam12894  28 RVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 528-619 4.32e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 4.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17538129   528 LKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQ-HNAAVKALAWSPHHHGLLVsggGTADRCLRFWNTLTAQPMQCVD 606
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDkEDLEVTSLAWRPDGKLLAV---GYSDGTVRLLDAENGKIVHHFS 77

                          90
                  ....*....|....
gi 17538129   607 TGS-QVCNVAWSKH 619
Cdd:pfam12894  78 AGSdLITCLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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