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Conserved domains on  [gi|193205139|ref|NP_496579|]
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SPK domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 40-162 1.09e-37

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


:

Pssm-ID: 380927  Cd Length: 127  Bit Score: 137.02  E-value: 1.09e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  40 TVIVQNAQRALRNEHEHVLVANKTILVNKPIIEMKGFMSLPPEIPCSVGST----PRTFMYYGIGGKPICITTSELGNYS 115
Cdd:cd10529    1 RKLTSRTVEKVVGKNRKGLVATEDISPGEPILEYKGEVSLRSEFKEDNGFFkrpsPFVFFYDGFEGLPLCVDARKYGNEA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 193205139 116 EITRRSCQNNSTLRHILGSKSNFRVMIVSTKVILQDHEITLPFDKNW 162
Cdd:cd10529   81 RFIRRSCRPNAELRHVVVSNGELRLFIFALKDIRKGTEITIPFDYDY 127
SPK smart00583
domain in SET and PHD domain containing proteins and protein kinases;
243-354 1.00e-31

domain in SET and PHD domain containing proteins and protein kinases;


:

Pssm-ID: 214732  Cd Length: 114  Bit Score: 119.59  E-value: 1.00e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139   243 DVDFLQFLAQKSSsDEIRPLFRFQICEEYIDTYEN--PSSENYLNNRFLRVLAMRIPLLRGFDLETKARMMFVAGIPLEE 320
Cdd:smart00583   2 LTRFMDFLVEKTK-DAIEPLVVPLKVFEEFSKLEGnsLLSYETYYKRFHNKLAPNMIKLNNYSIEERIRMMFALSGKVED 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 193205139   321 RFLIELRRYGSVELDEKHRITNFKANNGDFTLKG 354
Cdd:smart00583  81 DFLERIRTIGTVELDEKRRICKYKSNDGKLKLEG 114
SPK pfam04435
Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region ...
 530-632 4.32e-25

Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region represented by this family can is found to be repeated up to four time in some proteins.


:

Pssm-ID: 461308  Cd Length: 104  Bit Score: 100.29  E-value: 4.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  530 LFAFLAEKSKMATGPVILTPVLEEFRVEGRYLMTLETIRRRFRQRLArKISSLPDYDTDTKIRMLVFTSSAITDSFLKIL 609
Cdd:pfam04435   1 LLKFLAEKTKNATEPLSLTQLCREFKEKTGSKLSVSTLRKRFRRILA-KIHKLEEYDLETKVRMLFALSAPVDEDFLKEL 79

                          90       100
                  ....*....|....*....|...
gi 193205139  610 QQSAVVEVDDSNRITKYQAFDEN 632
Cdd:pfam04435  80 RKDATVELDEKNRIIKYKSNDGS 102
 
Name Accession Description Interval E-value
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 40-162 1.09e-37

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 137.02  E-value: 1.09e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  40 TVIVQNAQRALRNEHEHVLVANKTILVNKPIIEMKGFMSLPPEIPCSVGST----PRTFMYYGIGGKPICITTSELGNYS 115
Cdd:cd10529    1 RKLTSRTVEKVVGKNRKGLVATEDISPGEPILEYKGEVSLRSEFKEDNGFFkrpsPFVFFYDGFEGLPLCVDARKYGNEA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 193205139 116 EITRRSCQNNSTLRHILGSKSNFRVMIVSTKVILQDHEITLPFDKNW 162
Cdd:cd10529   81 RFIRRSCRPNAELRHVVVSNGELRLFIFALKDIRKGTEITIPFDYDY 127
SPK smart00583
domain in SET and PHD domain containing proteins and protein kinases;
243-354 1.00e-31

domain in SET and PHD domain containing proteins and protein kinases;


Pssm-ID: 214732  Cd Length: 114  Bit Score: 119.59  E-value: 1.00e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139   243 DVDFLQFLAQKSSsDEIRPLFRFQICEEYIDTYEN--PSSENYLNNRFLRVLAMRIPLLRGFDLETKARMMFVAGIPLEE 320
Cdd:smart00583   2 LTRFMDFLVEKTK-DAIEPLVVPLKVFEEFSKLEGnsLLSYETYYKRFHNKLAPNMIKLNNYSIEERIRMMFALSGKVED 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 193205139   321 RFLIELRRYGSVELDEKHRITNFKANNGDFTLKG 354
Cdd:smart00583  81 DFLERIRTIGTVELDEKRRICKYKSNDGKLKLEG 114
SPK pfam04435
Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region ...
 246-351 2.42e-30

Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region represented by this family can is found to be repeated up to four time in some proteins.


Pssm-ID: 461308  Cd Length: 104  Bit Score: 115.31  E-value: 2.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  246 FLQFLAQKSSsDEIRPLFRFQICEEYIDTYENPSSENYLNNRFLRVLAmRIPLLRGFDLETKARMMFVAGIPLEERFLIE 325
Cdd:pfam04435   1 LLKFLAEKTK-NATEPLSLTQLCREFKEKTGSKLSVSTLRKRFRRILA-KIHKLEEYDLETKVRMLFALSAPVDEDFLKE 78

                          90       100
                  ....*....|....*....|....*.
gi 193205139  326 LRRYGSVELDEKHRITNFKANNGDFT 351
Cdd:pfam04435  79 LRKDATVELDEKNRIIKYKSNDGSLE 104
SPK pfam04435
Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region ...
 530-632 4.32e-25

Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region represented by this family can is found to be repeated up to four time in some proteins.


Pssm-ID: 461308  Cd Length: 104  Bit Score: 100.29  E-value: 4.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  530 LFAFLAEKSKMATGPVILTPVLEEFRVEGRYLMTLETIRRRFRQRLArKISSLPDYDTDTKIRMLVFTSSAITDSFLKIL 609
Cdd:pfam04435   1 LLKFLAEKTKNATEPLSLTQLCREFKEKTGSKLSVSTLRKRFRRILA-KIHKLEEYDLETKVRMLFALSAPVDEDFLKEL 79

                          90       100
                  ....*....|....*....|...
gi 193205139  610 QQSAVVEVDDSNRITKYQAFDEN 632
Cdd:pfam04435  80 RKDATVELDEKNRIIKYKSNDGS 102
SPK smart00583
domain in SET and PHD domain containing proteins and protein kinases;
533-632 8.90e-15

domain in SET and PHD domain containing proteins and protein kinases;


Pssm-ID: 214732  Cd Length: 114  Bit Score: 71.06  E-value: 8.90e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139   533 FLAEKSKMATGPVILTP-VLEEF-RVEGRYLMTLETIRRRFRQRLARKISSLPDYDTDTKIRMLVFTSSAITDSFLKILQ 610
Cdd:smart00583   8 FLVEKTKDAIEPLVVPLkVFEEFsKLEGNSLLSYETYYKRFHNKLAPNMIKLNNYSIEERIRMMFALSGKVEDDFLERIR 87

                           90       100
                   ....*....|....*....|..
gi 193205139   611 QSAVVEVDDSNRITKYQAFDEN 632
Cdd:smart00583  88 TIGTVELDEKRRICKYKSNDGK 109
 
Name Accession Description Interval E-value
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 40-162 1.09e-37

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 137.02  E-value: 1.09e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  40 TVIVQNAQRALRNEHEHVLVANKTILVNKPIIEMKGFMSLPPEIPCSVGST----PRTFMYYGIGGKPICITTSELGNYS 115
Cdd:cd10529    1 RKLTSRTVEKVVGKNRKGLVATEDISPGEPILEYKGEVSLRSEFKEDNGFFkrpsPFVFFYDGFEGLPLCVDARKYGNEA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 193205139 116 EITRRSCQNNSTLRHILGSKSNFRVMIVSTKVILQDHEITLPFDKNW 162
Cdd:cd10529   81 RFIRRSCRPNAELRHVVVSNGELRLFIFALKDIRKGTEITIPFDYDY 127
SPK smart00583
domain in SET and PHD domain containing proteins and protein kinases;
243-354 1.00e-31

domain in SET and PHD domain containing proteins and protein kinases;


Pssm-ID: 214732  Cd Length: 114  Bit Score: 119.59  E-value: 1.00e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139   243 DVDFLQFLAQKSSsDEIRPLFRFQICEEYIDTYEN--PSSENYLNNRFLRVLAMRIPLLRGFDLETKARMMFVAGIPLEE 320
Cdd:smart00583   2 LTRFMDFLVEKTK-DAIEPLVVPLKVFEEFSKLEGnsLLSYETYYKRFHNKLAPNMIKLNNYSIEERIRMMFALSGKVED 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 193205139   321 RFLIELRRYGSVELDEKHRITNFKANNGDFTLKG 354
Cdd:smart00583  81 DFLERIRTIGTVELDEKRRICKYKSNDGKLKLEG 114
SPK pfam04435
Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region ...
 246-351 2.42e-30

Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region represented by this family can is found to be repeated up to four time in some proteins.


Pssm-ID: 461308  Cd Length: 104  Bit Score: 115.31  E-value: 2.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  246 FLQFLAQKSSsDEIRPLFRFQICEEYIDTYENPSSENYLNNRFLRVLAmRIPLLRGFDLETKARMMFVAGIPLEERFLIE 325
Cdd:pfam04435   1 LLKFLAEKTK-NATEPLSLTQLCREFKEKTGSKLSVSTLRKRFRRILA-KIHKLEEYDLETKVRMLFALSAPVDEDFLKE 78

                          90       100
                  ....*....|....*....|....*.
gi 193205139  326 LRRYGSVELDEKHRITNFKANNGDFT 351
Cdd:pfam04435  79 LRKDATVELDEKNRIIKYKSNDGSLE 104
SPK pfam04435
Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region ...
 530-632 4.32e-25

Domain of unknown function (DUF545); Family of uncharacterized C. elegans proteins. The region represented by this family can is found to be repeated up to four time in some proteins.


Pssm-ID: 461308  Cd Length: 104  Bit Score: 100.29  E-value: 4.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  530 LFAFLAEKSKMATGPVILTPVLEEFRVEGRYLMTLETIRRRFRQRLArKISSLPDYDTDTKIRMLVFTSSAITDSFLKIL 609
Cdd:pfam04435   1 LLKFLAEKTKNATEPLSLTQLCREFKEKTGSKLSVSTLRKRFRRILA-KIHKLEEYDLETKVRMLFALSAPVDEDFLKEL 79

                          90       100
                  ....*....|....*....|...
gi 193205139  610 QQSAVVEVDDSNRITKYQAFDEN 632
Cdd:pfam04435  80 RKDATVELDEKNRIIKYKSNDGS 102
SPK smart00583
domain in SET and PHD domain containing proteins and protein kinases;
533-632 8.90e-15

domain in SET and PHD domain containing proteins and protein kinases;


Pssm-ID: 214732  Cd Length: 114  Bit Score: 71.06  E-value: 8.90e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139   533 FLAEKSKMATGPVILTP-VLEEF-RVEGRYLMTLETIRRRFRQRLARKISSLPDYDTDTKIRMLVFTSSAITDSFLKILQ 610
Cdd:smart00583   8 FLVEKTKDAIEPLVVPLkVFEEFsKLEGNSLLSYETYYKRFHNKLAPNMIKLNNYSIEERIRMMFALSGKVEDDFLERIR 87

                           90       100
                   ....*....|....*....|..
gi 193205139   611 QSAVVEVDDSNRITKYQAFDEN 632
Cdd:smart00583  88 TIGTVELDEKRRICKYKSNDGK 109
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 53-184 3.35e-07

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 50.78  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  53 EHEHVLVANKTILVNKPIIEMKGFMSLPP--EIPCSVGSTPRTFM--YYGIGGKPICITTSELGNYSEITRRSCQNNSTL 128
Cdd:cd19181   16 KHRKILRAARDLALDTLIIEYRGKVMLRQqfEVNGHFFKRPYPFVlfYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEV 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 193205139 129 RHILgSKSNFRVMIVSTKVILQDHEITLPFDKNWILSETPLHCATHFDKMiECPME 184
Cdd:cd19181   96 RHMI-ADGMIHLCIYAVAAIAKDAEVTIAFDYEYSNCNYKVDCACHKGNR-NCPVQ 149
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 91-159 2.62e-04

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 41.80  E-value: 2.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193205139  91 PRTFMYYGIGGKPICITTSELGNYSEITRRSCQNNSTLRHILgSKSNFRVMIVSTKVILQDHEITLPFD 159
Cdd:cd19182   58 PFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHVI-EDGTIHLYIYSIRSIPKGTEITIAFD 125
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 58-159 7.67e-04

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 41.23  E-value: 7.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205139  58 LVANKTILVNKPIIEMKGFMSL------PPEIPCSVGSTPRTFMYYGIGGkPICITTSELGNYSEITRRSCQNNSTLRHI 131
Cdd:cd19183   16 LFADRPIPAGDPIQELLGEIGLqseyiaDPENQYQILGAPKPHVFFHPQS-PLYIDTRRSGSVARFIRRSCRPNAELVTV 94

                         90       100
                 ....*....|....*....|....*....
gi 193205139 132 -LGSKSNFRVMIVSTKVILQDHEITLPFD 159
Cdd:cd19183   95 aSDSGSVLKFVLYASRDISPGEEITIGWD 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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