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Conserved domains on  [gi|17556556|ref|NP_499801|]
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Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial [Caenorhabditis elegans]

Protein Classification

MMADHC domain-containing protein( domain architecture ID 10562971)

MMADHC domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MMADHC pfam10229
Methylmalonic aciduria and homocystinuria type D protein; This entry represents methylmalonic ...
5-274 6.33e-137

Methylmalonic aciduria and homocystinuria type D protein; This entry represents methylmalonic aciduria and homocystinuria type D protein and homologs. These proteins are involved in cobalamin (vitamin B12) metabolism.


:

Pssm-ID: 431154  Cd Length: 272  Bit Score: 387.16  E-value: 6.33e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556556     5 KGPQMRAFTQRVAAFSTQLQIDPIPIVFVGKGTTP-RQNSLLGPNDSQYPFQGDVSFAHKPLSIRQQVENSKIERVMDD- 82
Cdd:pfam10229   1 RVPGARAFSAAGSSGSDEPHIAISPPDYGPRTVWPdEAMGPFGPQDQRFQLPGNVGFDCHLEGTAEQKKTPVHKTVPDVl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556556    83 ------TEHNLINLLSNTNIEVDRTHLAQLKEEAMEEIQANAAdveIELSAIEAPKLLKKEMKYLFPQMETQkmnNVTVF 156
Cdd:pfam10229  81 tapsqsERHEFILAQFVNELQNFEKGPNSQKVSKAEQYFENAS---VECSIQSCPELLRKDLESLFPEAPAS---NITVV 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556556   157 NLTQKSEFDMKAWSEAMEEEREKLTASFIMSANAICSTLHRFGYWADFIDPSSGRPYMGDYTNHTLFETNDAYKQMGFKI 236
Cdd:pfam10229 155 TVTQKTQNDMTAWSEEVEQEREQLLAKFVLGAKEICDALQTEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSI 234
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 17556556   237 EDLGCCKVLQHACWGSNAFVGTIFTDAPVDGDAVRDIL 274
Cdd:pfam10229 235 EDLGCCKVIRHSLWGTHAFVGTIFTNAPPDSDIMKKLL 272
 
Name Accession Description Interval E-value
MMADHC pfam10229
Methylmalonic aciduria and homocystinuria type D protein; This entry represents methylmalonic ...
5-274 6.33e-137

Methylmalonic aciduria and homocystinuria type D protein; This entry represents methylmalonic aciduria and homocystinuria type D protein and homologs. These proteins are involved in cobalamin (vitamin B12) metabolism.


Pssm-ID: 431154  Cd Length: 272  Bit Score: 387.16  E-value: 6.33e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556556     5 KGPQMRAFTQRVAAFSTQLQIDPIPIVFVGKGTTP-RQNSLLGPNDSQYPFQGDVSFAHKPLSIRQQVENSKIERVMDD- 82
Cdd:pfam10229   1 RVPGARAFSAAGSSGSDEPHIAISPPDYGPRTVWPdEAMGPFGPQDQRFQLPGNVGFDCHLEGTAEQKKTPVHKTVPDVl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556556    83 ------TEHNLINLLSNTNIEVDRTHLAQLKEEAMEEIQANAAdveIELSAIEAPKLLKKEMKYLFPQMETQkmnNVTVF 156
Cdd:pfam10229  81 tapsqsERHEFILAQFVNELQNFEKGPNSQKVSKAEQYFENAS---VECSIQSCPELLRKDLESLFPEAPAS---NITVV 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556556   157 NLTQKSEFDMKAWSEAMEEEREKLTASFIMSANAICSTLHRFGYWADFIDPSSGRPYMGDYTNHTLFETNDAYKQMGFKI 236
Cdd:pfam10229 155 TVTQKTQNDMTAWSEEVEQEREQLLAKFVLGAKEICDALQTEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSI 234
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 17556556   237 EDLGCCKVLQHACWGSNAFVGTIFTDAPVDGDAVRDIL 274
Cdd:pfam10229 235 EDLGCCKVIRHSLWGTHAFVGTIFTNAPPDSDIMKKLL 272
 
Name Accession Description Interval E-value
MMADHC pfam10229
Methylmalonic aciduria and homocystinuria type D protein; This entry represents methylmalonic ...
5-274 6.33e-137

Methylmalonic aciduria and homocystinuria type D protein; This entry represents methylmalonic aciduria and homocystinuria type D protein and homologs. These proteins are involved in cobalamin (vitamin B12) metabolism.


Pssm-ID: 431154  Cd Length: 272  Bit Score: 387.16  E-value: 6.33e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556556     5 KGPQMRAFTQRVAAFSTQLQIDPIPIVFVGKGTTP-RQNSLLGPNDSQYPFQGDVSFAHKPLSIRQQVENSKIERVMDD- 82
Cdd:pfam10229   1 RVPGARAFSAAGSSGSDEPHIAISPPDYGPRTVWPdEAMGPFGPQDQRFQLPGNVGFDCHLEGTAEQKKTPVHKTVPDVl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556556    83 ------TEHNLINLLSNTNIEVDRTHLAQLKEEAMEEIQANAAdveIELSAIEAPKLLKKEMKYLFPQMETQkmnNVTVF 156
Cdd:pfam10229  81 tapsqsERHEFILAQFVNELQNFEKGPNSQKVSKAEQYFENAS---VECSIQSCPELLRKDLESLFPEAPAS---NITVV 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17556556   157 NLTQKSEFDMKAWSEAMEEEREKLTASFIMSANAICSTLHRFGYWADFIDPSSGRPYMGDYTNHTLFETNDAYKQMGFKI 236
Cdd:pfam10229 155 TVTQKTQNDMTAWSEEVEQEREQLLAKFVLGAKEICDALQTEGYWADFIDPSSGLAFFGPYTNNTLFETDERYRHLGFSI 234
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 17556556   237 EDLGCCKVLQHACWGSNAFVGTIFTDAPVDGDAVRDIL 274
Cdd:pfam10229 235 EDLGCCKVIRHSLWGTHAFVGTIFTNAPPDSDIMKKLL 272
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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