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Conserved domains on  [gi|25149799|ref|NP_501286|]
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IntraMembrane Protease (IMPAS) family [Caenorhabditis elegans]

Protein Classification

A22B family peptidase( domain architecture ID 3497)

A22B family peptidase similar to Arabidopsis thaliana signal peptide peptidase-like 1, an intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_A22B super family cl01342
Signal peptide peptidase; The members of this family are membrane proteins. In some proteins ...
 331-512 4.22e-06

Signal peptide peptidase; The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.


The actual alignment was detected with superfamily member pfam04258:

Pssm-ID: 470165  Cd Length: 286  Bit Score: 48.45  E-value: 4.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149799   331 YFYYHEESMMYASLLVSLSFGLYHECSGN-WISNDILAFASIYVVCSRIQAVSYQTAIIFVIGMSLFDLFFLYVVDLLS- 408
Cdd:pfam04258  77 FLPGRFSYSELVALLLCIVFAVWWALKRHeWILQDILGIALCINVIEILRLPNLKVGTLLLSGLFFYDIFWVFGSPYIFg 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149799   409 -----TVVKENRS-----PLMILVPR-----DTKGNKQSLAALDIMVPGVFLNVVLKYSSMYDTNL----FAITFAAVFA 469
Cdd:pfam04258 157 tsvmvTVATGPSStgediPMKLVFPRlsnmfDNWGPFSMLGLGDIVMPGLLIALCLRFDISKKKSThdiyFISTMIAYGL 236

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 25149799   470 SLVFSVFFSIWRSKTTPAMVLPAISAIIFSIGFANHTDDLWKF 512
Cdd:pfam04258 237 GLLITFVALNLFKAAQPALLYLVPCTLGTLLLLALWRGELKKL 279
 
Name Accession Description Interval E-value
Peptidase_A22B pfam04258
Signal peptide peptidase; The members of this family are membrane proteins. In some proteins ...
 331-512 4.22e-06

Signal peptide peptidase; The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.


Pssm-ID: 282158  Cd Length: 286  Bit Score: 48.45  E-value: 4.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149799   331 YFYYHEESMMYASLLVSLSFGLYHECSGN-WISNDILAFASIYVVCSRIQAVSYQTAIIFVIGMSLFDLFFLYVVDLLS- 408
Cdd:pfam04258  77 FLPGRFSYSELVALLLCIVFAVWWALKRHeWILQDILGIALCINVIEILRLPNLKVGTLLLSGLFFYDIFWVFGSPYIFg 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149799   409 -----TVVKENRS-----PLMILVPR-----DTKGNKQSLAALDIMVPGVFLNVVLKYSSMYDTNL----FAITFAAVFA 469
Cdd:pfam04258 157 tsvmvTVATGPSStgediPMKLVFPRlsnmfDNWGPFSMLGLGDIVMPGLLIALCLRFDISKKKSThdiyFISTMIAYGL 236

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 25149799   470 SLVFSVFFSIWRSKTTPAMVLPAISAIIFSIGFANHTDDLWKF 512
Cdd:pfam04258 237 GLLITFVALNLFKAAQPALLYLVPCTLGTLLLLALWRGELKKL 279
 
Name Accession Description Interval E-value
Peptidase_A22B pfam04258
Signal peptide peptidase; The members of this family are membrane proteins. In some proteins ...
 331-512 4.22e-06

Signal peptide peptidase; The members of this family are membrane proteins. In some proteins this region is found associated with pfam02225. This family corresponds with Merops subfamily A22B, the type example of which is signal peptide peptidase. There is a sequence-similarity relationship with pfam01080.


Pssm-ID: 282158  Cd Length: 286  Bit Score: 48.45  E-value: 4.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149799   331 YFYYHEESMMYASLLVSLSFGLYHECSGN-WISNDILAFASIYVVCSRIQAVSYQTAIIFVIGMSLFDLFFLYVVDLLS- 408
Cdd:pfam04258  77 FLPGRFSYSELVALLLCIVFAVWWALKRHeWILQDILGIALCINVIEILRLPNLKVGTLLLSGLFFYDIFWVFGSPYIFg 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149799   409 -----TVVKENRS-----PLMILVPR-----DTKGNKQSLAALDIMVPGVFLNVVLKYSSMYDTNL----FAITFAAVFA 469
Cdd:pfam04258 157 tsvmvTVATGPSStgediPMKLVFPRlsnmfDNWGPFSMLGLGDIVMPGLLIALCLRFDISKKKSThdiyFISTMIAYGL 236

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 25149799   470 SLVFSVFFSIWRSKTTPAMVLPAISAIIFSIGFANHTDDLWKF 512
Cdd:pfam04258 237 GLLITFVALNLFKAAQPALLYLVPCTLGTLLLLALWRGELKKL 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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