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Conserved domains on  [gi|17539522|ref|NP_501150|]
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Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

cuticular collagen family protein( domain architecture ID 18387949)

cuticular collagen family protein is a structural macromolecule of the extracellular matrix containing triple helix domains that form tight interactions and stabilize supramolecular aggregates

Gene Ontology:  GO:0042302|GO:0005581
PubMed:  1916105|21421911

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Col_cuticle_N smart01088
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 15-66 1.20e-12

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


:

Pssm-ID: 198156  Cd Length: 53  Bit Score: 61.71  E-value: 1.20e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 17539522     15 VANIAMCFAIVSVLTVCVSMPAIYMYMFHVKQLINTEVVSCEDHAREIWREV 66
Cdd:smart01088   2 VAYVAVAVSTVAVLSALVTLPSIYNDIQSFQSELLDEMDEFKARADDAWNEM 53
gly_rich_SclB super family cl45768
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 138-284 1.60e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


The actual alignment was detected with superfamily member NF038329:

Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 55.30  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  138 GKPGAPGLPGVPGKTTIQAPCEAASP--PPCRVCPVGMPGEQGVTGAPGDKGPAGQPGRNGPDGPNGEPGPKGPPGQPGA 215
Cdd:NF038329 138 GDRGETGPAGPAGPPGPQGERGEKGPagPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGE 217

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539522  216 DGQPGMPGEPGKDAPQEGSPVPGdpgppgdsgipgppgppgmagpdgiPGMGGAKGQNGPDGPPGASGE 284
Cdd:NF038329 218 AGPAGEDGPAGPAGDGQQGPDGD-------------------------PGPTGEDGPQGPDGPAGKDGP 261
 
Name Accession Description Interval E-value
Col_cuticle_N smart01088
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 15-66 1.20e-12

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 198156  Cd Length: 53  Bit Score: 61.71  E-value: 1.20e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 17539522     15 VANIAMCFAIVSVLTVCVSMPAIYMYMFHVKQLINTEVVSCEDHAREIWREV 66
Cdd:smart01088   2 VAYVAVAVSTVAVLSALVTLPSIYNDIQSFQSELLDEMDEFKARADDAWNEM 53
Col_cuticle_N pfam01484
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 18-66 7.98e-10

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens, see pfam01391. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 460226  Cd Length: 50  Bit Score: 53.62  E-value: 7.98e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 17539522    18 IAMCFAIVSVLTVCVSMPAIYMYMFHVKQLINTEVVSCEDHAREIWREV 66
Cdd:pfam01484   2 VAVAFSTVAILSSLITLPSIYNDIQELQSEVLDEMDEFKARSDDAWNEM 50
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 138-284 1.60e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 55.30  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  138 GKPGAPGLPGVPGKTTIQAPCEAASP--PPCRVCPVGMPGEQGVTGAPGDKGPAGQPGRNGPDGPNGEPGPKGPPGQPGA 215
Cdd:NF038329 138 GDRGETGPAGPAGPPGPQGERGEKGPagPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGE 217

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539522  216 DGQPGMPGEPGKDAPQEGSPVPGdpgppgdsgipgppgppgmagpdgiPGMGGAKGQNGPDGPPGASGE 284
Cdd:NF038329 218 AGPAGEDGPAGPAGDGQQGPDGD-------------------------PGPTGEDGPQGPDGPAGKDGP 261
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 138-284 1.77e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 55.30  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  138 GKPGAPGLPGVPGKTTIQAPCEAASPPPCRvcPVGMPGEQGVTGAPGDKGPAGQPGRNGPDGPNGEPGPKGPPGQpgaDG 217
Cdd:NF038329 204 GEQGPAGPAGPDGEAGPAGEDGPAGPAGDG--QQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDGK---DG 278

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539522  218 QPGMPGEPGKDApqegspvpgdpgppgdsgipgppgppgMAGPDGIPGMGGAKGQNGPDGPPGASGE 284
Cdd:NF038329 279 ERGPVGPAGKDG---------------------------QNGKDGLPGKDGKDGQNGKDGLPGKDGK 318
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 138-284 1.25e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 43.36  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  138 GKPGAPGLPGVPGKTTIQAPcEAASPPPCRVCPVGMPGEQGVTGAPGDKGPAGQPGRNGPDgpngepgpkgppgqpgadG 217
Cdd:NF038329 120 GEPGPAGPAGPAGEQGPRGD-RGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKD------------------G 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539522  218 QPGMPGEPGKDAPQEGSpvpgdpgppgdsgipgppgppgmagpdgipGMGGAKGQNGPDGPPGASGE 284
Cdd:NF038329 181 EAGAKGPAGEKGPQGPR------------------------------GETGPAGEQGPAGPAGPDGE 217
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 137-231 1.88e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 42.97  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  137 PGKPGAPGLPGVPGKTTIQAPCEAASPPpcrvcpvGMPGEQGVTGAPGDKGPAGQPGRNGPDGPNGEPGPKGPPGQPGAD 216
Cdd:NF038329 256 AGKDGPRGDRGEAGPDGPDGKDGERGPV-------GPAGKDGQNGKDGLPGKDGKDGQNGKDGLPGKDGKDGQPGKDGLP 328

                         90
                 ....*....|....*
gi 17539522  217 GQPGMPGEPGKDAPQ 231
Cdd:NF038329 329 GKDGKDGQPGKPAPK 343
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 138-230 1.86e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 39.89  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  138 GKPGAPGLPGVPGKTTIQAPceaaSPPPCRVCPVGMPGEQGVTGAPGDKGPAGQPGRNGPDGPNGEPGPKGPPGQPGADG 217
Cdd:NF038329 233 GQQGPDGDPGPTGEDGPQGP----DGPAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAGKDGQNGKDGLPGKDGKDGQNG 308

                         90
                 ....*....|...
gi 17539522  218 QPGMPGEPGKDAP 230
Cdd:NF038329 309 KDGLPGKDGKDGQ 321
 
Name Accession Description Interval E-value
Col_cuticle_N smart01088
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 15-66 1.20e-12

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 198156  Cd Length: 53  Bit Score: 61.71  E-value: 1.20e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 17539522     15 VANIAMCFAIVSVLTVCVSMPAIYMYMFHVKQLINTEVVSCEDHAREIWREV 66
Cdd:smart01088   2 VAYVAVAVSTVAVLSALVTLPSIYNDIQSFQSELLDEMDEFKARADDAWNEM 53
Col_cuticle_N pfam01484
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 18-66 7.98e-10

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens, see pfam01391. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 460226  Cd Length: 50  Bit Score: 53.62  E-value: 7.98e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 17539522    18 IAMCFAIVSVLTVCVSMPAIYMYMFHVKQLINTEVVSCEDHAREIWREV 66
Cdd:pfam01484   2 VAVAFSTVAILSSLITLPSIYNDIQELQSEVLDEMDEFKARSDDAWNEM 50
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 138-284 1.60e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 55.30  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  138 GKPGAPGLPGVPGKTTIQAPCEAASP--PPCRVCPVGMPGEQGVTGAPGDKGPAGQPGRNGPDGPNGEPGPKGPPGQPGA 215
Cdd:NF038329 138 GDRGETGPAGPAGPPGPQGERGEKGPagPQGEAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQGPAGPAGPDGE 217

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539522  216 DGQPGMPGEPGKDAPQEGSPVPGdpgppgdsgipgppgppgmagpdgiPGMGGAKGQNGPDGPPGASGE 284
Cdd:NF038329 218 AGPAGEDGPAGPAGDGQQGPDGD-------------------------PGPTGEDGPQGPDGPAGKDGP 261
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 138-284 1.77e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 55.30  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  138 GKPGAPGLPGVPGKTTIQAPCEAASPPPCRvcPVGMPGEQGVTGAPGDKGPAGQPGRNGPDGPNGEPGPKGPPGQpgaDG 217
Cdd:NF038329 204 GEQGPAGPAGPDGEAGPAGEDGPAGPAGDG--QQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDGK---DG 278

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539522  218 QPGMPGEPGKDApqegspvpgdpgppgdsgipgppgppgMAGPDGIPGMGGAKGQNGPDGPPGASGE 284
Cdd:NF038329 279 ERGPVGPAGKDG---------------------------QNGKDGLPGKDGKDGQNGKDGLPGKDGK 318
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 138-284 1.25e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 43.36  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  138 GKPGAPGLPGVPGKTTIQAPcEAASPPPCRVCPVGMPGEQGVTGAPGDKGPAGQPGRNGPDgpngepgpkgppgqpgadG 217
Cdd:NF038329 120 GEPGPAGPAGPAGEQGPRGD-RGETGPAGPAGPPGPQGERGEKGPAGPQGEAGPQGPAGKD------------------G 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17539522  218 QPGMPGEPGKDAPQEGSpvpgdpgppgdsgipgppgppgmagpdgipGMGGAKGQNGPDGPPGASGE 284
Cdd:NF038329 181 EAGAKGPAGEKGPQGPR------------------------------GETGPAGEQGPAGPAGPDGE 217
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 137-231 1.88e-04

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 42.97  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  137 PGKPGAPGLPGVPGKTTIQAPCEAASPPpcrvcpvGMPGEQGVTGAPGDKGPAGQPGRNGPDGPNGEPGPKGPPGQPGAD 216
Cdd:NF038329 256 AGKDGPRGDRGEAGPDGPDGKDGERGPV-------GPAGKDGQNGKDGLPGKDGKDGQNGKDGLPGKDGKDGQPGKDGLP 328

                         90
                 ....*....|....*
gi 17539522  217 GQPGMPGEPGKDAPQ 231
Cdd:NF038329 329 GKDGKDGQPGKPAPK 343
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 138-230 1.86e-03

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 39.89  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539522  138 GKPGAPGLPGVPGKTTIQAPceaaSPPPCRVCPVGMPGEQGVTGAPGDKGPAGQPGRNGPDGPNGEPGPKGPPGQPGADG 217
Cdd:NF038329 233 GQQGPDGDPGPTGEDGPQGP----DGPAGKDGPRGDRGEAGPDGPDGKDGERGPVGPAGKDGQNGKDGLPGKDGKDGQNG 308

                         90
                 ....*....|...
gi 17539522  218 QPGMPGEPGKDAP 230
Cdd:NF038329 309 KDGLPGKDGKDGQ 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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