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Conserved domains on  [gi|17534465|ref|NP_497017|]
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Protection of telomeres homolog 2 [Caenorhabditis elegans]

Protein Classification

single-stranded DNA-binding protein( domain architecture ID 11245033)

single-stranded DNA (ssDNA)-binding protein plays a key role in DNA replication, recombination, and repair

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POT1PC pfam16686
ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a ...
 19-174 2.64e-39

ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a family of fungal telomere protection protein 1 proteins. POT1PC is able to accommodate heterogeneous ssDNA ligands. Pot1 proteins are the proteins responsible for binding to and protecting the 3' single-stranded DNA (ssDNA) overhang at most eukaryotic telomeres.


:

Pssm-ID: 435514  Cd Length: 152  Bit Score: 133.55  E-value: 2.64e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534465    19 YYKQYHRYFDVLAQVHSVVETINGAQMLRVWRGRKFGPGASAERRERRLFHVTQDSFKryivppnPRIGKAIEENGKeLL 98
Cdd:pfam16686   2 KDVQPGQFFDLIVQVVKKAYDDGGKVLLYVWDYTENPPLFLYVSPEDGDFRGDDDDFK-------PRIGKWIGPFGK-LT 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17534465    99 IEIDVYDDHRDGLK-NLNSGDFVAIQNVHAASTR--QTEMQVLHGGGASYQRGITTVPVDFEHEAFQNFKKKVEAVLET 174
Cdd:pfam16686  74 LQITLYDPHASFAReNLKPGDFVRLRNVHIKYGRngLNLEGVLHGDRGYGRGIIVLVIDDNNDPRLKELKRRKREYEKT 152
 
Name Accession Description Interval E-value
POT1PC pfam16686
ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a ...
 19-174 2.64e-39

ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a family of fungal telomere protection protein 1 proteins. POT1PC is able to accommodate heterogeneous ssDNA ligands. Pot1 proteins are the proteins responsible for binding to and protecting the 3' single-stranded DNA (ssDNA) overhang at most eukaryotic telomeres.


Pssm-ID: 435514  Cd Length: 152  Bit Score: 133.55  E-value: 2.64e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534465    19 YYKQYHRYFDVLAQVHSVVETINGAQMLRVWRGRKFGPGASAERRERRLFHVTQDSFKryivppnPRIGKAIEENGKeLL 98
Cdd:pfam16686   2 KDVQPGQFFDLIVQVVKKAYDDGGKVLLYVWDYTENPPLFLYVSPEDGDFRGDDDDFK-------PRIGKWIGPFGK-LT 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17534465    99 IEIDVYDDHRDGLK-NLNSGDFVAIQNVHAASTR--QTEMQVLHGGGASYQRGITTVPVDFEHEAFQNFKKKVEAVLET 174
Cdd:pfam16686  74 LQITLYDPHASFAReNLKPGDFVRLRNVHIKYGRngLNLEGVLHGDRGYGRGIIVLVIDDNNDPRLKELKRRKREYEKT 152
hPOT1_OB2 cd04498
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of ...
 26-150 9.07e-34

hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with the sequence GGTTAG. The hPOT1 monomer consists of two closely connected OB folds (OB1-OB2) which cooperate to bind telomeric ssDNA. OB1 makes more extensive contact with the ssDNA than OB2. OB2 protects the 3' end of the ssDNA. hPOT1 is implicated in telomere length regulation.


Pssm-ID: 239944  Cd Length: 123  Bit Score: 118.29  E-value: 9.07e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534465  26 YFDVLAQVHSVVETINGAQMLRVWRGRKFGPGASAERRERrlFHVTQdsfkryivppNPRIGKAIEENGKELLIEIDVYD 105
Cdd:cd04498   1 YFDLLCQLLSVVETDSSSTLLKVWDGTKFPPPLRKVKVED--DVVLE----------GDRSLKHREEGGKQLTIDILVYD 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17534465 106 DHRDGLKNLNSGDFVAIQNVHAASTR----QTEMQVLH----GGGASYQRGIT 150
Cdd:cd04498  69 NHVELAKSLKPGDFVRIYNVHAKSYSskneHDENDHLHfhlvHGGTEYGRGIR 121
 
Name Accession Description Interval E-value
POT1PC pfam16686
ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a ...
 19-174 2.64e-39

ssDNA-binding domain of telomere protection protein; POT1PC is the ssDNA-binding domain on a family of fungal telomere protection protein 1 proteins. POT1PC is able to accommodate heterogeneous ssDNA ligands. Pot1 proteins are the proteins responsible for binding to and protecting the 3' single-stranded DNA (ssDNA) overhang at most eukaryotic telomeres.


Pssm-ID: 435514  Cd Length: 152  Bit Score: 133.55  E-value: 2.64e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534465    19 YYKQYHRYFDVLAQVHSVVETINGAQMLRVWRGRKFGPGASAERRERRLFHVTQDSFKryivppnPRIGKAIEENGKeLL 98
Cdd:pfam16686   2 KDVQPGQFFDLIVQVVKKAYDDGGKVLLYVWDYTENPPLFLYVSPEDGDFRGDDDDFK-------PRIGKWIGPFGK-LT 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17534465    99 IEIDVYDDHRDGLK-NLNSGDFVAIQNVHAASTR--QTEMQVLHGGGASYQRGITTVPVDFEHEAFQNFKKKVEAVLET 174
Cdd:pfam16686  74 LQITLYDPHASFAReNLKPGDFVRLRNVHIKYGRngLNLEGVLHGDRGYGRGIIVLVIDDNNDPRLKELKRRKREYEKT 152
hPOT1_OB2 cd04498
hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of ...
 26-150 9.07e-34

hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with the sequence GGTTAG. The hPOT1 monomer consists of two closely connected OB folds (OB1-OB2) which cooperate to bind telomeric ssDNA. OB1 makes more extensive contact with the ssDNA than OB2. OB2 protects the 3' end of the ssDNA. hPOT1 is implicated in telomere length regulation.


Pssm-ID: 239944  Cd Length: 123  Bit Score: 118.29  E-value: 9.07e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17534465  26 YFDVLAQVHSVVETINGAQMLRVWRGRKFGPGASAERRERrlFHVTQdsfkryivppNPRIGKAIEENGKELLIEIDVYD 105
Cdd:cd04498   1 YFDLLCQLLSVVETDSSSTLLKVWDGTKFPPPLRKVKVED--DVVLE----------GDRSLKHREEGGKQLTIDILVYD 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17534465 106 DHRDGLKNLNSGDFVAIQNVHAASTR----QTEMQVLH----GGGASYQRGIT 150
Cdd:cd04498  69 NHVELAKSLKPGDFVRIYNVHAKSYSskneHDENDHLHfhlvHGGTEYGRGIR 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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