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Conserved domains on  [gi|17554346|ref|NP_497903|]
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Annexin [Caenorhabditis elegans]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 87-151 2.85e-20

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 82.91  E-value: 2.85e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17554346    87 DVTELNRSVKGLGTNEKNLIEILTTRTNEEIEAAKNTYFMTYSKSLEDAISADTSGDFRRLLIVI 151
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 245-310 2.58e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.82  E-value: 2.58e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17554346   245 YFANSIHLATKGMGTRDKDLIRILVSRSENDLVIIEHEFQTLFGKPLTQLIKEECKAEYRDGLTML 310
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 19-79 1.41e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 72.89  E-value: 1.41e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17554346    19 EQLEKALR--NKEKLKILEILVSVNNTQRQMIRTPYKTRYGKDLEDEIKKAFSGDFEDFLVAL 79
Cdd:pfam00191   4 ELLRKAMKglGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 170-235 3.33e-14

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 66.34  E-value: 3.33e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17554346   170 HAAQILKSFDKKSGVEKFDAFKIFATCNGAHIQKVIEEVERQSGKEFQKLIDKELSGDFKNLVLSL 235
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 87-151 2.85e-20

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 82.91  E-value: 2.85e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17554346    87 DVTELNRSVKGLGTNEKNLIEILTTRTNEEIEAAKNTYFMTYSKSLEDAISADTSGDFRRLLIVI 151
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 245-310 2.58e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.82  E-value: 2.58e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17554346   245 YFANSIHLATKGMGTRDKDLIRILVSRSENDLVIIEHEFQTLFGKPLTQLIKEECKAEYRDGLTML 310
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 19-79 1.41e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 72.89  E-value: 1.41e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17554346    19 EQLEKALR--NKEKLKILEILVSVNNTQRQMIRTPYKTRYGKDLEDEIKKAFSGDFEDFLVAL 79
Cdd:pfam00191   4 ELLRKAMKglGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
32-79 3.27e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 71.28  E-value: 3.27e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 17554346     32 KILEILVSVNNTQRQMIRTPYKTRYGKDLEDEIKKAFSGDFEDFLVAL 79
Cdd:smart00335   6 TLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
99-151 3.52e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 71.28  E-value: 3.52e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 17554346     99 GTNEKNLIEILTTRTNEEIEAAKNTYFMTYSKSLEDAISADTSGDFRRLLIVI 151
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 170-235 3.33e-14

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 66.34  E-value: 3.33e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17554346   170 HAAQILKSFDKKSGVEKFDAFKIFATCNGAHIQKVIEEVERQSGKEFQKLIDKELSGDFKNLVLSL 235
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
258-310 1.12e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 64.35  E-value: 1.12e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 17554346    258 GTRDKDLIRILVSRSENDLVIIEHEFQTLFGKPLTQLIKEECKAEYRDGLTML 310
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
192-235 7.19e-04

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 37.00  E-value: 7.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 17554346    192 IFATCNGAHIQKVIEEVERQSGKEFQKLIDKELSGDFKNLVLSL 235
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 87-151 2.85e-20

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 82.91  E-value: 2.85e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17554346    87 DVTELNRSVKGLGTNEKNLIEILTTRTNEEIEAAKNTYFMTYSKSLEDAISADTSGDFRRLLIVI 151
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 245-310 2.58e-17

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 74.82  E-value: 2.58e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17554346   245 YFANSIHLATKGMGTRDKDLIRILVSRSENDLVIIEHEFQTLFGKPLTQLIKEECKAEYRDGLTML 310
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 19-79 1.41e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 72.89  E-value: 1.41e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17554346    19 EQLEKALR--NKEKLKILEILVSVNNTQRQMIRTPYKTRYGKDLEDEIKKAFSGDFEDFLVAL 79
Cdd:pfam00191   4 ELLRKAMKglGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
32-79 3.27e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 71.28  E-value: 3.27e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 17554346     32 KILEILVSVNNTQRQMIRTPYKTRYGKDLEDEIKKAFSGDFEDFLVAL 79
Cdd:smart00335   6 TLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
99-151 3.52e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 71.28  E-value: 3.52e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 17554346     99 GTNEKNLIEILTTRTNEEIEAAKNTYFMTYSKSLEDAISADTSGDFRRLLIVI 151
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 170-235 3.33e-14

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 66.34  E-value: 3.33e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17554346   170 HAAQILKSFDKKSGVEKFDAFKIFATCNGAHIQKVIEEVERQSGKEFQKLIDKELSGDFKNLVLSL 235
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
258-310 1.12e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 64.35  E-value: 1.12e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 17554346    258 GTRDKDLIRILVSRSENDLVIIEHEFQTLFGKPLTQLIKEECKAEYRDGLTML 310
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
192-235 7.19e-04

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 37.00  E-value: 7.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 17554346    192 IFATCNGAHIQKVIEEVERQSGKEFQKLIDKELSGDFKNLVLSL 235
Cdd:smart00335  10 ILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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