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Conserved domains on  [gi|71999659|ref|NP_500671|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-314 3.47e-89

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 269.33  E-value: 3.47e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    10 IVKDSCTLIAILTNSLLIYLALTKSPPKMGNYKYLLCYFSVLSITYVTLDFLAAPYVYTFEASSVLLMDLRNTIFTEYpa 89
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    90 VAFLIIVSACGCFGATLAAIAINFIYRLWALERKGRLRYFEGKLLIAWILLSLFTGFL-SACVFWTTGPNDQINNYIRHN 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIwGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659   169 LKEEYDLDVDQTSYIAFVYW-KSENRVDYLNILDTSKLMIVNIIMIIPFSIIFYCGLKSYYQIKELISKGeNEFSRRLQM 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYpTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71999659   248 QLYKALVAQTFIPTLFLFIPVSLFLVGPLIGINVTWALRAVTVFFSIYLATESLPIIFLVDDYRTAI 314
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-314 3.47e-89

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 269.33  E-value: 3.47e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    10 IVKDSCTLIAILTNSLLIYLALTKSPPKMGNYKYLLCYFSVLSITYVTLDFLAAPYVYTFEASSVLLMDLRNTIFTEYpa 89
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    90 VAFLIIVSACGCFGATLAAIAINFIYRLWALERKGRLRYFEGKLLIAWILLSLFTGFL-SACVFWTTGPNDQINNYIRHN 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIwGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659   169 LKEEYDLDVDQTSYIAFVYW-KSENRVDYLNILDTSKLMIVNIIMIIPFSIIFYCGLKSYYQIKELISKGeNEFSRRLQM 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYpTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71999659   248 QLYKALVAQTFIPTLFLFIPVSLFLVGPLIGINVTWALRAVTVFFSIYLATESLPIIFLVDDYRTAI 314
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-314 3.47e-89

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 269.33  E-value: 3.47e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    10 IVKDSCTLIAILTNSLLIYLALTKSPPKMGNYKYLLCYFSVLSITYVTLDFLAAPYVYTFEASSVLLMDLRNTIFTEYpa 89
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    90 VAFLIIVSACGCFGATLAAIAINFIYRLWALERKGRLRYFEGKLLIAWILLSLFTGFL-SACVFWTTGPNDQINNYIRHN 168
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIwGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659   169 LKEEYDLDVDQTSYIAFVYW-KSENRVDYLNILDTSKLMIVNIIMIIPFSIIFYCGLKSYYQIKELISKGeNEFSRRLQM 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYpTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71999659   248 QLYKALVAQTFIPTLFLFIPVSLFLVGPLIGINVTWALRAVTVFFSIYLATESLPIIFLVDDYRTAI 314
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAI 306
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 1-314 1.83e-33

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 125.43  E-value: 1.83e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659     1 MGIFVIIKLIVKDSCTLiAILTNSLLIYLALTKSPPKMGNYKYLLCYFSVLSITYVTLDFLAAPYVYTFEASSVLLmdLR 80
Cdd:pfam10319   1 MYINWAHYYIPKIFGVL-SFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVF--VS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    81 NTIFTEYPAVAFLIIVSACGCFGATLAAIAINFIYRLWALERKGRL-RYFEGK-LLIAWILLSLFTGFLSACVFWTTGPN 158
Cdd:pfam10319  78 DGPFFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWgILISILFFLFHGSVWTAICYFLLRAN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659   159 DQINNYIRHNLKEEYDLDVDQTSYIAFVYWKSENRVDYLNILDTsklMIVNIIMIIPFSIIFYCGLKSYYQIKElISKGE 238
Cdd:pfam10319 158 DEIRDYIREDFRETYGVDSMDINMLGALYWEASDETVFRSWLGI---LLLTVISVYSIILYIVLGYKIMRKLNK-MSVTM 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71999659   239 NEFSRRLQMQLYKALVAQTFIPTLFLFIPVSLFLVGPLIGINVTWALRAV-TVFFSIYLATESLPIIFLVDDYRTAI 314
Cdd:pfam10319 234 SKKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLeVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 15-314 2.89e-09

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 57.18  E-value: 2.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    15 CTLIAILTNSLLIYLALTKSPPKMGNYKYLLCYFSVLSITYVTLDFLAAPYVYTFEASSVLLMDLRNTIFTeyPAVAFLI 94
Cdd:pfam10317   8 FFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFG--PWFCYSG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    95 IVSACGCFGATLAAIAINFIYRLWALerkgRLRYFEGKLLIAWILLSLFTGFLSACVFWTTgpnDQINNYIRHNLKEEY- 173
Cdd:pfam10317  86 YSLLQHFLLHSGWSLLLTFYYRYYIL----KHVDPKRKKLILLIIIHYIPSLSQLIVIFLS---PTDFLPVEALTKELHp 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659   174 DLDVDQTSYIAFvywksenrVDYLNILDTSKLMIVNIIMIIPFSIIFYCglksYYQIKELISKGENEFS---RRLQMQLY 250
Cdd:pfam10317 159 NYNLTDYTVTGF--------SDLQSFPALINTLIMTIPVFPIPIIILIL----RRKILKLLNSNSVNMSpttKAQHRQLI 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71999659   251 KALVAQTFIPTLFLFIPVSLFLVGPLIGINVTWALRAVTVFFSIYLATESLPIIFLVDDYRTAI 314
Cdd:pfam10317 227 KGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 14-320 6.00e-06

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 47.15  E-value: 6.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    14 SCTLIAILTNSLLIYLALTKSPPKMGNYKYLLCYFSVLSITY-VTLDFLAAPYVYtFEASSVLLMdlrnTIFTEYPAVAF 92
Cdd:pfam10318  12 IITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLdLSLSFLTIPYIF-LPALAGYPL----GLLSYLGVPTP 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659    93 LIIVSACGCFGATLAAIAINFIYRLWALERkGRLRYFEGKLLIAWILLSLFTGFLSACVFWTTGPnDQiNNYIRHNLKE- 171
Cdd:pfam10318  87 IQFYIGVTSLALVGVSIILLFENRYSILFT-NKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIP-DQ-EAAKLKVLKKl 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999659   172 ----EYDLDVDQTSYIAFvywksenrvDYLNILDTSKLMIVnIIMIIPFSIIFYCGLKSYYQIKELISKGenefSRRLQM 247
Cdd:pfam10318 164 pclpPEFFDNPPVFVLAI---------DSTYFLICIVLLIL-ILIIQILFFVFLTIYYLFKSVKSSLSKK----TRKLQK 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71999659   248 QLYKALVAQTFIPTLFLFIPVSLFLVGPLIGINVTWALRAVTVFFSIYLATESLPIIFLVDDYRTAIANIFRR 320
Cdd:pfam10318 230 KFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 17-65 3.40e-03

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 38.68  E-value: 3.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 71999659    17 LIAILTNSLLIYLALTKSPpKMGNYKYLLCYFSVLS-ITYVTLDFLAAPY 65
Cdd:pfam10327  20 TISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCtLTDIHLTFLMQPI 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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