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Conserved domains on  [gi|392898495|ref|NP_500240|]
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GDNF/GAS1 domain-containing protein [Caenorhabditis elegans]

Protein Classification

GDNF family receptor( domain architecture ID 10492250)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF; similar to Homo sapiens GDNF family receptor alpha-like

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 23-102 4.75e-10

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 57.16  E-value: 4.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    23 CLHYRSICLRNDTCNQHLKRFQTTCGYDLNVCSG-TSPSDCVYYLHRIREIFPTKS------CTCYEAIGFSQECDFFRQ 95
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGcPNPARCLRAYRMTPNYVDNLGtslllwCTCKGSGNQDEECEEFRR 80


                   ....*..
gi 392898495    96 IIWNHSC 102
Cdd:pfam02351   81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 172-250 9.67e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 50.72  E-value: 9.67e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    172 CDAALyQVCLKHVSCSQLWSMFRKNCDVDLDNQCRMADREVCWQSFEGLTWS--------GLGDCQCASSNSSDCHWIRL 243
Cdd:smart00907    1 CLEAL-KACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAYCGLALRpfyddnssVLLFCTCAGNRDEECLEFRR 79


                    ....*..
gi 392898495    244 HTNYNKC 250
Cdd:smart00907   80 LFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 491-568 1.60e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 47.25  E-value: 1.60e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    491 CTQSVQKCDQDQRCKHIRYAMQAHC-PVRNGECSKTSLDDCRRTLLTAR-------ASILEQPCFCK-LSDVQCLAHQNs 561
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACsPSPSSSCPGENSEACLRAYCGLAlrpfyddNSSVLLFCTCAgNRDEECLEFRR- 79


                    ....*..
gi 392898495    562 MIPTNPC 568
Cdd:smart00907   80 LFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 403-480 7.24e-05

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 42.24  E-value: 7.24e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    403 CPDAIRRCESVDECRWHLGELRVRCASTAS----------CQREECAQSLQRFvtYVPFALIesIMFCHCA-PEDEGCLT 471
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPSPSsscpgenseaCLRAYCGLALRPF--YDDNSSV--LLFCTCAgNRDEECLE 76

                            90
                    ....*....|
gi 392898495    472 QQEIIY-PKC 480
Cdd:smart00907   77 FRRLFHsNPC 86
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 23-102 4.75e-10

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 57.16  E-value: 4.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    23 CLHYRSICLRNDTCNQHLKRFQTTCGYDLNVCSG-TSPSDCVYYLHRIREIFPTKS------CTCYEAIGFSQECDFFRQ 95
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGcPNPARCLRAYRMTPNYVDNLGtslllwCTCKGSGNQDEECEEFRR 80


                   ....*..
gi 392898495    96 IIWNHSC 102
Cdd:pfam02351   81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 172-250 9.67e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 50.72  E-value: 9.67e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    172 CDAALyQVCLKHVSCSQLWSMFRKNCDVDLDNQCRMADREVCWQSFEGLTWS--------GLGDCQCASSNSSDCHWIRL 243
Cdd:smart00907    1 CLEAL-KACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAYCGLALRpfyddnssVLLFCTCAGNRDEECLEFRR 79


                    ....*..
gi 392898495    244 HTNYNKC 250
Cdd:smart00907   80 LFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 23-102 2.05e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 49.56  E-value: 2.05e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495     23 CLHYRSICLRNDTCNQHLKRFQTTCGYDL-NVCSGTSPSDC-VYYLHR------IREIFPTKSCTCyeAIGFSQECDFFR 94
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPSPsSSCPGENSEAClRAYCGLalrpfyDDNSSVLLFCTC--AGNRDEECLEFR 78


                    ....*...
gi 392898495     95 QIIWNHSC 102
Cdd:smart00907   79 RLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 491-568 1.60e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 47.25  E-value: 1.60e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    491 CTQSVQKCDQDQRCKHIRYAMQAHC-PVRNGECSKTSLDDCRRTLLTAR-------ASILEQPCFCK-LSDVQCLAHQNs 561
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACsPSPSSSCPGENSEACLRAYCGLAlrpfyddNSSVLLFCTCAgNRDEECLEFRR- 79


                    ....*..
gi 392898495    562 MIPTNPC 568
Cdd:smart00907   80 LFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 403-480 7.24e-05

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 42.24  E-value: 7.24e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    403 CPDAIRRCESVDECRWHLGELRVRCASTAS----------CQREECAQSLQRFvtYVPFALIesIMFCHCA-PEDEGCLT 471
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPSPSsscpgenseaCLRAYCGLALRPF--YDDNSSV--LLFCTCAgNRDEECLE 76

                            90
                    ....*....|
gi 392898495    472 QQEIIY-PKC 480
Cdd:smart00907   77 FRRLFHsNPC 86
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 23-102 4.75e-10

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 57.16  E-value: 4.75e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    23 CLHYRSICLRNDTCNQHLKRFQTTCGYDLNVCSG-TSPSDCVYYLHRIREIFPTKS------CTCYEAIGFSQECDFFRQ 95
Cdd:pfam02351    1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGcPNPARCLRAYRMTPNYVDNLGtslllwCTCKGSGNQDEECEEFRR 80


                   ....*..
gi 392898495    96 IIWNHSC 102
Cdd:pfam02351   81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 172-250 9.67e-08

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 50.72  E-value: 9.67e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    172 CDAALyQVCLKHVSCSQLWSMFRKNCDVDLDNQCRMADREVCWQSFEGLTWS--------GLGDCQCASSNSSDCHWIRL 243
Cdd:smart00907    1 CLEAL-KACELDPVCRSRLADYLSACSPSPSSSCPGENSEACLRAYCGLALRpfyddnssVLLFCTCAGNRDEECLEFRR 79


                    ....*..
gi 392898495    244 HTNYNKC 250
Cdd:smart00907   80 LFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 23-102 2.05e-07

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 49.56  E-value: 2.05e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495     23 CLHYRSICLRNDTCNQHLKRFQTTCGYDL-NVCSGTSPSDC-VYYLHR------IREIFPTKSCTCyeAIGFSQECDFFR 94
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPSPsSSCPGENSEAClRAYCGLalrpfyDDNSSVLLFCTC--AGNRDEECLEFR 78


                    ....*...
gi 392898495     95 QIIWNHSC 102
Cdd:smart00907   79 RLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 491-568 1.60e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 47.25  E-value: 1.60e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    491 CTQSVQKCDQDQRCKHIRYAMQAHC-PVRNGECSKTSLDDCRRTLLTAR-------ASILEQPCFCK-LSDVQCLAHQNs 561
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACsPSPSSSCPGENSEACLRAYCGLAlrpfyddNSSVLLFCTCAgNRDEECLEFRR- 79


                    ....*..
gi 392898495    562 MIPTNPC 568
Cdd:smart00907   80 LFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 403-480 7.24e-05

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 42.24  E-value: 7.24e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392898495    403 CPDAIRRCESVDECRWHLGELRVRCASTAS----------CQREECAQSLQRFvtYVPFALIesIMFCHCA-PEDEGCLT 471
Cdd:smart00907    1 CLEALKACELDPVCRSRLADYLSACSPSPSsscpgenseaCLRAYCGLALRPF--YDDNSSV--LLFCTCAgNRDEECLE 76

                            90
                    ....*....|
gi 392898495    472 QQEIIY-PKC 480
Cdd:smart00907   77 FRRLFHsNPC 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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