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Conserved domains on  [gi|17544260|ref|NP_500087|]
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Protein SEC13 homolog [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-190 2.69e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 2.69e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  12 HRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRPNGqsyPMAELVGHSGPVWKVSWAHpkYGGLLASASYDKKVIIWNEQQ 91
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE---LLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  92 GrwQKAYEWAAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEwiSSKIQKCHEQGVNSVCWAPGsadpaaKK 171
Cdd:cd00200  83 G--ECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKV--WDVETGK--CLTTLRGHTDWVNSVAFSPD------GT 148

                       170
                ....*....|....*....
gi 17544260 172 RLVSAGNDKNVKIWALSQF 190
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTG 167
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-190 2.69e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 2.69e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  12 HRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRPNGqsyPMAELVGHSGPVWKVSWAHpkYGGLLASASYDKKVIIWNEQQ 91
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE---LLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  92 GrwQKAYEWAAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEwiSSKIQKCHEQGVNSVCWAPGsadpaaKK 171
Cdd:cd00200  83 G--ECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKV--WDVETGK--CLTTLRGHTDWVNSVAFSPD------GT 148

                       170
                ....*....|....*....
gi 17544260 172 RLVSAGNDKNVKIWALSQF 190
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTG 167
WD40 COG2319
WD40 repeat [General function prediction only];
25-188 4.63e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 4.63e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  25 GSRLATCGSDRLVKIFEVRpNGQsyPMAELVGHSGPVWKVSWAHPkyGGLLASASYDKKVIIWNEQQGRWQKayEWAAHE 104
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA-TGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLR--TLTGHS 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260 105 ASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWIssKIQKCHEQGVNSVCWAPGSadpaakKRLVSAGNDKNVKI 184
Cdd:COG2319 247 GSVRSVAFSPD--GRLLASGSADGTVRL--WDLATGELL--RTLTGHSGGVNSVAFSPDG------KLLASGSDDGTVRL 314


                ....
gi 17544260 185 WALS 188
Cdd:COG2319 315 WDLA 318
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 26-188 4.68e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 4.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260   26 SRLATCGSDRLVKIFEVrpnGQSYPMAELVGHSGPVWKV--SWAHPKyggLLASASYDKKVIIWNEQQGrwqKAYEWAAH 103
Cdd:PLN00181 546 SQVASSNFEGVVQVWDV---ARSQLVTEMKEHEKRVWSIdySSADPT---LLASGSDDGSVKLWSINQG---VSIGTIKT 616

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  104 EASTTCVAFaPHQYGLMLASASADGDIgiLRYDNSSnewisSKIQKC----HEQGVNSVCWAPGSAdpaakkrLVSAGND 179
Cdd:PLN00181 617 KANICCVQF-PSESGRSLAFGSADHKV--YYYDLRN-----PKLPLCtmigHSKTVSYVRFVDSST-------LVSSSTD 681


                 ....*....
gi 17544260  180 KNVKIWALS 188
Cdd:PLN00181 682 NTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 50-88 2.20e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 2.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17544260     50 PMAELVGHSGPVWKVSWAHpkYGGLLASASYDKKVIIWN 88
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
50-88 2.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17544260    50 PMAELVGHSGPVWKVSWahPKYGGLLASASYDKKVIIWN 88
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-190 2.69e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 2.69e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  12 HRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRPNGqsyPMAELVGHSGPVWKVSWAHpkYGGLLASASYDKKVIIWNEQQ 91
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE---LLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  92 GrwQKAYEWAAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEwiSSKIQKCHEQGVNSVCWAPGsadpaaKK 171
Cdd:cd00200  83 G--ECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDKTIKV--WDVETGK--CLTTLRGHTDWVNSVAFSPD------GT 148

                       170
                ....*....|....*....
gi 17544260 172 RLVSAGNDKNVKIWALSQF 190
Cdd:cd00200 149 FVASSSQDGTIKLWDLRTG 167
WD40 COG2319
WD40 repeat [General function prediction only];
25-188 4.63e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 4.63e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  25 GSRLATCGSDRLVKIFEVRpNGQsyPMAELVGHSGPVWKVSWAHPkyGGLLASASYDKKVIIWNEQQGRWQKayEWAAHE 104
Cdd:COG2319 174 GKLLASGSDDGTVRLWDLA-TGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLR--TLTGHS 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260 105 ASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWIssKIQKCHEQGVNSVCWAPGSadpaakKRLVSAGNDKNVKI 184
Cdd:COG2319 247 GSVRSVAFSPD--GRLLASGSADGTVRL--WDLATGELL--RTLTGHSGGVNSVAFSPDG------KLLASGSDDGTVRL 314


                ....
gi 17544260 185 WALS 188
Cdd:COG2319 315 WDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-190 8.01e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 8.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260   6 QRIDTQHRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRPNGQSYpmaELVGHSGPVWKVSWaHPKyGGLLASASYDKKVI 85
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR---TLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIK 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  86 IWNEQQGrwQKAYEWAAHEASTTCVAFapHQYGLMLASASADGDIGIlrYDNSSNewisskiqKC------HEQGVNSVC 159
Cdd:cd00200 119 VWDVETG--KCLTTLRGHTDWVNSVAF--SPDGTFVASSSQDGTIKL--WDLRTG--------KCvatltgHTGEVNSVA 184

                       170       180       190
                ....*....|....*....|....*....|.
gi 17544260 160 WAPGSadpaakKRLVSAGNDKNVKIWALSQF 190
Cdd:cd00200 185 FSPDG------EKLLSSSSDGTIKLWDLSTG 209
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-186 1.49e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 1.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  12 HRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRpngQSYPMAELVGHSGPVWKVSWaHPKyGGLLASASYDKKVIIWNEQQ 91
Cdd:cd00200 134 HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLR---TGKCVATLTGHTGEVNSVAF-SPD-GEKLLSSSSDGTIKLWDLST 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  92 GRWQKAYEwaAHEASTTCVAFAPHQYglMLASASADGDIgilRYDNSSNEWISSKIQkCHEQGVNSVCWAPGSadpaakK 171
Cdd:cd00200 209 GKCLGTLR--GHENGVNSVAFSPDGY--LLASGSEDGTI---RVWDLRTGECVQTLS-GHTNSVTSLAWSPDG------K 274

                       170
                ....*....|....*
gi 17544260 172 RLVSAGNDKNVKIWA 186
Cdd:cd00200 275 RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
12-188 8.76e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 8.76e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  12 HRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRpNGQsyPMAELVGHSGPVWKVSWaHPKyGGLLASASYDKKVIIWNEQQ 91
Cdd:COG2319 245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGE--LLRTLTGHSGGVNSVAF-SPD-GKLLASGSDDGTVRLWDLAT 319

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  92 GRWQKayEWAAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWISSKIQkcHEQGVNSVCWAPGSadpaakK 171
Cdd:COG2319 320 GKLLR--TLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRL--WDLATGELLRTLTG--HTGAVTSVAFSPDG------R 385

                       170
                ....*....|....*..
gi 17544260 172 RLVSAGNDKNVKIWALS 188
Cdd:COG2319 386 TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
2-185 2.71e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 2.71e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260   2 TTVRQRIDTQHRDAIHDAQLNIYGSRLATCGSDRLVKIFEVRpngQSYPMAELVGHSGPVWKVSWAHPkyGGLLASASYD 81
Cdd:COG2319  67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGHTGAVRSVAFSPD--GKTLASGSAD 141

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  82 KKVIIWNEQQGRWQKayEWAAHEASTTCVAFAPHqyGLMLASASADGDIGIlrYDNSSNEWIssKIQKCHEQGVNSVCWA 161
Cdd:COG2319 142 GTVRLWDLATGKLLR--TLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRL--WDLATGKLL--RTLTGHTGAVRSVAFS 213

                       170       180
                ....*....|....*....|....
gi 17544260 162 PGSadpaakKRLVSAGNDKNVKIW 185
Cdd:COG2319 214 PDG------KLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-194 5.53e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.20  E-value: 5.53e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  52 AELVGHSGPVWKVSWaHPKyGGLLASASYDKKVIIWNEQQGRWQKAYEwaAHEASTTCVAFAPHqyGLMLASASADGDIG 131
Cdd:cd00200   3 RTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVAASAD--GTYLASGSSDKTIR 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17544260 132 ILRYDNSSnewiSSKIQKCHEQGVNSVCWAPgsadpaAKKRLVSAGNDKNVKIWALSQFGAKI 194
Cdd:cd00200  77 LWDLETGE----CVRTLTGHTSYVSSVAFSP------DGRILSSSSRDKTIKVWDVETGKCLT 129
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 26-188 4.68e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 4.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260   26 SRLATCGSDRLVKIFEVrpnGQSYPMAELVGHSGPVWKV--SWAHPKyggLLASASYDKKVIIWNEQQGrwqKAYEWAAH 103
Cdd:PLN00181 546 SQVASSNFEGVVQVWDV---ARSQLVTEMKEHEKRVWSIdySSADPT---LLASGSDDGSVKLWSINQG---VSIGTIKT 616

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260  104 EASTTCVAFaPHQYGLMLASASADGDIgiLRYDNSSnewisSKIQKC----HEQGVNSVCWAPGSAdpaakkrLVSAGND 179
Cdd:PLN00181 617 KANICCVQF-PSESGRSLAFGSADHKV--YYYDLRN-----PKLPLCtmigHSKTVSYVRFVDSST-------LVSSSTD 681


                 ....*....
gi 17544260  180 KNVKIWALS 188
Cdd:PLN00181 682 NTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 50-88 2.20e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 2.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17544260     50 PMAELVGHSGPVWKVSWAHpkYGGLLASASYDKKVIIWN 88
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 12-88 1.03e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544260   12 HRDAIHDAQLN-IYGSRLATCGSDRLVKIFEVRPNGQSY-----PMAELVGHSGPVWKVSWaHPKYGGLLASASYDKKVI 85
Cdd:PTZ00420  73 HTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeikdPQCILKGHKKKISIIDW-NPMNYYIMCSSGFDSFVN 151


                 ...
gi 17544260   86 IWN 88
Cdd:PTZ00420 152 IWD 154
WD40 pfam00400
WD domain, G-beta repeat;
50-88 2.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17544260    50 PMAELVGHSGPVWKVSWahPKYGGLLASASYDKKVIIWN 88
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-185 3.92e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 3.92e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17544260    146 KIQKCHEQGVNSVCWAPGSadpaakKRLVSAGNDKNVKIW 185
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDG------KYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
149-185 5.97e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.47  E-value: 5.97e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 17544260   149 KCHEQGVNSVCWAPGSadpaakKRLVSAGNDKNVKIW 185
Cdd:pfam00400   8 EGHTGSVTSLAFSPDG------KLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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