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Conserved domains on  [gi|17556250|ref|NP_497647|]
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N-acylethanolamine-hydrolyzing acid amidase subunit beta [Caenorhabditis elegans]

Protein Classification

acid ceramidase family protein; Ntn hydrolase family protein( domain architecture ID 10634631)

acid ceramidase (AC) family protein similar to AC, which catalyzes the hydrolysis of ceramide to sphingosine and fatty acid, and to N-acylethanolamine-hydrolyzing acid amidase (NAAA), that that hydrolyzes bioactive N-acylethanolamines to fatty acids and ethanolamine at acidic pH| Ntn (N-terminal nucleophile) hydrolase family protein is activated autocatalytically via an N-terminally located nucleophilic amino acid, and may catalyze the hydrolysis of amide bonds in either protein or small molecule substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ntn_AC_NAAA cd01903
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also ...
 104-341 6.10e-117

AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and fatty acid. Ceramide is required for the biosynthesis of most sphingolipids and plays an important role in many signal transduction pathways by inducing apoptosis and/or arresting cell growth. An inherited deficiency of AC activity leads to the lysosomal storage disorder known as Farber disease. AC is considered a "rheostat" important for maintaining the proper intracellular levels of these lipids since hydrolysis of ceramide is the only source of sphingosine in cells. NAAA is a eukaryotic glycoprotein that hydrolyzes bioactive N-acylethanolamines, including anandamide (an endocannabinoid) and N-palmitoylethanolamine (an anti-inflammatory and neuroprotective substance), to fatty acids and ethanolamine at acidic pH. NAAA shows structural and functional similarity to acid ceramidase, but lacks the ceramide-hydrolyzing activity of AC.


:

Pssm-ID: 238886  Cd Length: 231  Bit Score: 338.09  E-value: 6.10e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 104 NILYDVAAFdrrhifglgCTSIVAQNSAGQIIHGRNLDYDMTELLKNITIHVDFVRNGTIQYSGLTFALYNGVLTGQRPG 183
Cdd:cd01903   1 NIFYEIFTF---------CTSIVAQDSNGTIYHARNLDFGFFEELSKLTVNVDFQRNGKIVFKGTTFAGYVGLLTGQKPG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 184 EYSVSLNARYSGAYIDNILMEFYTKFKRPVSFFIRDVLENQATYTEAVDAFSRTHLFSPSYIIVAGIKKNEGVVISRNRW 263
Cdd:cd01903  72 KFSLTINERFSLDGGYNGILALLKKDGIPVSWLIRETLENATSYEDAVEKLSTTPILAPAYFIVGGVKPGEGVVITRNRD 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 264 SAANVYPLNVDANQWFLVETNFDNWKKQG--DDRRITAIQKLKELGRRNFDEKSMVEVLSTVPVRNNLTVFSTVMVPGLP 341
Cdd:cd01903 152 SVADVYPLDLKNGTWFLVQTNYDRWKPPPflDDRRTPAIKCMNALGQANISFKTLYDVLSTKPVLNKLTIYTTLMSVRTG 231
NAAA-beta pfam15508
beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of ...
 21-78 1.69e-15

beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, pfam02275.


:

Pssm-ID: 464754  Cd Length: 63  Bit Score: 69.96  E-value: 1.69e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17556250    21 KPRHYEINLDEPPSQRWNQVIKDH----LEYLPGVVEETKKYIPKPLQPFVWWAASKIDRYF 78
Cdd:pfam15508   2 PVPWYVINLDLPPEERWTQVAKDYkpeiKSLIPALKDLLKSLVPGKLVPLVDKLAADLLRYL 63
 
Name Accession Description Interval E-value
Ntn_AC_NAAA cd01903
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also ...
 104-341 6.10e-117

AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and fatty acid. Ceramide is required for the biosynthesis of most sphingolipids and plays an important role in many signal transduction pathways by inducing apoptosis and/or arresting cell growth. An inherited deficiency of AC activity leads to the lysosomal storage disorder known as Farber disease. AC is considered a "rheostat" important for maintaining the proper intracellular levels of these lipids since hydrolysis of ceramide is the only source of sphingosine in cells. NAAA is a eukaryotic glycoprotein that hydrolyzes bioactive N-acylethanolamines, including anandamide (an endocannabinoid) and N-palmitoylethanolamine (an anti-inflammatory and neuroprotective substance), to fatty acids and ethanolamine at acidic pH. NAAA shows structural and functional similarity to acid ceramidase, but lacks the ceramide-hydrolyzing activity of AC.


Pssm-ID: 238886  Cd Length: 231  Bit Score: 338.09  E-value: 6.10e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 104 NILYDVAAFdrrhifglgCTSIVAQNSAGQIIHGRNLDYDMTELLKNITIHVDFVRNGTIQYSGLTFALYNGVLTGQRPG 183
Cdd:cd01903   1 NIFYEIFTF---------CTSIVAQDSNGTIYHARNLDFGFFEELSKLTVNVDFQRNGKIVFKGTTFAGYVGLLTGQKPG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 184 EYSVSLNARYSGAYIDNILMEFYTKFKRPVSFFIRDVLENQATYTEAVDAFSRTHLFSPSYIIVAGIKKNEGVVISRNRW 263
Cdd:cd01903  72 KFSLTINERFSLDGGYNGILALLKKDGIPVSWLIRETLENATSYEDAVEKLSTTPILAPAYFIVGGVKPGEGVVITRNRD 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 264 SAANVYPLNVDANQWFLVETNFDNWKKQG--DDRRITAIQKLKELGRRNFDEKSMVEVLSTVPVRNNLTVFSTVMVPGLP 341
Cdd:cd01903 152 SVADVYPLDLKNGTWFLVQTNYDRWKPPPflDDRRTPAIKCMNALGQANISFKTLYDVLSTKPVLNKLTIYTTLMSVRTG 231
C45_proenzyme NF040521
C45 family autoproteolytic acyltransferase/hydolase; Members of this family include hydrolases ...
 52-339 1.92e-20

C45 family autoproteolytic acyltransferase/hydolase; Members of this family include hydrolases and N-acyltransferases, and belong to the Ntn (N-terminal nucleophile) hydrolase family. Members have an invariant Cys residue (Cys-103 in XP_002569112.1) required both for autoproteolytic processing into alpha and beta chains and for activity. The family is described by MEROPs as a cysteine protease, family C45, because of its autoproteolytic activity. Characterized members include TAN from Drosophila, which removes beta-alanine from both carcinine and N-beta-alanyl dopamine, and isopenicillin-N N-acyltransferase from various fungi. The latter has been heavily studied because of its role in penicillin biosynthesis.


Pssm-ID: 468523 [Multi-domain]  Cd Length: 312  Bit Score: 90.43  E-value: 1.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250   52 VEETKKYIPKPLQPFVWWAASKIDRYFTtEIQEELKGIASESGLPIGEIVGMNILYDVAAFDRrhifglGCTSIVAQNSA 131
Cdd:NF040521  27 LRAWGLVSWRELRDFAKEFLAALEAFAP-ELWEELEGIADGLGLPFEDVLALNARTEILAAPD------GCSTFAVLGED 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250  132 GQIIHGRNLDYDmTELLKNiTIHVDFVRNGTIQYSGLTFAlynGVLTGQRPG--EY--SVSLNArysGAYIDnilmefYT 207
Cdd:NF040521 100 GEPILARNYDWH-PELYDG-CLLLTIRPDGGPRYASIGYA---GLLPGRTDGmnEAglAVTLNF---LDGRK------LP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250  208 KFKRPVSFFIRDVLENQATYTEAVDAFSRTHLFSPSYIIVAGiKKNEGVVIsrnRWSAANVYPlnVDANQWFLVETN-FD 286
Cdd:NF040521 166 GVGVPVHLLARAILENCKTVDEAIALLKEIPRASSFNLTLAD-ASGRAASV---EASPDRVVV--VRPEDGLLVHTNhFL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17556250  287 NWKKQGDDRRITA-----IQKLKELGRRNFDEKSMVEVLSTV---PVRNNL--------TVFSTVMVPG 339
Cdd:NF040521 240 SPELEEENRIATPssrerYERLEELLKGKLDAEDAKALLSDGyplPICRHPypdgdrfgTLATVVFDPA 308
NAAA-beta pfam15508
beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of ...
 21-78 1.69e-15

beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, pfam02275.


Pssm-ID: 464754  Cd Length: 63  Bit Score: 69.96  E-value: 1.69e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17556250    21 KPRHYEINLDEPPSQRWNQVIKDH----LEYLPGVVEETKKYIPKPLQPFVWWAASKIDRYF 78
Cdd:pfam15508   2 PVPWYVINLDLPPEERWTQVAKDYkpeiKSLIPALKDLLKSLVPGKLVPLVDKLAADLLRYL 63
COG4927 COG4927
Predicted choloylglycine hydrolase [General function prediction only];
64-258 1.54e-11

Predicted choloylglycine hydrolase [General function prediction only];


Pssm-ID: 443955 [Multi-domain]  Cd Length: 242  Bit Score: 63.43  E-value: 1.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250  64 QPFVWWAASKIDRYFTtEIQEELKGIASESGLPIGEIVGMNILYDVAAFdrrhifglGCTSIVAQNsAGQIIHGRNLDY- 142
Cdd:COG4927  39 RPFLAEARAALRRYMP-ELWEELEGLADGLDVPLEELLLLNGGYYLPLS--------GCSQFAVAP-EGEPLLARNYDFh 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 143 -DMTELLKNITIHVDfvrngtiqySGLTFALYNGVLTGQRPG--EY--SVSLNARYSGAYIDNIlmefytkfkrPVSFFI 217
Cdd:COG4927 109 pDLYEGRLLLTVQPD---------GGYAFIGVTDGLIGRLDGmnEKglAVGLNFVGRKVAGPGF----------PIPLLI 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 17556250 218 RDVLENQATYTEAVDAFSRTHLFSPSYIIVAGiKKNEGVVI 258
Cdd:COG4927 170 RYILETCSTVDEAIALLKEIPHASSYNLTLAD-ASGNAAVV 209
CBAH pfam02275
Linear amide C-N hydrolases, choloylglycine hydrolase family; This family includes several ...
 122-289 1.52e-09

Linear amide C-N hydrolases, choloylglycine hydrolase family; This family includes several hydrolases which cleave carbon-nitrogen bonds, other than peptide bonds, in linear amides. These include choloylglycine hydrolase (conjugated bile acid hydrolase, CBAH) EC:3.5.1.24, penicillin acylase EC:3.5.1.11 and acid ceramidase EC:3.5.1.23. This domain forms the alpha-subunit for members from vertebral species, see family NAAA-beta, pfam15508.


Pssm-ID: 396726  Cd Length: 316  Bit Score: 58.29  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250   122 CTSIVAQNSAGQIIHGRNLDYDM----------------TELLKNITIHVD-FVRNGTIQYSGLTFAL-YNgvltgqrpg 183
Cdd:pfam02275   1 CTSITLETKKGNLLFGRNMDFGIsygeeviitprnyklvFEKLGNMLVTKYaVIGMGTDVGSYPLFYDgLN--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250   184 EYSVSLNARYSGAYIDNILMEFYTKFKRPVSFFIRDVLENQATYTEAVDAFSRTHLFSPSYIIVAGI---------KKNE 254
Cdd:pfam02275  72 EKGLGIAGLYFPGYAFYSKGPKKDKVNIQPGELILWVLGNFTSVEEVKELLTKLNIVNEALDILGGKaplhwiisdASGE 151

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 17556250   255 GVVIsRNRWSAANVY--PLNVDANQ--WFLVETNFDNWK 289
Cdd:pfam02275 152 SIVI-EPRKEGLKVYdnEVGVMTNSptFDWHLTNLNNYT 189
 
Name Accession Description Interval E-value
Ntn_AC_NAAA cd01903
AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also ...
 104-341 6.10e-117

AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and fatty acid. Ceramide is required for the biosynthesis of most sphingolipids and plays an important role in many signal transduction pathways by inducing apoptosis and/or arresting cell growth. An inherited deficiency of AC activity leads to the lysosomal storage disorder known as Farber disease. AC is considered a "rheostat" important for maintaining the proper intracellular levels of these lipids since hydrolysis of ceramide is the only source of sphingosine in cells. NAAA is a eukaryotic glycoprotein that hydrolyzes bioactive N-acylethanolamines, including anandamide (an endocannabinoid) and N-palmitoylethanolamine (an anti-inflammatory and neuroprotective substance), to fatty acids and ethanolamine at acidic pH. NAAA shows structural and functional similarity to acid ceramidase, but lacks the ceramide-hydrolyzing activity of AC.


Pssm-ID: 238886  Cd Length: 231  Bit Score: 338.09  E-value: 6.10e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 104 NILYDVAAFdrrhifglgCTSIVAQNSAGQIIHGRNLDYDMTELLKNITIHVDFVRNGTIQYSGLTFALYNGVLTGQRPG 183
Cdd:cd01903   1 NIFYEIFTF---------CTSIVAQDSNGTIYHARNLDFGFFEELSKLTVNVDFQRNGKIVFKGTTFAGYVGLLTGQKPG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 184 EYSVSLNARYSGAYIDNILMEFYTKFKRPVSFFIRDVLENQATYTEAVDAFSRTHLFSPSYIIVAGIKKNEGVVISRNRW 263
Cdd:cd01903  72 KFSLTINERFSLDGGYNGILALLKKDGIPVSWLIRETLENATSYEDAVEKLSTTPILAPAYFIVGGVKPGEGVVITRNRD 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 264 SAANVYPLNVDANQWFLVETNFDNWKKQG--DDRRITAIQKLKELGRRNFDEKSMVEVLSTVPVRNNLTVFSTVMVPGLP 341
Cdd:cd01903 152 SVADVYPLDLKNGTWFLVQTNYDRWKPPPflDDRRTPAIKCMNALGQANISFKTLYDVLSTKPVLNKLTIYTTLMSVRTG 231
Ntn_CGH_like cd01935
Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins ...
 122-336 9.40e-40

Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which cleave non-peptide carbon-nitrogen bonds in bile salt constituents. These enzymes have an N-terminal nucleophilic cysteine, as do other members of the Ntn hydrolase family to which they belong. This nucleophilic cysteine is exposed by post-translational prossessing of the precursor protein.


Pssm-ID: 238910  Cd Length: 229  Bit Score: 140.18  E-value: 9.40e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 122 CTSIVAQNSAGQIIHGRNLDYDMTELLKNITIHVDFVRNGTI---------QYSGLTFALYNGVLTGQRPGEYSVSLNAR 192
Cdd:cd01935   1 CTSIVAQTKDGGVYLGRNMDFSFDYELRLLVFPRGYQRNGQTgdkskwyakYGSGGTSAGYIGLVDGMNEKGLSVSLLYF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 193 YSGAYIDNILMEfyTKFKRPVSFFIRDVLENQATYTEAVDAFSRTHLF----------SPSYIIVAGiKKNEGVVISRNR 262
Cdd:cd01935  81 PGYAYYPAGIKE--GKDGLPAFELIRWVLENCDSVEEVKEALKKIPIVdfpiplggpaAPLHYILSD-KSGDSAVIEPID 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17556250 263 WSAANVYplnvdaNQWFLVETNFDNWKKQgDDRRITAIQKLKELGRRNFDE----KSMVEVLSTVPVRNNLTVFSTVM 336
Cdd:cd01935 158 GGLKIYD------NPWFGVMTNHPTFDWH-LPRRFVRVAYLKNTAQKNKETvedvKNLFHILESVPIPNGLTVYTTVM 228
C45_proenzyme NF040521
C45 family autoproteolytic acyltransferase/hydolase; Members of this family include hydrolases ...
 52-339 1.92e-20

C45 family autoproteolytic acyltransferase/hydolase; Members of this family include hydrolases and N-acyltransferases, and belong to the Ntn (N-terminal nucleophile) hydrolase family. Members have an invariant Cys residue (Cys-103 in XP_002569112.1) required both for autoproteolytic processing into alpha and beta chains and for activity. The family is described by MEROPs as a cysteine protease, family C45, because of its autoproteolytic activity. Characterized members include TAN from Drosophila, which removes beta-alanine from both carcinine and N-beta-alanyl dopamine, and isopenicillin-N N-acyltransferase from various fungi. The latter has been heavily studied because of its role in penicillin biosynthesis.


Pssm-ID: 468523 [Multi-domain]  Cd Length: 312  Bit Score: 90.43  E-value: 1.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250   52 VEETKKYIPKPLQPFVWWAASKIDRYFTtEIQEELKGIASESGLPIGEIVGMNILYDVAAFDRrhifglGCTSIVAQNSA 131
Cdd:NF040521  27 LRAWGLVSWRELRDFAKEFLAALEAFAP-ELWEELEGIADGLGLPFEDVLALNARTEILAAPD------GCSTFAVLGED 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250  132 GQIIHGRNLDYDmTELLKNiTIHVDFVRNGTIQYSGLTFAlynGVLTGQRPG--EY--SVSLNArysGAYIDnilmefYT 207
Cdd:NF040521 100 GEPILARNYDWH-PELYDG-CLLLTIRPDGGPRYASIGYA---GLLPGRTDGmnEAglAVTLNF---LDGRK------LP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250  208 KFKRPVSFFIRDVLENQATYTEAVDAFSRTHLFSPSYIIVAGiKKNEGVVIsrnRWSAANVYPlnVDANQWFLVETN-FD 286
Cdd:NF040521 166 GVGVPVHLLARAILENCKTVDEAIALLKEIPRASSFNLTLAD-ASGRAASV---EASPDRVVV--VRPEDGLLVHTNhFL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17556250  287 NWKKQGDDRRITA-----IQKLKELGRRNFDEKSMVEVLSTV---PVRNNL--------TVFSTVMVPG 339
Cdd:NF040521 240 SPELEEENRIATPssrerYERLEELLKGKLDAEDAKALLSDGyplPICRHPypdgdrfgTLATVVFDPA 308
NAAA-beta pfam15508
beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of ...
 21-78 1.69e-15

beta subunit of N-acylethanolamine-hydrolyzing acid amidase; NAAA-beta is a family of vertebral sequences that form the beta subunit of vertebral N-acylethanolamine-hydrolyzing acid amidase, a member of the choloylglycine hydrolase acid ceramidase family. The alpha subunit is represented by family CBAH, pfam02275.


Pssm-ID: 464754  Cd Length: 63  Bit Score: 69.96  E-value: 1.69e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17556250    21 KPRHYEINLDEPPSQRWNQVIKDH----LEYLPGVVEETKKYIPKPLQPFVWWAASKIDRYF 78
Cdd:pfam15508   2 PVPWYVINLDLPPEERWTQVAKDYkpeiKSLIPALKDLLKSLVPGKLVPLVDKLAADLLRYL 63
COG4927 COG4927
Predicted choloylglycine hydrolase [General function prediction only];
64-258 1.54e-11

Predicted choloylglycine hydrolase [General function prediction only];


Pssm-ID: 443955 [Multi-domain]  Cd Length: 242  Bit Score: 63.43  E-value: 1.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250  64 QPFVWWAASKIDRYFTtEIQEELKGIASESGLPIGEIVGMNILYDVAAFdrrhifglGCTSIVAQNsAGQIIHGRNLDY- 142
Cdd:COG4927  39 RPFLAEARAALRRYMP-ELWEELEGLADGLDVPLEELLLLNGGYYLPLS--------GCSQFAVAP-EGEPLLARNYDFh 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250 143 -DMTELLKNITIHVDfvrngtiqySGLTFALYNGVLTGQRPG--EY--SVSLNARYSGAYIDNIlmefytkfkrPVSFFI 217
Cdd:COG4927 109 pDLYEGRLLLTVQPD---------GGYAFIGVTDGLIGRLDGmnEKglAVGLNFVGRKVAGPGF----------PIPLLI 169

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 17556250 218 RDVLENQATYTEAVDAFSRTHLFSPSYIIVAGiKKNEGVVI 258
Cdd:COG4927 170 RYILETCSTVDEAIALLKEIPHASSYNLTLAD-ASGNAAVV 209
CBAH pfam02275
Linear amide C-N hydrolases, choloylglycine hydrolase family; This family includes several ...
 122-289 1.52e-09

Linear amide C-N hydrolases, choloylglycine hydrolase family; This family includes several hydrolases which cleave carbon-nitrogen bonds, other than peptide bonds, in linear amides. These include choloylglycine hydrolase (conjugated bile acid hydrolase, CBAH) EC:3.5.1.24, penicillin acylase EC:3.5.1.11 and acid ceramidase EC:3.5.1.23. This domain forms the alpha-subunit for members from vertebral species, see family NAAA-beta, pfam15508.


Pssm-ID: 396726  Cd Length: 316  Bit Score: 58.29  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250   122 CTSIVAQNSAGQIIHGRNLDYDM----------------TELLKNITIHVD-FVRNGTIQYSGLTFAL-YNgvltgqrpg 183
Cdd:pfam02275   1 CTSITLETKKGNLLFGRNMDFGIsygeeviitprnyklvFEKLGNMLVTKYaVIGMGTDVGSYPLFYDgLN--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556250   184 EYSVSLNARYSGAYIDNILMEFYTKFKRPVSFFIRDVLENQATYTEAVDAFSRTHLFSPSYIIVAGI---------KKNE 254
Cdd:pfam02275  72 EKGLGIAGLYFPGYAFYSKGPKKDKVNIQPGELILWVLGNFTSVEEVKELLTKLNIVNEALDILGGKaplhwiisdASGE 151

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 17556250   255 GVVIsRNRWSAANVY--PLNVDANQ--WFLVETNFDNWK 289
Cdd:pfam02275 152 SIVI-EPRKEGLKVYdnEVGVMTNSptFDWHLTNLNNYT 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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