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Conserved domains on  [gi|115534406|ref|NP_501662|]
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BRCT domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
785-865 4.76e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 4.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534406  785 IDQEADKN--------ALCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLIRNGADRGAFNVEN 856
Cdd:COG0666   140 LEAGADVNaqdndgntPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219


                  ....*....
gi 115534406  857 KTPEQVLAE 865
Cdd:COG0666   220 KTALDLAAE 228
BRCT smart00292
breast cancer carboxy-terminal domain;
938-996 3.30e-04

breast cancer carboxy-terminal domain;


:

Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 40.44  E-value: 3.30e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115534406    938 YESFIERYKGNVTDQMSG--VTHFIVLTDATGLFEsddfgYIMCIFLPTLIMKQQWMNDCL 996
Cdd:smart00292   23 LKELIEALGGKVTSSLSSktTTHVIVGSPEGGKLE-----LLKAIALGIPIVKEEWLLDCL 78
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
785-865 4.76e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 4.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534406  785 IDQEADKN--------ALCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLIRNGADRGAFNVEN 856
Cdd:COG0666   140 LEAGADVNaqdndgntPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219


                  ....*....
gi 115534406  857 KTPEQVLAE 865
Cdd:COG0666   220 KTALDLAAE 228
Ank_4 pfam13637
Ankyrin repeats (many copies);
792-843 2.30e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 2.30e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 115534406   792 NALCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLI 843
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 806-867 6.18e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 6.18e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115534406  806 VKVLVDKGVFINVYNMFGNTLLHA--AAKYGHVKIADFLIRNGADRGAFNVENKTPEQVLAESV 867
Cdd:PHA03095  100 IKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSR 163
BRCT smart00292
breast cancer carboxy-terminal domain;
938-996 3.30e-04

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 40.44  E-value: 3.30e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115534406    938 YESFIERYKGNVTDQMSG--VTHFIVLTDATGLFEsddfgYIMCIFLPTLIMKQQWMNDCL 996
Cdd:smart00292   23 LKELIEALGGKVTSSLSSktTTHVIVGSPEGGKLE-----LLKAIALGIPIVKEEWLLDCL 78
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 823-848 1.35e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 1.35e-03
                            10        20
                    ....*....|....*....|....*.
gi 115534406    823 GNTLLHAAAKYGHVKIADFLIRNGAD 848
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGAD 27
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
785-865 4.76e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 4.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534406  785 IDQEADKN--------ALCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLIRNGADRGAFNVEN 856
Cdd:COG0666   140 LEAGADVNaqdndgntPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219


                  ....*....
gi 115534406  857 KTPEQVLAE 865
Cdd:COG0666   220 KTALDLAAE 228
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
783-859 4.94e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 4.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534406  783 FWIDQEADKNA--------LCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLIRNGADRGAFNV 854
Cdd:COG0666   105 LLLEAGADVNArdkdgetpLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDN 184


                  ....*
gi 115534406  855 ENKTP 859
Cdd:COG0666   185 DGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
785-859 3.30e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.66  E-value: 3.30e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115534406  785 IDQEADKNALCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLIRNGADRGAFNVENKTP 859
Cdd:COG0666    82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156
Ank_4 pfam13637
Ankyrin repeats (many copies);
792-843 2.30e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 2.30e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 115534406   792 NALCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLI 843
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
785-859 4.85e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534406  785 IDQEADKN--------ALCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLIRNGADRGAFNVEN 856
Cdd:COG0666   173 LEAGADVNardndgetPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDG 252


                  ...
gi 115534406  857 KTP 859
Cdd:COG0666   253 LTA 255
Ank_2 pfam12796
Ankyrin repeats (3 copies);
794-845 2.63e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.65  E-value: 2.63e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 115534406   794 LCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLIRN 845
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH 52
Ank_2 pfam12796
Ankyrin repeats (3 copies);
791-848 3.16e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.65  E-value: 3.16e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 115534406   791 KNALCEAVREINFDQVKVLVDKgVFINVYNMfGNTLLHAAAKYGHVKIADFLIRNGAD 848
Cdd:pfam12796   31 RTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGAD 86
PHA03095 PHA03095
ankyrin-like protein; Provisional
 806-867 6.18e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 6.18e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 115534406  806 VKVLVDKGVFINVYNMFGNTLLHA--AAKYGHVKIADFLIRNGADRGAFNVENKTPEQVLAESV 867
Cdd:PHA03095  100 IKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSR 163
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 797-846 2.70e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.04  E-value: 2.70e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 115534406  797 AVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLIRNG 846
Cdd:PHA02874  164 AIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHG 213
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 822-848 4.53e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 41.47  E-value: 4.53e-05
                           10        20
                   ....*....|....*....|....*..
gi 115534406   822 FGNTLLHAAAKYGHVKIADFLIRNGAD 848
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGAD 27
Ank_5 pfam13857
Ankyrin repeats (many copies);
809-859 9.72e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 9.72e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 115534406   809 LVDKGVF-INVYNMFGNTLLHAAAKYGHVKIADFLIRNGADRGAFNVENKTP 859
Cdd:pfam13857    1 LLEHGPIdLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTA 52
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 823-848 1.21e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 1.21e-04
                           10        20
                   ....*....|....*....|....*..
gi 115534406   823 GNTLLHAAA-KYGHVKIADFLIRNGAD 848
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGAD 28
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 772-868 1.39e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534406  772 EAVTNLHWRYsFWI--------DQEADKNALCEAVREINFDQVKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLI 843
Cdd:PLN03192  597 NAISAKHHKI-FRIlyhfasisDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLI 675

                          90       100
                  ....*....|....*....|....*
gi 115534406  844 RNGADRGAFNVENKTPEQVLAESVQ 868
Cdd:PLN03192  676 MNGADVDKANTDDDFSPTELRELLQ 700
BRCT smart00292
breast cancer carboxy-terminal domain;
938-996 3.30e-04

breast cancer carboxy-terminal domain;


Pssm-ID: 214602 [Multi-domain]  Cd Length: 78  Bit Score: 40.44  E-value: 3.30e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115534406    938 YESFIERYKGNVTDQMSG--VTHFIVLTDATGLFEsddfgYIMCIFLPTLIMKQQWMNDCL 996
Cdd:smart00292   23 LKELIEALGGKVTSSLSSktTTHVIVGSPEGGKLE-----LLKAIALGIPIVKEEWLLDCL 78
PHA02743 PHA02743
Viral ankyrin protein; Provisional
 805-859 8.94e-04

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 41.34  E-value: 8.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 115534406  805 QVKVLVDKGVFINVYNM-FGNTLLHAAAKYGHVKIADFLIRN-GADRGAFNVENKTP 859
Cdd:PHA02743   75 KIELLVNMGADINARELgTGNTLLHIAASTKNYELAEWLCRQlGVNLGAINYQHETA 131
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 823-848 1.35e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 1.35e-03
                            10        20
                    ....*....|....*....|....*.
gi 115534406    823 GNTLLHAAAKYGHVKIADFLIRNGAD 848
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGAD 27
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 806-866 3.34e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 3.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 115534406  806 VKVLVDKGVFINVYNMFGNTLLHAAAKYGHVKIADFLIRNGADRGAFNVENKTPEQVLAES 866
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEEN 158
Ank_2 pfam12796
Ankyrin repeats (3 copies);
827-859 6.31e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.02  E-value: 6.31e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 115534406   827 LHAAAKYGHVKIADFLIRNGADRGAFNVENKTP 859
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTA 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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