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Conserved domains on  [gi|17542120|ref|NP_501129|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 11-319 2.75e-105

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 310.93  E-value: 2.75e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    11 LHIFTKCSLFFAILFNTFLVYLILTKSPRQLGVYKYLMVFISIFEILYSLLEVTLTPIHYSYRSSVVVLITTSDKLFSRD 90
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    91 ILLTLNSFYWGFFGSSLAIFAIHFVYRYLVISGNALLQTFQSWKLILWLMIPLVIGFIWSLTGIFLCGPTEEFTEFMRND 170
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120   171 VWEVFHENIEEFEYLGALMYEKSwATKNMIIYWSPIAGMTIMSLTVLASFLVIVICGYKCYLRIKLLLKNGgtsSARSQV 250
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTD-ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRK 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17542120   251 LQTQLFNALAIQTLIPILLLHTPVVLKFSFAIFDAGLGAYCFAMSITIALYPAIDPLPNFFIISPYRKA 319
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 11-319 2.75e-105

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 310.93  E-value: 2.75e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    11 LHIFTKCSLFFAILFNTFLVYLILTKSPRQLGVYKYLMVFISIFEILYSLLEVTLTPIHYSYRSSVVVLITTSDKLFSRD 90
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    91 ILLTLNSFYWGFFGSSLAIFAIHFVYRYLVISGNALLQTFQSWKLILWLMIPLVIGFIWSLTGIFLCGPTEEFTEFMRND 170
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120   171 VWEVFHENIEEFEYLGALMYEKSwATKNMIIYWSPIAGMTIMSLTVLASFLVIVICGYKCYLRIKLLLKNGgtsSARSQV 250
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTD-ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRK 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17542120   251 LQTQLFNALAIQTLIPILLLHTPVVLKFSFAIFDAGLGAYCFAMSITIALYPAIDPLPNFFIISPYRKA 319
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 11-319 2.75e-105

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 310.93  E-value: 2.75e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    11 LHIFTKCSLFFAILFNTFLVYLILTKSPRQLGVYKYLMVFISIFEILYSLLEVTLTPIHYSYRSSVVVLITTSDKLFSRD 90
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    91 ILLTLNSFYWGFFGSSLAIFAIHFVYRYLVISGNALLQTFQSWKLILWLMIPLVIGFIWSLTGIFLCGPTEEFTEFMRND 170
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120   171 VWEVFHENIEEFEYLGALMYEKSwATKNMIIYWSPIAGMTIMSLTVLASFLVIVICGYKCYLRIKLLLKNGgtsSARSQV 250
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTD-ENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG---SEKTRK 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17542120   251 LQTQLFNALAIQTLIPILLLHTPVVLKFSFAIFDAGLGAYCFAMSITIALYPAIDPLPNFFIISPYRKA 319
Cdd:pfam10326 237 LQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 10-318 3.59e-38

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 138.14  E-value: 3.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    10 YLHIFTKCSLFFAILFNTFLVYLILTKSPRQLGVYKYLMVFISIFEILYSLLEVtLTPIH-YSYRSSVVVLITTSDKLFS 88
Cdd:pfam10319   6 AHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVEL-LVPLDiHSYRYCFVVFVSDGPFFEY 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    89 RDILLTLNSFYWGFFGSSLAIFAIHFVYRYLVISGNALLQT-FQSWKLILWLMIPLVIGFIWSLTGIFLCGPTEEFTEFM 167
Cdd:pfam10319  85 SELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHyFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120   168 RNDVWEVFHENIEEFEYLGALMYEKSWATKnmiiyWSPIAGMTIMSLTVLASFLVIVICGYKCylrIKLLLKNGGTSSAR 247
Cdd:pfam10319 165 REDFRETYGVDSMDINMLGALYWEASDETV-----FRSWLGILLLTVISVYSIILYIVLGYKI---MRKLNKMSVTMSKK 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17542120   248 SQVLQTQLFNALAIQTLIPILLLHTPVVLKFSFAIF--DAGLGAYCFAMsITIALYPAIDPLPNFFIISPYRK 318
Cdd:pfam10319 237 TKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFgiDLGRWNNYLEV-IALSAFPFIDPLAIILCLPVYRN 308
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 11-321 2.23e-18

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 84.14  E-value: 2.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    11 LHIFTKCSLFFAILFNTFLVYLILTKSPRQLGVYKYLMVFISIFEILYSLLEVTLTPIHYSYRSSVVVLITTSDKLFSRD 90
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    91 ILLTLNSFYWGFFGSSLAIFAIHFVYRYLVISGNAlLQTFQSWKLILWLMIPLVIGFIWSLTGIflcgpteeftefmrND 170
Cdd:pfam10317  81 FCYSGYSLLQHFLLHSGWSLLLTFYYRYYILKHVD-PKRKKLILLIIIHYIPSLSQLIVIFLSP--------------TD 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120   171 VWEVFHENIEEFEYLGALMYEKSWATknMIIYWSPIAGMTIMSLTVLASFLVIVICGYKCylrIKLLLKNGGTSSARSQV 250
Cdd:pfam10317 146 FLPVEALTKELHPNYNLTDYTVTGFS--DLQSFPALINTLIMTIPVFPIPIIILILRRKI---LKLLNSNSVNMSPTTKA 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17542120   251 LQTQLFNALAIQTLIPILLLHTPVVLKFSFAIFDAGLGAYCFAMSITIALYPAIDPLPNFFIISPYRKAAL 321
Cdd:pfam10317 221 QHRQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 6-325 5.75e-06

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 47.54  E-value: 5.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120     6 DLPQYLHIFTKCSLFFAILFNTFLVYLILTKSPRQLGVYKYLM----VFISIFEILYSLLevtLTPIHYsyrssVVVLIT 81
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLlnlhFWSALLDLSLSFL---TIPYIF-----LPALAG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120    82 TSDKLFSRDILLTLNSFYWGFFGSSLAIFAI--HFVYRYLVISGNALLQTFQSWKlILWLMIPLVIGFIWSLTGIFLCGP 159
Cdd:pfam10318  73 YPLGLLSYLGVPTPIQFYIGVTSLALVGVSIilLFENRYSILFTNKKRITWKKTR-VLYLIFNYIIALLFLIPIYLNIPD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120   160 TEEftefMRNDVWEVFHENIEEFeylgalmyeksWATKNMII----YWSPIAGMTIMSLTVLASFLVIVICgykcyLRIK 235
Cdd:pfam10318 152 QEA----AKLKVLKKLPCLPPEF-----------FDNPPVFVlaidSTYFLICIVLLILILIIQILFFVFL-----TIYY 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542120   236 LLLKNGGTSSARSQVLQTQLFNALAIQTLIPILLLHTPVVLKFSFAIFDAGLGAYCFAMSITIALYPAIDPLPNFFIISP 315
Cdd:pfam10318 212 LFKSVKSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKP 291

                         330
                  ....*....|
gi 17542120   316 YRKAALGCFK 325
Cdd:pfam10318 292 YRKFVLSLFK 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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