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Conserved domains on  [gi|17544258|ref|NP_500086|]
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Protein SEC13 homolog [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-282 1.71e-33

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 1.71e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  25 GSRLATCGSDRLVKIFEVRpNGQsyPMAELVGHSGPVWKVSWAHPkyGGLLASASYDKKVIIWNEQQGRWQKayEWAAHE 104
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA-TGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLR--TLTGHS 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 105 ASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWIssKIQKCHEQGVNSVCWAPGSadpaakKRLVSAGNDKNVKI 184
Cdd:COG2319 247 GSVRSVAFSPD--GRLLASGSADGTVRL--WDLATGELL--RTLTGHSGGVNSVAFSPDG------KLLASGSDDGTVRL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 185 WafdDATNEWILeKTLAGHTDFVREAAWCPvtnNGQhTIVSCGMEGNLVLFrtsNIETEEWKAKLLETAPcALYHSSFSP 264
Cdd:COG2319 315 W---DLATGKLL-RTLTGHTGAVRSVAFSP---DGK-TLASGSDDGTVRLW---DLATGELLRTLTGHTG-AVTSVAFSP 382

                       250
                ....*....|....*...
gi 17544258 265 CGSFLSVAGDDNVITIWR 282
Cdd:COG2319 383 DGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-282 1.71e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 1.71e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  25 GSRLATCGSDRLVKIFEVRpNGQsyPMAELVGHSGPVWKVSWAHPkyGGLLASASYDKKVIIWNEQQGRWQKayEWAAHE 104
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA-TGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLR--TLTGHS 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 105 ASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWIssKIQKCHEQGVNSVCWAPGSadpaakKRLVSAGNDKNVKI 184
Cdd:COG2319 247 GSVRSVAFSPD--GRLLASGSADGTVRL--WDLATGELL--RTLTGHSGGVNSVAFSPDG------KLLASGSDDGTVRL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 185 WafdDATNEWILeKTLAGHTDFVREAAWCPvtnNGQhTIVSCGMEGNLVLFrtsNIETEEWKAKLLETAPcALYHSSFSP 264
Cdd:COG2319 315 W---DLATGKLL-RTLTGHTGAVRSVAFSP---DGK-TLASGSDDGTVRLW---DLATGELLRTLTGHTG-AVTSVAFSP 382

                       250
                ....*....|....*...
gi 17544258 265 CGSFLSVAGDDNVITIWR 282
Cdd:COG2319 383 DGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-282 2.82e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.98  E-value: 2.82e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  12 HRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRPNGqsyPMAELVGHSGPVWKVSWAHpkYGGLLASASYDKKVIIWNEQQ 91
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE---LLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  92 GrwQKAYEWAAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEwiSSKIQKCHEQGVNSVCWAPGsadpaaKK 171
Cdd:cd00200  83 G--ECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKV--WDVETGK--CLTTLRGHTDWVNSVAFSPD------GT 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 172 RLVSAGNDKNVKIWafDDATNEwiLEKTLAGHTDFVREAAWCPvtnNGQHtIVSCGMEGNLVLFrtsNIETEEWKaKLLE 251
Cdd:cd00200 149 FVASSSQDGTIKLW--DLRTGK--CVATLTGHTGEVNSVAFSP---DGEK-LLSSSSDGTIKLW---DLSTGKCL-GTLR 216

                       250       260       270
                ....*....|....*....|....*....|.
gi 17544258 252 TAPCALYHSSFSPCGSFLSVAGDDNVITIWR 282
Cdd:cd00200 217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 50-88 2.46e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17544258     50 PMAELVGHSGPVWKVSWAHpkYGGLLASASYDKKVIIWN 88
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 26-205 3.34e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 3.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258   26 SRLATCGSDRLVKIFEVrpnGQSYPMAELVGHSGPVWKV--SWAHPKyggLLASASYDKKVIIWNEQQGrwqKAYEWAAH 103
Cdd:PLN00181 546 SQVASSNFEGVVQVWDV---ARSQLVTEMKEHEKRVWSIdySSADPT---LLASGSDDGSVKLWSINQG---VSIGTIKT 616

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  104 EASTTCVAFaPHQYGLMLASASADGDigILRYDNSsnewiSSKIQKC----HEQGVNSVCWAPGSAdpaakkrLVSAGND 179
Cdd:PLN00181 617 KANICCVQF-PSESGRSLAFGSADHK--VYYYDLR-----NPKLPLCtmigHSKTVSYVRFVDSST-------LVSSSTD 681

                        170       180
                 ....*....|....*....|....*....
gi 17544258  180 KNVKIWAFD---DATNEWILEkTLAGHTD 205
Cdd:PLN00181 682 NTLKLWDLSmsiSGINETPLH-SFMGHTN 709
WD40 pfam00400
WD domain, G-beta repeat;
50-88 2.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17544258    50 PMAELVGHSGPVWKVSWahPKYGGLLASASYDKKVIIWN 88
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-282 1.71e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.95  E-value: 1.71e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  25 GSRLATCGSDRLVKIFEVRpNGQsyPMAELVGHSGPVWKVSWAHPkyGGLLASASYDKKVIIWNEQQGRWQKayEWAAHE 104
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA-TGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLR--TLTGHS 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 105 ASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWIssKIQKCHEQGVNSVCWAPGSadpaakKRLVSAGNDKNVKI 184
Cdd:COG2319 247 GSVRSVAFSPD--GRLLASGSADGTVRL--WDLATGELL--RTLTGHSGGVNSVAFSPDG------KLLASGSDDGTVRL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 185 WafdDATNEWILeKTLAGHTDFVREAAWCPvtnNGQhTIVSCGMEGNLVLFrtsNIETEEWKAKLLETAPcALYHSSFSP 264
Cdd:COG2319 315 W---DLATGKLL-RTLTGHTGAVRSVAFSP---DGK-TLASGSDDGTVRLW---DLATGELLRTLTGHTG-AVTSVAFSP 382

                       250
                ....*....|....*...
gi 17544258 265 CGSFLSVAGDDNVITIWR 282
Cdd:COG2319 383 DGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-282 2.82e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.98  E-value: 2.82e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  12 HRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRPNGqsyPMAELVGHSGPVWKVSWAHpkYGGLLASASYDKKVIIWNEQQ 91
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE---LLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  92 GrwQKAYEWAAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEwiSSKIQKCHEQGVNSVCWAPGsadpaaKK 171
Cdd:cd00200  83 G--ECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKV--WDVETGK--CLTTLRGHTDWVNSVAFSPD------GT 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 172 RLVSAGNDKNVKIWafDDATNEwiLEKTLAGHTDFVREAAWCPvtnNGQHtIVSCGMEGNLVLFrtsNIETEEWKaKLLE 251
Cdd:cd00200 149 FVASSSQDGTIKLW--DLRTGK--CVATLTGHTGEVNSVAFSP---DGEK-LLSSSSDGTIKLW---DLSTGKCL-GTLR 216

                       250       260       270
                ....*....|....*....|....*....|.
gi 17544258 252 TAPCALYHSSFSPCGSFLSVAGDDNVITIWR 282
Cdd:cd00200 217 GHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
2-281 5.39e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 5.39e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258   2 TTVRQRIDTQHRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRpngQSYPMAELVGHSGPVWKVSWAHPkyGGLLASASYD 81
Cdd:COG2319  67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSAD 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  82 KKVIIWNEQQGRWQKayEWAAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWIssKIQKCHEQGVNSVCWA 161
Cdd:COG2319 142 GTVRLWDLATGKLLR--TLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRL--WDLATGKLL--RTLTGHTGAVRSVAFS 213

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 162 PGSadpaakKRLVSAGNDKNVKIWafDDATNEWIleKTLAGHTDFVREAAWCPvtnNGQhTIVSCGMEGNLVLFrtsNIE 241
Cdd:COG2319 214 PDG------KLLASGSADGTVRLW--DLATGKLL--RTLTGHSGSVRSVAFSP---DGR-LLASGSADGTVRLW---DLA 276

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 17544258 242 TEEWKaKLLETAPCALYHSSFSPCGSFLSVAGDDNVITIW 281
Cdd:COG2319 277 TGELL-RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
2-282 1.09e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 1.09e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258   2 TTVRQRIDTQHRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRpNGQsyPMAELVGHSGPVWKVSWAHPkyGGLLASASYD 81
Cdd:COG2319 109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDD 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  82 KKVIIWNEQQGRWQKAYEwaAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWIssKIQKCHEQGVNSVCWA 161
Cdd:COG2319 184 GTVRLWDLATGKLLRTLT--GHTGAVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLL--RTLTGHSGSVRSVAFS 255

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 162 PGSadpaakKRLVSAGNDKNVKIWafDDATNEWIleKTLAGHTDFVREAAWCPvtnNGQhTIVSCGMEGNLVLFRTSNIE 241
Cdd:COG2319 256 PDG------RLLASGSADGTVRLW--DLATGELL--RTLTGHSGGVNSVAFSP---DGK-LLASGSDDGTVRLWDLATGK 321

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 17544258 242 TeewkAKLLETAPCALYHSSFSPCGSFLSVAGDDNVITIWR 282
Cdd:COG2319 322 L----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-282 3.57e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 3.57e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258   6 QRIDTQHRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRPNGQSYpmaELVGHSGPVWKVSWaHPKyGGLLASASYDKKVI 85
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR---TLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIK 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  86 IWNEQQGrwQKAYEWAAHEASTTCVAFapHQYGLMLASASADGDIGIlrYDNSSNewisskiqKC------HEQGVNSVC 159
Cdd:cd00200 119 VWDVETG--KCLTTLRGHTDWVNSVAF--SPDGTFVASSSQDGTIKL--WDLRTG--------KCvatltgHTGEVNSVA 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 160 WAPGSadpaakKRLVSAGNDKNVKIWAFDdatnEWILEKTLAGHTDFVREAAWCPvtnnGQHTIVSCGMEGNLVLFRTsn 239
Cdd:cd00200 185 FSPDG------EKLLSSSSDGTIKLWDLS----TGKCLGTLRGHENGVNSVAFSP----DGYLLASGSEDGTIRVWDL-- 248

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 17544258 240 ieteeWKAKLLETAPCalyHSS------FSPCGSFLSVAGDDNVITIWR 282
Cdd:cd00200 249 -----RTGECVQTLSG---HTNsvtslaWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-282 1.00e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.00e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258   2 TTVRQRIDTQHRDAIHDAQLNIYGSRLATCGSDRLVKifeVRPNGQSYPMAELVGHSGPVWKVSWAHPkyGGLLASASYD 81
Cdd:COG2319  25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLL---LLDAAAGALLATLLGHTAAVLSVAFSPD--GRLLASASAD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  82 KKVIIWNEQQGRWQKAYEwaAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWIssKIQKCHEQGVNSVCWA 161
Cdd:COG2319 100 GTVRLWDLATGLLLRTLT--GHTGAVRSVAFSPD--GKTLASGSADGTVRL--WDLATGKLL--RTLTGHSGAVTSVAFS 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 162 PGSadpaakKRLVSAGNDKNVKIWafDDATNEWIleKTLAGHTDFVREAAWCPvtnNGQhTIVSCGMEGNLVLFrtsNIE 241
Cdd:COG2319 172 PDG------KLLASGSDDGTVRLW--DLATGKLL--RTLTGHTGAVRSVAFSP---DGK-LLASGSADGTVRLW---DLA 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 17544258 242 TEEWKaKLLETAPCALYHSSFSPCGSFLSVAGDDNVITIWR 282
Cdd:COG2319 235 TGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-292 2.59e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 2.59e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  52 AELVGHSGPVWKVSWaHPKyGGLLASASYDKKVIIWNEQQGRWQKAYEwaAHEASTTCVAFAPHqyGLMLASASADGDIG 131
Cdd:cd00200   3 RTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASAD--GTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 132 ILRYDNSSnewiSSKIQKCHEQGVNSVCWAPgsadpaAKKRLVSAGNDKNVKIWAFDDATnewiLEKTLAGHTDFVREAA 211
Cdd:cd00200  77 LWDLETGE----CVRTLTGHTSYVSSVAFSP------DGRILSSSSRDKTIKVWDVETGK----CLTTLRGHTDWVNSVA 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258 212 WCPvtnnGQHTIVSCGMEGNLVLFRTSNIETEewkaKLLETAPCALYHSSFSPCGSFLSVAGDDNVITIWrENLQGQWIK 291
Cdd:cd00200 143 FSP----DGTFVASSSQDGTIKLWDLRTGKCV----ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW-DLSTGKCLG 213


                .
gi 17544258 292 V 292
Cdd:cd00200 214 T 214
WD40 COG2319
WD40 repeat [General function prediction only];
12-189 6.97e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 6.97e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  12 HRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRpNGQsyPMAELVGHSGPVWKVSWaHPKyGGLLASASYDKKVIIWNEQQ 91
Cdd:COG2319 245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGE--LLRTLTGHSGGVNSVAF-SPD-GKLLASGSDDGTVRLWDLAT 319

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  92 GRWQKayEWAAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWISSKIQkcHEQGVNSVCWAPGSadpaakK 171
Cdd:COG2319 320 GKLLR--TLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRL--WDLATGELLRTLTG--HTGAVTSVAFSPDG------R 385

                       170
                ....*....|....*...
gi 17544258 172 RLVSAGNDKNVKIWAFDD 189
Cdd:COG2319 386 TLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 50-88 2.46e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.46e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17544258     50 PMAELVGHSGPVWKVSWAHpkYGGLLASASYDKKVIIWN 88
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 26-205 3.34e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 3.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258   26 SRLATCGSDRLVKIFEVrpnGQSYPMAELVGHSGPVWKV--SWAHPKyggLLASASYDKKVIIWNEQQGrwqKAYEWAAH 103
Cdd:PLN00181 546 SQVASSNFEGVVQVWDV---ARSQLVTEMKEHEKRVWSIdySSADPT---LLASGSDDGSVKLWSINQG---VSIGTIKT 616

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258  104 EASTTCVAFaPHQYGLMLASASADGDigILRYDNSsnewiSSKIQKC----HEQGVNSVCWAPGSAdpaakkrLVSAGND 179
Cdd:PLN00181 617 KANICCVQF-PSESGRSLAFGSADHK--VYYYDLR-----NPKLPLCtmigHSKTVSYVRFVDSST-------LVSSSTD 681

                        170       180
                 ....*....|....*....|....*....
gi 17544258  180 KNVKIWAFD---DATNEWILEkTLAGHTD 205
Cdd:PLN00181 682 NTLKLWDLSmsiSGINETPLH-SFMGHTN 709
WD40 pfam00400
WD domain, G-beta repeat;
50-88 2.44e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17544258    50 PMAELVGHSGPVWKVSWahPKYGGLLASASYDKKVIIWN 88
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 12-88 2.67e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544258   12 HRDAIHDAQLN-IYGSRLATCGSDRLVKIFEVRPNGQSY-----PMAELVGHSGPVWKVSWaHPKYGGLLASASYDKKVI 85
Cdd:PTZ00420  73 HTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeikdPQCILKGHKKKISIIDW-NPMNYYIMCSSGFDSFVN 151


                 ...
gi 17544258   86 IWN 88
Cdd:PTZ00420 152 IWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-185 4.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17544258    146 KIQKCHEQGVNSVCWAPGSadpaakKRLVSAGNDKNVKIW 185
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDG------KYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
149-185 6.36e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 6.36e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 17544258   149 KCHEQGVNSVCWAPGSadpaakKRLVSAGNDKNVKIW 185
Cdd:pfam00400   8 EGHTGSVTSLAFSPDG------KLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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