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Conserved domains on  [gi|17540124|ref|NP_501227|]
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Importin subunit alpha-3 [Caenorhabditis elegans]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
19-513 3.57e-166

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 480.54  E-value: 3.57e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124  19 KEKRNEEVVSIRKDKREEAISKRRNINTQIEDDSETSTTPPGPFDANLLRLTvAAAQSSDPAEQLTAVQQARKMLSTDRN 98
Cdd:COG5064  26 RRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLT-QQLFSDDIEQQLQAVYKFRKLLSKETS 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124  99 PPIDDLIGSGILPVLVQCLSSTDPN-LQFEAAWALTNIASGTSEQTQAVVNAGAVPLFLQLLSCGNLNVCEQSVWALGNI 177
Cdd:COG5064 105 PPIQPVIDAGVVPRFVEFMDEIQRDmLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNI 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 178 IGDGPHFRDYCLELGILQPLLQFINPE-IPIGFLRNVTWVIVNLCRCKDPAPSPAVVRTILPALSLLIHHQDTNILIDTV 256
Cdd:COG5064 185 AGDSEGCRDYVLQCGALEPLLGLLLSSaIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDAC 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 257 WALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVGNIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKIN 336
Cdd:COG5064 265 WAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIR 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 337 KEAVWFVSNITAGNQQQVQDVFDAGIMPMIIHLLDRGDFPTQKEAAWAISNVTISG--RPNQVEQMVKLGVLRPFCAMLS 414
Cdd:COG5064 345 KEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGlnRPDIIRYLVSQGFIKPLCDLLD 424

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 415 CTDSQIIQVVLDGINNILKMA-------GEAAEQVTSEIEECGGLDKIENLQNHENEDIYKLAFEIIDNFFSSDDETGNV 487
Cdd:COG5064 425 VVDNKIIEVALDAIENILKVGeqdrlryGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDEL 504

                       490       500
                ....*....|....*....|....*.
gi 17540124 488 EgaqssafggdvppvPDAPNGGWNFG 513
Cdd:COG5064 505 A--------------PETAGNTFTFG 516
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
19-513 3.57e-166

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 480.54  E-value: 3.57e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124  19 KEKRNEEVVSIRKDKREEAISKRRNINTQIEDDSETSTTPPGPFDANLLRLTvAAAQSSDPAEQLTAVQQARKMLSTDRN 98
Cdd:COG5064  26 RRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLT-QQLFSDDIEQQLQAVYKFRKLLSKETS 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124  99 PPIDDLIGSGILPVLVQCLSSTDPN-LQFEAAWALTNIASGTSEQTQAVVNAGAVPLFLQLLSCGNLNVCEQSVWALGNI 177
Cdd:COG5064 105 PPIQPVIDAGVVPRFVEFMDEIQRDmLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNI 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 178 IGDGPHFRDYCLELGILQPLLQFINPE-IPIGFLRNVTWVIVNLCRCKDPAPSPAVVRTILPALSLLIHHQDTNILIDTV 256
Cdd:COG5064 185 AGDSEGCRDYVLQCGALEPLLGLLLSSaIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDAC 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 257 WALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVGNIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKIN 336
Cdd:COG5064 265 WAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIR 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 337 KEAVWFVSNITAGNQQQVQDVFDAGIMPMIIHLLDRGDFPTQKEAAWAISNVTISG--RPNQVEQMVKLGVLRPFCAMLS 414
Cdd:COG5064 345 KEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGlnRPDIIRYLVSQGFIKPLCDLLD 424

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 415 CTDSQIIQVVLDGINNILKMA-------GEAAEQVTSEIEECGGLDKIENLQNHENEDIYKLAFEIIDNFFSSDDETGNV 487
Cdd:COG5064 425 VVDNKIIEVALDAIENILKVGeqdrlryGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDEL 504

                       490       500
                ....*....|....*....|....*.
gi 17540124 488 EgaqssafggdvppvPDAPNGGWNFG 513
Cdd:COG5064 505 A--------------PETAGNTFTFG 516
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 446-483 6.30e-20

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 83.02  E-value: 6.30e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17540124   446 IEECGGLDKIENLQNHENEDIYKLAFEIIDNFFSSDDE 483
Cdd:pfam16186   3 IEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEE 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 97-137 5.77e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 51.66  E-value: 5.77e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17540124     97 RNPPIDDLIGSGILPVLVQCLSSTDPNLQFEAAWALTNIAS 137
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
19-513 3.57e-166

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 480.54  E-value: 3.57e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124  19 KEKRNEEVVSIRKDKREEAISKRRNINTQIEDDSETSTTPPGPFDANLLRLTvAAAQSSDPAEQLTAVQQARKMLSTDRN 98
Cdd:COG5064  26 RRRREEQQVELRKQKREELLNKRRNLADVSEEAESSFIPMEQQFYSELPQLT-QQLFSDDIEQQLQAVYKFRKLLSKETS 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124  99 PPIDDLIGSGILPVLVQCLSSTDPN-LQFEAAWALTNIASGTSEQTQAVVNAGAVPLFLQLLSCGNLNVCEQSVWALGNI 177
Cdd:COG5064 105 PPIQPVIDAGVVPRFVEFMDEIQRDmLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGNI 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 178 IGDGPHFRDYCLELGILQPLLQFINPE-IPIGFLRNVTWVIVNLCRCKDPAPSPAVVRTILPALSLLIHHQDTNILIDTV 256
Cdd:COG5064 185 AGDSEGCRDYVLQCGALEPLLGLLLSSaIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDAC 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 257 WALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVGNIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKIN 336
Cdd:COG5064 265 WAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIR 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 337 KEAVWFVSNITAGNQQQVQDVFDAGIMPMIIHLLDRGDFPTQKEAAWAISNVTISG--RPNQVEQMVKLGVLRPFCAMLS 414
Cdd:COG5064 345 KEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGlnRPDIIRYLVSQGFIKPLCDLLD 424

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 415 CTDSQIIQVVLDGINNILKMA-------GEAAEQVTSEIEECGGLDKIENLQNHENEDIYKLAFEIIDNFFSSDDETGNV 487
Cdd:COG5064 425 VVDNKIIEVALDAIENILKVGeqdrlryGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDEL 504

                       490       500
                ....*....|....*....|....*.
gi 17540124 488 EgaqssafggdvppvPDAPNGGWNFG 513
Cdd:COG5064 505 A--------------PETAGNTFTFG 516
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 446-483 6.30e-20

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 83.02  E-value: 6.30e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17540124   446 IEECGGLDKIENLQNHENEDIYKLAFEIIDNFFSSDDE 483
Cdd:pfam16186   3 IEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEE 40
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 5-87 9.29e-16

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 72.18  E-value: 9.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124     5 RQAYYKN---NAKEqiGKEKRNEEVVSIRKDKREEAISKRRNINTQIEDDSETSTTPPGPFDAnllrlTVAAAQSSDPAE 81
Cdd:pfam01749   1 RRKSFKNkgkDADE--LRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAESQLLESLPE-----MVQGVNSDDPEL 73


                  ....*.
gi 17540124    82 QLTAVQ 87
Cdd:pfam01749  74 QLEATQ 79
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 98-137 8.54e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 56.69  E-value: 8.54e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 17540124    98 NPPIDDLIGSGILPVLVQCLSSTDPNLQFEAAWALTNIAS 137
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 139-177 4.87e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 54.77  E-value: 4.87e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17540124   139 TSEQTQAVVNAGAVPLFLQLLSCGNLNVCEQSVWALGNI 177
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 97-137 5.77e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 51.66  E-value: 5.77e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17540124     97 RNPPIDDLIGSGILPVLVQCLSSTDPNLQFEAAWALTNIAS 137
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 139-177 2.23e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.12  E-value: 2.23e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17540124    139 TSEQTQAVVNAGAVPLFLQLLSCGNLNVCEQSVWALGNI 177
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 267-306 2.51e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.06  E-value: 2.51e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 17540124   267 NEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVGNIVT 306
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 350-389 4.34e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 4.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 17540124    350 NQQQVQDVFDAGIMPMIIHLLDRGDFPTQKEAAWAISNVT 389
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 267-305 4.98e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.27  E-value: 4.98e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17540124    267 NEHIQMVIEAQVVTHLVPLLGHVDVKVQTAALRAVGNIV 305
Cdd:smart00185   2 DENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 350-389 5.09e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.29  E-value: 5.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 17540124   350 NQQQVQDVFDAGIMPMIIHLLDRGDFPTQKEAAWAISNVT 389
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 122-177 1.13e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 45.44  E-value: 1.13e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17540124   122 PNLQFEAAWALTNIASGTSEQTQAVVNAgAVPLFLQLLSCGNLNVCEQSVWALGNI 177
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
110-304 1.28e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 47.70  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 110 LPVLVQCLSSTDPNLQFEAAWALTNIASgtseqtqavvnAGAVPLFLQLLSCGNLNVCEQSVWALGNIigdgphfrdycl 189
Cdd:COG1413  18 VPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI------------ 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 190 elgilqpllqfinpeipigflrnvtwvivnlcrckdpaPSPAVVRTILPALslliHHQDTNILIDTVWALSYLTDggneh 269
Cdd:COG1413  75 --------------------------------------GDPEAVPALIAAL----KDEDPEVRRAAAEALGRLGD----- 107

                       170       180       190
                ....*....|....*....|....*....|....*
gi 17540124 270 iqmvieAQVVTHLVPLLGHVDVKVQTAALRAVGNI 304
Cdd:COG1413 108 ------PAAVPALLEALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 308-348 6.67e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.11  E-value: 6.67e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 17540124    308 TDEQTQLVLDSGVLRFMPGLLAHYKEKINKEAVWFVSNITA 348
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 308-348 3.39e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 38.20  E-value: 3.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 17540124   308 TDEQTQLVLDSGVLRFMPGLLAHYKEKINKEAVWFVSNITA 348
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 110-177 4.87e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 39.24  E-value: 4.87e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17540124   110 LPVLVQCL-SSTDPNLQFEAAWALTNIAsgtseqtqavvNAGAVPLFLQLLSCGNLNVCEQSVWALGNI 177
Cdd:pfam13646   1 LPALLQALlRDPDPEVRAAAIRALGRIG-----------DPEAVPALLELLKDEDPAVRRAAAEALGKI 58
HEAT COG1413
HEAT repeat [General function prediction only];
237-387 7.51e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 7.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124 237 LPALSLLIHHQDTNILIDTVWALSYLTDggnehiqmvieAQVVTHLVPLLGHVDVKVQTAALRAVGNIvtGTDEQTQLVL 316
Cdd:COG1413  18 VPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI--GDPEAVPALI 84

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17540124 317 DsgvlrfmpgLLAHYKEKINKEAVWFVSNITagnqqqvqdvfDAGIMPMIIHLLDRGDFPTQKEAAWAISN 387
Cdd:COG1413  85 A---------ALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEALKDPDWEVRRAAARALGR 135
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 225-264 7.39e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 34.35  E-value: 7.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 17540124   225 DPAPSPAVVRT-ILPALSLLIHHQDTNILIDTVWALSYLTD 264
Cdd:pfam00514   1 SPENKQAVIEAgAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 69-159 7.76e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 35.78  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540124    69 LTVAAAQSSDPAEQLTAVqqarKMLSTDRNPpiddligsGILPVLVQCLSSTDPNLQFEAAWALTNIASgtseqtqavvn 148
Cdd:pfam13646   4 LLQALLRDPDPEVRAAAI----RALGRIGDP--------EAVPALLELLKDEDPAVRRAAAEALGKIGD----------- 60

                          90
                  ....*....|.
gi 17540124   149 AGAVPLFLQLL 159
Cdd:pfam13646  61 PEALPALLELL 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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