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Conserved domains on  [gi|17552992|ref|NP_497203|]
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Cell division cycle protein 23 homolog [Caenorhabditis elegans]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 13537404)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
407-560 3.29e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 90.45  E-value: 3.29e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 407 ANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAY 486
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17552992 487 ALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFE 560
Cdd:COG0457  95 ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 248-558 1.69e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 73.96  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   248 GLKDLAEKSFRNVVIREPRIWPAWEALSRLIADIEDADKfvtsaevkslwmgdwfmtlvlqrfhqhsmAIQKAEQLVTRG 327
Cdd:TIGR02917 479 GDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDD-----------------------------AIQRFEKVLTID 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   328 MTGLPmIITKIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETCCIVA 407
Cdd:TIGR02917 530 PKNLR-AILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLG 608

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   408 NYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYA 487
Cdd:TIGR02917 609 RAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESA 688

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17552992   488 LFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYlfgDVEGNALwSLAKLHERYSDDNKAAQA 558
Cdd:TIGR02917 689 KKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKAL---KRAPSSQ-NAIKLHRALLASGNTAEA 755
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
407-560 3.29e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 90.45  E-value: 3.29e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 407 ANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAY 486
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17552992 487 ALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFE 560
Cdd:COG0457  95 ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 248-558 1.69e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 73.96  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   248 GLKDLAEKSFRNVVIREPRIWPAWEALSRLIADIEDADKfvtsaevkslwmgdwfmtlvlqrfhqhsmAIQKAEQLVTRG 327
Cdd:TIGR02917 479 GDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDD-----------------------------AIQRFEKVLTID 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   328 MTGLPmIITKIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETCCIVA 407
Cdd:TIGR02917 530 PKNLR-AILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLG 608

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   408 NYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYA 487
Cdd:TIGR02917 609 RAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESA 688

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17552992   488 LFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYlfgDVEGNALwSLAKLHERYSDDNKAAQA 558
Cdd:TIGR02917 689 KKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKAL---KRAPSSQ-NAIKLHRALLASGNTAEA 755
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 337-467 6.52e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 6.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 337 KIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETCCIVANYHAIRRDS 416
Cdd:COG4783   9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDY 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 17552992 417 EHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPAD 467
Cdd:COG4783  89 DEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 407-560 1.30e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.62  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   407 ANYHAIRRDSEHAIKFFQRALRLNPG-LAALWVLIghEFMEMKNNAAACVS-YRRAIEIDPADHRGWYGLGQMYDIMKMP 484
Cdd:TIGR02917 506 ARIDIQEGNPDDAIQRFEKVLTIDPKnLRAILALA--GLYLRTGNEEEAVAwLEKAAELNPQEIEPALALAQYYLGKGQL 583

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17552992   485 AYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFE 560
Cdd:TIGR02917 584 KKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLK 659
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 419-477 1.42e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.54  E-value: 1.42e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 419 AIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDP-ADHRGWYGLGQM 477
Cdd:cd24142  19 ALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPdGGYEKYLYLGQL 78
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 416-559 1.67e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 45.07  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   416 SEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDP-ADHRG-----------WYGLGQMYDIMKM 483
Cdd:PRK11447  285 GGKAIPELQQAVRANPKDSEALGALGQAYSQQGDRARAVAQFEKALALDPhSSNRDkwesllkvnryWLLIQQGDAALKA 364

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17552992   484 --PAYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNkaAQAF 559
Cdd:PRK11447  365 nnLAQAERLYQQARQVDNTDSYAVLGLGDVAMARKDYAAAERYYQQALRMDPGNTNAVRGLANLYRQQSPEK--ALAF 440
TPR_11 pfam13414
TPR repeat;
441-478 7.05e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 37.45  E-value: 7.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17552992   441 GHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMY 478
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAY 38
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
407-560 3.29e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 90.45  E-value: 3.29e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 407 ANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAY 486
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEE 94

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17552992 487 ALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFE 560
Cdd:COG0457  95 ALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 344-560 4.00e-18

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 85.17  E-value: 4.00e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 344 ARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETCCIVANYHAIRRDSEHAIKFF 423
Cdd:COG2956  54 RRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVL 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 424 QRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSR 503
Cdd:COG2956 134 ERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLP 213

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17552992 504 LLVALGDIYSKLNRIEDAEKCFTGAYLfGDVEGNALWSLAKLHERYSDDNKAAQAFE 560
Cdd:COG2956 214 ALPRLAELYEKLGDPEEALELLRKALE-LDPSDDLLLALADLLERKEGLEAALALLE 269
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 337-529 6.07e-18

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 88.13  E-value: 6.07e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 337 KIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETCCI---VANYHAIR 413
Cdd:COG3914  12 LAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALlelAALLLQAL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 414 RDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQE 493
Cdd:COG3914  92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRR 171

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 17552992 494 AQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAY 529
Cdd:COG3914 172 ALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRAL 207
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
427-607 6.35e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 77.74  E-value: 6.35e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 427 LRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLV 506
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 507 ALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFEVFLvvyelvtSAEEKIIYAIAFLANH 586
Cdd:COG0457  81 NLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERAL-------ELDPDDADALYNLGIA 153

                       170       180
                ....*....|....*....|.
gi 17552992 587 FFKIEDFDKASEYATKCLAFE 607
Cdd:COG0457 154 LEKLGRYEEALELLEKLEAAA 174
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 364-627 1.58e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.46  E-value: 1.58e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 364 YRLGDLHLLSDslyirnDQKKLSTLAIEVYKVHKFRWETCCIVANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHE 443
Cdd:COG2956  12 YFKGLNYLLNG------QPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQD 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 444 FMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEK 523
Cdd:COG2956  86 YLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIE 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 524 CFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAfevflvvYELVTSAEEKIIYAIAFLANHFFKIEDFDKASEYATKC 603
Cdd:COG2956 166 ALEKALKLDPDCARALLLLAELYLEQGDYEEAIAA-------LERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKA 238

                       250       260
                ....*....|....*....|....
gi 17552992 604 LAFETLCQEGNRLFREIAKIQARE 627
Cdd:COG2956 239 LELDPSDDLLLALADLLERKEGLE 262
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 347-605 2.08e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 77.08  E-value: 2.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 347 DHDQAISNFEDVRKADPYRLgDLHLLSDSLYIRNDQKKlstLAIEVY----KVHKFRWETCCIVANYHAIRRDSEHAIKF 422
Cdd:COG2956  23 QPDKAIDLLEEALELDPETV-EAHLALGNLYRRRGEYD---RAIRIHqkllERDPDRAEALLELAQDYLKAGLLDRAEEL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 423 FQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDS 502
Cdd:COG2956  99 LEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCA 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 503 RLLVALGDIYSKLNRIEDAEKCFTGAYlfgDVEGNALWSLAKLHERYSDDNKAAQAFEVFLVVYELVTSAEEKIiyaiaF 582
Cdd:COG2956 179 RALLLLAELYLEQGDYEEAIAALERAL---EQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLL-----A 250

                       250       260
                ....*....|....*....|...
gi 17552992 583 LANHFFKIEDFDKASEYATKCLA 605
Cdd:COG2956 251 LADLLERKEGLEAALALLERQLR 273
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 407-525 1.76e-14

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 70.99  E-value: 1.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 407 ANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAY 486
Cdd:COG4783  11 AQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 17552992 487 ALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCF 525
Cdd:COG4783  91 ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAAL 129
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 248-558 1.69e-13

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 73.96  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   248 GLKDLAEKSFRNVVIREPRIWPAWEALSRLIADIEDADKfvtsaevkslwmgdwfmtlvlqrfhqhsmAIQKAEQLVTRG 327
Cdd:TIGR02917 479 GDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDD-----------------------------AIQRFEKVLTID 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   328 MTGLPmIITKIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETCCIVA 407
Cdd:TIGR02917 530 PKNLR-AILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLG 608

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   408 NYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYA 487
Cdd:TIGR02917 609 RAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESA 688

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17552992   488 LFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYlfgDVEGNALwSLAKLHERYSDDNKAAQA 558
Cdd:TIGR02917 689 KKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKAL---KRAPSSQ-NAIKLHRALLASGNTAEA 755
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 419-525 5.01e-13

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 66.57  E-value: 5.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 419 AIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCK 498
Cdd:COG4235   2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                        90       100
                ....*....|....*....|....*..
gi 17552992 499 PHDSRLLVALGDIYSKLNRIEDAEKCF 525
Cdd:COG4235  82 PDNPEALYLLGLAAFQQGDYAEAIAAW 108
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 407-587 7.02e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.40  E-value: 7.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 407 ANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAY 486
Cdd:COG3914 119 GNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEE 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 487 ALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKC----------------FTGAYLFGDVEGNalwsLAKLHERYS 550
Cdd:COG3914 199 AIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFeellaalargpselspFALLYLPDDDPAE----LLALARAWA 274

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 17552992 551 DdnKAAQAFEVFLVVYELVTSAEEKIIyaIAFLANHF 587
Cdd:COG3914 275 Q--LVAAAAAPELPPPPNPRDPDRKLR--IGYVSADF 307
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
413-499 4.59e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 56.72  E-value: 4.59e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 413 RRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAAcVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQ 492
Cdd:COG3063   5 LGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83


                ....*..
gi 17552992 493 EAQKCKP 499
Cdd:COG3063  84 RALELDP 90
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 429-629 5.68e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 5.68e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 429 LNPGLAAL-WVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLVA 507
Cdd:COG2956   2 LLPVAAALgWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 508 LGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFEvflvvyELVTSAEEKIIYAIAfLANHF 587
Cdd:COG2956  82 LAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLE------RLLKLGPENAHAYCE-LAELY 154

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 17552992 588 FKIEDFDKASEYATKCLAFETLCQegnRLFREIAKIQARESR 629
Cdd:COG2956 155 LEQGDYDEAIEALEKALKLDPDCA---RALLLLAELYLEQGD 193
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 407-502 7.68e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 57.32  E-value: 7.68e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 407 ANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAY 486
Cdd:COG4235  24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAE 103

                        90
                ....*....|....*.
gi 17552992 487 ALFYYQEAQKCKPHDS 502
Cdd:COG4235 104 AIAAWQKLLALLPADA 119
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 452-563 4.34e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.01  E-value: 4.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 452 AACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLF 531
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 17552992 532 GDVEGNALWSLAKLHERYSDDNKAAQAFEVFL 563
Cdd:COG4235  81 DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLL 112
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 434-560 5.07e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 5.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 434 AALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLVALGDIYS 513
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 17552992 514 KLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFE 560
Cdd:COG4783  84 KAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALE 130
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 410-499 6.21e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.35  E-value: 6.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 410 HAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALF 489
Cdd:COG5010  64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKA 143

                        90
                ....*....|
gi 17552992 490 YYQEAQKCKP 499
Cdd:COG5010 144 ALQRALGTSP 153
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
338-585 6.22e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.32  E-value: 6.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 338 IAACSNARHDHDQAisnfedvrkadpyrlgdlhllsdslyirndqkklstlaievykvhkfrwetccivanyhairrdse 417
Cdd:COG0457  48 LGLAYLRLGRYEEA------------------------------------------------------------------ 61

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 418 haIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKC 497
Cdd:COG0457  62 --LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALEL 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 498 KPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFEVFLVVYELVTSAEEKII 577
Cdd:COG0457 140 DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAAL 219


                ....*...
gi 17552992 578 YAIAFLAN 585
Cdd:COG0457 220 AELLLLAL 227
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 413-501 1.90e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.66  E-value: 1.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 413 RRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQ 492
Cdd:COG4783  51 LGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALE 130


                ....*....
gi 17552992 493 EAQKCKPHD 501
Cdd:COG4783 131 KALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 407-525 5.57e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 52.66  E-value: 5.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 407 ANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAY 486
Cdd:COG5010  27 YEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDE 106

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 17552992 487 ALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCF 525
Cdd:COG5010 107 AKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAAL 145
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 337-467 6.52e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.12  E-value: 6.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 337 KIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETCCIVANYHAIRRDS 416
Cdd:COG4783   9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDY 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 17552992 417 EHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPAD 467
Cdd:COG4783  89 DEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
444-525 7.90e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 50.55  E-value: 7.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 444 FMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALfYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEK 523
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALA 80


                ..
gi 17552992 524 CF 525
Cdd:COG3063  81 YL 82
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
407-516 1.12e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 53.00  E-value: 1.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 407 ANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAY 486
Cdd:COG4785  80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYEL 159

                        90       100       110
                ....*....|....*....|....*....|
gi 17552992 487 ALFYYQEAQKCKPHDSRLLVALGDIYSKLN 516
Cdd:COG4785 160 AIADLEKALELDPNDPERALWLYLAERKLD 189
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 251-526 4.51e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.16  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   251 DLAEKSFRNVVIREPRIWPAWEALSRLIA---DIEDADKFVTSAEVKSlwMGDWFMTLVLQRFHQHSMAIQKAEqLVTRG 327
Cdd:TIGR02917 516 DDAIQRFEKVLTIDPKNLRAILALAGLYLrtgNEEEAVAWLEKAAELN--PQEIEPALALAQYYLGKGQLKKAL-AILNE 592

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   328 MTGL----PMIITKIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYIRNDQKKLSTLAIEVYKVHKFRWETC 403
Cdd:TIGR02917 593 AADAapdsPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQ 672

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   404 CIVANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPAD------HRGWYGLGQM 477
Cdd:TIGR02917 673 IGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSqnaiklHRALLASGNT 752

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 17552992   478 YDIMKMpayalfyYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFT 526
Cdd:TIGR02917 753 AEAVKT-------LEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQ 794
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 407-560 1.30e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.62  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   407 ANYHAIRRDSEHAIKFFQRALRLNPG-LAALWVLIghEFMEMKNNAAACVS-YRRAIEIDPADHRGWYGLGQMYDIMKMP 484
Cdd:TIGR02917 506 ARIDIQEGNPDDAIQRFEKVLTIDPKnLRAILALA--GLYLRTGNEEEAVAwLEKAAELNPQEIEPALALAQYYLGKGQL 583

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17552992   485 AYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFE 560
Cdd:TIGR02917 584 KKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLK 659
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 466-605 2.34e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.80  E-value: 2.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 466 ADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKL 545
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 546 HERYSDDNKAAQAFEVFLvvyelvtSAEEKIIYAIAFLANHFFKIEDFDKASEYATKCLA 605
Cdd:COG4783  82 LLKAGDYDEALALLEKAL-------KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 219-464 5.34e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 5.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 219 LYQRMEDKKlRENEDVWFEylMGLLEVELGLKDLAEKSFRNVVIREPRIWPAWEALSRLIADIEDADKfvtsaevkslwm 298
Cdd:COG2956  64 IHQKLLERD-PDRAEALLE--LAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEK------------ 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 299 gdwfmtlvlqrfhqhsmAIQKAEQLVTRGmTGLPMIITKIAACSNARHDHDQAISNFEDVRKADPYRLGDLHLLSDSLYI 378
Cdd:COG2956 129 -----------------AIEVLERLLKLG-PENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLE 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 379 RNDQKKLSTLAIEVYKVHKFRWETCCIVANYHAIRRDSEHAIKFFQRALRLNPGLAALWVLiGHEFMEMKNNAAACVSYR 458
Cdd:COG2956 191 QGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLAL-ADLLERKEGLEAALALLE 269


                ....*.
gi 17552992 459 RAIEID 464
Cdd:COG2956 270 RQLRRH 275
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 419-477 1.42e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.54  E-value: 1.42e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 419 AIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDP-ADHRGWYGLGQM 477
Cdd:cd24142  19 ALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPdGGYEKYLYLGQL 78
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 416-559 1.67e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 45.07  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   416 SEHAIKFFQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDP-ADHRG-----------WYGLGQMYDIMKM 483
Cdd:PRK11447  285 GGKAIPELQQAVRANPKDSEALGALGQAYSQQGDRARAVAQFEKALALDPhSSNRDkwesllkvnryWLLIQQGDAALKA 364

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17552992   484 --PAYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNkaAQAF 559
Cdd:PRK11447  365 nnLAQAERLYQQARQVDNTDSYAVLGLGDVAMARKDYAAAERYYQQALRMDPGNTNAVRGLANLYRQQSPEK--ALAF 440
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 425-560 2.14e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.25  E-value: 2.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 425 RALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRL 504
Cdd:COG5010  11 PLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPEL 90

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17552992 505 LVALGDIYSKLNRIEDAEKCFTGAYLFGDVEGNALWSLAKLHERYSDDNKAAQAFE 560
Cdd:COG5010  91 YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQ 146
TPR_11 pfam13414
TPR repeat;
441-478 7.05e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 37.45  E-value: 7.05e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17552992   441 GHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMY 478
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAY 38
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 238-521 9.95e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 9.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   238 YLMGLLEVELGLKDLAEKSFRNVVIREPRIWPAwealSRLIADIEDADKFVTSA-----------EVKSLWMGDWFMTLV 306
Cdd:TIGR02917 299 LLAGASEYQLGNLEQAYQYLNQILKYAPNSHQA----RRLLASIQLRLGRVDEAiatlspalgldPDDPAALSLLGEAYL 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   307 LQR-FHQHSMAIQKAEQLVTrgmtGLPMIITKIAACSNARHDHDQAISNFEDVRKADPyRLGDLHLLSDSLYIRNDQ--K 383
Cdd:TIGR02917 375 ALGdFEKAAEYLAKATELDP----ENAAARTQLGISKLSQGDPSEAIADLETAAQLDP-ELGRADLLLILSYLRSGQfdK 449

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992   384 KLSTLAievykvhkfRWEtccivANYhairrdsehaikffqralrlnPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEI 463
Cdd:TIGR02917 450 ALAAAK---------KLE-----KKQ---------------------PDNASLHNLLGAIYLGKGDLAKAREAFEKALSI 494

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17552992   464 DPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLVALGDIYSKLNRIEDA 521
Cdd:TIGR02917 495 EPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEA 552
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
407-469 1.78e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 38.23  E-value: 1.78e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17552992 407 ANYHAIRRDSEHAIKFfQRALRLNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHR 469
Cdd:COG3063  33 GLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPSALR 94
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
429-540 7.06e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.74  E-value: 7.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552992 429 LNPGLAALWVLIGHEFMEMKNNAAACVSYRRAIEIDPADHRGWYGLGQMYDIMKMPAYALFYYQEAQKCKPHDSRLLVAL 508
Cdd:COG4785  68 ALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNR 147

                        90       100       110
                ....*....|....*....|....*....|...
gi 17552992 509 GDIYSKLNRIEDAEKCFTGAY-LFGDVEGNALW 540
Cdd:COG4785 148 GIALYYLGRYELAIADLEKALeLDPNDPERALW 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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