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Conserved domains on  [gi|392894459|ref|NP_497718|]
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Uncharacterized protein CELE_C34C12.7 [Caenorhabditis elegans]

Protein Classification

PAN/Apple domain-containing protein( domain architecture ID 10099731)

PAN/Apple domain-containing protein similar to Homo sapiens plasminogen-like proteins A and B, which may bind noncovalently to lysine binding sites present in the kringle structures of plasminogen

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
36-107 1.08e-07

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


:

Pssm-ID: 238532  Cd Length: 80  Bit Score: 48.62  E-value: 1.08e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392894459  36 LECFEFKK--NYWIVGHAFHTSSVQFKDECLRMCLTSsiRKAKCLSAMHVPNDDECVISDQNQVTKPDLFIEND 107
Cdd:cd01099    1 LNDFKFVLvlNKILVSEVKTEITVASLEECLRKCLEE--TEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDS 72
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
36-107 1.08e-07

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 48.62  E-value: 1.08e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392894459  36 LECFEFKK--NYWIVGHAFHTSSVQFKDECLRMCLTSsiRKAKCLSAMHVPNDDECVISDQNQVTKPDLFIEND 107
Cdd:cd01099    1 LNDFKFVLvlNKILVSEVKTEITVASLEECLRKCLEE--TEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDS 72
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
34-103 4.62e-05

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 41.03  E-value: 4.62e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894459    34 KLLECFEFKKNYWIVGHAFHTSSVQFKDECLRMCLTSSIRkakCLSAMHVPNDDECVISDQNQVTKPDLF 103
Cdd:smart00473   1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNSNCS---CRSFTYNNGTKGCLLWSESSLGDARLF 67
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
39-121 3.08e-04

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 38.69  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894459   39 FEFKKNYWIVGHAFHTSSVQFKDECLRMCLTSsirkAKCLSAMHVPNDDECVISDQNQVTKPDLFIENDtpgtfTVNFFR 118
Cdd:pfam00024   3 FERVPGSSLSGVDVSTVTVSSAEECAQRCTNE----PRCRSFTYNPKSKKCHLKSSSSGSLPRLKRSDN-----KVDYYE 73

                  ...
gi 392894459  119 NIC 121
Cdd:pfam00024  74 KSC 76
 
Name Accession Description Interval E-value
PAN_AP_HGF cd01099
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
36-107 1.08e-07

Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.


Pssm-ID: 238532  Cd Length: 80  Bit Score: 48.62  E-value: 1.08e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392894459  36 LECFEFKK--NYWIVGHAFHTSSVQFKDECLRMCLTSsiRKAKCLSAMHVPNDDECVISDQNQVTKPDLFIEND 107
Cdd:cd01099    1 LNDFKFVLvlNKILVSEVKTEITVASLEECLRKCLEE--TEFTCRSFNYNYKSKECILSDEDRMSSGVKLLYDS 72
PAN_AP smart00473
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
34-103 4.62e-05

divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.


Pssm-ID: 214680  Cd Length: 78  Bit Score: 41.03  E-value: 4.62e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894459    34 KLLECFEFKKNYWIVGHAFHTSSVQFKDECLRMCLTSSIRkakCLSAMHVPNDDECVISDQNQVTKPDLF 103
Cdd:smart00473   1 KSDDCFVRLPNTKLPGFSRIVISVASLEECASKCLNSNCS---CRSFTYNNGTKGCLLWSESSLGDARLF 67
PAN_1 pfam00024
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
39-121 3.08e-04

PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.


Pssm-ID: 459635  Cd Length: 76  Bit Score: 38.69  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894459   39 FEFKKNYWIVGHAFHTSSVQFKDECLRMCLTSsirkAKCLSAMHVPNDDECVISDQNQVTKPDLFIENDtpgtfTVNFFR 118
Cdd:pfam00024   3 FERVPGSSLSGVDVSTVTVSSAEECAQRCTNE----PRCRSFTYNPKSKKCHLKSSSSGSLPRLKRSDN-----KVDYYE 73

                  ...
gi 392894459  119 NIC 121
Cdd:pfam00024  74 KSC 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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