|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03206 |
PLN03206 |
phosphoribosylformylglycinamidine synthase; Provisional |
26-1323 |
0e+00 |
|
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain] Cd Length: 1307 Bit Score: 1512.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 26 EKKFNRKIDVSVEYCYHVITQEPeLISSNWEKLVTLLSHSpFE-TSVWKESQL--HPEHGKN---IEIGPRTAVKTAACT 99
Cdd:PLN03206 9 TKVSNDIVSIETEQCFNVGLESP-LSAEKLETLKWLLRET-FEpENLGTESFLeaKKSEGLNavvVEVGPRLSFTTAWST 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 100 NILSIFESSGIKNVERIERGIRYLVE-----DDVDVNEFFEIAADKMTEAIYGNDVKFDDESHQIEKVFLIDVL-ESKQN 173
Cdd:PLN03206 87 NAVSICSACGLTEVTRLERSRRYLLFsssplDESQINAFAAMVHDRMTECVYPQPLTSFESGVVPEPVYTVPVMeEGRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 174 LIKANEELGLALDQLDLDFYYDFFVNKVKKNPTDVELFDLAQSDSEHSRHWFFRGEIWIDDRKRDGSLMKTIRETLDSSN 253
Cdd:PLN03206 167 LEEINKEMGLAFDEQDLDYYTRLFRDDIKRDPTNVELFDIAQSNSEHSRHWFFSGKLVIDGQPMPKTLFQMVKDTLKANP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 254 DNSLIAFCDNSSAIRGFEsVCRLRPNDPTTVSPMIAIFPPSHLIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATGRGA 333
Cdd:PLN03206 247 NNSVIGFKDNSSAIRGFV-VQPLRPVSPGSPSPLAPVDRDLDILLTAETHNFPCAVAPYPGAETGAGGRIRDTHATGRGS 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 334 YEIAGTVGYSFGNLNLPGLPLPWEDETFEYPTSISEPAKIAIEASNGASDYGNKFGEPVISGFARSFGQRLENGERCEYL 413
Cdd:PLN03206 326 FVVAGTAGYCVGNLRIEGSYAPWEDSSFVYPSNLASPLQILIDASNGASDYGNKFGEPLIQGYTRTFGMRLPNGERREWL 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 414 KPIMFSGGIGAIDKDEVRKEPCAPHQKVVKIGGPVYRIGVGGGAASSVsVQGNRENQLDFAAVQRGDAEMGGKLHRVVRA 493
Cdd:PLN03206 406 KPIMFSGGIGQIDHTHLTKGEPDIGMLVVKIGGPAYRIGMGGGAASSM-VSGQNDAELDFNAVQRGDAEMSQKLYRVVRA 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 494 CAERIGGNPLMAIHDQGAGGNGNVIKELVEGCGVTVKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKR 573
Cdd:PLN03206 485 CVEMGEDNPIVSIHDQGAGGNCNVVKEIIYPKGAEIDIRAVVVGDHTLSVLEIWGAEYQEQDALLIKPESRDLLQSICDR 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 574 EKCHVSVVGEVEKEQRVKLLGKS------------GEIAVDLDTRQ-LGEREKKVFKLKSAPRVLKKLELPENLTVRKAL 640
Cdd:PLN03206 565 ERCSMAVIGTIDGSGRVVLVDSAapekceanglppPPPAVDLDLEKvLGDMPQKTFEFKRVANKLEPLDIPPGITVMDAL 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 641 KRVLMLPSVASKRYLTCKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSHFDTVGGAVSLGEQPIKMLIDAEKGARMCIA 720
Cdd:PLN03206 645 KRVLRLPSVCSKRFLTTKVDRCVTGLVAQQQTVGPLQIPLADVAVIAQTHTGLTGGACAIGEQPIKGLVDPKAMARLAVG 724
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 721 ETIMNLIWAPITDLKDVKMSGNWMWAAKCDGEGARLVDAVGALCRGLREIGCAIDGGKDSLSMAVTAHGEVVKSPGTLVL 800
Cdd:PLN03206 725 EALTNLVWAKVTALSDVKASGNWMYAAKLDGEGADMYDAAVALRDAMIELGVAIDGGKDSLSMAAQAGGEVVKAPGNLVI 804
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 801 SAYAPCTNVTKVVNPSLKAVPGSKILWIKIGSSeeKMRLGGSALAQVYSQIGDDCPDIENFSEISKVFSIVQQLlnreel 880
Cdd:PLN03206 805 SAYVTCPDITKTVTPDLKLGDDGVLLHVDLGKG--KRRLGGSALAQAYDQIGDDCPDLDDVAYLKKAFEATQDL------ 876
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 881 agpLRKPIILAGHDISDGGLLTAILEMAFAGNVSIDIDIkpPNQNIKPIDILFAEECGILLEVS--NPENVLHIFSEAGI 958
Cdd:PLN03206 877 ---IAKRLISAGHDISDGGLVVTLLEMAFAGNCGINVDL--PSSGHSAFETLFAEELGLVLEVSrkNLDAVMEKLAAAGV 951
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 959 KCQEIGKASAvfGPDAHVKihVNGHLEINEKLVDLREEWELVGDRLGEFQTNPKSLKEAREVRRTCQKINYKCDFdwyyN 1038
Cdd:PLN03206 952 TAEVIGQVTA--SPLIEVK--VDGATCLSEKTASLRDMWEETSFQLEKLQRLESCVAQEKEGLKSRKAPTWKLSF----T 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1039 PAFIhNEQYFSTA--PRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGH-TLEAYRGVAFVGGFSYADVLGSAK 1115
Cdd:PLN03206 1024 PAFT-DKKIMNATskPKVAIIREEGSNGDREMAAAFYAAGFEPWDVTMSDLLNGRiSLDDFRGIVFVGGFSYADVLDSAK 1102
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1116 GWAAGVQFNESVSKQFEAFRSRPDTFSYGVCNGCQLMAQLGWI------------GDEEQkgPTvFLdENECGRFDSSFG 1183
Cdd:PLN03206 1103 GWAGSIRFNEPLLQQFQEFYNRPDTFSLGVCNGCQLMALLGWVpgpqvggglgagGDPSQ--PR-FV-HNESGRFECRFT 1178
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1184 PVKIEKNVSIMLSGMENSVLGLWSSHGEGRFTYRNLQNFQNLKTNGQVCIRFCDdrgmtgaDHGSVKLPYPWNPNGSIDD 1263
Cdd:PLN03206 1179 SVTIEDSPAIMLKGMEGSTLGVWAAHGEGRAYFPDESVLDEVLKSNLAPVRYCD-------DDGEPTEQYPFNPNGSPLG 1251
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392894769 1264 VAAICSRDGRHLAMMPHADRSFLTWQWaessevPWN-ARFDQKTVALSPWIKMFRNAYNWC 1323
Cdd:PLN03206 1252 IAALCSPDGRHLAMMPHPERCFLMWQF------PWYpKEWGVDPAGPSPWLKMFQNAREWC 1306
|
|
| FGAM_synt |
TIGR01735 |
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ... |
10-1322 |
0e+00 |
|
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain] Cd Length: 1310 Bit Score: 1325.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 10 AKAVESRKLDQIQKDFEKKFNRKIDVSVEYCYHViTQEPELISSNWEKLVTLLSH-SPFETSV-WKESQLhpehgknIEI 87
Cdd:TIGR01735 5 PSALSGFRLEKLLQKLQTKVPELTGVYAEFCYFV-GWESALTADEEEKLQLLLLAgSVLEPPQsPLGRGL-------LEV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 88 GPRTAVKTAACTNILSIFESSGIKNVERIERGIRYLVEDDVDVNE--FFEIAA---DKMTEAIYGN-DVKFDDESHQIEK 161
Cdd:TIGR01735 77 GPRLGTISPWSSKATSIARNCGLAKVDRIERGRRYYLSGAHPLSEeqEAQAAAllhDRMTESVLPHeIEAFELFSVPEPL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 162 VFL-IDVL-ESKQNLIKANEELGLALDQLDLDFYYDFFvNKVKKNPTDVELFDLAQSDSEHSRHWFFRGEIWIDDRKRDG 239
Cdd:TIGR01735 157 NLTtIDVLgGGRLALEKANQELGLALDEDEIDYLTKRF-QELQRNPSDVELMMFAQANSEHCRHKIFNADWIIDGKKQDK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 240 SLMKTIRETLDSSNDNSLIAFCDNSSAIRGFEsVCRLRPNDPTTVSPMIAIFPPSHLIYSAETHNFPTAVCPFQGATTGT 319
Cdd:TIGR01735 236 SLFQMIKSTHEANPENTVSAYKDNSSVIEGHK-VGRLRPDPPTRPEYRQHQEDLVHILMKVETHNHPTAIAPFPGASTGA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 320 GGRIRDIHATGRGAYEIAGTVGYSFGNLNLPGLPLPWEDeTFEYPTSISEPAKIAIEASNGASDYGNKFGEPVISGFARS 399
Cdd:TIGR01735 315 GGEIRDEGATGRGAKPKAGLTGFCVSNLNIPGLEQPWED-PFQKPERIASPLDIMIEAPLGAAAFNNEFGRPNLLGYFRT 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 400 FGQR--LENGERCEYLKPIMFSGGIGAIDKDEVRKEPCAPHQKVVKIGGPVYRIGVGGGAASSVsVQGNRENQLDFAAVQ 477
Cdd:TIGR01735 394 FELKasLPGGQVRGYHKPIMLAGGIGSIDAEHIQKGEIEPGALLIVLGGPAMLIGLGGGAASSM-VSGTNTADLDFASVQ 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 478 RGDAEMGGKLHRVVRACAERIGGNPLMAIHDQGAGGNGNVIKELVEGCGVTVKSDT--FQLGDESISLRELWTAEYQEND 555
Cdd:TIGR01735 473 RGNPEMERRCQEVIDRCWQLGEKNPIISIHDVGAGGLSNALPELIHDGGRGAVIDLraVPLDDPGLSPLEIWCNESQERY 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 556 AALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKL--------LGKSGEI------AVDLDTRQ-LGEREKKVFKLKS 620
Cdd:TIGR01735 553 VLLVRAENLEIFTAICERERCPFAVVGTATGDGRLTLvddtpvrrNGQGDAPshfpnnPVDLPLEVlLGKMPKMTRFVQR 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 621 APRVLKKLELPENLTVRKALKRVLMLPSVASKRYLTCKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSHFDTVGGAVSL 700
Cdd:TIGR01735 633 KAPMLQPLDIPPGLDLHEALERVLRLPAVASKRFLITIGDRSVGGLVARDQMVGPWQTPLADVAVTAASFDTYTGEAMAI 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 701 GEQPIKMLIDAEKGARMCIAETIMNLIWAPITDLKDVKMSGNWMWAAKCDGEGARLVDAVGALCRGLREIGCAIDGGKDS 780
Cdd:TIGR01735 713 GERPPKALLDPKASARLAVGEAITNLAAALVGDLSDVKLSANWMAAAGHPGEDAALYDAVKAVSELCPALGIAIPVGKDS 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 781 LSMAVTAHG----EVVKSPGTLVLSAYAPCTNVTKVVNPSLKAVPGSKILWIkIGSSEEKMRLGGSALAQVYSQIGDDCP 856
Cdd:TIGR01735 793 LSMKTRWQDngetKSVTAPGSLVISAFAPVPDVRKTVTPDLKHDKGDSHLLL-VDLGPGKNRLGGSALAQVFGQLGGDCP 871
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 857 DIENFSEISKVFSIVQQLLNREELagplrkpiiLAGHDISDGGLLTAILEMAFAGNVSIDIDIKPPNQNIKPIdiLFAEE 936
Cdd:TIGR01735 872 DLDDPERLKAFFAVMQGLVAEGLL---------LAYHDRSDGGLVTTLLEMAFAGHCGLDVDLDALGDSLFAV--LFNEE 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 937 CGILLEVSNP--ENVLHIFSEAGIKCQEIGKASAVFGPDahVKIHVNGHLEINEKLVDLREEWELVGDRLGEFQTNPKSL 1014
Cdd:TIGR01735 941 LGAVIQVAKPdlAAVLELLRAAGLTALILGIGTPTGHPM--IRISVNGATLLSEKRSELRDIWEETSFQLQRLRDNPECA 1018
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1015 KEAREVRRTCQKINYKCDFDwyYNPAFIHNEQYFSTA--PRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGH- 1091
Cdd:TIGR01735 1019 EEEFEGLRDRDGPGLKLPLT--FDVNEDIAAPFINKGvkPKVAILREQGVNGDREMAAAFDRAGFEAWDVHMSDLLAGRv 1096
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1092 TLEAYRGVAFVGGFSYADVLGSAKGWAAGVQFNESVSKQFEAFRSRPDTFSYGVCNGCQLMAQL-GWIGDEEQKGPTVfl 1170
Cdd:TIGR01735 1097 HLDEFRGLAACGGFSYGDVLGAGKGWAKSILFNPRLRDQFQAFFKRPDTFSLGVCNGCQMLSNLlEWIPGTENWPHFV-- 1174
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1171 dENECGRFDSSFGPVKIEKNVSIMLSGMENSVLGLWSSHGEGRFTYRNLQNFQNLKTNGQVCIRFCDdrgmtgaDHGSVK 1250
Cdd:TIGR01735 1175 -RNNSERFEARVASVRVGESPSIMLRGMAGSRLPVAVAHGEGYAAFSSPELQAQADASGLAALRYID-------DDGNPT 1246
|
1290 1300 1310 1320 1330 1340 1350
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392894769 1251 LPYPWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLTWQWAESSEvPWNarfdqktvALSPWIKMFRNAYNW 1322
Cdd:TIGR01735 1247 EAYPLNPNGSPGGIAGITSCDGRVTIMMPHPERVFRAWQNSWRPE-DWD--------EDTPWLRLFRNARNW 1309
|
|
| PurL1 |
COG0046 |
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ... |
165-998 |
0e+00 |
|
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain] Cd Length: 747 Bit Score: 588.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 165 IDVLESKQNLIKANEELGLALDQLDldfyYDFFVNKVKKNPTDVELFDLAQSDSEHSRHWFFRGEIwiddrkrdgslmkt 244
Cdd:COG0046 4 VDLEGGREALEEANRELGLALSDDE----YDYIVEILGRNPTDVELGMFSQMWSEHCSYKSSNALL-------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 245 irETLDSSNDNSLIAFCDNSSAIRGFEsvcrlrpndpttvspmiaifpPSHLIYSAETHNFPTAVCPFQGATTGTGGRIR 324
Cdd:COG0046 66 --KSLPTEGPRVLSGPGDNAGVVDIGD---------------------GLAVVFKVESHNHPSAIEPYQGAATGVGGIIR 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 325 DIHatGRGAYEIAGTVGYSFGNLNLPGLplpwedetfeyptsisEPAKIAIEASNGASDYGNKFGEPVISGFARSFGQrl 404
Cdd:COG0046 123 DIF--GMGARPIAGLDSLRFGNLDQPPA----------------SPRYILIGVVAGIADYGNCFGVPTVGGEVRFDES-- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 405 ENGerceylKPIMFSGGIGAIDKDEVRK-EPCAPHQKVVKIGGPVYRIGVGGGAASSVSVqgNRENQLDFAAVQRGDAEM 483
Cdd:COG0046 183 YEG------NPLVNAGGVGIIRADHIFKaKAPGVGNKVVYVGGPTGRDGIGGATFASEEL--GEDSELDRPAVQVGDPFM 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 484 GGKLHRVVRACAERiggNPLMAIHDQGAGGNGNVIKELVE--GCGVTVKSDTFQLGDESISLRELWTAEYQENDAALVDA 561
Cdd:COG0046 255 EKRLIEAILELGDT---GLIVGIQDMGAGGLSSASSEMAAkgGLGAEIDLDKVPLREPGMSPYEIWLSESQERMLLVVKP 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 562 SLLDALQTISKREKCHVSVVGEVEKEQRVKLLGKsGEIAVDLDTRQLGE------REKKvfklksAPRVLKKLELPENLT 635
Cdd:COG0046 332 EKLEEFEAIFERWRLPAAVIGEVTDDGRLVVTDH-GETVADLPLDFLAGgapkyhRPAK------RPAYLEPLDLPEPID 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 636 VRKALKRVLMLPSVASKRYLTCKVDRSVTGLVAQQQcvgplhtPLADVAVVALSHfDTVGGAVSLGEQPIKMLIDAEKGA 715
Cdd:COG0046 405 LEEALLRLLSSPNVASKEWLYRQYDREVGGNTVRDP-------GVADAAVVRVDG-TYKGLAMSTGENPRYALLDPYAGA 476
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 716 RMCIAETIMNLIWAPITDLkDVKMSGNWMWAAKcDGEGARLVDAV---GALCRGLreiGCAIDGGKDSLSMavTAHGEVV 792
Cdd:COG0046 477 RMAVAEAARNLAAVGAEPL-AITDCLNWGNPEK-PEEMAQLVEAVkglADACRAL---GIPVPSGNVSLYN--ETKDGKV 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 793 KSPGTLVLSAYAPCTNVTKVVNPSLKAvPGSKILWIkigsSEEKMRLGGSALAQVYSQIGDDCPDIeNFSEISKVFSIVQ 872
Cdd:COG0046 550 AIPPTPVIGAVGLVDDVRKTVTPDLKK-EGDLLYLI----GETKNELGGSEYAQVLGQLGGEPPDV-DLEAEKALFEAVQ 623
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 873 QlLNREELagplrkpiILAGHDISDGGLLTAILEMAFAGNVSIDIDIkPPNQNIKPIDILFAEECG-ILLEVSNP--ENV 949
Cdd:COG0046 624 E-LIREGL--------ILAAHDVSDGGLAVALAEMAFAGGLGADIDL-DALGDLRPDAALFSESQGrAVVQVAPEdaEAV 693
|
810 820 830 840
....*....|....*....|....*....|....*....|....*....
gi 392894769 950 LHIFSEAGIKCQEIGKAsavfGPDAHVKIHVNGHLEINEKLVDLREEWE 998
Cdd:COG0046 694 EALLAEAGLPAHVIGTV----TGDDRLVIRRGGETLLSLSLAELRDAWE 738
|
|
| GATase_5 |
pfam13507 |
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ... |
1052-1323 |
1.27e-121 |
|
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain] Cd Length: 260 Bit Score: 378.00 E-value: 1.27e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1052 PRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGH-TLEAYRGVAFVGGFSYADVLGSAKGWAAGVQFNESVSKQ 1130
Cdd:pfam13507 2 PRVAILREPGTNGEYEMAAAFERAGFDAVDVHMSDLLSGRvSLDDFQGLAAPGGFSYGDVLGSGKGWAASILFNPKLRDA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1131 FEAFRSRPDTFSYGVCNGCQLMAQLGWI--GDEEQKGPTVFLDENECGRFDSSFGPVKI-EKNVSIMLSGMEnsVLGLWS 1207
Cdd:pfam13507 82 FEAFFNRPDTFSLGICNGCQLLSKLGLIpgGEGDLAERWPTLTRNDSGRFESRWVNVKIsEKSPSVFLRGMD--GSGLPV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1208 SHGEGRFTYRNLQNFQNLKTNGQVCIRFCDdrgmtgaDHGSVKLPYPWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLT 1287
Cdd:pfam13507 160 AHGEGRFVFRSEEVLARLEANGQVALRYVD-------NAGNPTEEYPFNPNGSPLGIAGICSPDGRVLGLMPHPERVFRP 232
|
250 260 270
....*....|....*....|....*....|....*.
gi 392894769 1288 WQWaessevPWNARFDQKTValSPWIKMFRNAYNWC 1323
Cdd:pfam13507 233 WQW------PHWPPGEWEEV--SPWLRLFRNARKWV 260
|
|
| PurL_repeat1 |
cd02203 |
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ... |
209-603 |
1.99e-110 |
|
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain] Cd Length: 313 Bit Score: 349.85 E-value: 1.99e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 209 ELFDLAQSDSEHSRHWFFRgeiwiddrkrdgSLMKTIRetldssndnsliafcdnssairgfesvcrlrpndpttvspmi 288
Cdd:cd02203 1 ELGMFAQMWSEHCRHKSFK------------SLLKMIW------------------------------------------ 26
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 289 aifppsHLIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATgrGAYEIAGTVGYSFGNLNLPGlplpwedetfEYPTSIS 368
Cdd:cd02203 27 ------AVVFKVETHNHPSAIEPFGGAATGVGGIIRDILSM--GARPIALLDGLRFGDLDIPG----------YEPKGKL 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 369 EPAKIAIEASNGASDYGNKFGEPVISGFARSFGQRlengerceYLKPIMFSGGIGAIDKDEVRK-EPCAPHQKVVKIGGP 447
Cdd:cd02203 89 SPRRILDGVVAGISDYGNCIGIPTVGGEVRFDPSY--------YGNPLVNVGCVGIVPKDHIVKsKAPGPGDLVVLVGGR 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 448 VYRIGVGGGAASSVSVQGNRENqLDFAAVQRGDAEMGGKLHRVVRACAERiggNPLMAIHDQGAGGNGNVIKELVE--GC 525
Cdd:cd02203 161 TGRDGIGGATFSSKELSENSSE-LDRPAVQVGDPFMEKKLQEAILEARET---GLIVGIQDLGAGGLSSAVSEMAAkgGL 236
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894769 526 GVTVKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKLLGKsGEIAVDL 603
Cdd:cd02203 237 GAEIDLDKVPLREPGMSPWEIWISESQERMLLVVPPEDLEEFLAICKKEDLEAAVIGEVTDDGRLRLYYK-GEVVADL 313
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN03206 |
PLN03206 |
phosphoribosylformylglycinamidine synthase; Provisional |
26-1323 |
0e+00 |
|
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 178745 [Multi-domain] Cd Length: 1307 Bit Score: 1512.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 26 EKKFNRKIDVSVEYCYHVITQEPeLISSNWEKLVTLLSHSpFE-TSVWKESQL--HPEHGKN---IEIGPRTAVKTAACT 99
Cdd:PLN03206 9 TKVSNDIVSIETEQCFNVGLESP-LSAEKLETLKWLLRET-FEpENLGTESFLeaKKSEGLNavvVEVGPRLSFTTAWST 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 100 NILSIFESSGIKNVERIERGIRYLVE-----DDVDVNEFFEIAADKMTEAIYGNDVKFDDESHQIEKVFLIDVL-ESKQN 173
Cdd:PLN03206 87 NAVSICSACGLTEVTRLERSRRYLLFsssplDESQINAFAAMVHDRMTECVYPQPLTSFESGVVPEPVYTVPVMeEGRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 174 LIKANEELGLALDQLDLDFYYDFFVNKVKKNPTDVELFDLAQSDSEHSRHWFFRGEIWIDDRKRDGSLMKTIRETLDSSN 253
Cdd:PLN03206 167 LEEINKEMGLAFDEQDLDYYTRLFRDDIKRDPTNVELFDIAQSNSEHSRHWFFSGKLVIDGQPMPKTLFQMVKDTLKANP 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 254 DNSLIAFCDNSSAIRGFEsVCRLRPNDPTTVSPMIAIFPPSHLIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATGRGA 333
Cdd:PLN03206 247 NNSVIGFKDNSSAIRGFV-VQPLRPVSPGSPSPLAPVDRDLDILLTAETHNFPCAVAPYPGAETGAGGRIRDTHATGRGS 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 334 YEIAGTVGYSFGNLNLPGLPLPWEDETFEYPTSISEPAKIAIEASNGASDYGNKFGEPVISGFARSFGQRLENGERCEYL 413
Cdd:PLN03206 326 FVVAGTAGYCVGNLRIEGSYAPWEDSSFVYPSNLASPLQILIDASNGASDYGNKFGEPLIQGYTRTFGMRLPNGERREWL 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 414 KPIMFSGGIGAIDKDEVRKEPCAPHQKVVKIGGPVYRIGVGGGAASSVsVQGNRENQLDFAAVQRGDAEMGGKLHRVVRA 493
Cdd:PLN03206 406 KPIMFSGGIGQIDHTHLTKGEPDIGMLVVKIGGPAYRIGMGGGAASSM-VSGQNDAELDFNAVQRGDAEMSQKLYRVVRA 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 494 CAERIGGNPLMAIHDQGAGGNGNVIKELVEGCGVTVKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKR 573
Cdd:PLN03206 485 CVEMGEDNPIVSIHDQGAGGNCNVVKEIIYPKGAEIDIRAVVVGDHTLSVLEIWGAEYQEQDALLIKPESRDLLQSICDR 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 574 EKCHVSVVGEVEKEQRVKLLGKS------------GEIAVDLDTRQ-LGEREKKVFKLKSAPRVLKKLELPENLTVRKAL 640
Cdd:PLN03206 565 ERCSMAVIGTIDGSGRVVLVDSAapekceanglppPPPAVDLDLEKvLGDMPQKTFEFKRVANKLEPLDIPPGITVMDAL 644
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 641 KRVLMLPSVASKRYLTCKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSHFDTVGGAVSLGEQPIKMLIDAEKGARMCIA 720
Cdd:PLN03206 645 KRVLRLPSVCSKRFLTTKVDRCVTGLVAQQQTVGPLQIPLADVAVIAQTHTGLTGGACAIGEQPIKGLVDPKAMARLAVG 724
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 721 ETIMNLIWAPITDLKDVKMSGNWMWAAKCDGEGARLVDAVGALCRGLREIGCAIDGGKDSLSMAVTAHGEVVKSPGTLVL 800
Cdd:PLN03206 725 EALTNLVWAKVTALSDVKASGNWMYAAKLDGEGADMYDAAVALRDAMIELGVAIDGGKDSLSMAAQAGGEVVKAPGNLVI 804
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 801 SAYAPCTNVTKVVNPSLKAVPGSKILWIKIGSSeeKMRLGGSALAQVYSQIGDDCPDIENFSEISKVFSIVQQLlnreel 880
Cdd:PLN03206 805 SAYVTCPDITKTVTPDLKLGDDGVLLHVDLGKG--KRRLGGSALAQAYDQIGDDCPDLDDVAYLKKAFEATQDL------ 876
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 881 agpLRKPIILAGHDISDGGLLTAILEMAFAGNVSIDIDIkpPNQNIKPIDILFAEECGILLEVS--NPENVLHIFSEAGI 958
Cdd:PLN03206 877 ---IAKRLISAGHDISDGGLVVTLLEMAFAGNCGINVDL--PSSGHSAFETLFAEELGLVLEVSrkNLDAVMEKLAAAGV 951
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 959 KCQEIGKASAvfGPDAHVKihVNGHLEINEKLVDLREEWELVGDRLGEFQTNPKSLKEAREVRRTCQKINYKCDFdwyyN 1038
Cdd:PLN03206 952 TAEVIGQVTA--SPLIEVK--VDGATCLSEKTASLRDMWEETSFQLEKLQRLESCVAQEKEGLKSRKAPTWKLSF----T 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1039 PAFIhNEQYFSTA--PRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGH-TLEAYRGVAFVGGFSYADVLGSAK 1115
Cdd:PLN03206 1024 PAFT-DKKIMNATskPKVAIIREEGSNGDREMAAAFYAAGFEPWDVTMSDLLNGRiSLDDFRGIVFVGGFSYADVLDSAK 1102
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1116 GWAAGVQFNESVSKQFEAFRSRPDTFSYGVCNGCQLMAQLGWI------------GDEEQkgPTvFLdENECGRFDSSFG 1183
Cdd:PLN03206 1103 GWAGSIRFNEPLLQQFQEFYNRPDTFSLGVCNGCQLMALLGWVpgpqvggglgagGDPSQ--PR-FV-HNESGRFECRFT 1178
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1184 PVKIEKNVSIMLSGMENSVLGLWSSHGEGRFTYRNLQNFQNLKTNGQVCIRFCDdrgmtgaDHGSVKLPYPWNPNGSIDD 1263
Cdd:PLN03206 1179 SVTIEDSPAIMLKGMEGSTLGVWAAHGEGRAYFPDESVLDEVLKSNLAPVRYCD-------DDGEPTEQYPFNPNGSPLG 1251
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392894769 1264 VAAICSRDGRHLAMMPHADRSFLTWQWaessevPWN-ARFDQKTVALSPWIKMFRNAYNWC 1323
Cdd:PLN03206 1252 IAALCSPDGRHLAMMPHPERCFLMWQF------PWYpKEWGVDPAGPSPWLKMFQNAREWC 1306
|
|
| FGAM_synt |
TIGR01735 |
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a ... |
10-1322 |
0e+00 |
|
phosphoribosylformylglycinamidine synthase, single chain form; This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 188163 [Multi-domain] Cd Length: 1310 Bit Score: 1325.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 10 AKAVESRKLDQIQKDFEKKFNRKIDVSVEYCYHViTQEPELISSNWEKLVTLLSH-SPFETSV-WKESQLhpehgknIEI 87
Cdd:TIGR01735 5 PSALSGFRLEKLLQKLQTKVPELTGVYAEFCYFV-GWESALTADEEEKLQLLLLAgSVLEPPQsPLGRGL-------LEV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 88 GPRTAVKTAACTNILSIFESSGIKNVERIERGIRYLVEDDVDVNE--FFEIAA---DKMTEAIYGN-DVKFDDESHQIEK 161
Cdd:TIGR01735 77 GPRLGTISPWSSKATSIARNCGLAKVDRIERGRRYYLSGAHPLSEeqEAQAAAllhDRMTESVLPHeIEAFELFSVPEPL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 162 VFL-IDVL-ESKQNLIKANEELGLALDQLDLDFYYDFFvNKVKKNPTDVELFDLAQSDSEHSRHWFFRGEIWIDDRKRDG 239
Cdd:TIGR01735 157 NLTtIDVLgGGRLALEKANQELGLALDEDEIDYLTKRF-QELQRNPSDVELMMFAQANSEHCRHKIFNADWIIDGKKQDK 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 240 SLMKTIRETLDSSNDNSLIAFCDNSSAIRGFEsVCRLRPNDPTTVSPMIAIFPPSHLIYSAETHNFPTAVCPFQGATTGT 319
Cdd:TIGR01735 236 SLFQMIKSTHEANPENTVSAYKDNSSVIEGHK-VGRLRPDPPTRPEYRQHQEDLVHILMKVETHNHPTAIAPFPGASTGA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 320 GGRIRDIHATGRGAYEIAGTVGYSFGNLNLPGLPLPWEDeTFEYPTSISEPAKIAIEASNGASDYGNKFGEPVISGFARS 399
Cdd:TIGR01735 315 GGEIRDEGATGRGAKPKAGLTGFCVSNLNIPGLEQPWED-PFQKPERIASPLDIMIEAPLGAAAFNNEFGRPNLLGYFRT 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 400 FGQR--LENGERCEYLKPIMFSGGIGAIDKDEVRKEPCAPHQKVVKIGGPVYRIGVGGGAASSVsVQGNRENQLDFAAVQ 477
Cdd:TIGR01735 394 FELKasLPGGQVRGYHKPIMLAGGIGSIDAEHIQKGEIEPGALLIVLGGPAMLIGLGGGAASSM-VSGTNTADLDFASVQ 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 478 RGDAEMGGKLHRVVRACAERIGGNPLMAIHDQGAGGNGNVIKELVEGCGVTVKSDT--FQLGDESISLRELWTAEYQEND 555
Cdd:TIGR01735 473 RGNPEMERRCQEVIDRCWQLGEKNPIISIHDVGAGGLSNALPELIHDGGRGAVIDLraVPLDDPGLSPLEIWCNESQERY 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 556 AALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKL--------LGKSGEI------AVDLDTRQ-LGEREKKVFKLKS 620
Cdd:TIGR01735 553 VLLVRAENLEIFTAICERERCPFAVVGTATGDGRLTLvddtpvrrNGQGDAPshfpnnPVDLPLEVlLGKMPKMTRFVQR 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 621 APRVLKKLELPENLTVRKALKRVLMLPSVASKRYLTCKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSHFDTVGGAVSL 700
Cdd:TIGR01735 633 KAPMLQPLDIPPGLDLHEALERVLRLPAVASKRFLITIGDRSVGGLVARDQMVGPWQTPLADVAVTAASFDTYTGEAMAI 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 701 GEQPIKMLIDAEKGARMCIAETIMNLIWAPITDLKDVKMSGNWMWAAKCDGEGARLVDAVGALCRGLREIGCAIDGGKDS 780
Cdd:TIGR01735 713 GERPPKALLDPKASARLAVGEAITNLAAALVGDLSDVKLSANWMAAAGHPGEDAALYDAVKAVSELCPALGIAIPVGKDS 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 781 LSMAVTAHG----EVVKSPGTLVLSAYAPCTNVTKVVNPSLKAVPGSKILWIkIGSSEEKMRLGGSALAQVYSQIGDDCP 856
Cdd:TIGR01735 793 LSMKTRWQDngetKSVTAPGSLVISAFAPVPDVRKTVTPDLKHDKGDSHLLL-VDLGPGKNRLGGSALAQVFGQLGGDCP 871
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 857 DIENFSEISKVFSIVQQLLNREELagplrkpiiLAGHDISDGGLLTAILEMAFAGNVSIDIDIKPPNQNIKPIdiLFAEE 936
Cdd:TIGR01735 872 DLDDPERLKAFFAVMQGLVAEGLL---------LAYHDRSDGGLVTTLLEMAFAGHCGLDVDLDALGDSLFAV--LFNEE 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 937 CGILLEVSNP--ENVLHIFSEAGIKCQEIGKASAVFGPDahVKIHVNGHLEINEKLVDLREEWELVGDRLGEFQTNPKSL 1014
Cdd:TIGR01735 941 LGAVIQVAKPdlAAVLELLRAAGLTALILGIGTPTGHPM--IRISVNGATLLSEKRSELRDIWEETSFQLQRLRDNPECA 1018
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1015 KEAREVRRTCQKINYKCDFDwyYNPAFIHNEQYFSTA--PRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGH- 1091
Cdd:TIGR01735 1019 EEEFEGLRDRDGPGLKLPLT--FDVNEDIAAPFINKGvkPKVAILREQGVNGDREMAAAFDRAGFEAWDVHMSDLLAGRv 1096
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1092 TLEAYRGVAFVGGFSYADVLGSAKGWAAGVQFNESVSKQFEAFRSRPDTFSYGVCNGCQLMAQL-GWIGDEEQKGPTVfl 1170
Cdd:TIGR01735 1097 HLDEFRGLAACGGFSYGDVLGAGKGWAKSILFNPRLRDQFQAFFKRPDTFSLGVCNGCQMLSNLlEWIPGTENWPHFV-- 1174
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1171 dENECGRFDSSFGPVKIEKNVSIMLSGMENSVLGLWSSHGEGRFTYRNLQNFQNLKTNGQVCIRFCDdrgmtgaDHGSVK 1250
Cdd:TIGR01735 1175 -RNNSERFEARVASVRVGESPSIMLRGMAGSRLPVAVAHGEGYAAFSSPELQAQADASGLAALRYID-------DDGNPT 1246
|
1290 1300 1310 1320 1330 1340 1350
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392894769 1251 LPYPWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLTWQWAESSEvPWNarfdqktvALSPWIKMFRNAYNW 1322
Cdd:TIGR01735 1247 EAYPLNPNGSPGGIAGITSCDGRVTIMMPHPERVFRAWQNSWRPE-DWD--------EDTPWLRLFRNARNW 1309
|
|
| PRK05297 |
PRK05297 |
phosphoribosylformylglycinamidine synthase; Provisional |
10-1323 |
0e+00 |
|
phosphoribosylformylglycinamidine synthase; Provisional
Pssm-ID: 235394 [Multi-domain] Cd Length: 1290 Bit Score: 1239.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 10 AKAVESRKLDQIQKDFEKKFNRKIDVSVEYCYHVITQEPeLISSNWEKLVTLLSHSPFEtsvwkesqlHPEHGKNIEIGP 89
Cdd:PRK05297 7 SPALSAFRLQKLLARLQAAVLPVTSIYAEYVHFADLSAP-LSAEEQAKLERLLTYGPAE---------HEPAGRLFLVTP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 90 RTAVKTAACTNILSIFESSGIKNVERIERGIRYLVEDDVDVNEFFEIAA---DKMTEAIYGNdvkFDDES-----HQIEK 161
Cdd:PRK05297 77 RPGTISPWSSKATDIAHNCGLAGIRRIERGIAYYVEAALSAEQRAALAAllhDRMTESVFAD---LDDAEalfshHEPKP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 162 VFLIDVL-ESKQNLIKANEELGLALDQLDLDFYYDFFvNKVKKNPTDVELFDLAQSDSEHSRHWFFRGEIWIDDRKRDGS 240
Cdd:PRK05297 154 LTSVDVLgGGRAALEAANVELGLALAEDEIDYLVEAF-TKLGRNPTDVELMMFAQANSEHCRHKIFNADWTIDGEEQPKS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 241 LMKTIRETLDSSNDNSLIAFCDNSSAIRGFEsVCRLRPNDPTtvsPMIAIFP-PSHLIYSAETHNFPTAVCPFQGATTGT 319
Cdd:PRK05297 233 LFKMIKNTHETNPDGVLSAYKDNAAVMEGSK-VGRFFPDPDT---GRYGYHQePAHILMKVETHNHPTAISPFPGAATGS 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 320 GGRIRDIHATGRGAYEIAGTVGYSFGNLNLPGLPLPWEDEtFEYPTSISEPAKIAIEASNGASDYGNKFGEPVISGFARS 399
Cdd:PRK05297 309 GGEIRDEGATGRGSKPKAGLTGFSVSNLRIPGFEQPWEED-YGKPERIASALDIMIEGPLGGAAFNNEFGRPNLLGYFRT 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 400 FGQRLENG--ERCEYLKPIMFSGGIGAIDKDEVRKEPCAPHQKVVKIGGPVYRIGVGGGAASSVsVQGNRENQLDFAAVQ 477
Cdd:PRK05297 388 FEQKVNSHneEVRGYHKPIMLAGGIGNIRADHVQKGEIPVGAKLIVLGGPAMRIGLGGGAASSM-ASGQSSEDLDFASVQ 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 478 RGDAEMGGKLHRVVRACAERIGGNPLMAIHDQGAGGNGNVIKELVEGCGVTVKsdtFQL-----GDESISLRELWTAEYQ 552
Cdd:PRK05297 467 RGNPEMERRCQEVIDRCWQLGDDNPILSIHDVGAGGLSNAFPELVNDGGRGGR---FDLrkipnDEPGMSPLEIWCNESQ 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 553 ENDAALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKLL-GKSGEIAVDLDTRQL-GEREKKVFKLKSAPRVLKKLEL 630
Cdd:PRK05297 544 ERYVLAIAPEDLELFEAICERERCPFAVVGEATEERHLTLEdSHFDNKPVDLPLDVLlGKPPKMHRDVKTVKAKGPALDY 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 631 pENLTVRKALKRVLMLPSVASKRYLTCKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSHFDTVGGAVSLGEQPIKMLID 710
Cdd:PRK05297 624 -SGIDLAEAVERVLRLPTVASKSFLITIGDRSVTGLVARDQMVGPWQVPVADCAVTAASYDGYAGEAMAMGERTPVALLD 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 711 AEKGARMCIAETIMNLIWAPITDLKDVKMSGNWMWAAKCDGEGARLVDAVGA----LCRGLreiGCAIDGGKDSLSM--A 784
Cdd:PRK05297 703 AAASARMAVGEALTNIAAAPIGDLKRIKLSANWMAAAGHPGEDARLYDAVKAvgmeLCPAL---GITIPVGKDSLSMktK 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 785 VTAHGE--VVKSPGTLVLSAYAPCTNVTKVVNPSLKAVPGSKILWIKIGSSeeKMRLGGSALAQVYSQIGDDCPDIENFS 862
Cdd:PRK05297 780 WQEGGEdkEVTSPLSLIISAFAPVEDVRKTLTPQLRTDKDTALLLIDLGRG--KNRLGGSALAQVYNQLGDKAPDVDDAE 857
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 863 EISKVFSIVQQlLNREELagplrkpiILAGHDISDGGLLTAILEMAFAGNVSIDIDIKPPNQNIkpIDILFAEECGILLE 942
Cdd:PRK05297 858 DLKGFFNAIQA-LVAEGL--------LLAYHDRSDGGLLTTLAEMAFAGHCGLDIDLDALGDDA--LAALFNEELGAVIQ 926
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 943 VSNP--ENVLHIFSEAGIK--CQEIGKASavfgPDAHVKIHVNGHLEINEKLVDLREEWELVGDRLGEFQTNPKSLKEAR 1018
Cdd:PRK05297 927 VRAAdrDAVEAILAEHGLSdcVHVIGKPN----AGDRIVITRNGKTVFSESRTELRRWWSETSYQMQRLRDNPECADQEF 1002
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1019 EVR--RTCQKINYKCDFDwyYNPAFIhnEQYFSTA--PRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAG-HTL 1093
Cdd:PRK05297 1003 DAIldQADPGLNVKLTFD--PNEDIA--APFIATGarPKVAILREQGVNSHVEMAAAFDRAGFDAIDVHMSDLLAGrVTL 1078
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1094 EAYRGVAFVGGFSYADVLGSAKGWAAGVQFNESVSKQFEAFRSRPDTFSYGVCNGCQLMAQLGWIGDEEQKGPTvFLdEN 1173
Cdd:PRK05297 1079 EDFKGLVACGGFSYGDVLGAGEGWAKSILFNPRLRDQFEAFFARPDTFALGVCNGCQMMSNLKEIIPGAEHWPR-FV-RN 1156
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1174 ECGRFDSSFGPVKIEKNVSIMLSGMENSVLGLWSSHGEGRFTYRNlQNFQNLKTNGQVCIRFCDDRGMtGADHgsvklpY 1253
Cdd:PRK05297 1157 RSEQFEARFSLVEVQESPSIFLQGMAGSRLPIAVAHGEGRAEFPD-AHLAALEAKGLVALRYVDNHGQ-VTET------Y 1228
|
1290 1300 1310 1320 1330 1340 1350
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392894769 1254 PWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLTWQWA----ESSEVpwnarfdqktvalSPWIKMFRNAYNWC 1323
Cdd:PRK05297 1229 PANPNGSPNGITGLTTADGRVTIMMPHPERVFRTVQNSwhpeEWGED-------------SPWMRMFRNARKWV 1289
|
|
| PurL1 |
COG0046 |
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and ... |
165-998 |
0e+00 |
|
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439816 [Multi-domain] Cd Length: 747 Bit Score: 588.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 165 IDVLESKQNLIKANEELGLALDQLDldfyYDFFVNKVKKNPTDVELFDLAQSDSEHSRHWFFRGEIwiddrkrdgslmkt 244
Cdd:COG0046 4 VDLEGGREALEEANRELGLALSDDE----YDYIVEILGRNPTDVELGMFSQMWSEHCSYKSSNALL-------------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 245 irETLDSSNDNSLIAFCDNSSAIRGFEsvcrlrpndpttvspmiaifpPSHLIYSAETHNFPTAVCPFQGATTGTGGRIR 324
Cdd:COG0046 66 --KSLPTEGPRVLSGPGDNAGVVDIGD---------------------GLAVVFKVESHNHPSAIEPYQGAATGVGGIIR 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 325 DIHatGRGAYEIAGTVGYSFGNLNLPGLplpwedetfeyptsisEPAKIAIEASNGASDYGNKFGEPVISGFARSFGQrl 404
Cdd:COG0046 123 DIF--GMGARPIAGLDSLRFGNLDQPPA----------------SPRYILIGVVAGIADYGNCFGVPTVGGEVRFDES-- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 405 ENGerceylKPIMFSGGIGAIDKDEVRK-EPCAPHQKVVKIGGPVYRIGVGGGAASSVSVqgNRENQLDFAAVQRGDAEM 483
Cdd:COG0046 183 YEG------NPLVNAGGVGIIRADHIFKaKAPGVGNKVVYVGGPTGRDGIGGATFASEEL--GEDSELDRPAVQVGDPFM 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 484 GGKLHRVVRACAERiggNPLMAIHDQGAGGNGNVIKELVE--GCGVTVKSDTFQLGDESISLRELWTAEYQENDAALVDA 561
Cdd:COG0046 255 EKRLIEAILELGDT---GLIVGIQDMGAGGLSSASSEMAAkgGLGAEIDLDKVPLREPGMSPYEIWLSESQERMLLVVKP 331
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 562 SLLDALQTISKREKCHVSVVGEVEKEQRVKLLGKsGEIAVDLDTRQLGE------REKKvfklksAPRVLKKLELPENLT 635
Cdd:COG0046 332 EKLEEFEAIFERWRLPAAVIGEVTDDGRLVVTDH-GETVADLPLDFLAGgapkyhRPAK------RPAYLEPLDLPEPID 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 636 VRKALKRVLMLPSVASKRYLTCKVDRSVTGLVAQQQcvgplhtPLADVAVVALSHfDTVGGAVSLGEQPIKMLIDAEKGA 715
Cdd:COG0046 405 LEEALLRLLSSPNVASKEWLYRQYDREVGGNTVRDP-------GVADAAVVRVDG-TYKGLAMSTGENPRYALLDPYAGA 476
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 716 RMCIAETIMNLIWAPITDLkDVKMSGNWMWAAKcDGEGARLVDAV---GALCRGLreiGCAIDGGKDSLSMavTAHGEVV 792
Cdd:COG0046 477 RMAVAEAARNLAAVGAEPL-AITDCLNWGNPEK-PEEMAQLVEAVkglADACRAL---GIPVPSGNVSLYN--ETKDGKV 549
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 793 KSPGTLVLSAYAPCTNVTKVVNPSLKAvPGSKILWIkigsSEEKMRLGGSALAQVYSQIGDDCPDIeNFSEISKVFSIVQ 872
Cdd:COG0046 550 AIPPTPVIGAVGLVDDVRKTVTPDLKK-EGDLLYLI----GETKNELGGSEYAQVLGQLGGEPPDV-DLEAEKALFEAVQ 623
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 873 QlLNREELagplrkpiILAGHDISDGGLLTAILEMAFAGNVSIDIDIkPPNQNIKPIDILFAEECG-ILLEVSNP--ENV 949
Cdd:COG0046 624 E-LIREGL--------ILAAHDVSDGGLAVALAEMAFAGGLGADIDL-DALGDLRPDAALFSESQGrAVVQVAPEdaEAV 693
|
810 820 830 840
....*....|....*....|....*....|....*....|....*....
gi 392894769 950 LHIFSEAGIKCQEIGKAsavfGPDAHVKIHVNGHLEINEKLVDLREEWE 998
Cdd:COG0046 694 EALLAEAGLPAHVIGTV----TGDDRLVIRRGGETLLSLSLAELRDAWE 738
|
|
| GATase_5 |
pfam13507 |
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not ... |
1052-1323 |
1.27e-121 |
|
CobB/CobQ-like glutamine amidotransferase domain; This family captures members that are not found in pfam00310, pfam07685 and pfam13230.
Pssm-ID: 463904 [Multi-domain] Cd Length: 260 Bit Score: 378.00 E-value: 1.27e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1052 PRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGH-TLEAYRGVAFVGGFSYADVLGSAKGWAAGVQFNESVSKQ 1130
Cdd:pfam13507 2 PRVAILREPGTNGEYEMAAAFERAGFDAVDVHMSDLLSGRvSLDDFQGLAAPGGFSYGDVLGSGKGWAASILFNPKLRDA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1131 FEAFRSRPDTFSYGVCNGCQLMAQLGWI--GDEEQKGPTVFLDENECGRFDSSFGPVKI-EKNVSIMLSGMEnsVLGLWS 1207
Cdd:pfam13507 82 FEAFFNRPDTFSLGICNGCQLLSKLGLIpgGEGDLAERWPTLTRNDSGRFESRWVNVKIsEKSPSVFLRGMD--GSGLPV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1208 SHGEGRFTYRNLQNFQNLKTNGQVCIRFCDdrgmtgaDHGSVKLPYPWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLT 1287
Cdd:pfam13507 160 AHGEGRFVFRSEEVLARLEANGQVALRYVD-------NAGNPTEEYPFNPNGSPLGIAGICSPDGRVLGLMPHPERVFRP 232
|
250 260 270
....*....|....*....|....*....|....*.
gi 392894769 1288 WQWaessevPWNARFDQKTValSPWIKMFRNAYNWC 1323
Cdd:pfam13507 233 WQW------PHWPPGEWEEV--SPWLRLFRNARKWV 260
|
|
| PurL_repeat1 |
cd02203 |
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. ... |
209-603 |
1.99e-110 |
|
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100034 [Multi-domain] Cd Length: 313 Bit Score: 349.85 E-value: 1.99e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 209 ELFDLAQSDSEHSRHWFFRgeiwiddrkrdgSLMKTIRetldssndnsliafcdnssairgfesvcrlrpndpttvspmi 288
Cdd:cd02203 1 ELGMFAQMWSEHCRHKSFK------------SLLKMIW------------------------------------------ 26
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 289 aifppsHLIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATgrGAYEIAGTVGYSFGNLNLPGlplpwedetfEYPTSIS 368
Cdd:cd02203 27 ------AVVFKVETHNHPSAIEPFGGAATGVGGIIRDILSM--GARPIALLDGLRFGDLDIPG----------YEPKGKL 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 369 EPAKIAIEASNGASDYGNKFGEPVISGFARSFGQRlengerceYLKPIMFSGGIGAIDKDEVRK-EPCAPHQKVVKIGGP 447
Cdd:cd02203 89 SPRRILDGVVAGISDYGNCIGIPTVGGEVRFDPSY--------YGNPLVNVGCVGIVPKDHIVKsKAPGPGDLVVLVGGR 160
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 448 VYRIGVGGGAASSVSVQGNRENqLDFAAVQRGDAEMGGKLHRVVRACAERiggNPLMAIHDQGAGGNGNVIKELVE--GC 525
Cdd:cd02203 161 TGRDGIGGATFSSKELSENSSE-LDRPAVQVGDPFMEKKLQEAILEARET---GLIVGIQDLGAGGLSSAVSEMAAkgGL 236
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894769 526 GVTVKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKLLGKsGEIAVDL 603
Cdd:cd02203 237 GAEIDLDKVPLREPGMSPWEIWISESQERMLLVVPPEDLEEFLAICKKEDLEAAVIGEVTDDGRLRLYYK-GEVVADL 313
|
|
| PHA03366 |
PHA03366 |
FGAM-synthase; Provisional |
564-1324 |
5.67e-93 |
|
FGAM-synthase; Provisional
Pssm-ID: 223058 [Multi-domain] Cd Length: 1304 Bit Score: 328.14 E-value: 5.67e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 564 LDALQTISKREKCHVSVVGE-VEKeqrvkllgKSGEIAVDLDTRQLGEREKKVFKLKS--------APRVLKKLELPEN- 633
Cdd:PHA03366 507 LDALKRACRLAGCPVHILGRtVPL--------PGIHFVNDLGNPVYGELRDDQFKPTFplqpsrplSPVSATSEDTRPSp 578
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 634 ---------LTVRKALKRVLMLPSVASKRYLTCKVDRSVTGLVAQQQCVGPLHTPLADVAVVALSHFDT----------- 693
Cdd:PHA03366 579 qdesidwalFNLNSTLLQILSHPTVGSKEYIVRHIDRCGNGRVAQQPGVGPLDLPVSDYSIVVHSSVKTrraietpsste 658
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 694 ------------------------------VGGAVSLGEQPIKMLIDAEKGARMCIAETIMNLIWAPITDLKDVKMSGNW 743
Cdd:PHA03366 659 dltyqeadelinspltwfdpddesvlhpavPGTCSALGEQGYKVQLDPILGAKYAIVEALTNLMLAPVANLEDITITLSV 738
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 744 MWaakcdGEGA-------RLVDAVGALCRGLReIGCAIDGGKDSlsmaVTAHGEVVKSPG--TLVLSAYAPCTNVTKVVN 814
Cdd:PHA03366 739 TW-----PPTDqaaselyRALAACKEFCRELG-VNFTFTSASSS----PRQDQPPQPGPLfnTIVFTASAPVPSSTPRLT 808
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 815 PSLKAvPGSKILWIKIGSseeKMRLGGSALAQVYSQIGDDCPDIENfSEISKVFSIVQQLLNREelagplrkpIILAGHD 894
Cdd:PHA03366 809 PDLKK-PGSALVHLSISP---EYTLAGSVFEQIFGLKSGTLPDISP-SYLKNLFRAVQHLISEG---------LVVSGHD 874
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 895 ISDGGLLTAILEMAFAGNVSIDIDIkPPNQNikPIDILFAEECGILLEV--SNPENVLHIFSEAGIKCQEIGKASAVfGP 972
Cdd:PHA03366 875 VSDGGLIACLAEMALAGGRGVTITV-PAGED--PLQFLFSETPGVVIEVppSHLSAVLTRLRSRNIICYPIGTVGPS-GP 950
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 973 DAHVKIHVNGHLEINEKLVDLREEWELVGDRLGEFQTNPKSLKEArevrrtcqkinYKCDfdwYYNPA--FIHNEQYFST 1050
Cdd:PHA03366 951 SNTFSVSHNGTVLFRESLSSLRSTWRSFSDEQFELLRPDLTEESM-----------YRKD---YGNNEvdLGPLEEGLTT 1016
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1051 AP-----------RVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGHTLEAYRGVAFVGGFSYADVLGSAKGWAA 1119
Cdd:PHA03366 1017 SPlrlytcpdkrhRVAVLLLPGCPGPHALLAAFTNAGFDPYPVSIEELKDGTFLDEFSGLVIGGSSGAEDSYTGARAAVA 1096
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1120 GVQFNESVSKQFEAFRSRPDTFSYGVCN-GCQLMAQLGWIGDEEQKGP---------TVFLDENECGRFDSSFGPVKI-E 1188
Cdd:PHA03366 1097 ALLSNPAVRDALLRFLNRPDTFSLGCGElGCQILFALKAVGSTAPSPVpgteteeqwPITLEPNASGLYESRWLNFYIpE 1176
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1189 KNVSIMLSGMENSVLGLWS--SH-GegrFTYRNLQNFQNLKTNGQVCIRFcddrgmtgadHGSVKLP------YPWNPNG 1259
Cdd:PHA03366 1177 TTKSVALRPLRGSVLPCWAqgTHlG---FRYPNDGMEYILRNSGQIAATF----------HGADVDPgnparhYPRNPTG 1243
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392894769 1260 SiDDVAAICSRDGRHLAMMPHADRSFLTWQWAessEVPwnarFDQKTVALSPWIKMFRNAYNWCL 1324
Cdd:PHA03366 1244 N-SNVAGLCSADGRHLALLFDPSLSFHPWQWQ---HVP----PENGPLKVSPWKLMFQDLHLWCL 1300
|
|
| GATase1_FGAR_AT |
cd01740 |
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ... |
1054-1320 |
4.69e-90 |
|
Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT). FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. FGAR-AT is a glutamine amidotransferase. Glutamine amidotransferase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. FGAR-AT belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site
Pssm-ID: 153211 [Multi-domain] Cd Length: 238 Bit Score: 291.06 E-value: 4.69e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1054 VAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAG-HTLEAYRGVAFVGGFSYADVLGSAKGWAAGVQFNESVskqfe 1132
Cdd:cd01740 1 VAVLRFPGSNCDRDMAYAFELAGFEAEDVWHNDLLAGrKDLDDYDGVVLPGGFSYGDYLRAGAIAAASPLLMEEV----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1133 AFRSRPDTFSYGVCNGCQLMAQLGWIGDEEQKGPTVFLDENECGRFdssfGPVKIEKNVSIMLSG-MENSVLGLWSSHGE 1211
Cdd:cd01740 76 KEFAERGGLVLGICNGFQILVELGLLPGALIRNKGLKFICRWQNRF----VTLRVENNDSPFTKGyMEGEVLRIPVAHGE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1212 GRFTYRNlQNFQNLKTNGQVcIRFCDDrgmtgadHGSVKLPYPWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLTWQWA 1291
Cdd:cd01740 152 GRFYADD-ETLAELEENGQI-AQYVDD-------DGNVTERYPANPNGSLDGIAGICNEDGRVLGMMPHPERAVEPWQWE 222
|
250 260
....*....|....*....|....*....
gi 392894769 1292 ESSEVpwnarfdqktvalSPWIKMFRNAY 1320
Cdd:cd01740 223 RLLGG-------------SDGLKLFRNAV 238
|
|
| PurL_repeat2 |
cd02204 |
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. ... |
682-965 |
1.45e-74 |
|
PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100035 [Multi-domain] Cd Length: 264 Bit Score: 248.60 E-value: 1.45e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 682 DVAVVALSHFDTVGGAVSLGEQPIKMLIDAEKGARMCIAETIMNLIWAPITDLkDVKMSGNWMWAAKCDGEGARLVDAVG 761
Cdd:cd02204 1 DAAVLRIPGETDKGLAMSTGENPRYSLLDPYAGAALAVAEAVRNLVAVGADPL-AITDCLNFGNPEKPEGEMGQLVEAVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 762 ALCRGLREIGCAIDGGKDSLSMAVtahgEVVKSPGTLVLSAYAPCTNVTKVVNPSLKAvPGSKILWikIGSSEEKMRLGG 841
Cdd:cd02204 80 GLGDACRALGTPVIGGKDSLYNET----EGVAIPPTLVIGAVGVVDDVRKIVTLDFKK-EGDLLYL--IGETKDELGGSE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 842 SALAqvYSQIGDDCPDIENFSEISKVFSIVQQLLNREelagplrkpIILAGHDISDGGLLTAILEMAFAGNVSIDIDIKP 921
Cdd:cd02204 153 YALA--YHGLGGGAPPLVDLEREKALFDAVQELIKEG---------LVLSAHDVSDGGLAVALAEMAFAGGLGAEVDLSK 221
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 392894769 922 PNqniKPIDILFAEECGILLEVSNPENVLHI-FSEAGIKCQEIGK 965
Cdd:cd02204 222 DD---AEDELLFSESLGRVLVEVKPENEEVFeAEEAGVPATVIGT 263
|
|
| PurL2 |
COG0047 |
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain ... |
1052-1323 |
3.91e-70 |
|
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain is part of the Pathway/BioSystem: Purine biosynthesis
Pssm-ID: 439817 [Multi-domain] Cd Length: 236 Bit Score: 234.95 E-value: 3.91e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1052 PRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILagHTLEAYRGVAFVGGFSYADVLGSAKGWAAgvqfnESVSKQF 1131
Cdd:COG0047 1 PKVAILVFPGSNCDRDMAAAFERAGAEAEDVWHSDLR--TDLDDFDGLVLPGGFSYGDYLRAGAIAAF-----SPIMDAV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1132 EAFrSRPDTFSYGVCNGCQLMAQLGWIgdeeqKGPTVFLDENECGRFDSSFGPVKIEKNVSIMLSGME-NSVLGLWSSHG 1210
Cdd:COG0047 74 REF-ARRGGLVLGICNGFQILTELGLL-----PGIWPALTRNRSLRFICRWVYLRVENNDSPFTSGMEaGEVIPIPIAHG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1211 EGRFtYRNLQNFQNLKTNGQVCIRFCDDRGmtgadhgsvKLPYPWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLTWQw 1290
Cdd:COG0047 148 EGRY-VADEETLAELEANGQVAFRYVDADG---------NVTYPANPNGSLNNIAGITNEDGNVLGMMPHPERAVEPLL- 216
|
250 260 270
....*....|....*....|....*....|...
gi 392894769 1291 aesseVPWNArfdqktvalSPWIKMFRNAYNWC 1323
Cdd:COG0047 217 -----GPGES---------TDGLRIFRSAVKYF 235
|
|
| FGAM_synth_II |
TIGR01736 |
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a ... |
194-998 |
1.93e-52 |
|
phosphoribosylformylglycinamidine synthase II; Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273781 [Multi-domain] Cd Length: 715 Bit Score: 197.52 E-value: 1.93e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 194 YDFFVNKVKKNPTDVELFDLAQSDSEH-----SRHWFfrgeiwiddrkrdgslmktirETLDSSNDNSLIAFCDNSSAIR 268
Cdd:TIGR01736 6 MELIREILGREPNDTELAMFSAMWSEHcsyksSKKLL---------------------KQFPTKGPNVIQGPGEDAGVVD 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 269 GFESVCrlrpndpttvspmiaifppshLIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATGrgAYEIAGTVGYSFGNLn 348
Cdd:TIGR01736 65 IGDGYA---------------------VVFKMESHNHPSAIEPYNGAATGVGGILRDILSMG--ARPIALLDSLRFGPL- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 349 lpglplpwEDETFEYptsisepakIAIEASNGASDYGNKFGEPVISG---FARSFgqrleNGerceylKPIMFSGGIGAI 425
Cdd:TIGR01736 121 --------DDPKNRY---------LFEGVVAGISDYGNRIGVPTVGGeveFDESY-----NG------NPLVNVMCVGLV 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 426 DKDEV---RKEPcaPHQKVVKIGGPVYRIGVGGGAASSVSVQGNRENQlDFAAVQRGDAEMGGKLhrvVRACAERIGGNP 502
Cdd:TIGR01736 173 RKDDIvtgKAKG--PGNKLVLVGGKTGRDGIGGATFASEELSEEAEEE-DRPAVQVGDPFTEKLL---IEATLEAVDTGL 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 503 LMAIHDQGAGGNGNVIKELVE--GCGVTVKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSV 580
Cdd:TIGR01736 247 VKGIKDLGAAGLTSASSEMAAkgGLGAEIYLDKVPLREPGMTPYEIMLSESQERMLLVVAPEDVEEVLEIFEKYELPASV 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 581 VGEVEKEQRVKLLGKsGEIAVDLDTRQLGE-----REKKVFKLKSAPRVLKKLElpenlTVRKALKRVLMLPSVASKRYL 655
Cdd:TIGR01736 327 IGEVTDEGRIRLYYK-GEVVADLPIELLADapeyeRPSEPPKYPEEEKEPEPPA-----DLEDAFLKVLSSPNIASKEWV 400
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 656 TCKVDRSVTGLVAQqqcvgplhTPLADVAVVALSHFDTVGGAVSLGEQPIKMLIDAEKGARMCIAETIMNLIWA---P-- 730
Cdd:TIGR01736 401 YRQYDHEVQTRTVV--------KPGEDAAVLRIKETGKLGLALTADCNPRYVYLDPYAGAAGAVAEAYRNLAAVgaePla 472
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 731 ITDLKDVkmsGN-----WMWaakcdgegaRLVDAVGALCRGLREIGCAIDGGKDSLsmavtaHGEVVKSP--GTLVLSAY 803
Cdd:TIGR01736 473 AVDCLNF---GNperpeVYW---------QFVEAVKGLGDACRALGTPVVGGNVSL------YNETNGVPiaPTPTIGMV 534
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 804 APCTNVTKVVNPSLKAVPGSKILWikigsSEEKMRLGGSALAQVYSQIGDDCPDIENFSEiskvfsivqQLLNREELAGP 883
Cdd:TIGR01736 535 GLVEDVEKLLTSNFKKEGDAIYLI-----GETKDELGGSEYLRVIHGIVSGQVPAVDLEE---------EKELADAVREA 600
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 884 LRKPIILAGHDISDGGLLTAILEMAFAGNVSIDIDIKPPNqNIKPIDILFAEECG-ILLEVSNPENVLHIFSeAGIKCQE 962
Cdd:TIGR01736 601 IRAGLVSAAHDVSRGGLAVALAEMAAASGIGAEVDIDEIA-SARPDELLFSESNGrAIVAVPEEKAEEAVKS-KGVPAKV 678
|
810 820 830
....*....|....*....|....*....|....*.
gi 392894769 963 IGKasaVFGPDAHVKIhvnGHLEINEKLVDLREEWE 998
Cdd:TIGR01736 679 IGK---TGGDRLTIKT---GDDTISVSVKELRDAWE 708
|
|
| PurL |
cd02193 |
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ... |
295-584 |
6.29e-42 |
|
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain] Cd Length: 272 Bit Score: 155.15 E-value: 6.29e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 295 HLIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATGRGAYEIAGTVGYSFGNLNlpglplPWEDetfeyptsisepaKIA 374
Cdd:cd02193 2 GEAMKIEEHNHPAAIDPAAGAATGVGGAIRDIAATGIDAKPIALSANWMASAGH------PGED-------------AIL 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 375 IEASNGASDYGNKFGEPVISGFARSFGQRL--ENGERCE-YLKPIMFSGGIGAIDKDEVRK-EPCAPHQKVVKIGGPVYR 450
Cdd:cd02193 63 YDAVKGVAELCNQLGLPIPVGKDRMSMKTRwqEGNEQREmTHPPSLVISAFGRVRDDRHTLpQLSTEGNALLLIGGGKGH 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 451 IGVGGGAASSVSVQGnreNQLDFAAVQRGDAEMGGKLHRVVRACAERiggNPLMAIHDQGAGGNGNVIKELVE--GCGVT 528
Cdd:cd02193 143 NGLGGTALASVALSY---RQLGDKSAQVRDPAQEKGFYEAMQALVAA---GKLLAWHDRGAGGLLVALAELVFagHCGVQ 216
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 392894769 529 VKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSVVGEV 584
Cdd:cd02193 217 VDLAALGDDEPDMEPLEIALFESQERGVIQVRAEDRDAVEEAQYGLADCVHVLGQA 272
|
|
| PRK01213 |
PRK01213 |
phosphoribosylformylglycinamidine synthase subunit PurL; |
301-998 |
8.63e-41 |
|
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 234921 [Multi-domain] Cd Length: 724 Bit Score: 162.19 E-value: 8.63e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 301 ETHNFPTAVCPFQGATTGTGGRIRDIHATGrgAYEIAGTVGYSFGNLN-------LPGLplpwedetfeyptsisepakI 373
Cdd:PRK01213 88 ESHNHPSAVEPYQGAATGVGGILRDIFSMG--ARPIALLDSLRFGELDhpktrylLEGV--------------------V 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 374 AieasnGASDYGNKFGEPVISG---FARSFgqrleNGerceylKPIMFSGGIGAIDKDEVRKepcaphQKVVKIGGPVY- 449
Cdd:PRK01213 146 A-----GIGGYGNCIGVPTVGGevyFDESY-----NG------NPLVNAMCVGLVRHDDIVL------AKASGVGNPVVy 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 450 ------RIGVGGgaASSVSVQGNRENQLDFAAVQRGDAEMGgKLhrVVRACAERIGGNPLMAIHDQGAGGNGNVIKELVE 523
Cdd:PRK01213 204 vgaktgRDGIGG--ASFASAELSEESEEKRPAVQVGDPFME-KL--LIEACLELIKTGLVVGIQDMGAAGLTCSSSEMAA 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 524 --GCGVTVKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKLLGKsGEIAV 601
Cdd:PRK01213 279 kgGLGIELDLDKVPLREEGMTPYEIMLSESQERMLLVVKPGKEEEVLAIFEKWDLDAAVIGEVTDDGRLRVYHH-GEVVA 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 602 DLDTRQLGErEKKVFKLKSAPRVLKKLELPENLTVRKALKRVLMLPSVASKRYLTCKVDRSVTG--LVAqqqcvgplhtP 679
Cdd:PRK01213 358 DVPAEALAD-EAPVYDRPYKEPAYLDELQADPEDLKEALLKLLSSPNIASKEWVYEQYDHEVQTntVVK----------P 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 680 LADVAVVALSHFDTvGGAVSLGEQPIKMLIDAEKGARMCIAETIMNLIWA---P--ITD-LkdvkmsgNW--------MW 745
Cdd:PRK01213 427 GGDAAVLRIRGGGK-GLALTTDCNPRYVYLDPYEGAKLAVAEAARNLAAVgatPlaITDcL-------NFgnpekpevMW 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 746 aakcdgegaRLVDAvgalCRGL----REIGCAIDGGKDSLsmavtaHGEVVKSP----------GTLvlsayapcTNVTK 811
Cdd:PRK01213 499 ---------QFVEA----VRGLadacRALGTPVVGGNVSL------YNETGGTAiyptpvigmvGLI--------DDVSK 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 812 VVnPSLKAVPGSKILWIkiGssEEKMRLGGSALAQV-YSQIGDDCPDIeNFSEISKVFSIVQQLLNREelagplrkpIIL 890
Cdd:PRK01213 552 RT-TSGFKKEGDLIYLL--G--ETKDELGGSEYLKViHGHVGGRPPKV-DLEAEKRLQELVREAIREG---------LVT 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 891 AGHDISDGGLLTAILEMAFAGNVSIDIDIkppNQNIKPIDILFAEECG-ILLEVS--NPENVLHIFSEAGIKCQEIGKAS 967
Cdd:PRK01213 617 SAHDVSEGGLAVALAEMAIAGGLGAEVDL---SDGLRPDALLFSESQGrYVVSVPpeNEEAFEALAEAAGVPATRIGVVG 693
|
730 740 750
....*....|....*....|....*....|.
gi 392894769 968 avfgpDAHVKIHVNGHLEINEklvdLREEWE 998
Cdd:PRK01213 694 -----GDALKVKGNDTESLEE----LREAWE 715
|
|
| PRK01175 |
PRK01175 |
phosphoribosylformylglycinamidine synthase I; Provisional |
1052-1289 |
4.20e-33 |
|
phosphoribosylformylglycinamidine synthase I; Provisional
Pssm-ID: 234913 [Multi-domain] Cd Length: 261 Bit Score: 129.50 E-value: 4.20e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1052 PRVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDILAGH-TLEAYRGVAFVGGFSYADVLgsakgwAAGVQFNESV--- 1127
Cdd:PRK01175 4 IRVAVLRMEGTNCEDETVKAFRRLGVEPEYVHINDLAAERkSVSDYDCLVIPGGFSAGDYI------RAGAIFAARLkav 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1128 -SKQFEAF--RSRPdtfSYGVCNGCQLMAQLGWIG--DEEQKGPTVFLDENECGRFDSSFGPVKIEKNVSIMLSGMENSV 1202
Cdd:PRK01175 78 lRKDIEEFidEGYP---IIGICNGFQVLVELGLLPgfDEIAEKPEMALTVNESNRFECRPTYLKKENRKCIFTKLLKKDV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1203 LGLWSSHGEGRFTYRNLQNFQNLKTNGQVCIRFCDDRGMTGAdhgsvklpYPWNPNGSIDDVAAICSRDGRHLAMMPHAD 1282
Cdd:PRK01175 155 FQVPVAHAEGRVVFSEEEILERLIENDQIVFRYVDENGNYAG--------YPWNPNGSIYNIAGITNEKGNVIGLMPHPE 226
|
....*..
gi 392894769 1283 RSFLTWQ 1289
Cdd:PRK01175 227 RAFYGYQ 233
|
|
| FGAM_synth_I |
TIGR01737 |
phosphoribosylformylglycinamidine synthase I; In some species, ... |
1053-1287 |
9.14e-30 |
|
phosphoribosylformylglycinamidine synthase I; In some species, phosphoribosylformylglycinamidine synthase is composed of a single polypeptide chain. This model describes the PurQ protein of Bacillus subtilis (where PurL, PurQ, and PurS are required for phosphoribosylformylglycinamidine synthase activity) and functionally equivalent proteins from other bacteria and archaea. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Pssm-ID: 273782 [Multi-domain] Cd Length: 227 Bit Score: 118.63 E-value: 9.14e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1053 RVAIIREEGSNGDREMASAFTLAGFQTFDVTMTDilagHTLEAYRGVAFVGGFSYADVLGSAkgwaAGVQFNESVSKQFE 1132
Cdd:TIGR01737 2 KVAVIRFPGTNCDRDTVYALRLLGVDAEIVWYED----GSLPDYDGVVLPGGFSYGDYLRAG----AIAAASPIMQEVRE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1133 -AFRSRPdtfSYGVCNGCQLMAQLGWIgdeeqKGPtvfLDENECGRFDSSFGPVKIEKNVSIMLSGM-ENSVLGLWSSHG 1210
Cdd:TIGR01737 74 fAEKGVP---VLGICNGFQILVEAGLL-----PGA---LLPNDSLRFICRWVYLRVENADTIFTKNYkKGEVIRIPIAHG 142
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392894769 1211 EGRFTYRNlQNFQNLKTNGQVCIRFCDDRGmtgadhgsvKLPYPWNPNGSIDDVAAICSRDGRHLAMMPHADRSFLT 1287
Cdd:TIGR01737 143 EGRYYADD-ETLARLESNDQVVFRYCDEDG---------DVAEEANPNGSVGNIAGIVNERGNVLGMMPHPERASEK 209
|
|
| AIRS_C |
pfam02769 |
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ... |
437-592 |
4.30e-24 |
|
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain] Cd Length: 152 Bit Score: 99.73 E-value: 4.30e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 437 PHQKVVKIGGpvyrIGVGGGAASSVSVQGNREnqlDFAAVQRGDAEMGGKLHRVVRACAERigGNPLMAIHDQGAGGNGN 516
Cdd:pfam02769 2 PGDVLILLGS----SGLHGAGLSLSRKGLEDS---GLAAVQLGDPLLEPTLIYVKLLLAAL--GGLVKAMHDITGGGLAG 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894769 517 VIKELVE--GCGVTVKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKL 592
Cdd:pfam02769 73 ALAEMAPasGVGAEIDLDKVPIFEELMLPLEMLLSENQGRGLVVVAPEEAEAVLAILEKEGLEAAVIGEVTAGGRLTV 150
|
|
| PRK03619 |
PRK03619 |
phosphoribosylformylglycinamidine synthase subunit PurQ; |
1053-1283 |
4.72e-21 |
|
phosphoribosylformylglycinamidine synthase subunit PurQ;
Pssm-ID: 235140 [Multi-domain] Cd Length: 219 Bit Score: 93.26 E-value: 4.72e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1053 RVAIIREEGSNGDREMASAF-TLAGFQTFDVTMTDilagHTLEAYRGVAFVGGFSYADVL--GSAkgwAAGVQFNESVsK 1129
Cdd:PRK03619 2 KVAVIVFPGSNCDRDMARALrDLLGAEPEYVWHKE----TDLDGVDAVVLPGGFSYGDYLrcGAI---AAFSPIMKAV-K 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 1130 QFeAFRSRPdtfSYGVCNGCQLMAQLGWIgdeeqkgPTVFLdENECGRFDSSFGPVKIEKNVSIMLSGME-NSVLGLWSS 1208
Cdd:PRK03619 74 EF-AEKGKP---VLGICNGFQILTEAGLL-------PGALT-RNASLKFICRDVHLRVENNDTPFTSGYEkGEVIRIPIA 141
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392894769 1209 HGEGRFtYRNLQNFQNLKTNGQVCIRFCDDrgmtgadhgsvklpypwNPNGSIDDVAAICSRDGRHLAMMPHADR 1283
Cdd:PRK03619 142 HGEGNY-YADEETLKRLEGNGQVVFRYCDE-----------------NPNGSVNDIAGIVNEKGNVLGMMPHPER 198
|
|
| AIRS_C |
pfam02769 |
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression ... |
821-976 |
6.51e-21 |
|
AIR synthase related protein, C-terminal domain; This family includes Hydrogen expression/formation protein HypE, AIR synthases EC:6.3.3.1, FGAM synthase EC:6.3.5.3 and selenide, water dikinase EC:2.7.9.3. The function of the C-terminal domain of AIR synthase is unclear, but the cleft formed between N and C domains is postulated as a sulphate binding site.
Pssm-ID: 460684 [Multi-domain] Cd Length: 152 Bit Score: 90.48 E-value: 6.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 821 PGSKIlwIKIGSSEekmrLGGSALAQVYSQIGDdcpdiENFSEISKVFSIVQQLLNREELAGPLRKPIILAGHDISDGGL 900
Cdd:pfam02769 2 PGDVL--ILLGSSG----LHGAGLSLSRKGLED-----SGLAAVQLGDPLLEPTLIYVKLLLAALGGLVKAMHDITGGGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 901 LTAILEMAFAGNVSIDIDIKPP---NQNIKPIDILFAEECGILLEVSNPEN---VLHIFSEAGIKCQEIGKASAVFGPDA 974
Cdd:pfam02769 71 AGALAEMAPASGVGAEIDLDKVpifEELMLPLEMLLSENQGRGLVVVAPEEaeaVLAILEKEGLEAAVIGEVTAGGRLTV 150
|
..
gi 392894769 975 HV 976
Cdd:pfam02769 151 IV 152
|
|
| PurL |
cd02193 |
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent ... |
697-936 |
1.29e-16 |
|
Formylglycinamide ribonucleotide amidotransferase (FGAR-AT) catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, phosphate, and glutamate in the fourth step of the purine biosynthetic pathway. In eukaryotes and Gram-negative bacteria, FGAR-AT is encoded by the purL gene as a multidomain protein with a molecular mass of about 140 kDa. In Gram-positive bacteria and archaea FGAR-AT is a complex of three proteins: PurS, PurL, and PurQ. PurL itself contains two tandem N- and C-terminal domains (four domains altogether). The N-terminal domains bind ATP and are related to the ATP-binding domains of HypE, ThiL, SelD and PurM.
Pssm-ID: 100029 [Multi-domain] Cd Length: 272 Bit Score: 81.57 E-value: 1.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 697 AVSLGEQPIKMLIDAEKGARMCIAETIMNlIWAPITDLKDVKMSGNWMWAAKCDGEGARLVDAVGALCRGLREIGCAIDG 776
Cdd:cd02193 4 AMKIEEHNHPAAIDPAAGAATGVGGAIRD-IAATGIDAKPIALSANWMASAGHPGEDAILYDAVKGVAELCNQLGLPIPV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 777 GKDSLSM-AVTAHGEVVK---SPGTLVLSAYAPCTNVtKVVNPSLkAVPGSKILWIKIGsseeKMR--LGGSALAQV--- 847
Cdd:cd02193 83 GKDRMSMkTRWQEGNEQRemtHPPSLVISAFGRVRDD-RHTLPQL-STEGNALLLIGGG----KGHngLGGTALASVals 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 848 YSQIGDDCPDIENFSEISKVFSIVQQLLNreelAGPlrkpiILAGHDISDGGLLTAILEMAFAGN--VSIDIDIKPPNQ- 924
Cdd:cd02193 157 YRQLGDKSAQVRDPAQEKGFYEAMQALVA----AGK-----LLAWHDRGAGGLLVALAELVFAGHcgVQVDLAALGDDEp 227
|
250
....*....|..
gi 392894769 925 NIKPIDILFAEE 936
Cdd:cd02193 228 DMEPLEIALFES 239
|
|
| PRK14090 |
PRK14090 |
phosphoribosylformylglycinamidine synthase subunit PurL; |
296-637 |
7.13e-13 |
|
phosphoribosylformylglycinamidine synthase subunit PurL;
Pssm-ID: 184499 [Multi-domain] Cd Length: 601 Bit Score: 72.96 E-value: 7.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 296 LIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATGrgayeiagtvgysfgnlnlpglplpwedetfEYPTSISEP---AK 372
Cdd:PRK14090 63 IAFKIESHNHPSAIEPYNGAATGVGGIIRDVLAMG-------------------------------ARPTAIFDSlhmSR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 373 IAIEASNGASDYGNKFGEPVISGfarsfGQRLENGERCEYLKPIMfSGGIGAiDKDEVRKEPCAPHQKVVKIGGPVYRIG 452
Cdd:PRK14090 112 IIDGIIEGIADYGNSIGVPTVGG-----ELRISSLYAHNPLVNVL-AAGVVR-NDMLVDSKASRPGQVIVIFGGATGRDG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 453 VGGGAASSVSVQGNRENQLdfaAVQRGD--AEmggklHRVVRACAERIGGNPLMAIHDQGAGGNGNVIKELVE--GCGVT 528
Cdd:PRK14090 185 IHGASFASEDLTGEKATKL---SIQVGDpfAE-----KMLIEAFLEMVEEGLVEGAQDLGAGGVLSATSELVAkgGLGAI 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 529 VKSDTFQLGDESISLRELWTAEYQENDAALVDASLLDALQTISKREKCHVSVVGEVEKEQRVKLLGKsGEIAVDLDTRQL 608
Cdd:PRK14090 257 VHLDRVPLREPDMEPWEILISESQERMAVVTSPEKASRILEIAKKHLLFGDIVAEVIDDPIYRVMYR-DDLVMEVPVQLL 335
|
330 340 350
....*....|....*....|....*....|
gi 392894769 609 GER-EKKVFKLKSAprvlkklELPENLTVR 637
Cdd:PRK14090 336 ANApEEEIVEYTPG-------EIPEFKRVE 358
|
|
| PurM-like |
cd00396 |
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ... |
706-965 |
5.10e-09 |
|
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain] Cd Length: 222 Bit Score: 58.18 E-value: 5.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 706 KMLIDAEKGARMCIAETIMNLIwapITDLKDVKMSGNWMWAAKCDGEGA-RLVDAVGALCRglrEIGCAIDGGKDS---- 780
Cdd:cd00396 12 PLAINPWAGGRLAVGGAVNDIA---AMGARPIALLASLSLSNGLEVDILeDVVDGVAEACN---QLGVPIVGGHTSvspg 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 781 -----LSMAVTAHGEVVKSPGTlvlsayapctnvtkvvnPSLKAVPGSKILWIKIGSSEEKMRLGGsalaqvysqigddc 855
Cdd:cd00396 86 tmghkLSLAVFAIGVVEKDRVI-----------------DSSGARPGDVLILTGVDAVLELVAAGD-------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 856 pdienfseiskvfsivqqllnreelagplrkpiILAGHDISDGGLLTAILEMAFAGNVSIDIDIK------PPNQNIK-- 927
Cdd:cd00396 135 ---------------------------------VHAMHDITDGGLLGTLPELAQASGVGAEIDLEaipldeVVRWLCVeh 181
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 392894769 928 PIDIL-FAEECGILLEVSNPE--NVLHIFSEAGIKCQEIGK 965
Cdd:cd00396 182 IEEALlFNSSGGLLIAVPAEEadAVLLLLNGNGIDAAVIGR 222
|
|
| FGAR-AT_linker |
pfam18072 |
Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain ... |
174-223 |
8.09e-09 |
|
Formylglycinamide ribonucleotide amidotransferase linker domain; This is the linker domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. The structure analysis of Salmonella typhimurium FGAR-AT reveals that this linker domain is made up of a long hydrophilic belt with an extended conformation.
Pssm-ID: 465632 [Multi-domain] Cd Length: 50 Bit Score: 52.47 E-value: 8.09e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 392894769 174 LIKANEELGLALDQLDLDFYYDFFvNKVKKNPTDVELFDLAQSDSEHSRH 223
Cdd:pfam18072 1 LEEANRYLGLALSDDEIDYLVEYF-AGLGRNPTDVELGMFAQMWSEHCRH 49
|
|
| FGAR-AT_N |
pfam18076 |
Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain ... |
38-146 |
5.78e-08 |
|
Formylglycinamide ribonucleotide amidotransferase N-terminal; This is the N-terminal domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT), also known as Phosphoribosylformylglycinamidine synthase (EC:6.3.5.3), PurL and formylglycinamidine ribonucleotide (FGAM) synthase. This enzyme catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide and glutamine to formylglycinamidine ribonucleotide, ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway.
Pssm-ID: 465635 [Multi-domain] Cd Length: 115 Bit Score: 52.47 E-value: 5.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 38 EYCYHVITQEPeLISSNWEKLVTLLSHSPfetsvwkESQLHPEHGKNIEIGPR--T----AVKtaaCTNILSIfesSGIK 111
Cdd:pfam18076 1 EYVHFVELEAP-LSAAERARLEQLLTYGP-------PLEEPEPEGELLLVTPRlgTispwSSK---ATDIAHN---CGLD 66
|
90 100 110
....*....|....*....|....*....|....*....
gi 392894769 112 NVERIERGIRYLVE-DDVDVNEFFEIAA---DKMTEAIY 146
Cdd:pfam18076 67 AVRRIERGIAYYLTgKPLSAAELAALAAllhDRMTESVL 105
|
|
| PurM-like |
cd00396 |
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen ... |
295-583 |
2.20e-07 |
|
AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain of AIR synthase forms the dimer interface of the protein, and is suggested as a putative ATP binding domain.
Pssm-ID: 100027 [Multi-domain] Cd Length: 222 Bit Score: 53.17 E-value: 2.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 295 HLIYSAETHNFPTAVCPFQGATTGTGGRIRDIHATgrGAYEIAGTVGYSFGNLNLPGlplpwedetfeyptsisepakIA 374
Cdd:cd00396 1 SLAMSTDGINPPLAINPWAGGRLAVGGAVNDIAAM--GARPIALLASLSLSNGLEVD---------------------IL 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 375 IEASNGASDYGNKFGEPVISG-FARSfgqrlengERCEYLKPIMFSGGIGAIDKDEVRKEPCA-PHQKVVKIGgpvyrig 452
Cdd:cd00396 58 EDVVDGVAEACNQLGVPIVGGhTSVS--------PGTMGHKLSLAVFAIGVVEKDRVIDSSGArPGDVLILTG------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 453 vgggaassvsvqgnrenqldfaavqrgdaemggklhrvVRACAERIGGNPLMAIHDQGAGGNGNVIKELVE--GCGVTVK 530
Cdd:cd00396 123 --------------------------------------VDAVLELVAAGDVHAMHDITDGGLLGTLPELAQasGVGAEID 164
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392894769 531 SDTFQL--GDESISLRELWTAEYQENDAALV------DASLLDALQtisKREKCHVSVVGE 583
Cdd:cd00396 165 LEAIPLdeVVRWLCVEHIEEALLFNSSGGLLiavpaeEADAVLLLL---NGNGIDAAVIGR 222
|
|
| PurM-like1 |
cd06061 |
AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM ... |
754-965 |
1.81e-06 |
|
AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two conserved domains and seem to dimerize. The N-terminal domain forms the dimer interface and is a putative ATP binding domain.
Pssm-ID: 100037 [Multi-domain] Cd Length: 298 Bit Score: 51.44 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 754 ARLVDAVGALCRglrEIGCAIDGGKDSLSMAV-------TAHGEVVKSpgtlvlsayapctnvtKVVNPSlKAVPGSKIL 826
Cdd:cd06061 97 KAIMREINEAAK---ELGVSIVGGHTEVTPGVtrpiisvTAIGKGEKD----------------KLVTPS-GAKPGDDIV 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894769 827 wikigsseekmrLGGSALAQVYSQIGDDCPDienfsEISKVFS--IVQQLLNREELAGPLRKPIILAG------HDISDG 898
Cdd:cd06061 157 ------------MTKGAGIEGTAILANDFEE-----ELKKRLSeeELREAAKLFYKISVVKEALIAAEagvtamHDATEG 219
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392894769 899 GLLTAILEMAFAGNVSIDIDI-KPP-NQNIKPI------DILFAEECGILLEVSNPENVLHI---FSEAGIKCQEIGK 965
Cdd:cd06061 220 GILGALWEVAEASGVGLRIEKdKIPiRQETKEIcealgiDPLRLISSGTLLITVPPEKGDELvdaLEEAGIPASVIGK 297
|
|
| |
