Cyclin-C [Caenorhabditis elegans]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| CYCLIN_CCNC_rpt1 | cd20513 | first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ... |
40-154 | 2.51e-37 | |||||
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. : Pssm-ID: 410217 [Multi-domain] Cd Length: 101 Bit Score: 128.10 E-value: 2.51e-37
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| ccl1 super family | cl31014 | cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ... |
8-281 | 2.80e-18 | |||||
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair] The actual alignment was detected with superfamily member TIGR00569: Pssm-ID: 129660 [Multi-domain] Cd Length: 305 Bit Score: 83.34 E-value: 2.80e-18
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| Name | Accession | Description | Interval | E-value | |||||
| CYCLIN_CCNC_rpt1 | cd20513 | first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ... |
40-154 | 2.51e-37 | |||||
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410217 [Multi-domain] Cd Length: 101 Bit Score: 128.10 E-value: 2.51e-37
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| CCL1 | COG5333 | Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ... |
34-256 | 1.30e-20 | |||||
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]; Pssm-ID: 227640 [Multi-domain] Cd Length: 297 Bit Score: 89.41 E-value: 1.30e-20
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| ccl1 | TIGR00569 | cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ... |
8-281 | 2.80e-18 | |||||
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 129660 [Multi-domain] Cd Length: 305 Bit Score: 83.34 E-value: 2.80e-18
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| CYCLIN_CCNC_rpt2 | cd20514 | second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ... |
162-269 | 5.03e-15 | |||||
second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410218 [Multi-domain] Cd Length: 92 Bit Score: 69.19 E-value: 5.03e-15
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| CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
65-108 | 3.36e-07 | |||||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 47.20 E-value: 3.36e-07
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| Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
65-117 | 8.59e-07 | |||||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 47.13 E-value: 8.59e-07
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| Name | Accession | Description | Interval | E-value | |||||
| CYCLIN_CCNC_rpt1 | cd20513 | first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ... |
40-154 | 2.51e-37 | |||||
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410217 [Multi-domain] Cd Length: 101 Bit Score: 128.10 E-value: 2.51e-37
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| CCL1 | COG5333 | Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ... |
34-256 | 1.30e-20 | |||||
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]; Pssm-ID: 227640 [Multi-domain] Cd Length: 297 Bit Score: 89.41 E-value: 1.30e-20
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| ccl1 | TIGR00569 | cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ... |
8-281 | 2.80e-18 | |||||
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 129660 [Multi-domain] Cd Length: 305 Bit Score: 83.34 E-value: 2.80e-18
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| CYCLIN_CCNC_rpt2 | cd20514 | second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ... |
162-269 | 5.03e-15 | |||||
second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410218 [Multi-domain] Cd Length: 92 Bit Score: 69.19 E-value: 5.03e-15
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| CYCLIN_CCNH_rpt1 | cd20524 | first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ... |
8-155 | 1.01e-12 | |||||
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410228 Cd Length: 150 Bit Score: 64.54 E-value: 1.01e-12
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| CYCLIN_CCNK_rpt1 | cd20530 | first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ... |
65-108 | 1.47e-12 | |||||
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410233 [Multi-domain] Cd Length: 115 Bit Score: 63.02 E-value: 1.47e-12
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| CYCLIN_AtCycC_rpt1 | cd20571 | first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ... |
65-110 | 1.60e-11 | |||||
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410274 [Multi-domain] Cd Length: 107 Bit Score: 59.87 E-value: 1.60e-11
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| CYCLIN_SpCG1C-like_rpt1 | cd20545 | first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ... |
35-108 | 2.08e-11 | |||||
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410248 [Multi-domain] Cd Length: 116 Bit Score: 60.13 E-value: 2.08e-11
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| CYCLIN_CCNM_CCNQ_rpt1 | cd20534 | first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ... |
64-108 | 5.38e-11 | |||||
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410237 [Multi-domain] Cd Length: 110 Bit Score: 58.72 E-value: 5.38e-11
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| CYCLIN_CCNL_rpt1 | cd20532 | first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ... |
65-109 | 6.57e-11 | |||||
first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410235 [Multi-domain] Cd Length: 127 Bit Score: 58.72 E-value: 6.57e-11
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| CYCLIN_CCNH_rpt2 | cd20525 | second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ... |
161-281 | 4.36e-10 | |||||
second cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410229 Cd Length: 126 Bit Score: 56.53 E-value: 4.36e-10
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| CYCLIN_SpCG1C_ScCTK2-like_rpt2 | cd20546 | second cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1), Saccharomyces ... |
198-263 | 2.81e-09 | |||||
second cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1), Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2), and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. This group also includes yeast RNA polymerase II holoenzyme cyclin-like subunit, a component of the SRB8-11 complex, a regulatory module of the Mediator complex which is involved in regulation of basal and activated RNA polymerase II-dependent transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410249 [Multi-domain] Cd Length: 97 Bit Score: 53.52 E-value: 2.81e-09
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| CYCLIN_AcCycH_rpt1 | cd20585 | first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ... |
65-111 | 3.97e-09 | |||||
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410288 Cd Length: 170 Bit Score: 54.83 E-value: 3.97e-09
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| CYCLIN_CCNT_rpt1 | cd20538 | first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ... |
65-109 | 1.41e-08 | |||||
first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410241 [Multi-domain] Cd Length: 137 Bit Score: 52.39 E-value: 1.41e-08
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| CYCLIN_AcCycT_rpt1 | cd20587 | first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ... |
65-108 | 3.08e-08 | |||||
first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410290 [Multi-domain] Cd Length: 124 Bit Score: 51.37 E-value: 3.08e-08
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| CYCLIN | smart00385 | domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ... |
65-108 | 3.36e-07 | |||||
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control. Pssm-ID: 214641 [Multi-domain] Cd Length: 83 Bit Score: 47.20 E-value: 3.36e-07
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| CYCLIN_CCNT2_rpt1 | cd20596 | first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit ... |
68-109 | 3.98e-07 | |||||
first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410299 [Multi-domain] Cd Length: 139 Bit Score: 48.50 E-value: 3.98e-07
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| CYCLIN_SF | cd00043 | Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ... |
64-109 | 6.26e-07 | |||||
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box. Pssm-ID: 410207 [Multi-domain] Cd Length: 82 Bit Score: 46.25 E-value: 6.26e-07
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| CYCLIN_CCNT1_rpt1 | cd20595 | first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ... |
68-109 | 6.49e-07 | |||||
first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410298 [Multi-domain] Cd Length: 138 Bit Score: 47.74 E-value: 6.49e-07
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| Cyclin_N | pfam00134 | Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ... |
65-117 | 8.59e-07 | |||||
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain. Pssm-ID: 459686 [Multi-domain] Cd Length: 127 Bit Score: 47.13 E-value: 8.59e-07
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| CYCLIN_CCNL_rpt2 | cd20533 | second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ... |
202-263 | 8.60e-07 | |||||
second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410236 [Multi-domain] Cd Length: 92 Bit Score: 46.44 E-value: 8.60e-07
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| CYCLIN_ScCTK2-like_rpt1 | cd20547 | first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ... |
47-108 | 1.10e-05 | |||||
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410250 [Multi-domain] Cd Length: 110 Bit Score: 43.49 E-value: 1.10e-05
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| CYCLIN_AcCycL_rpt1 | cd20591 | first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ... |
65-108 | 2.53e-05 | |||||
first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain. Pssm-ID: 410294 [Multi-domain] Cd Length: 128 Bit Score: 42.90 E-value: 2.53e-05
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| CYCLIN_AtCycC_rpt2 | cd20572 | second cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ... |
162-281 | 2.78e-04 | |||||
second cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain. Pssm-ID: 410275 [Multi-domain] Cd Length: 102 Bit Score: 39.37 E-value: 2.78e-04
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