|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
51-458 |
0e+00 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 544.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 51 ALLAHFGFAISFGIRSNFGVAKNRMINNFTDAYG---EVHEKEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNK 127
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGgkvIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 128 LFMLGILFASLLNIVTAICLNFHpftDIFVMVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGL 207
Cdd:cd17382 81 VFGLAIFVTSTLNMLIPIAARVH---YGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 208 PASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGtspethgyisadekkyitekvgsvavknmtlttlpwrdmmtstAV 287
Cdd:cd17382 158 PLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLVSM-------------------------------------------PV 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 288 WAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRSSGKMSTEAVRKSVNTFG 367
Cdd:cd17382 195 YAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGG 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 368 FTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVNHFDIAPRHAPILMGIANGLGAIAGVGGIVTNSLTYQN-- 445
Cdd:cd17382 275 FGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHkt 354
|
410
....*....|...
gi 17554148 446 PDGWQWVFLLAMS 458
Cdd:cd17382 355 REEWQYVFLIASL 367
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
51-456 |
1.03e-110 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 336.13 E-value: 1.03e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 51 ALLAHFGFAISFGIRSNFGVAKNRMINN----------FTDAYGEVHEKEFFWTGTEVGMMESSFFYGYAASQIPAGVIA 120
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNStathdnnntsTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 121 AKFAPNKLFMLGILFASLLNIVTAICLNFHPftdIFVMVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGAS 200
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGY---GALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 201 VGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGtspethgyisadekkyitekvgsvavknmtlttlpwrd 280
Cdd:cd17318 158 FGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVL-------------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 281 mmtstAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRSSGKMSTEAVR 360
Cdd:cd17318 200 -----PVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVR 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 361 KSVNTFGFTVEAVMLGCLAFV-RDPVIAVTFLIIACSGAGAVLSGFNVNHFDIAPRHAPILMGIANGLGAIAG------V 433
Cdd:cd17318 275 KLFTSIGFLGPGVFLIALGYLgSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGiispliV 354
|
410 420
....*....|....*....|...
gi 17554148 434 GGIVTNSltyQNPDGWQWVFLLA 456
Cdd:cd17318 355 GAIVKND---QTIGQWRIVFFIS 374
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
50-458 |
1.28e-81 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 261.25 E-value: 1.28e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 50 IALLAHFGFAISFGIRSNFGVAKNRMINNFTD---------------AYGEVHE---KEFFWTGTEVGMMESSFFYGYAA 111
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTlpsnnssnacpehssSPSVEHNetgKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 112 SQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFtdiFVMVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKL 191
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAG---YLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 192 ATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVsgtspethgyisadekkyitekvgsvavknm 271
Cdd:cd17381 158 LTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWL------------------------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 272 tltTLPwrdmmtstaVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRSS 351
Cdd:cd17381 207 ---VMP---------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREK 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 352 GKMSTEAVRKSVNTFGFTVEAVMLGCLAFVR-DPVIAVTFLIIACSGAGAVLSGFNVNHFDIAPRHAPILMGIANGLGAI 430
Cdd:cd17381 275 QNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGcNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATI 354
|
410 420 430
....*....|....*....|....*....|
gi 17554148 431 AG-VGGIVTNSLTYQNP-DGWQWVFLLAMS 458
Cdd:cd17381 355 PGmVGPVIAKSLTHNNTvEEWQTVFYISAA 384
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
89-456 |
3.30e-66 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 219.73 E-value: 3.30e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 89 KEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFtdiFVMVIQVMQGLAL 168
Cdd:cd17380 27 KEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLP---LLILSRILLGLGE 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 169 GVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSgtspeth 248
Cdd:cd17380 104 GVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 249 gyisadekkyitekvgsvavknmtlttlpwrdmmtsTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLhIDIKNSGLIAI 328
Cdd:cd17380 177 ------------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 329 FPQLGMCIVTLTSGQLSDYLRSSGkMSTEAVRKSVNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVN 408
Cdd:cd17380 220 VPWLVMFPSSNVAGWLADHLISRG-WTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVN 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 17554148 409 HFDIAPRHAPILMGIANGLGAIAG-VGGIVTNSLTyQNPDGWQWVFLLA 456
Cdd:cd17380 299 HQDIAPNYAGIVFGISNTAGTIPGiVGVYLTGYIL-EATGSWSLVFVLA 346
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
38-485 |
3.13e-65 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 220.00 E-value: 3.13e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 38 DNKFFLRKV------RWQIALLAHFGFAISFGIRSNFGVAKNRMINNfTDAYG-----------EVHEKEFFWTGTEVGM 100
Cdd:TIGR00894 2 ENVFASTKLpyfcsfRLFLSFLLHICNVIIIAQRICLSLTMVAMVNK-ENSTDlaclsaeneldNIKNPNFKWSGALQGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 101 MESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpfTDIFVMVIQVMQGLALGVCYPAMHGVWK 180
Cdd:TIGR00894 81 ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGG---GIALVVFCRVIQGLAQGSVSPATHKIIV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 181 YWAPPLERSKLATTTFTGASVGVMVGLPASAYLV-SHFSWSTPFYVFGALGIVWSILWIYVSGTSPETHGYISADEKKYI 259
Cdd:TIGR00894 158 KWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 260 TEKVgsVAVKNMTLTTLPWRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTL 339
Cdd:TIGR00894 238 NSSL--QGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 340 TSGQLSDYLRSSGKMSTEAVRKSVNTFGFTVEAVMLGCLAFV-RDPVIAVTFLIIACSGAGAVLSGFNVNHFDIAPRHAP 418
Cdd:TIGR00894 316 FAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLsAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLG 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17554148 419 ILMGIANGLGAIAG-VGGIVTNSLTYQNPDG-WQWVFLLAMSIDIFGIIFFLIFAKGDVLPWAREPEKE 485
Cdd:TIGR00894 396 FIKGITGLPGFIGGlIASTLAGNILSQDSKNvWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDT 464
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
44-456 |
6.54e-47 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 168.12 E-value: 6.54e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 44 RKVRWQIALLAHFGFAISFGIRSNFGVAKNRMInnftdaygevheKEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKF 123
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQ------------ADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 124 APNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGV 203
Cdd:COG2271 73 GRRRVLAIGLLLWGLATLLFGFATSF-----WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGG 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 204 MVGLPASAYLVSHFSWSTPFYVFGALGIVWSILwiyvsgtspethgyisadekkyitekvgsvavknmtlttlpwrdmmt 283
Cdd:COG2271 148 ALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 284 stAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRSSGKMSTeavrksv 363
Cdd:COG2271 181 --RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL------- 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 364 nTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVNHFDIAPRH-APILMGIANGLGAIAG-VGGIVTNSL 441
Cdd:COG2271 252 -AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGaLGPLLVGYL 330
|
410
....*....|....*
gi 17554148 442 TYQNpdGWQWVFLLA 456
Cdd:COG2271 331 LDAT--GYQAAFLLL 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
47-443 |
9.10e-43 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 156.58 E-value: 9.10e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 47 RWQIALLAHFGFAISFGIRSNFGVAKNRMInnftdaygevheKEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPN 126
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIM------------KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGAR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 127 KLFMLGILFASLLNIVTAICLNFHPFtdifvMVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVG 206
Cdd:cd17319 69 KVLAVSMLLWSLFTALTGFATSLTSL-----YVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 207 LPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTspethgyisadekkyitekvgsvavknmtlttlpwrdmmtsta 286
Cdd:cd17319 144 PPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 287 VWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRSsgkmsteAVRKSVNTF 366
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR-------GARRLVIII 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 367 GFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVNHFDIAPR-HAPILMGIANGLGAIAG------VGGIVTN 439
Cdd:cd17319 254 GLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGfvapllIGYLVDA 333
|
....
gi 17554148 440 SLTY 443
Cdd:cd17319 334 TGSY 337
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
45-457 |
5.21e-31 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 124.61 E-value: 5.21e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 45 KVRWQIALLAHFGFAISFGIRSNFGVAKNRMinnftdaygevhEKEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFA 124
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL------------AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 125 PNKLFMLGILFASLLNIVTAICLNFHPFtdifvMVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVM 204
Cdd:COG2223 69 PRRVLLIGLLLLGIGLLLLALAVSYWLL-----LLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 205 VGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTSPEthgyisadekkyitekvGSVAVKNMTLTTlpWRDMMTS 284
Cdd:COG2223 144 VAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA-----------------GAAAAAKASLRD--QLEALRD 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 285 TAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRssgkmsteavRKSVN 364
Cdd:COG2223 205 PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG----------GRRVL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 365 TFGFTVEAVMLGCLAFVRDPVIAVTFLIIAcsgAGAVLSGFNVNHFDIAP-----RHAPILMGIANGLGAIAGVGGIVTN 439
Cdd:COG2223 275 LIVFALMALGLLLLALALGSLWLFLVLFLL---LGLALGGGNGAVFALVPdifptKNAGAVYGLVGAAGGLGGFLGPLLF 351
|
410
....*....|....*...
gi 17554148 440 SLTYQNPDGWQWVFLLAM 457
Cdd:COG2223 352 GALLDATGSYTAAFLVFA 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
89-435 |
2.13e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 115.98 E-value: 2.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 89 KEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGLAL 168
Cdd:pfam07690 25 EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL-----WLLLVLRVLQGLGA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 169 GVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVsgTSPETH 248
Cdd:pfam07690 100 GALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLP--RPPPES 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 249 GYISADEKKYItekvgsvavknmtLTTLPWRDMMTSTAVWAIIIcsFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAI 328
Cdd:pfam07690 178 KRPKPAEEARL-------------SLIVAWKALLRDPVLWLLLA--LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 329 FPQLGMCIVTLTSGQLSDYLRSsgkmsteAVRKSVNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVN 408
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGR-------RRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNAL 315
|
330 340
....*....|....*....|....*...
gi 17554148 409 HFDIAP-RHAPILMGIANGLGAIAGVGG 435
Cdd:pfam07690 316 VSDLAPkEERGTASGLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
89-432 |
2.85e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 115.84 E-value: 2.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 89 KEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFtdifvMVIQVMQGLAL 168
Cdd:COG2814 38 ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLL-----LAARFLQGLGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 169 GVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIV-WSILWIYVSGTSPET 247
Cdd:COG2814 113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 248 HGYISAdekkyitekvgsvavknmtlttlPWRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIA 327
Cdd:COG2814 193 RARLRG-----------------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 328 IFPQLGMCIVTLTSGQLSDYLRssgkmsteavRKSVNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNV 407
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFG----------RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA 319
|
330 340
....*....|....*....|....*.
gi 17554148 408 NHFDIAPRHAP-ILMGIANGLGAIAG 432
Cdd:COG2814 320 LVAELAPPEARgRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
73-457 |
5.27e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 107.13 E-value: 5.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 73 NRMINNFTDAYGEVHEKEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpf 152
Cdd:cd06174 8 TGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 153 tdIFVMVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSH--FSWSTPFYVFGALG 230
Cdd:cd06174 85 --WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 231 IVWSILWIYVsgtSPETHGYISADEKkyitekvgsvaVKNMTLTTLPWRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLT 310
Cdd:cd06174 163 LLAAILLLLV---VPDPPESARAKNE-----------EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 311 YMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRSsgkmsteavRKSVNTFGFTVEAVMLGCLAFVRDP-VIAVT 389
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG---------RKPLLLIGLLLMALGLALLLLAPSLlLLLLL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17554148 390 FLIIACSGAGAVLSGFNVNHFDIAPRHAPILMGIANGLGAIAG-VGGIVTNSLTYQNPdGWQWVFLLAM 457
Cdd:cd06174 300 LLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGaIGPLLAGFLLAATF-GLTGAFLVLA 367
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
56-451 |
7.16e-18 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 85.51 E-value: 7.16e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 56 FGFAISFGIRSNFGVAKNRMInnftdaygevheKEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILF 135
Cdd:TIGR00881 2 IGYAAYYLVRKNFALAMPYLV------------EEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLIL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 136 ASLLNIVTAICLNFHPFTdIFVMVIQVMQGLALGVCYPAMhgvwKYWAPPLER----SKLATTTFTGASVGVMVGLPASA 211
Cdd:TIGR00881 70 CAIVNLFFGFSTSLWVMA-ALWALNGIFQGMGWPPCGRTV----TKWFSRSERgtwvSFWNCSHNVGGGLLPPLVLFGIA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 212 YlvsHFSWSTPFYVFGALGIVWSILWIYVSGTSPETHGyISADEKKYITEKVGSVAVK--NMTLTTLPWRDMMTSTAVWA 289
Cdd:TIGR00881 145 E---LYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCG-LPPAEEMPNEEPDGDAEKKeeELTKKQIFLQYVLLNKVLWY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 290 IIICSF--------CRSWSfflllgnqLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRSSGKMSTEAVRK 361
Cdd:TIGR00881 221 ISLGYVfvyvvrtgILDWS--------PLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFM 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 362 SvntfGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAV-LSGFNVNhfDIAPRHApilMGIANGL-GAIAGVGGIVTN 439
Cdd:TIGR00881 293 A----LIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQmLIGVIAS--ELAPKKA---AGTAAGFvGFFAYLGGILAG 363
|
410
....*....|..
gi 17554148 440 SLTYQNPDGWQW 451
Cdd:TIGR00881 364 LPLGYLADGFGW 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
94-456 |
1.12e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 81.85 E-value: 1.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 94 TGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASllnIVTAICLNFHPFTdiFVMVIQVMQGLALGVCYP 173
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLA---VSTLLFAFATSYW--QLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 174 AMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVwSILWIYVsgtspethgyisA 253
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-ALVLALL------------L 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 254 DEKKYITEKVGSVAVKNMtltTLPWRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLG 333
Cdd:cd17325 171 LPEPRPPPNKRAVSAARL---RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 334 MCIVTLTSGQLSDYLRssgkmsteavRKSVNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVNHFDIA 413
Cdd:cd17325 248 SALSQPPAGKLSDRIG----------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 17554148 414 PR-HAPILMGIAN---GLGAIAG--VGGIVTNSLtyqnpdGWQWVFLLA 456
Cdd:cd17325 318 PPeGRGTAMGLFNtafSLGMVLGplLGGFLYDAF------GFATPFLAA 360
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
47-455 |
8.24e-14 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 73.43 E-value: 8.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 47 RWQIALLAHFGFAISFGIRSNFGVAKNRMInnftDAYGevhekeffWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPN 126
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLI----EQYG--------LSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 127 KLFMLGILFASLLNIVTAICLnfHPFTDIFVMVI-QVMQGLALGVCYPAMHGVWKYWAPPLERSKLATT-----TFTGAS 200
Cdd:cd17345 69 RFLAIGLILSAIINILIGFVP--SATSSVGLMFIlLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIwnishNVGGGL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 201 VGVMVGLpaSAYLVSHFSWSTPFYVFGALGIVWSIL-WIYVSGTsPETHGYISADEKK--YITEKVGSVAVKNMTLTTLP 277
Cdd:cd17345 147 VGPLAGL--GLAIFGDGWWRGAFIFPAIIAIIVAVIvLFLGKDT-PESEGLPPIEEYKgdYPEEADGEEEEQELSAWEIF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 278 WRDMMTSTAVWAIIICS----FCR----SWSfflllgnqLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLR 349
Cdd:cd17345 224 VKYVLKNKLLWYIAIANvfvyLVRygilDWA--------PTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLF 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 350 SSGKMSTeavrksvNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIacsgAGAVLSG----FNVNHFDIAPRHApilMGIAN 425
Cdd:cd17345 296 KGRRAPT-------GIIFMILVIVALIVYWLAPNVLVDLIALIA----LGFLIYGpvmlIGLQALELVPKKA---AGTAA 361
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 17554148 426 GL-----------GAIAGVGGIVTNSltyqnpdGWQWVFLL 455
Cdd:cd17345 362 GLtglfgylggsvLATALIGIIVDHF-------GWNGGFIV 395
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
96-456 |
8.94e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.97 E-value: 8.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 96 TEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGLALGVCYPAM 175
Cdd:cd17324 34 AQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSF-----ALLLLARALAGLAHGGFWAIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 176 HGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSI-LWIYVSGTSPETHGyisad 254
Cdd:cd17324 109 AAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALlLWRLLPSLPPKKPG----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 255 ekkyitekvgsvavknMTLTTLPWRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKN-SGLIAIFpQLG 333
Cdd:cd17324 184 ----------------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAiIGLLLLF-GVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 334 MCIVTLTSGQLSDYLRssgkmsteavRKSVNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVNHFDIA 413
Cdd:cd17324 247 GVVGSPLAGRLADRGG----------RRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 17554148 414 PRHAPILMGIANGLGAIAGVGGIVTNSLTYQNpDGWQWVFLLA 456
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALGAALGGLVLDH-GGWAGVGWVG 358
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
47-348 |
1.90e-12 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 68.84 E-value: 1.90e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 47 RWQIALLAHFGFAISFGIRSNFGVAKNRMinnftdaygeVHEKEFfwTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPN 126
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPI----------VEEIGL--SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 127 KLFMLGILFASLLNIVtaicLNFHPFTDIFVmVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVG 206
Cdd:cd17312 69 RFMSAGLLLSALANIF----MGFSTSLWFFA-VLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 207 LPASAYLVSHFSWSTPFYVFGALGIVWSI-LWIYVSGTSPethgyisadekkyitekvgsvavknmtlttlpwrdmmtst 285
Cdd:cd17312 144 PILAASLASYYGWRAAFLVPGIVGLVVAIiLFFFLRDSPP---------------------------------------- 183
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17554148 286 AVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYL 348
Cdd:cd17312 184 YVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKL 246
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
45-400 |
8.26e-12 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 67.27 E-value: 8.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 45 KVRWQIALLAHFGFAISFGIRSNFGVAKnrmINNFTDAYGEVhekeffwtGTEVGMMESSFFYGYAASQIPAGVIAAKFA 124
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISNAA---VMGMKEDLKLV--------GNQYNWGNTVFYVGYIIFELPGNLLLQRFP 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 125 PNKLFMLGILFASLLNIVTAICLNFHPFtdifvMVIQVMQGLALGVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVM 204
Cdd:cd17327 70 PSKWLSVFIVLWGLLTLLTAAVKNFGGL-----IALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 205 V-GLPASAYLVSHFS-----WSTPFYVFGALGIVWSILWIYVSGTSPETHGYISADEKKYITEKV----GSVAVKNMTLT 274
Cdd:cd17327 145 FgGLLAYGVFKILGVgglagWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLranqTGKGDQKFKWK 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 275 TlpWRDMMTSTAVWAIIICSFCrSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRssGKM 354
Cdd:cd17327 225 Q--IKEAFKDPRTWLLFLFFFC-SQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFK--KRG 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 17554148 355 STEAVRKSVNTFGFTVeavmlgcLAFVRDPVIAVTFLIIACSGAGA 400
Cdd:cd17327 300 LFAIFACVLALVGSII-------LLAAPNPPGAYFAAYILGGGSYA 338
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
48-432 |
1.94e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 65.76 E-value: 1.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 48 WQIALLAHFGFAISFGIRSNFGVAKNRMInnftdaygevheKEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNK 127
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPII------------AEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 128 LFMLGILFASLLNIVTAICLNFHpftdIFVMVIQVMQGLALGVCY-PAMHGVWKYWAPPlERSKLATTTFTGASVGVMVG 206
Cdd:cd17355 70 VMLLGLLLLAAGLVLLALATSLW----QLYLLWGLLGGGGAGTLAaVAFATVAAWWFER-RRGLALGILTAGGGLGSLVF 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 207 LPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTSPETHGYISADEKKYITekvgsvavknmtlTTLPWRDMMTSTA 286
Cdd:cd17355 145 LPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS-------------PGSTLKEALRSAS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 287 VW----AIIICSFcrSWSFflLLGNQLTYMKDvLHIDIKNS----GLIAIFPQLGmcivTLTSGQLSDylRSSgkmstea 358
Cdd:cd17355 212 FWllalAFFLCGF--AVVG--LIVHLVPYLAD-RGISPAAAavalALIGLFNIVG----RLLSGWLGD--RYS------- 273
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17554148 359 vRKSVNTFGFTVEAVMLGCLAFVRDPVIAVtFLIIACSGAGAV----LSGFNVNHFdIAPRHAPILMGIANGLGAIAG 432
Cdd:cd17355 274 -PRRLLAASYALRALGLALLLLLPFPPLAL-LLFAALFGLGWGatvpLTAALAARY-FGARSYGTLFGLVFAPHQLGS 348
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
97-456 |
3.66e-10 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 61.97 E-value: 3.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 97 EVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFTdifvmVIQVMQGLALGVCYPAMH 176
Cdd:cd17343 39 DLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFS-----ILWFLNGLAQGLGWPPCA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 177 GVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTSPETHGyisadeK 256
Cdd:cd17343 114 KILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVG------L 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 257 KYITEKVGSVAVKNMTLTTLPWRDMMTSTAVWAIIICSF--------CRSWSfflllgnQLTYMKDVLHIDIKNSGLIAI 328
Cdd:cd17343 188 NNIEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLvvfgvktaVTDWG-------QLFLIQDKGQSALTGSSFMSS 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 329 FpQLGMCIVTLTSGQLSDYL-RSSGKMSTEAVRKSVNTFGFTVEAVMLGCLAFVRDP-----VIAVTFLIIACSGAGAvL 402
Cdd:cd17343 261 L-EVGGFVGSIAAGYLSDWAvAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSdsselFILLLGFLIGFSLYGP-I 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 17554148 403 SGFNVNHFDIAPRHapiLMGIANGLGAIAG-VGGIVTN---SLTYQNPDgWQWVFLLA 456
Cdd:cd17343 339 AIFGVIANESAPSH---LCGTSHAIVALAAnVGGVLAGlpfSYIAKHYD-WRTAFLLL 392
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
89-253 |
4.75e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 54.82 E-value: 4.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 89 KEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGLAL 168
Cdd:COG0477 42 ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSP-----ELLIAARALQGIGA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 169 GVCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVsgtsPETH 248
Cdd:COG0477 117 GGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL----PESR 192
|
....*
gi 17554148 249 GYISA 253
Cdd:COG0477 193 GLLLA 197
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
90-457 |
8.40e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.49 E-value: 8.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 90 EFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGLALG 169
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV-----ALLLAGTALIGAGIA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 170 VCYPAMHGVWKYWAPplERSKLATTTFT-GASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTSPETH 248
Cdd:COG2807 122 VGNVLLPGLIKRWFP--DRVGLMTGLYTaAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 249 GYISAdekkyitekvgsvavknmtltTLPWRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDvLHIDIKNSGLIAI 328
Cdd:COG2807 200 AAAPA---------------------AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 329 FPQLGMCIVTLTSGQLSDYLRSsgkmsteavRKSVNTFGFTVEAVMLGCLAFVRD--PVIAVTFLIIACSGAGAVLSGFN 406
Cdd:COG2807 258 LFQLAGIPGSLLVPLLADRLGD---------RRPLLLLLGLLGLAGLLGLLLAPGslPWLWAVLLGLGQGGLFPLALTLI 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 17554148 407 VNHFDiAPRHAPILMGIANGLG-AIAGVGGIVTNSLtYQNPDGWQWVFLLAM 457
Cdd:COG2807 329 GLRAR-TPAEAAALSGMAQSVGyLLAALGPLLVGAL-HDATGSWTAALLLLA 378
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
187-437 |
1.40e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 187 ERSKLATTTFTGASVGVMVGLPASAYLVSHFS------WSTPFYVFGALGIVwsILWIYVSGTspethgyisadeKKYIT 260
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLL--AFLLTFFGT------------KERPV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 261 EKVGSVAVKNMtlttlpWRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLT 340
Cdd:COG2211 210 PEEEKVSLKES------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 341 SGQLSDYLRssgkmsteavRKSVNTFGFTVEAVMLGCLAFVrdPVIAVTFLIIACSGAGAVLSGFNVNHF----DIAP-- 414
Cdd:COG2211 284 WPRLAKRFG----------KKKAFIIGLLLAALGLLLLFFL--GPGNLWLLLVLAALAGIGLGAILVLPWamlaDVVDyd 351
|
250 260 270
....*....|....*....|....*....|....
gi 17554148 415 ------RHAPILMGIAN-----GLGAIAGVGGIV 437
Cdd:COG2211 352 ewktgrRREGLYFGIFTfaiklGQALAGALAGLL 385
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
94-445 |
1.88e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 53.37 E-value: 1.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 94 TGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFtdifvMVIQVMQGLALGVCYP 173
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL-----LVLRLIHGIGWGAFTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 174 AMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTSPethgyisa 253
Cdd:cd17489 104 AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPP-------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 254 dekkyitekvgsVAVKNMTLTTLPWRDMMtSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLhidIKNSGLIAIFPQLG 333
Cdd:cd17489 176 ------------VAAEEAEAGTRAFRRLV-EKKVLPPALILFLASIAYGAISTFLPLYAAERG---ISNAGLFFTVYAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 334 MCIVTLTSGQLSDYLRssgkmsteavRKSVNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVNHFDIA 413
Cdd:cd17489 240 LLLSRPFSGKLSDRKG----------PKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309
|
330 340 350
....*....|....*....|....*....|....*...
gi 17554148 414 PRH------APILMGIANGLGAIAGVGGIVTNSLTYQN 445
Cdd:cd17489 310 PPHrrgaanGTFFIFFDLGIGLGGLLLGLVAELFGYRA 347
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
96-456 |
3.02e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 3.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 96 TEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASllnIVTAICLNFHPFTdiFVMVIQVMQGL---ALGVCY 172
Cdd:cd17474 34 AQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFG---IGGLLCGLSDSFA--LLLAGRALQGIgaaGLGPLA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 173 PAMHGvwKYWAPPlERSKLATTTFTGASVGVMVGlPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTSPEThgyis 252
Cdd:cd17474 109 LTLIG--DLFEGG-ERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEK----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 253 ADEKKYITEKVGSVAVKNMTLTTlpwrdmmtstavwaIIICSFCrswsFFLLLGNQLTYMKDVLHIDIKNS----GLIAI 328
Cdd:cd17474 180 AKSSSATKLRDLKKALRGRGLLT--------------FLVSAFL----YFFLYFAFLTYLPFLLELLYGISpiiiGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 329 FPQLGMCIVTLTSGQLSDyLRSSGKMSTeavrksvnTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVN 408
Cdd:cd17474 242 GWSVLLALGSLFVGRLLK-KRFGARRIL--------VIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTL 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 17554148 409 HFDIAPRHA-PILMGIANGLGAIAGVGGIVTNSLTYQNpDGWQWVFLLA 456
Cdd:cd17474 313 VTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEI-FGLSAPFLVG 360
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
91-405 |
7.60e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 51.59 E-value: 7.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 91 FFWTGTEVGMMESSFFYGYAASqipagviaaKFAPNKLFMLGILFASLLNIVTAICLNFHPFtdifvMVIQVMQGLALGV 170
Cdd:TIGR00895 56 FLFSAGLIGMAFGALFFGPLAD---------RIGRRRVLLWSILLFSVFTLLCALATNVTQL-----LILRFLAGLGLGG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 171 CYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALG-IVWSILWIYVsgtsPETHG 249
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPlLLLLLLMRFL----PESID 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 250 YISADEKKYITEKVGSVAVKNM--TLTTLP--------WRDMM-------TSTAVWAIIICSFCRSWSFFlLLGNQLTYM 312
Cdd:TIGR00895 198 FLVSKRPETVRRIVNAIAPQMQaeAQSALPeqkstqgtKRSVFkalfqgkTARITVLLWLLYFMLLVGVY-FLTNWLPKL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 313 KDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRSsgkmsteavrkSVNTFGFTVEAVMLGCLAF-VRDPVIAVTFL 391
Cdd:TIGR00895 277 MVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGP-----------RVTALLLLLGAVFAVLVGStLFSPTLLLLLG 345
|
330
....*....|....
gi 17554148 392 IIACSGAGAVLSGF 405
Cdd:TIGR00895 346 AIAGFFVNGGQSGL 359
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
47-456 |
1.53e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 50.69 E-value: 1.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 47 RWQIaLLAHFGFAISFGIRSNFGVAKNRMINNFTdaygevhekeffWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPN 126
Cdd:cd17353 2 RWLV-LLGAVLMHLILGYQYAWSVFNPPLSSALG------------WSLASVALAFTLTIVFLAISAPFAGRLVDRGGPR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 127 KLFMLGILFASLLNIVTAiclnFHPFTDIFVMVIQVMQGLALGVCYPAMHGVWKYWAPplERSKLAT-TTFTGASVGVMV 205
Cdd:cd17353 69 KAILIGGILFGLGFILSA----FAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFP--DKRGLATgIVIAGFGLGSLI 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 206 GLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTSPEThgyiSADEKKYITEKVGSVAVKNMTlttlpWRDMMTST 285
Cdd:cd17353 143 FSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKG----WVPPGVDPLANNAENSPRDYT-----PREMLRTP 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 286 AVWAIIIcSFCRSWSFFLLLGNQLTYM-KDVLHIDIKN----SGLIAIFPQLGMCIVtltsGQLSDYLRssgkmsteavR 360
Cdd:cd17353 214 TFWLLWL-MFFLNATAGLMLIGQAKPIgQEFAGLDAGIaalaVSILSIFNGGGRPFW----GWLSDKIG----------R 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 361 KSVNTFGFTVEAVMLGCLAFVRDP---VIAVTFLIIACSGAG-AVLSGFNVNHFdiAPRHAPILMGI---ANGLGAIagV 433
Cdd:cd17353 279 KNTLSIAFLIQGVAMFLLPFIGSVavlFVLGVALIGFCYGGGfALFPALTADFF--GTKNAGTNYGLlytAKGVGGL--I 354
|
410 420
....*....|....*....|...
gi 17554148 434 GGIVTNSltYQNPDGWQWVFLLA 456
Cdd:cd17353 355 GPIIAAY--VLYTGGYNAAFIIA 375
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-238 |
1.92e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.27 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 17 LRRTFSSKTWEHREQLHSLQEDNKFFLRKVRWQIALLAHFGFAISFGirsnfgvaknrMINNFTDAYGEvheKEFFWTGT 96
Cdd:cd17325 170 LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFG-----------ALEPFLPLYAA---ELGGLSPA 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 97 EVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGLALGVCYPAMH 176
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF-----WLLLLLLALLGLGLGLVFPATL 310
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17554148 177 GVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWI 238
Cdd:cd17325 311 ALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
105-236 |
8.52e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 45.72 E-value: 8.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 105 FFYGYAASQI----PAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpfTDIFVMviQVMQGLALGVCYPAMHGVWK 180
Cdd:TIGR00880 3 LLAGYALGQLiyspLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNI---TVLIIA--RFLQGFGAAFALVAGAALIA 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 17554148 181 YWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSIL 236
Cdd:TIGR00880 78 DIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFIL 133
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
98-456 |
9.41e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.00 E-value: 9.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 98 VGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFTDIFVMVIQVMQGLALGVCYPAMHG 177
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 178 VWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYV--FGALGIVWSILWIYVSGTSPETHgyiSADE 255
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAInaLSFLLSALLLLFIRRPPPAAPGE---SSSL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 256 KKYITEKVGSVAVKNMTLTTLpwrdmMTSTAVWAIIICSFcrsWSFFLLlgnqltYMKDVLHIDIKNSGLIAIFPQLGMC 335
Cdd:cd06173 193 LLRDLREGLRYLRRSPLLRLL-----LLALALFALLGGAL---TVLLPL------LAKEVLGGGAAGYGLLLAAFGVGAL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 336 IVTLTSGQLSDYLRSSGKMSteavrksvntFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVnhfdIAPR 415
Cdd:cd06173 259 LGALLLGRLSKRRRRGRLLL----------IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT----LLQL 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 17554148 416 HAP------------ILMGIANGLGAIagVGGIVTNSLtyqnpdGWQWVFLLA 456
Cdd:cd06173 325 RVPdelrgrvfsvynALNSGAMPLGAL--LAGLLADAL------GLSAVFLLA 369
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
96-458 |
1.31e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 96 TEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIvtaICLNFHPFTdiFVMVIQVMQGLALGVCYPAM 175
Cdd:cd17475 31 AQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAAL---LMALVGSYP--VLLVLLFLVGAGYGSVQPGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 176 HGVWKYWAPPLERSkLATTTF-TGASVGVMVG---LPasaYLVSHFSWSTPFYVFGALGIVWSILWIYVsgtspethgYI 251
Cdd:cd17475 106 GRAIMRWFPPRERG-LAMGIRqTGVPLGGALAaalLP---PLALHYGWRAAFVVAGLVSILAAVLFWLF---------YR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 252 SADEKKYITEKvgsvavKNMTLTTLpwRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQ 331
Cdd:cd17475 173 EPPAASAATES------ASTLLRSL--KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 332 LGMCIVTLTSGQLSDYLRSSGkmsteavRKSVNTFGFTVEAVMLGCLAFVrDPVIAVTFLIIACSGAGAVLSGFNVNHF- 410
Cdd:cd17475 245 LGGALGRIGLGRVSDRVFGGR-------RRPVLVITAAIAAAALLVLSLL-SPGTPLWLLVLLLILLGLFAIGWNGLYLt 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 17554148 411 ---DIAP-RHAPILMGIANG---LGAIAG---VGGIVTNSLTYQnpdgWQWVFLLAMS 458
Cdd:cd17475 317 lvaESAGpEQAGTALGLANTinfIGIAIGpplFGLLVDATHSYA----PAWLALALLL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
96-437 |
2.85e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 96 TEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGLALGVCYPAM 175
Cdd:COG0738 43 AQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY-----PLLLLALFLLGLGLGLLDVAA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 176 HgvwkYWAPPLERSKLATT-TFTGA--SVGVMVGLPASAYLVSH---FSWSTPFYVFGALGIVWSILWIYVSGTSPETHG 249
Cdd:COG0738 118 N----PYVAALGPETAASRlNLLHAffSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 250 YISADEKKyitekvgsvavknmtlttlPWRDMMTSTAVWAIIICSFC--------RSWSFflllgnqlTYMKDVLHIDIK 321
Cdd:COG0738 194 EEAAGSAA-------------------SLKSLLKNPRLLLGGLAIFLyvgaegaiGDWLP--------LYLKDVLGLSEA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 322 NSGLIAIFPQLGMCIVTLTSGQLSDYLRssgkmsteavRKSVNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIacsgAGAV 401
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFG----------PVRLLRLSALLAAVGLLLALLAPGPWLALIGLAL----VGLG 312
|
330 340 350
....*....|....*....|....*....|....*..
gi 17554148 402 LSGFNVNHFDIAPRHAPILMGIANGLGAIAG-VGGIV 437
Cdd:COG0738 313 LSLMFPTIFSLALDGLGKRTAAAVSAVLIMGiVGGAI 349
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
88-236 |
6.93e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.26 E-value: 6.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 88 EKEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAIclnfhpFTDIFVMVI-QVMQGL 166
Cdd:cd17504 23 QREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF------APNLPVLIAgRALQGI 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17554148 167 ALGV---CYPAMHGVWkywapPLERSKLATTTFTG-ASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSIL 236
Cdd:cd17504 97 GGAVfplAFALVREEF-----PPERVPVAQGILSAtFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
94-232 |
1.03e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.88 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 94 TGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFtdifvMVIQVMQGLALGVCYP 173
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQL-----ALLRFLTGLGLGAAMP 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 17554148 174 AMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIV 232
Cdd:cd17365 107 NAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI 165
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
93-240 |
1.06e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.86 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 93 WTGTEVGMMESSFFYGYAASQIPAGVIAAKFapNKLFMLGILFASLLNIVTAICLNFHPfTDIFVMVIQVMQGLALGVCY 172
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL--GRRRKLVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAF 289
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17554148 173 PAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYV 240
Cdd:COG2271 290 GLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
90-348 |
1.14e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.60 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 90 EFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGLALG 169
Cdd:cd17371 28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNY-----WQLLILRALAGLGFG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 170 VCYPAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWIYVSGTSPETHG 249
Cdd:cd17371 103 GEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 250 YISADEKKYITEKVGSVAV---KNMTLTTLPWrdmmTSTAVWAIIICSFCRSWsffllLGnqlTYMKDVLHIDIKNSGLI 326
Cdd:cd17371 183 WQAARAARRHFADRPSLRElfsPPLLRTTLLA----SLLATGALGGYYGITTW-----LP---SYLTGERGLSFEGSAGY 250
|
250 260
....*....|....*....|..
gi 17554148 327 AIFPQLGMCIVTLTSGQLSDYL 348
Cdd:cd17371 251 LVVTILGGFLGYLAGGFLADRI 272
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
286-456 |
1.28e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 286 AVWAIIICSFCRSWSFFLLLGNqLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRssgkmsteavRKSVNT 365
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPA-LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG----------RRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 366 FGFTVEAVMLGCLAFVRDPviavTFLIIACSGAGAVLSGFNVNHFDIAPRHAPI--------LMGIANGLGAIAG--VGG 435
Cdd:COG2814 80 LGLLLFALGSLLCALAPSL----WLLLAARFLQGLGAGALFPAALALIADLVPPerrgralgLLGAGLGLGPALGplLGG 155
|
170 180
....*....|....*....|.
gi 17554148 436 IVTNSLtyqnpdGWQWVFLLA 456
Cdd:COG2814 156 LLADLF------GWRWVFLVN 170
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
87-438 |
3.49e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.97 E-value: 3.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 87 HEKEFFWTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGL 166
Cdd:cd17316 27 AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP-----ILLLVLRFLQGI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 167 ALGVCYPamhGVWKY---WAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFS----WSTPFYVFGALGIVwsILWIy 239
Cdd:cd17316 102 GIGGEYP---GASTYvaeFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIGALPALL--ALLL- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 240 vsgtspethgyisadekkyitekvgsvavknmtlttlpWRDMMTSTAVWaiiicsFCRSWSFFLLLGNQLTYMKDVLHID 319
Cdd:cd17316 176 --------------------------------------RRRTLLLILLW------FFISFGYYGLTTFLPTYLQTVLGLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 320 IKNSGLIAIFPQLGMCIVTLTSGQLSDYLRssgkmsteavRKSVNTFGFTVEAVMLGCLAFVRDP----VIAVTFLIIAC 395
Cdd:cd17316 212 PATSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGsptlLLLLLFILSFF 281
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 17554148 396 -SGAGAVLSGFNVNHFDIAPRHapILMGIANGLGAIAGVGGIVT 438
Cdd:cd17316 282 vGGVWGALYAYLAELFPTEVRA--TGVGLSYNLGRLGGGGAPPL 323
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
290-456 |
7.28e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 290 IIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRssgkmsteavRKSVNTFGFT 369
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----------RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 370 VEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSGFNVNHFDIAPR-HAPILMGI---ANGLGAIAG--VGGIVTNSLty 443
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPeERGRALGLvsaGFGLGAALGplLGGLLASLF-- 148
|
170
....*....|...
gi 17554148 444 qnpdGWQWVFLLA 456
Cdd:pfam07690 149 ----GWRAAFLIL 157
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
116-409 |
1.13e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 116 AGVIAAKFAPNKLFMLGILFASLLNIVTAIclnfhpFTDIFVMVI-QVMQGLALGVCYP-AMHGVWKYWAPPlERSKLAT 193
Cdd:cd17473 55 AGWLADRFGRKRLLIAGLLLYGIGGVAGLF------LDSLYALLAsRALLGIGVAGIMTlATALIGDYFEGE-ERAKMLG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 194 TTFTGASVGVMVGLPASAYLVShFSWSTPFYVFGALGIVWSILWIYVSGTSPethgyisadekkyitEKVGSVAVKNMTL 273
Cdd:cd17473 128 LQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPAR---------------KSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 274 TTLPWRdmmtstAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTLTSGQLSDYLRssgk 353
Cdd:cd17473 192 AALPWK------RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLG---- 261
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 17554148 354 msteavRKSVNTFGFTVEAVMLGCLAFVRDPVIAVTFLIIACSGAGAVLSgfNVNH 409
Cdd:cd17473 262 ------KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLP--TLNS 309
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
21-239 |
1.29e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.44 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 21 FSSKTWEHREQLHSLQEDNKFFLRKVRWQIALLAHFGFAISFGIRSNFGvaknrminnftdaygEVHEKEFFWTGTEVGM 100
Cdd:cd17490 170 IKEERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFT---------------PLIAKQLGASSFQLGL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 101 MESSFFYGYAAsqipAGVIAAKFAPNKLFMLGILFASLLniVTAICLNFHPFTD--IFVMVIQVMQGLALGVCYP----- 173
Cdd:cd17490 235 LSIIYLLPNAL----ASLLSGTLFYKKLGERNTIIIGFL--LLGAYCFLIPFAPnlTLLYLLQALNGFGTGILFPllmsl 308
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17554148 174 AMHGVwkywapPLERSKLATTTF-----TGASVG-VMVGlpasaYLVSHFSWSTPFYVFGALGIVWSILWIY 239
Cdd:cd17490 309 SIEGV------PAEQRSTAMGFFqaiyaLGMFLGpVLVG-----IISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
98-242 |
1.80e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.15 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 98 VGMMESSFFYGYaasqipagvIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFtdifvMVIQVMQGLALGVCYPAMHG 177
Cdd:TIGR00898 138 VGVLLGSFVFGY---------LSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVF-----LVFRLLVGMGIGGIWVQAVV 203
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17554148 178 VWKYWAPPLERSKLATTTFTGASVGVMVgLPASAYLVSHFSW-----STPFYVFGALgiVW----SILWIYVSG 242
Cdd:TIGR00898 204 LNTEFLPKKQRAIVGTLIQVFFSLGLVL-LPLVAYFIPDWRWlqlavSLPTFLFFLL--SWfvpeSPRWLISQG 274
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
116-236 |
5.95e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.18 E-value: 5.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 116 AGVIAAKFAPNKLF----MLGILFASLLNIVTAICLNFHPFTDIFVMVIQVMQGLALGVcyPAMhgVWKYWAPPLERSKL 191
Cdd:cd17312 234 AGTILAGLLSDKLFggrrAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGG--PIN--LIGGAAAQDIGRKE 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 17554148 192 ATTTFTG-----ASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSIL 236
Cdd:cd17312 310 AAGTATGfvglfGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLL 359
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
302-453 |
7.42e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 39.15 E-value: 7.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 302 FLLLGNQLTYMKDVLHiDIKNSGLIAIFPQLGMCIVTLTSGQLSDYlrssgkmsteavrksvntFG---FTVEAVMLGCL 378
Cdd:cd06179 14 VTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDL------------------FGrrwFFIGGNLLGVV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 379 AFV------RDPVIAVTFLIIACsGAGAVLSGFNVNHFDIAPRHAPILMGIAN-GLGAIAGVGGIVTNSLTYQNPDGWQW 451
Cdd:cd06179 75 GSIvagtakSVNMLIGGQALIGI-GAGTQGLGAAVASELVPNKYRGLVQGVVNlVASPGSALGPLIAGALVEANAAGWRW 153
|
..
gi 17554148 452 VF 453
Cdd:cd06179 154 IF 155
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
103-458 |
7.56e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 38.71 E-value: 7.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 103 SSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFHPFtdifvMVIQVMQGLALGVCYPAMHGVWKYW 182
Cdd:cd17320 41 SAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQL-----LIARFLQGLGAAAGSVVARAIVRDL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 183 APPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIV---WSILWIyvsgtsPETHgyiSADEKKYI 259
Cdd:cd17320 116 YSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLlllLVLLFL------PETL---PEEKRKPL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 260 TEKVGSVavknmtlttlpWRDMMTSTAVWAIIICSFCRSWSFFLLLGNQLTYMKDVLHIDIKNSGLIAIFPQLGMCIVTL 339
Cdd:cd17320 187 LSSLLRA-----------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 340 TSGQLsdylrsSGKMSTEAVRKSVNTFGFTVEAVMLGC-LAFVRDPVIAVTFLIIACSGAGAVLSGFNVNHFDIAPRHAp 418
Cdd:cd17320 256 LNGRL------VRRFGPRRLLRLGLLLLLAAALVLLLAaLLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVA- 328
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 17554148 419 ilmGIANGL-GAIAGVGGIVTNSLTYQNPDGWQWVFLLAMS 458
Cdd:cd17320 329 ---GTASALlGFLQFLIGALAGALVGLLPNGTALPMGLLIL 366
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
352-455 |
7.92e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 38.70 E-value: 7.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 352 GKMSTEAVRKSVNTFGFTVeaVMLGCL--AFVRDPVIAVTFLIIACSGAGAVLSG-FNVNHFDIAPRHAPILMGIAN--- 425
Cdd:cd17502 51 GKLSDLFGRKWVLLIAIVI--FELGSLlcGLAPNMTMLIVGRAIQGIGGGGLMSLaFIIIADLVPPRERGKYQGYIGavf 128
|
90 100 110
....*....|....*....|....*....|..
gi 17554148 426 GLGAIAG--VGGIVTNSLTyqnpdgWQWVFLL 455
Cdd:cd17502 129 GIASVAGplIGGAFTDHLS------WRWCFYI 154
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
93-238 |
8.50e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 8.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 93 WTGTEVGMMESSFFYGYAASQIPAGVIAAKFAPNKLFMLGILFASLLNIVTAICLNFhpftdIFVMVIQVMQGLALGVCY 172
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL-----WLLLAALFLLGLAGGLFN 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17554148 173 PAMHGVWKYWAPPLERSKLATTTFTGASVGVMVGLPASAYLVSHFSWSTPFYVFGALGIVWSILWI 238
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
47-260 |
8.57e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.55 E-value: 8.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 47 RWQIALLAHFGFAISFGIRSNFGVAKNRMINNFTDAYGEVhekEFFWTGTEVGMMESSFFYGYaasqipagvIAAKFAPN 126
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQI---ATAASLSNLGMLLTQPILGF---------IADSFGPR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17554148 127 KLFMLGILFASLLNIVTAICLNFHPFTDIFVMVIqvmqGLALGVCYPAMHGVWKYWAPPLERSKLATTTfTGASVGVMVG 206
Cdd:cd17314 69 PLMALAGIMVLAGYTYLSYVFNSFPLSYACFVFI----GAGTGILYGSAVLVTTQYFPDTKGLALGLPT-TGYSLGLVLG 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 17554148 207 LPASAYLVSHFSWSTPFYVFGAL-GIVWSILWIYVSGTSPETHGYISADEKKYIT 260
Cdd:cd17314 144 SPLLRILWVFYGLALVYTILGILaAIVLSVVSLLGFKEPPDNQARLHVQKKKTQT 198
|
|
| |
