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Conserved domains on  [gi|17552580|ref|NP_497517|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box domain-containing protein( domain architecture ID 12198939)

F-box domain-containing protein with an FTH domain, may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 135-268 1.26e-48

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


:

Pssm-ID: 396410  Cd Length: 141  Bit Score: 158.89  E-value: 1.26e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552580   135 DFMKILVESLKSEECIHAKEITLQECS---LLAILPFFDA--LESIQMFACDE--EFEQIIHSDQWKNAKKFRFEASWLH 207
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSfseVASILPYFDAgtLEEIELSSESDedQFEEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17552580   208 SKYIEHLFHLQNFYIyEMIDFSTQAAIKIRDDLMRRSTFESCEIYIREAHPIELAKVFKPD 268
Cdd:pfam01827  82 SFPIEHLFHFEEFDI-KLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
FBOX smart00256
A Receptor for Ubiquitination Targets;
11-48 9.24e-08

A Receptor for Ubiquitination Targets;


:

Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 9.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 17552580     11 LDVAEQVFEKMEPLDLLVSRKVCRSLRTAVDKFGICFD 48
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 135-268 1.26e-48

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 158.89  E-value: 1.26e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552580   135 DFMKILVESLKSEECIHAKEITLQECS---LLAILPFFDA--LESIQMFACDE--EFEQIIHSDQWKNAKKFRFEASWLH 207
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSfseVASILPYFDAgtLEEIELSSESDedQFEEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17552580   208 SKYIEHLFHLQNFYIyEMIDFSTQAAIKIRDDLMRRSTFESCEIYIREAHPIELAKVFKPD 268
Cdd:pfam01827  82 SFPIEHLFHFEEFDI-KLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
FBOX smart00256
A Receptor for Ubiquitination Targets;
11-48 9.24e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 9.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 17552580     11 LDVAEQVFEKMEPLDLLVSRKVCRSLRTAVDKFGICFD 48
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 7-51 4.21e-06

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 42.86  E-value: 4.21e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17552580   7 LLDI-LDVAEQVFEKMEPLDLLVSRKVCRSLRTAVDKFGICFDEIH 51
Cdd:cd22150   1 LSDLpIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 11-48 6.27e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.75  E-value: 6.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17552580    11 LDVAEQVFEKMEPLDLLVSRKVCRSLRTAVDKFGICFD 48
Cdd:pfam00646   6 DDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Name Accession Description Interval E-value
FTH pfam01827
FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is ...
 135-268 1.26e-48

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.


Pssm-ID: 396410  Cd Length: 141  Bit Score: 158.89  E-value: 1.26e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17552580   135 DFMKILVESLKSEECIHAKEITLQECS---LLAILPFFDA--LESIQMFACDE--EFEQIIHSDQWKNAKKFRFEASWLH 207
Cdd:pfam01827   2 KIIESFLNILKSKKCLHVKEISLSGLSfseVASILPYFDAgtLEEIELSSESDedQFEEIVELEQWKNAKSLKIEGSSLS 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17552580   208 SKYIEHLFHLQNFYIyEMIDFSTQAAIKIRDDLMRRSTFESCEIYIREAHPIELAKVFKPD 268
Cdd:pfam01827  82 SFPIEHLFHFEEFDI-KLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIEIAKVFDPD 141
FBOX smart00256
A Receptor for Ubiquitination Targets;
11-48 9.24e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 47.43  E-value: 9.24e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 17552580     11 LDVAEQVFEKMEPLDLLVSRKVCRSLRTAVDKFGICFD 48
Cdd:smart00256   3 DEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFK 40
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 7-51 4.21e-06

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 42.86  E-value: 4.21e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17552580   7 LLDI-LDVAEQVFEKMEPLDLLVSRKVCRSLRTAVDKFGICFDEIH 51
Cdd:cd22150   1 LSDLpIEILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDPGFKKIS 46
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 11-48 6.27e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 36.75  E-value: 6.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17552580    11 LDVAEQVFEKMEPLDLLVSRKVCRSLRTAVDKFGICFD 48
Cdd:pfam00646   6 DDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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