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Conserved domains on  [gi|71999671|ref|NP_500677|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-315 5.07e-111

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 325.18  E-value: 5.07e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671     8 KSFVQFVTVSFSLVINSILIYLVITKSSKKLGNYRHLMCYFSLFSMVYAVLDWIVQPFIHSHGASFSMIMDLRESALNKK 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671    88 VAFFFVASLAGCFGVSIYAIAINFIFRYFALQREGRLRYFAGKRLILWFCIPLFGGLSWVFLCWCSMAPDPEFTNYLRDS 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671   168 IRANYDLDADFITYTGSYFYRFERDGSVKWSIENSLGALGLNVLMIIPFFIILIFGYRSYKKISKLMAQGeCDYTKRLQM 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71999671   248 QLYKALVAQTIIPMVLLSFPIGILFSAPLLHLDIENGSIIVTFFYSLYPAIDPIPIILFIDDFRNAFF 315
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-315 5.07e-111

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 325.18  E-value: 5.07e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671     8 KSFVQFVTVSFSLVINSILIYLVITKSSKKLGNYRHLMCYFSLFSMVYAVLDWIVQPFIHSHGASFSMIMDLRESALNKK 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671    88 VAFFFVASLAGCFGVSIYAIAINFIFRYFALQREGRLRYFAGKRLILWFCIPLFGGLSWVFLCWCSMAPDPEFTNYLRDS 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671   168 IRANYDLDADFITYTGSYFYRFERDGSVKWSIENSLGALGLNVLMIIPFFIILIFGYRSYKKISKLMAQGeCDYTKRLQM 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71999671   248 QLYKALVAQTIIPMVLLSFPIGILFSAPLLHLDIENGSIIVTFFYSLYPAIDPIPIILFIDDFRNAFF 315
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 8-315 5.07e-111

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 325.18  E-value: 5.07e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671     8 KSFVQFVTVSFSLVINSILIYLVITKSSKKLGNYRHLMCYFSLFSMVYAVLDWIVQPFIHSHGASFSMIMDLRESALNKK 87
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671    88 VAFFFVASLAGCFGVSIYAIAINFIFRYFALQREGRLRYFAGKRLILWFCIPLFGGLSWVFLCWCSMAPDPEFTNYLRDS 167
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671   168 IRANYDLDADFITYTGSYFYRFERDGSVKWSIENSLGALGLNVLMIIPFFIILIFGYRSYKKISKLMAQGeCDYTKRLQM 247
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQK 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71999671   248 QLYKALVAQTIIPMVLLSFPIGILFSAPLLHLDIENGSIIVTFFYSLYPAIDPIPIILFIDDFRNAFF 315
Cdd:pfam10326 240 QLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 18-314 1.88e-40

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 143.92  E-value: 1.88e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671    18 FSLVINSILIYLVITKSSKKLGNYRHLMCYFSLFSMVYAVLDWIVQPFIHSHGASFSMIMDLRESALNKKVAFFFVASLA 97
Cdd:pfam10319  17 LSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELGQHALSARC 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671    98 GCFGVSIYAIAINFIFRYFALQREGRL-RYFAGKRLILWFCIPLFGGLSWVFLCWCSMAPDPEFTNYLRDSIRANYDLDA 176
Cdd:pfam10319  97 SFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGVDS 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671   177 DFITYTGSYFYrferDGSVKWSIENSLGALGLNVLMIIPFFIILIFGYRSYKKISKlMAQGECDYTKRLQMQLYKALVAQ 256
Cdd:pfam10319 177 MDINMLGALYW----EASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNK-MSVTMSKKTKRLQKQLLKALIVQ 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 71999671   257 TIIPMVLLSFPIGILFSAPLLHLDIENG-SIIVTFFYSLYPAIDPIPIILFIDDFRNAF 314
Cdd:pfam10319 252 TIIPICISFSPCVLAWYSPIFGIDLGRWnNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 14-314 8.45e-09

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 56.02  E-value: 8.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671    14 VTVSFSLVINSILIYLVITKSSKKLGNYRHLMCYFSLFSMVYAVLDWIVQPFIHSHGASFSMIMDLRESALNKKVAFFFV 93
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671    94 ASLAGCFGVSIYAIAINFIFRYFALqREGRLRYFAGKRLILWFCIPLFgglswVFLCWCSMAPDPEFTNYLRDSIRA-NY 172
Cdd:pfam10317  87 SLLQHFLLHSGWSLLLTFYYRYYIL-KHVDPKRKKLILLIIIHYIPSL-----SQLIVIFLSPTDFLPVEALTKELHpNY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671   173 DLDADFITYTGSYFyrferdgsvkwsienSLGALGLNVLMIIPFFIILIFGYRSYKKISKLMAQGEC---DYTKRLQMQL 249
Cdd:pfam10317 161 NLTDYTVTGFSDLQ---------------SFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVnmsPTTKAQHRQL 225

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71999671   250 YKALVAQTIIPMVLLsFPIGILFSapLLHLDIENGSI---IVTFFYSLYPAIDPIPIILFIDDFRNAF 314
Cdd:pfam10317 226 IKGLTIQALLPLFSY-IPGVTLYL--LSQLTGTEFLIleyFIFVLPALPPLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 9-320 2.68e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 42.14  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671     9 SFVQFVTVSFSLVINSILIYLVITKSSKKLGNYRHLMCYFSLFSMVyavLD----WIVQPFIHSHGASFSMIMDLRESAL 84
Cdd:pfam10318   7 STSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSAL---LDlslsFLTIPYIFLPALAGYPLGLLSYLGV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671    85 NKKVAFFFVASLAGCFGVSIYAIainFIFRYFALQRegRLRYFAGKRL-ILWFCIPLFGGLSWVFLCWCsMAPDPEftNY 163
Cdd:pfam10318  84 PTPIQFYIGVTSLALVGVSIILL---FENRYSILFT--NKKRITWKKTrVLYLIFNYIIALLFLIPIYL-NIPDQE--AA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71999671   164 LRDSIRANYDLDADFITYTGSYFyrferdgsvkWSIENSLGALGLNVLMIIPFFIILIFGYRSYKKISKLMAQGECDYTK 243
Cdd:pfam10318 156 KLKVLKKLPCLPPEFFDNPPVFV----------LAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTR 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71999671   244 RLQMQLYKALVAQTIIPMVLLSFPIGILFSAPLLHLDIENGSIIVTFFYSLYPAIDPIPIILFIDDFRNAFFGVFQR 320
Cdd:pfam10318 226 KLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 17-66 8.45e-04

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 40.61  E-value: 8.45e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 71999671    17 SFSLVINSILIYLVITKsSKKLGNYRHLMCYFSLFSMVYAV-LDWIVQPFI 66
Cdd:pfam10327  20 TISLILNLLGIYLIIFK-SGKIDNFRYYLLYFQISCTLTDIhLTFLMQPIP 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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