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Conserved domains on  [gi|17552576|ref|NP_497513|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box domain-containing protein( domain architecture ID 12198939)

F-box domain-containing protein with an FTH domain, may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 114-254 1.59e-48

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 158.12  E-value: 1.59e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552576   114 QAITSSINDMLEN-KCIAVESVVLYNFPHDDILNIISSCQAEVLKDIVLWHRDGVELSERITCLDQWKKARTLHCRFLFC 192
Cdd:pfam01827   1 EKIIESFLNILKSkKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEIVELEQWKNAKSLKIEGSSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17552576   193 DLVPIEHFFHFEEFSIQIDNLSMPNAIKIRDDLMNKTTFKTCTIsTHHNVQSIELARIFQPD 254
Cdd:pfam01827  81 SSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTI-RSPDLNPIEIAKVFDPD 141
FBOX smart00256
A Receptor for Ubiquitination Targets;
1-41 9.74e-11

A Receptor for Ubiquitination Targets;


:

Pssm-ID: 197608  Cd Length: 41  Bit Score: 55.91  E-value: 9.74e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17552576      1 MPLEISDEILSKLPAMDLLSCRKVCKSLRSAVDQSGNHLNR 41
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 114-254 1.59e-48

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 158.12  E-value: 1.59e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552576   114 QAITSSINDMLEN-KCIAVESVVLYNFPHDDILNIISSCQAEVLKDIVLWHRDGVELSERITCLDQWKKARTLHCRFLFC 192
Cdd:pfam01827   1 EKIIESFLNILKSkKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEIVELEQWKNAKSLKIEGSSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17552576   193 DLVPIEHFFHFEEFSIQIDNLSMPNAIKIRDDLMNKTTFKTCTIsTHHNVQSIELARIFQPD 254
Cdd:pfam01827  81 SSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTI-RSPDLNPIEIAKVFDPD 141
FBOX smart00256
A Receptor for Ubiquitination Targets;
1-41 9.74e-11

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 55.91  E-value: 9.74e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17552576      1 MPLEISDEILSKLPAMDLLSCRKVCKSLRSAVDQSGNHLNR 41
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 1-43 6.77e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 47.87  E-value: 6.77e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 17552576   1 MPLEISDEILSKLPAMDLLSCRKVCKSLRSAVDQSGNHLNRIS 43
Cdd:cd22150   4 LPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 1-33 3.88e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 45.99  E-value: 3.88e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 17552576     1 MPLEISDEILSKLPAMDLLSCRKVCKSLRSAVD 33
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 114-254 1.59e-48

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 158.12  E-value: 1.59e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552576   114 QAITSSINDMLEN-KCIAVESVVLYNFPHDDILNIISSCQAEVLKDIVLWHRDGVELSERITCLDQWKKARTLHCRFLFC 192
Cdd:pfam01827   1 EKIIESFLNILKSkKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEIVELEQWKNAKSLKIEGSSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17552576   193 DLVPIEHFFHFEEFSIQIDNLSMPNAIKIRDDLMNKTTFKTCTIsTHHNVQSIELARIFQPD 254
Cdd:pfam01827  81 SSFPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTI-RSPDLNPIEIAKVFDPD 141
FBOX smart00256
A Receptor for Ubiquitination Targets;
1-41 9.74e-11

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 55.91  E-value: 9.74e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17552576      1 MPLEISDEILSKLPAMDLLSCRKVCKSLRSAVDQSGNHLNR 41
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 1-43 6.77e-08

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 47.87  E-value: 6.77e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 17552576   1 MPLEISDEILSKLPAMDLLSCRKVCKSLRSAVDQSGNHLNRIS 43
Cdd:cd22150   4 LPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 1-33 3.88e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 45.99  E-value: 3.88e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 17552576     1 MPLEISDEILSKLPAMDLLSCRKVCKSLRSAVD 33
Cdd:pfam00646   4 LPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD 36
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 2-33 4.76e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 40.16  E-value: 4.76e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 17552576     2 PLEISDEILSKLPAMDLLSCRKVCKSLRSAVD 33
Cdd:pfam12937   5 PDEILLQIFSYLDPKDLLRLALVCRRWRELAS 36
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 1-33 9.31e-05

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 38.96  E-value: 9.31e-05
                        10        20        30
                ....*....|....*....|....*....|...
gi 17552576   1 MPLEISDEILSKLPAMDLLSCRKVCKSLRSAVD 33
Cdd:cd09917   3 LPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 2-30 1.62e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 35.52  E-value: 1.62e-03
                        10        20
                ....*....|....*....|....*....
gi 17552576   2 PLEISDEILSKLPAMDLLSCRKVCKSLRS 30
Cdd:cd22157   4 PDDLVEEILSRLPAKSLLRFRCVCKQWNS 32
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
 1-33 2.10e-03

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 35.06  E-value: 2.10e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 17552576   1 MPLEISDEILSKLPAMDLL-SCRKVCKSLRSAVD 33
Cdd:cd22083   4 IPEELLLEILTHVPATSLItNCRLVCTLWRDIID 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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