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Conserved domains on  [gi|17540330|ref|NP_500789|]
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TLC domain-containing protein [Caenorhabditis elegans]

Protein Classification

TLC domain-containing protein( domain architecture ID 10653905)

TLC (TRAM, LAG1 and CLN8) domain-containing protein may possess one of multiple functions such as lipid trafficking, metabolism, or sensing

PubMed:  12151215

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
56-253 4.60e-28

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


:

Pssm-ID: 214789  Cd Length: 205  Bit Score: 106.99  E-value: 4.60e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330     56 FKRYRLQNLTVCWLHAVIVGGGDLILMFSHPHEIFHDVIDWYNPIAAQLPLISVAYFFQDAFDMLMYEWNSYT--LELLL 133
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLFQDLKRKdfKEMLV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330    134 HHFATCAALVAPGLTGKFTLAAGWALLMEVNSIFLHARTILQICGLstQFPGVFRVVVYSNIISFFFFRIVSQILWTNWA 213
Cdd:smart00724  81 HHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGR--KKSLLYDVNFVLFAVVFFVFRLILFPFLILTV 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 17540330    214 IYNVPGLHWY-----YVLVGLGGPIIFGCINGMLFLRLLASDGFL 253
Cdd:smart00724 159 TVHYAQAESGlfpplLYLLFLLLLLCLQLLNIYWFFLILRMARKL 203
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
56-253 4.60e-28

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 106.99  E-value: 4.60e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330     56 FKRYRLQNLTVCWLHAVIVGGGDLILMFSHPHEIFHDVIDWYNPIAAQLPLISVAYFFQDAFDMLMYEWNSYT--LELLL 133
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLFQDLKRKdfKEMLV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330    134 HHFATCAALVAPGLTGKFTLAAGWALLMEVNSIFLHARTILQICGLstQFPGVFRVVVYSNIISFFFFRIVSQILWTNWA 213
Cdd:smart00724  81 HHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGR--KKSLLYDVNFVLFAVVFFVFRLILFPFLILTV 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 17540330    214 IYNVPGLHWY-----YVLVGLGGPIIFGCINGMLFLRLLASDGFL 253
Cdd:smart00724 159 TVHYAQAESGlfpplLYLLFLLLLLCLQLLNIYWFFLILRMARKL 203
TRAM_LAG1_CLN8 pfam03798
TLC domain;
60-247 6.91e-15

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 71.54  E-value: 6.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330    60 RLQNLTVCWLHAVIVGGGDLILMFSHP--HEIFHDVIDWYNPIAAQLP-------LISVAYFFQDAFDMLMYEWNSY-TL 129
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPwfWNPTELWYDYPNRVLGYTSwlvkfyyLIQLGYFIWDLLVLLFYEKRRKdFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330   130 ELLLHHFATCAALVAPGLTGKFTLAAGWALLMEVNSIFLHARTILQICGlstqFPGVFRVVVYSNIISFFFFRIVSQILW 209
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLG----KGTSCDVLFVLFLVSFFVTRLVLGPFW 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 17540330   210 TNWAIYNVPGLH-----WYYVLVGLGGPIIFGCINGMLFLRLL 247
Cdd:pfam03798 157 ILLSILDYAGLDvptgpFLLYYIFLILLLVLQLLNIYWFYLII 199
 
Name Accession Description Interval E-value
TLC smart00724
TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane ...
56-253 4.60e-28

TRAM, LAG1 and CLN8 homology domains; Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.


Pssm-ID: 214789  Cd Length: 205  Bit Score: 106.99  E-value: 4.60e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330     56 FKRYRLQNLTVCWLHAVIVGGGDLILMFSHPHEIFHDVIDWYNPIAAQLPLISVAYFFQDAFDMLMYEWNSYT--LELLL 133
Cdd:smart00724   1 SKFNESSNRLVSYLHSVIAGLYALYSEPWLSDPKSLYPIQGMSPLAKFYYLFSLGYFIHDLVALLLFQDLKRKdfKEMLV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330    134 HHFATCAALVAPGLTGKFTLAAGWALLMEVNSIFLHARTILQICGLstQFPGVFRVVVYSNIISFFFFRIVSQILWTNWA 213
Cdd:smart00724  81 HHIATLLLISLSYVLNFTRLGLLLLLLHELSDPFLHLRKLLNYAGR--KKSLLYDVNFVLFAVVFFVFRLILFPFLILTV 158
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 17540330    214 IYNVPGLHWY-----YVLVGLGGPIIFGCINGMLFLRLLASDGFL 253
Cdd:smart00724 159 TVHYAQAESGlfpplLYLLFLLLLLCLQLLNIYWFFLILRMARKL 203
TRAM_LAG1_CLN8 pfam03798
TLC domain;
60-247 6.91e-15

TLC domain;


Pssm-ID: 461055  Cd Length: 200  Bit Score: 71.54  E-value: 6.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330    60 RLQNLTVCWLHAVIVGGGDLILMFSHP--HEIFHDVIDWYNPIAAQLP-------LISVAYFFQDAFDMLMYEWNSY-TL 129
Cdd:pfam03798   1 KFSESGVSLVYYLVSTILGLYVLSSEPwfWNPTELWYDYPNRVLGYTSwlvkfyyLIQLGYFIWDLLVLLFYEKRRKdFW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540330   130 ELLLHHFATCAALVAPGLTGKFTLAAGWALLMEVNSIFLHARTILQICGlstqFPGVFRVVVYSNIISFFFFRIVSQILW 209
Cdd:pfam03798  81 EMLLHHVITLVLIVLSYFRNFTRVGLLVLLLHELSDPFLNLAKILNYLG----KGTSCDVLFVLFLVSFFVTRLVLGPFW 156
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 17540330   210 TNWAIYNVPGLH-----WYYVLVGLGGPIIFGCINGMLFLRLL 247
Cdd:pfam03798 157 ILLSILDYAGLDvptgpFLLYYIFLILLLVLQLLNIYWFYLII 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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