|
Name |
Accession |
Description |
Interval |
E-value |
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
116-1000 |
4.85e-161 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 492.92 E-value: 4.85e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 116 TEPAKYYPFQLDAFQKQAILCIDNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRVIYTSPIKALSNQKYRELEEEF--K 193
Cdd:COG4581 16 ADFAEERGFELDPFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARGRRSFYTAPIKALSNQKFFDLVERFgaE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 194 DVGLMTGDVTLNPDASCLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERGVVWEETIILMSKNIKQAFLSATIP 273
Cdd:COG4581 96 NVGLLTGDASVNPDAPIVVMTTEILRNMLYREGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHLPARVQLVLLSATVG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 274 NARQFAQWVASIKqQPVNVVYTDYRPTPL-QHWiypVGGEGMYEVVNVKGEFREDKFRDAmsglatagdsagsfnkrrtg 352
Cdd:COG4581 176 NAEEFAEWLTRVR-GETAVVVSEERPVPLeFHY---LVTPRLFPLFRVNPELLRPPSRHE-------------------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 353 ggtqgdsnvlkIIRSVASNDGLNCIVFSFSRKECESYAISLKDMDFNKDHEKGMVKSVYESAiaqlsPEDQKLPQILNIL 432
Cdd:COG4581 232 -----------VIEELDRGGLLPAIVFIFSRRGCDEAAQQLLSARLTTKEERAEIREAIDEF-----AEDFSVLFGKTLS 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 433 PLLRRGIGVHHSGLMPILKETIEILFGEGLVKVLFATETFSMGLNMPARTVVFTSARKFDGSDNRYITSGEYIQMAGRAG 512
Cdd:COG4581 296 RLLRRGIAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQIAGRAG 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 513 RRGKDDRGTVILMVDSAMSADDAKQIIKGATDPLNSQFRLTYNMVLNLM-RVEGMAVSWIINNSFHQFQSYAKIPEIDKK 591
Cdd:COG4581 376 RRGIDTEGHVVVLAPEHDDPKKFARLASARPEPLRSSFRPSYNMVLNLLaRPGLERARELLEDSFAQFQADRSVVGLARR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 592 CVQVERKIASFnfpWENEMRTLVDLQDqLEATRQRIIQIQREpkyivgflhagrlfkvksgdrdfkwgilnqfkKEQNPD 671
Cdd:COG4581 456 ARELERALAGV---VERLACDLGDLQE-YFALRQPLSPLEAL--------------------------------ERESPA 499
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 672 DRNDQIYLCdmmiaintEGRFDptNPATLVPGFDLPKRRwirvpmtidriTAISAVRLKVPADidkpdgqmrldgmmaaa 751
Cdd:COG4581 500 YALDVVSVP--------EATLE--DPRPVLLAQDRRARG-----------EAAAAMKAAIEYD----------------- 541
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 752 tkrfgnqiplldpiQDMEIKTVEMKELIAREKSLEGRLETHSMTKRdnmkdLKKQFEQKQDAVKelnalkaerksvqstl 831
Cdd:COG4581 542 --------------ERMERLEEVLRPHPLHECPLERAFELYRETHP-----WVRDIELRPKSVA---------------- 586
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 832 hlEELNNRKRVLRRLGYLGNDDALVlKGSVACELSasdelILTEMLLKGIFNTLDVAQTAALLSCFVFQ----DKCAAPK 907
Cdd:COG4581 587 --RDFDRFCELLREYGYLDDLTLTS-EGLLLRYLY-----DAAEALRQGVPDDLDPEELAALISWLVEEvrrvDSSEWER 658
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 908 L-ATELQTCLSELHEQARNVakvsneckMEVMEDKYVSSFNPGLMDvvyQWVNGATFSEIVKTTDVFEGSIIRTLRRL-- 984
Cdd:COG4581 659 LpSPANRRAFVLVNALFRRL--------ELLERRHGLPELDPGLAG---AWASGADLAEVLDATDLDAGDFVRWVRQVid 727
|
890
....*....|....*..
gi 17542826 985 -EEVLREMINAAKALAN 1000
Cdd:COG4581 728 pDPELRRTARAAVDLIR 744
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
95-298 |
7.14e-151 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 446.12 E-value: 7.14e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 95 CTHEVAIPPNAEFAEL-RENSGTEPAKYYPFQLDAFQKQAILCIDNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRVIY 173
Cdd:cd18024 1 CTHEVALPPDYDYTPIsAHKPPGNPARTYPFTLDPFQKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 174 TSPIKALSNQKYRELEEEFKDVGLMTGDVTLNPDASCLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERGVVWE 253
Cdd:cd18024 81 TSPIKALSNQKYRELQEEFGDVGLMTGDVTINPNASCLVMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDKERGVVWE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 17542826 254 ETIILMSKNIKQAFLSATIPNARQFAQWVASIKQQPVNVVYTDYR 298
Cdd:cd18024 161 ETIILLPDKVRYVFLSATIPNARQFAEWICKIHKQPCHVVYTDYR 205
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
118-295 |
2.44e-82 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 264.51 E-value: 2.44e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 118 PAKYYPFQLDAFQKQAILCIDNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRVIYTSPIKALSNQKYRELEEEFKDVGL 197
Cdd:cd18027 1 PAFKWPFELDVFQKQAILHLEAGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFGDVGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 198 MTGDVTLNPDASCLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERGVVWEETIILMSKNIKQAFLSATIPNARQ 277
Cdd:cd18027 81 ITGDVQLNPEASCLIMTTEILRSMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNTVE 160
|
170
....*....|....*...
gi 17542826 278 FAQWVASIKQQPVNVVYT 295
Cdd:cd18027 161 FADWIGRIKKKNIYVIST 178
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
98-550 |
5.74e-81 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 273.31 E-value: 5.74e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 98 EVAIPPNAEFAELRENSGTEpaKYYPFQLDAFQKqailCIDNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRVIYTSPI 177
Cdd:COG1204 2 KVAELPLEKVIEFLKERGIE--ELYPPQAEALEA----GLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKALYIVPL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 178 KALSNQKYRELEEEFKD----VGLMTGDVTLNP----DASCLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERG 249
Cdd:COG1204 76 RALASEKYREFKRDFEElgikVGVSTGDYDSDDewlgRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDESRG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 250 VVWEETIILMSKNIKQA---FLSATIPNARQFAQWVasikqqPVNVVYTDYRPTPLqhwiypvggegmYEVVNVKGEFRe 326
Cdd:COG1204 156 PTLEVLLARLRRLNPEAqivALSATIGNAEEIAEWL------DAELVKSDWRPVPL------------NEGVLYDGVLR- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 327 dkFRDamsglatagdsagsfnkrrtgGGTQGDSNVLKIIRSVASNDGlNCIVFSFSRKECESYAISLKD-MDFNK-DHEK 404
Cdd:COG1204 217 --FDD---------------------GSRRSKDPTLALALDLLEEGG-QVLVFVSSRRDAESLAKKLADeLKRRLtPEER 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 405 GMVKSVYE--SAIAQLSPEDQKLPQilnilpLLRRGIGVHHSGLMPILKETIEILFGEGLVKVLFATETFSMGLNMPART 482
Cdd:COG1204 273 EELEELAEelLEVSEETHTNEKLAD------CLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARR 346
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17542826 483 VVFTSARKFDGSDnryITSGEYIQMAGRAGRRGKDDRGTVILMVDSAMSADD-AKQIIKGATDPLNSQF 550
Cdd:COG1204 347 VIIRDTKRGGMVP---IPVLEFKQMAGRAGRPGYDPYGEAILVAKSSDEADElFERYILGEPEPIRSKL 412
|
|
| rRNA_proc-arch |
pfam13234 |
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating ... |
570-826 |
1.57e-66 |
|
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homolog of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity.
Pssm-ID: 463813 Cd Length: 267 Bit Score: 224.47 E-value: 1.57e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 570 WIINNSFHQFQSYAKIPEIDKKCVQVERKIASFNFPWENEMRTLVDLQDQLEATRQRIIQIQREPKYIVGFLHAGRLFKV 649
Cdd:pfam13234 2 YMLKRSFSQFQNQASLPELEKKLKELEKELASIKIPDEEDIKEYYDLRQQLEKLNEDIREVILHPPYGLPFLQPGRLVVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 650 KS-GDRDFKWGILNQFKKEQNPDDRND--QIYLCDMMIAI------NTEGRFDPTNPATLVPGFDLPKRRWIRVPMTIDR 720
Cdd:pfam13234 82 KDnGDQDFGWGVVVNFKKRKKNGKAEPpqESYIVDVLLVLalvsspEDLDKFNDVNPEGFRPAPPGEKGEMEVVPVPLSD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 721 ITAISAVRLKVPADIDKPDGQMRLDGMMAAATKRFGNQIPLLDPIQDMEIKTVEMKELIAREKSLEGRLETHSMTKRDNM 800
Cdd:pfam13234 162 IEAISSVRLKLPKDLRPAEAREAVLKALQELKRRFPDGIPLLDPIEDMKIKDDEFKELLRKIEVLESRLESHPLHKSPRL 241
|
250 260
....*....|....*....|....*.
gi 17542826 801 KDLKKQFEQKQDAVKELNALKAERKS 826
Cdd:pfam13234 242 EELYALYHEKVELQEEIKELKKEISD 267
|
|
| DSHCT |
pfam08148 |
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box ... |
853-1019 |
1.12e-58 |
|
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases.
Pssm-ID: 462374 Cd Length: 154 Bit Score: 198.06 E-value: 1.12e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 853 DALVLKGSVACELSASDELILTEMLLKGIFNTLDVAQTAALLSCFVFQDKCAAPKLAT-ELQTCLSELHEQARNVAkvsn 931
Cdd:pfam08148 1 DVVTLKGRVACEIRSENELLLTELLFSGVFDDLDPEELAALLSAFVFEEKRREPYLPSpELAEALRLLEEIAHRIA---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 932 eckmevmedkyVSSF-NPGLMDVVYQWVNGATFSEIVKTTDVFEGSIIRTLRRLEEVLREMINAAKALANKELEQKFEDA 1010
Cdd:pfam08148 77 -----------VSRFlDFGLMEVVYAWARGASFAEICKLTDLDEGDIVRLIRRLDELLRQIANAAKIIGDPELREKAEEA 145
|
....*....
gi 17542826 1011 RKNLKRDIV 1019
Cdd:pfam08148 146 IELIKRDIV 154
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
126-281 |
7.64e-58 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 196.71 E-value: 7.64e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 126 LDAFQKQAILCIDN-NQSVLVSAHTSAGKTVVATYAIAKCLRE-KQRVIYTSPIKALSNQKYRELEEEF----KDVGLMT 199
Cdd:cd17921 2 LNPIQREALRALYLsGDSVLVSAPTSSGKTLIAELAILRALATsGGKAVYIAPTRALVNQKEADLRERFgplgKNVGLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 200 GDVTLN----PDASCLVMTTEILRSMLYRGSE-IMKEVGWVVYDEIHYMRDKERGVVWEETIILM---SKNIKQAFLSAT 271
Cdd:cd17921 82 GDPSVNklllAEADILVATPEKLDLLLRNGGErLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLlriNKNARFVGLSAT 161
|
170
....*....|
gi 17542826 272 IPNARQFAQW 281
Cdd:cd17921 162 LPNAEDLAEW 171
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
298-527 |
1.06e-57 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 195.46 E-value: 1.06e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 298 RPTPLQHWIYPVGGEGMYEVVNVKGEFREDKFrdamsglatagdsagsfnkrrtgggtqgdsnVLKIIRSVAsnDGLNCI 377
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKFDSDII-------------------------------VLLKIETVS--EGKPVL 47
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 378 VFSFSRKECESYAISLkdmdfnkdhekgmvksvyesaiaqlspedqklpqilnilpllrRGIGVHHSGLMPILKETIEIL 457
Cdd:cd18795 48 VFCSSRKECEKTAKDL-------------------------------------------AGIAFHHAGLTREDRELVEEL 84
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 458 FGEGLVKVLFATETFSMGLNMPARTVVFTSARKFDGSDNRYITSGEYIQMAGRAGRRGKDDRGTVILMVD 527
Cdd:cd18795 85 FREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGRPGFDTRGEAIIMTK 154
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
124-624 |
6.13e-47 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 179.69 E-value: 6.13e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 124 FQLDAFQKQAILCIDNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRVIYTSPIKALSNQKYRELeEEFKDVGLMT---- 199
Cdd:PRK01172 21 FELYDHQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFLAGLKSIYIVPLRSLAMEKYEEL-SRLRSLGMRVkisi 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 200 GDVTLNPD----ASCLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERGVVWE---ETIILMSKNIKQAFLSATI 272
Cdd:PRK01172 100 GDYDDPPDfikrYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDEDRGPTLEtvlSSARYVNPDARILALSATV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 273 PNARQFAQWVASikqqpvNVVYTDYRPTPLQHWIYpvggegmyevvnvkgeFREDKFRDamsglatagdsagsfnkrrtg 352
Cdd:PRK01172 180 SNANELAQWLNA------SLIKSNFRPVPLKLGIL----------------YRKRLILD--------------------- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 353 GGTQGDSNVLKIIRSVAsNDGLNCIVFSFSRKECESYAISLKDMdFNKDHEkgmvksvyesaIAQLSPEDQKLPQILNil 432
Cdd:PRK01172 217 GYERSQVDINSLIKETV-NDGGQVLVFVSSRKNAEDYAEMLIQH-FPEFND-----------FKVSSENNNVYDDSLN-- 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 433 PLLRRGIGVHHSGLMPILKETIEILFGEGLVKVLFATETFSMGLNMPARTVVFTSARKFDGSDNRYITSGEYIQMAGRAG 512
Cdd:PRK01172 282 EMLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQMIGRAG 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 513 RRGKDDRGTVILMVDSAMSADDAKQIIKGATDPLNSQFRLTYNMVLNLMRV--EGMAVSWIINNSFHQFQSYAKIPEIDk 590
Cdd:PRK01172 362 RPGYDQYGIGYIYAASPASYDAAKKYLSGEPEPVISYMGSQRKVRFNTLAAisMGLASSMEDLILFYNETLMAIQNGVD- 440
|
490 500 510
....*....|....*....|....*....|....*
gi 17542826 591 kcvQVERKI-ASFNFPWENemrTLVDLQDQLEATR 624
Cdd:PRK01172 441 ---EIDYYIeSSLKFLKEN---GFIKGDVTLRATR 469
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
98-534 |
1.45e-40 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 160.89 E-value: 1.45e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 98 EVAIPPnaEFAELRENSGTEpaKYYPFQLDAFQKQAIlcidNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRVIYTSPI 177
Cdd:PRK02362 5 ELPLPE--GVIEFYEAEGIE--ELYPPQAEAVEAGLL----DGKNLLAAIPTASGKTLIAELAMLKAIARGGKALYIVPL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 178 KALSNQKYRELeEEFKDVGLMTGDVTLNPDAS--------CLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERG 249
Cdd:PRK02362 77 RALASEKFEEF-ERFEELGVRVGISTGDYDSRdewlgdndIIVATSEKVDSLLRNGAPWLDDITCVVVDEVHLIDSANRG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 250 VVWEETII-LMSKN--IKQAFLSATIPNARQFAQWV-ASIkqqpvnvVYTDYRPTPLQhwiypvggegmyevvnvKGEFR 325
Cdd:PRK02362 156 PTLEVTLAkLRRLNpdLQVVALSATIGNADELADWLdAEL-------VDSEWRPIDLR-----------------EGVFY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 326 EDK--FRDAMSGLATAgdsagsfnkrrtgGGTQGDSNVLKIIrsvasNDGLNCIVFSFSRKECESYAislkdmdfnkdhe 403
Cdd:PRK02362 212 GGAihFDDSQREVEVP-------------SKDDTLNLVLDTL-----EEGGQCLVFVSSRRNAEGFA------------- 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 404 KGMVKSVYESAIAQLSPEDQKLPQ-IL--------NILPL-LRRGIGVHHSGLMPILKETIEILFGEGLVKVLFATETFS 473
Cdd:PRK02362 261 KRAASALKKTLTAAERAELAELAEeIRevsdtetsKDLADcVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLA 340
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17542826 474 MGLNMPARTVVFTSARKFDGSD-NRYITSGEYIQMAGRAGRRGKDDRGTVILMVDSAMSADD 534
Cdd:PRK02362 341 AGLNLPARRVIIRDYRRYDGGAgMQPIPVLEYHQMAGRAGRPGLDPYGEAVLLAKSYDELDE 402
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
122-549 |
3.83e-34 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 140.72 E-value: 3.83e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 122 YPFQLDAFqKQAILcidNNQSVLVSAHTSAGKTVVATYAIA-KCLREKQRVIYTSPIKALSNQKYREleeeFKD------ 194
Cdd:PRK00254 25 YPPQAEAL-KSGVL---EGKNLVLAIPTASGKTLVAEIVMVnKLLREGGKAVYLVPLKALAEEKYRE----FKDweklgl 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 195 -VGLMTGDVTLNPD----ASCLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERGVVWEETIILMSKNIKQAFLS 269
Cdd:PRK00254 97 rVAMTTGDYDSTDEwlgkYDIIIATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGSYDRGATLEMILTHMLGRAQILGLS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 270 ATIPNARQFAQWVASikqqpvNVVYTDYRPTPLQHWIYPVGgegmyEVvnvkgeFREDkfrdamsglatagdsaGSFNKR 349
Cdd:PRK00254 177 ATVGNAEELAEWLNA------ELVVSDWRPVKLRKGVFYQG-----FL------FWED----------------GKIERF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 350 RtgggTQGDSNVLKIIRSvasndGLNCIVFSFSRKECESYAISL--KDMDFNKDHEKGMVKSVYESaiAQLSPEDQKLPQ 427
Cdd:PRK00254 224 P----NSWESLVYDAVKK-----GKGALVFVNTRRSAEKEALELakKIKRFLTKPELRALKELADS--LEENPTNEKLKK 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 428 IlnilplLRRGIGVHHSGLMPILKETIEILFGEGLVKVLFATETFSMGLNMPARTVVFTSARKFDGSDNRYITSGEYIQM 507
Cdd:PRK00254 293 A------LRGGVAFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRDTKRYSNFGWEDIPVLEIQQM 366
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 17542826 508 AGRAGRRGKDDRGTVILMVDSAMSADDAKQIIKGATDPLNSQ 549
Cdd:PRK00254 367 MGRAGRPKYDEVGEAIIVATTEEPSKLMERYIFGKPEKLFSM 408
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
120-305 |
7.24e-31 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 120.67 E-value: 7.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 120 KYYPFQLDAFQKQAILCI-DNNQSVLVSAHTSAGKTVVATYAIAKCLRE--KQRVIYTSPIKALSNQKYRELEEEFKD-- 194
Cdd:smart00487 3 KFGFEPLRPYQKEAIEALlSGLRDVILAAPTGSGKTLAALLPALEALKRgkGGRVLVLVPTRELAEQWAEELKKLGPSlg 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 195 ---VGLMTGDVT-------LNPDASCLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERGVVWEETIILMSKNIK 264
Cdd:smart00487 83 lkvVGLYGGDSKreqlrklESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQ 162
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 17542826 265 QAFLSATIPNARQFAQWvaSIKQQPVNVVYTDYRPTPLQHW 305
Cdd:smart00487 163 LLLLSATPPEEIENLLE--LFLNDPVFIDVGFTPLEPIEQF 201
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
130-273 |
5.30e-30 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 116.57 E-value: 5.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 130 QKQAILCIDNNQSVLVSAHTSAGKTVVATYAIAKCLREKQ---RVIYTSPIKALSNQKYRELEEEFKDVGL-----MTGD 201
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDngpQALVLAPTRELAEQIYEELKKLGKGLGLkvaslLGGD 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17542826 202 VTL-------NPDasCLVMTTEILRSMLYRgSEIMKEVGWVVYDEIHYMRDKERGVVWEETIILMSKNIKQAFLSATIP 273
Cdd:pfam00270 84 SRKeqleklkGPD--ILVGTPGRLLDLLQE-RKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLP 159
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
122-281 |
1.20e-28 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 113.20 E-value: 1.20e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 122 YPFQLDAFQKQailcIDNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRVIYTSPIKALSNQKYRE---LEEEFKDVGLM 198
Cdd:cd18028 3 YPPQAEAVRAG----LLKGENLLISIPTASGKTLIAEMAMVNTLLEGGKALYLVPLRALASEKYEEfkkLEEIGLKVGIS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 199 TGD----VTLNPDASCLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERGVVWEETIILM---SKNIKQAFLSAT 271
Cdd:cd18028 79 TGDydedDEWLGDYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVARLrrlNPNTQIIGLSAT 158
|
170
....*....|
gi 17542826 272 IPNARQFAQW 281
Cdd:cd18028 159 IGNPDELAEW 168
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
127-287 |
6.48e-28 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 111.69 E-value: 6.48e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 127 DAFQKQAILCIDNNQSVLVSAHTSAGKTVVATYAIAKCLRE--KQRVIYTSPIKALSNQKYRELEEEFKD---------V 195
Cdd:cd18025 3 DAWQRELLDIVDRRESALIVAPTSSGKTFISYYCMEKVLREsdDGVVVYVAPTKALVNQVVAEVYARFSKkyppsgkslW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 196 GLMTGDVTLNPDASCLVMTT--EILRSMLYRGS--EIMKEVGWVVYDEIHYMRDKERGVVWEETIILmsknIKQAF--LS 269
Cdd:cd18025 83 GVFTRDYRHNNPMNCQVLITvpECLEILLLSPHnaSWVPRIKYVIFDEIHSIGQSEDGAVWEQLLLL----IPCPFlaLS 158
|
170
....*....|....*...
gi 17542826 270 ATIPNARQFAQWVASIKQ 287
Cdd:cd18025 159 ATIGNPQKFHEWLQSVQR 176
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
85-527 |
2.88e-22 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 103.43 E-value: 2.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 85 VHTIRTDnencthEVAIPPnaEFAELRENSGTEpakYYPFQldafqkqaILCIDN----NQSVLVSAHTSAGKTVVATYA 160
Cdd:COG1202 185 VDTVPVD------DLDLPP--ELKDLLEGRGEE---LLPVQ--------SLAVENglleGKDQLVVSATATGKTLIGELA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 161 -IAKCLREKQRVIYTSPIKALSNQKYRELEEEFK---DVGLMTG-------DVTLNPDASCLVMTTEILRSMLyRGSEIM 229
Cdd:COG1202 246 gIKNALEGKGKMLFLVPLVALANQKYEDFKDRYGdglDVSIRVGasrirddGTRFDPNADIIVGTYEGIDHAL-RTGRDL 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 230 KEVGWVVYDEIHYMRDKERGVVWEETIILMSKNIKQA---FLSATIPNARQFAqwvasiKQQPVNVVYTDYRPTPLQ-HW 305
Cdd:COG1202 325 GDIGTVVIDEVHMLEDPERGHRLDGLIARLKYYCPGAqwiYLSATVGNPEELA------KKLGAKLVEYEERPVPLErHL 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 306 IYpVGGEGMYEVVN--VKGEFredkfrdamsglatagdsagsfnKRRTGGGTQGDSnvlkiirsvasndglncIVFSFSR 383
Cdd:COG1202 399 TF-ADGREKIRIINklVKREF-----------------------DTKSSKGYRGQT-----------------IIFTNSR 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 384 KECESYAISLkdmdfnkdhekGMVKSVYesaiaqlspedqklpqilnilpllrrgigvhHSGLMPILKETIEILFGEGLV 463
Cdd:COG1202 438 RRCHEIARAL-----------GYKAAPY-------------------------------HAGLDYGERKKVERRFADQEL 475
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17542826 464 KVLFATETFSMGLNMPARTVVFTSARKfdgsDNRYITSGEYIQMAGRAGRRGKDDRGTVILMVD 527
Cdd:COG1202 476 AAVVTTAALAAGVDFPASQVIFDSLAM----GIEWLSVQEFHQMLGRAGRPDYHDRGKVYLLVE 535
|
|
| KOW_Mtr4 |
cd13154 |
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a ... |
640-763 |
1.19e-20 |
|
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a core DExH region that cooperates with the eukaryotic nuclear exosome in RNA processing and degradation. KOW_Mtr4 motif might be involved in presenting RNA substrates to the helicase core. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW motif is located at the extended insertion of Mtr4 protein.
Pssm-ID: 240518 Cd Length: 129 Bit Score: 88.79 E-value: 1.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 640 FLHAGRLFKVKSGDRDFKWGILNQFKKEQNPDDRNDQ-----IYLCDMMIAINTEGRFDPTNPATLVPGFDLPKRRWIRV 714
Cdd:cd13154 1 FLQPGRLVKVKVGDDDFGWGVVVNFQKRPNKKNGSENsppqeSYVVDVLLNCSSGSSINNGSPSGIRPPGPGEKGEMEVV 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 17542826 715 PMTIDRITAISAVRLKVPADIDKPDGQMRLDGMMAAATKRFGNQIPLLD 763
Cdd:cd13154 81 PVLLSLIQAISSIRLYLPKDLRSADARQSVGKSLQEVKRRFPDGLPLLD 129
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
130-282 |
5.93e-18 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 83.56 E-value: 5.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 130 QKQAI-LCIDNNQSVLVSAHTSAGKTVVATYAIAKCLRE-------KQRVIYTSPIKALSNQKYRELEEEFKDVGL---- 197
Cdd:cd18023 6 QSEVFpDLLYSDKNFVVSAPTGSGKTVLFELAILRLLKErnplpwgNRKVVYIAPIKALCSEKYDDWKEKFGPLGLscae 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 198 MTGDVTLNPD---ASC-LVMTT-EILRSMLYRGSE---IMKEVGWVVYDEIHYMRDkERGVVWE-------------ETI 256
Cdd:cd18023 86 LTGDTEMDDTfeiQDAdIILTTpEKWDSMTRRWRDngnLVQLVALVLIDEVHIIKE-NRGATLEvvvsrmktlssssELR 164
|
170 180
....*....|....*....|....*.
gi 17542826 257 ILMSKNIKQAFLSATIPNARQFAQWV 282
Cdd:cd18023 165 GSTVRPMRFVAVSATIPNIEDLAEWL 190
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
140-282 |
6.32e-16 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 76.47 E-value: 6.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 140 NQSVLVSAHTSAGKTVVA-TYAIAKCLREKQ---RVIYTSPIKALSNQKYRELEEEFKD------VGLMTGDVTLN---- 205
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAfLPALSSLADEPEkgvQVLYISPLKALINDQERRLEEPLDEidleipVAVRHGDTSQSekak 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 206 -----PDAscLVMTTEILRSMLY--RGSEIMKEVGWVVYDEIHYMRDKERGVVWEETIILMSKNIKQAF----LSATIPN 274
Cdd:cd17922 81 qlknpPGI--LITTPESLELLLVnkKLRELFAGLRYVVVDEIHALLGSKRGVQLELLLERLRKLTGRPLrrigLSATLGN 158
|
....*...
gi 17542826 275 ARQFAQWV 282
Cdd:cd17922 159 LEEAAAFL 166
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
427-515 |
1.24e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 69.93 E-value: 1.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 427 QILNILPLLRRGIGVHHSGLMPILKETIEILFGEGLVKVLFATETFSMGLNMP-ARTVVFTSARkfdgsdnryITSGEYI 505
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDLP---------WSPASYI 72
|
90
....*....|
gi 17542826 506 QMAGRAGRRG 515
Cdd:smart00490 73 QRIGRAGRAG 82
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
130-281 |
6.98e-14 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 71.25 E-value: 6.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 130 QKQAILCIDN-NQSVLVSAHTSAGKTVVATYAIAKCLRE--KQRVIYTSPIKALSNQKYRELEEEFKDV-GL----MTGD 201
Cdd:cd18022 6 QTQVFHTLYHtDNNVLLGAPTGSGKTIAAELAMFRAFNKypGSKVVYIAPLKALVRERVDDWKKRFEEKlGKkvveLTGD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 202 VTLNP----DASCLVMTTE----ILRSMLYRgsEIMKEVGWVVYDEIHyMRDKERGVVWEETIILMS-------KNIKQA 266
Cdd:cd18022 86 VTPDMkalaDADIIITTPEkwdgISRSWQTR--EYVQQVSLIIIDEIH-LLGSDRGPVLEVIVSRMNyissqteKPVRLV 162
|
170
....*....|....*
gi 17542826 267 FLSATIPNARQFAQW 281
Cdd:cd18022 163 GLSTALANAGDLANW 177
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
120-299 |
8.78e-14 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 71.09 E-value: 8.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 120 KYYPFQLDAFQKQAILcidNNQSVLVSAHTSAGKTVVATYAIAKCLREKQR-VIYTSPIKALSNQKYRELEEEFKDVGL- 197
Cdd:cd18026 16 KLYDWQKECLSLPGLL---EGRNLVYSLPTSGGKTLVAEILMLKRLLERRKkALFVLPYVSIVQEKVDALSPLFEELGFr 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 198 ---MTGDVTLNP-----DASCLVMTTEILRSMLYRGSEIMK--EVGWVVYDEIHYMRDKERGVVWEET---IILMSKNIK 264
Cdd:cd18026 93 vegYAGNKGRSPpkrrkSLSVAVCTIEKANSLVNSLIEEGRldELGLVVVDELHMLGDGHRGALLELLltkLLYAAQKNI 172
|
170 180 190
....*....|....*....|....*....|....*..
gi 17542826 265 QAF-LSATIPNARQFAQWV-ASikqqpvnVVYTDYRP 299
Cdd:cd18026 173 QIVgMSATLPNLEELASWLrAE-------LYTTNFRP 202
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
80-524 |
1.01e-13 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 75.64 E-value: 1.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 80 MENI--IVHTIRTDNE---NCTHEVAIPPN-AEFAELRENSGTEPAKYY----PFQLDAFQKQAILCIDNNQSVLVSAHT 149
Cdd:COG1205 1 MARLeeLLERLRASPRygdQIVHVRTIPAReARYAPWPDWLPPELRAALkkrgIERLYSHQAEAIEAARAGKNVVIATPT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 150 SAGKTVVATY-AIAKCLREKQ-RVIYTSPIKALSNQKYRELEEEFKDVGL------MTGD--------VTLNPDascLVM 213
Cdd:COG1205 81 ASGKSLAYLLpVLEALLEDPGaTALYLYPTKALARDQLRRLRELAEALGLgvrvatYDGDtppeerrwIREHPD---IVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 214 TT-EIL-RSMLYRG---SEIMKEVGWVVYDEIH-YmrdkeRGV----V-W--------------EETIILMsknikqafl 268
Cdd:COG1205 158 TNpDMLhYGLLPHHtrwARFFRNLRYVVIDEAHtY-----RGVfgshVaNvlrrlrricrhygsDPQFILA--------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 269 SATIPNARQFAQwvaSIKQQPVNVVYTDYRPTPLQHWIypvggegMYE-VVNVKGEFRedkfrdamSGLATAGDSAGSFN 347
Cdd:COG1205 224 SATIGNPAEHAE---RLTGRPVTVVDEDGSPRGERTFV-------LWNpPLVDDGIRR--------SALAEAARLLADLV 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 348 KRrtgggtqgdsnvlkiirsvasndGLNCIVFSFSRKECESYAISLKDMDFNkdhekgmvksvyesaiaqlspedqklpq 427
Cdd:COG1205 286 RE-----------------------GLRTLVFTRSRRGAELLARYARRALRE---------------------------- 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 428 ilnilPLLRRGIGVHHSGLMPILKETIEILFGEGLVKVLFATETFSMGLNMPARTVVFTSArkFDGSdnryITSgeYIQM 507
Cdd:COG1205 315 -----PDLADRVAAYRAGYLPEERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAG--YPGT----RAS--FWQQ 381
|
490
....*....|....*..
gi 17542826 508 AGRAGRRGKDdrGTVIL 524
Cdd:COG1205 382 AGRAGRRGQD--SLVVL 396
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
457-525 |
3.90e-13 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 67.58 E-value: 3.90e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17542826 457 LF--GEGLVKVLFATETFSMGLNMPARTVVFTSARKFDGSDNRYITSGEYIQMAGRAGRRG-KDDRGTVILM 525
Cdd:cd18805 63 LFndPESGYDVLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGsHFPEGEVTTL 134
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
143-271 |
5.85e-13 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 67.43 E-value: 5.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 143 VLVSAHTSAGKTVVAtYAIAKCLREKQ--RVIYTSPIKALSNQKYRELEEEFK---DVGLMTGDVTL-------NPDASC 210
Cdd:cd00046 4 VLITAPTGSGKTLAA-LLAALLLLLKKgkKVLVLVPTKALALQTAERLRELFGpgiRVAVLVGGSSAeereknkLGDADI 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17542826 211 LVMTTE-ILRSMLYRGSEIMKEVGWVVYDEIHYMRDKERGVVWEETII--LMSKNIKQAFLSAT 271
Cdd:cd00046 83 IIATPDmLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVrkAGLKNAQVILLSAT 146
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
80-527 |
1.80e-12 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 71.21 E-value: 1.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 80 MENIIVHTIRTDNENCTHEVAIPPNAEFAELRENSGTEPAKY--YPFQLDAFQKQAILCIDNNQSVLVSAHTSAGKTVVA 157
Cdd:COG1061 38 RRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSFelRPYQQEALEALLAALERGGGRGLVVAPTGTGKTVLA 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 158 TYAIAKcLREKQRVIYTSPIKALSNQKYRELEEEFKDVGLMTGDVtlNPDASCLVMTTEILRSMLYRgSEIMKEVGWVVY 237
Cdd:COG1061 118 LALAAE-LLRGKRVLVLVPRRELLEQWAEELRRFLGDPLAGGGKK--DSDAPITVATYQSLARRAHL-DELGDRFGLVII 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 238 DEIHYMRDKergvVWEETIilmsKNIKQAF---LSATiPnarqfaqwvasikqqpvnvVYTDYRPTPLQHWIYPVGGEGM 314
Cdd:COG1061 194 DEAHHAGAP----SYRRIL----EAFPAAYrlgLTAT-P-------------------FRSDGREILLFLFDGIVYEYSL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 315 YEVVNvKGEFREDKF---RDAMSGLATAGDSAGSFNKRRTgggTQGDSNVLKIIRSVASN--DGLNCIVFsfsrkeCEsy 389
Cdd:COG1061 246 KEAIE-DGYLAPPEYygiRVDLTDERAEYDALSERLREAL---AADAERKDKILRELLREhpDDRKTLVF------CS-- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 390 aislkdmdfNKDHEKgmvksvyesAIAQLspedqklpqilnilpLLRRGIGVHH-SGLMPiLKETIEIL--FGEGLVKVL 466
Cdd:COG1061 314 ---------SVDHAE---------ALAEL---------------LNEAGIRAAVvTGDTP-KKEREEILeaFRDGELRIL 359
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17542826 467 FATETFSMGLNMP-ARTVVFTSARKfdgsdnryiTSGEYIQMAGRAGRRGKD-DRGTVILMVD 527
Cdd:COG1061 360 VTVDVLNEGVDVPrLDVAILLRPTG---------SPREFIQRLGRGLRPAPGkEDALVYDFVG 413
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
125-291 |
5.83e-12 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 65.74 E-value: 5.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 125 QLDAFQKQAILCI-DNNQSVLVSAHTSAGKTVVATYAIAKCLR--EKQRVIYTSPIKALSNQKYRELEEEF-----KDVG 196
Cdd:cd18021 3 FFNPIQTQVFNSLyNTDDNVFVGAPTGSGKTVCAELALLRHWRqnPKGRAVYIAPMQELVDARYKDWRAKFgpllgKKVV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 197 LMTGDVTLNP---DASCLVMTT----EILrSMLYRGSEIMKEVGWVVYDEIHyMRDKERGVVWEETI---ILMS----KN 262
Cdd:cd18021 83 KLTGETSTDLkllAKSDVILATpeqwDVL-SRRWKQRKNVQSVELFIADELH-LIGGENGPVYEVVVsrmRYISsqleKP 160
|
170 180
....*....|....*....|....*....
gi 17542826 263 IKQAFLSATIPNARQFAQWVASIKQQPVN 291
Cdd:cd18021 161 IRIVGLSSSLANARDVGEWLGASKSTIFN 189
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
130-250 |
5.15e-10 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 63.75 E-value: 5.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 130 QKQAILCIDNNQSVLVSAHTSAGKTVVATYAI---------AKCLREKQRVIYTSPIKALSNQKYRELEEEFKD------ 194
Cdd:PRK13767 37 QRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIidelfrlgrEGELEDKVYCLYVSPLRALNNDIHRNLEEPLTEireiak 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17542826 195 ----------VGLMTGDVT-------LNPDASCLVMTTEILRSMLY--RGSEIMKEVGWVVYDEIHYMRDKERGV 250
Cdd:PRK13767 117 ergeelpeirVAIRTGDTSsyekqkmLKKPPHILITTPESLAILLNspKFREKLRTVKWVIVDEIHSLAENKRGV 191
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
122-271 |
3.67e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 56.16 E-value: 3.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 122 YPFQLDAfqKQAILCIDNNQSVLVSAHTSAGKTVVATYAIAKCLreKQRVIYTSPIKALSNQKYRELEEEFKD--VGLMT 199
Cdd:cd17926 2 RPYQEEA--LEAWLAHKNNRRGILVLPTGSGKTLTALALIAYLK--ELRTLIVVPTDALLDQWKERFEDFLGDssIGLIG 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17542826 200 GDVT-LNPDASCLVMTTEILRSMLYRGSEIMKEVGWVVYDEIHYMRDKErgvvWEEtIILMSKNIKQAFLSAT 271
Cdd:cd17926 78 GGKKkDFDDANVVVATYQSLSNLAEEEKDLFDQFGLLIVDEAHHLPAKT----FSE-ILKELNAKYRLGLTAT 145
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
145-533 |
8.60e-09 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 59.94 E-value: 8.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 145 VSAHTSAGKTVVA-TYAIAKCLREK------------QRVIYTSPIKALSNQKYRELEEEFK----------------DV 195
Cdd:PRK09751 1 VIAPTGSGKTLAAfLYALDRLFREGgedtreahkrktSRILYISPIKALGTDVQRNLQIPLKgiaderrrrgetevnlRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 196 GLMTGDVTLN---------PDasCLVMTTEILRSMLY-RGSEIMKEVGWVVYDEIHYMRDKERG----VVWEETIILMSK 261
Cdd:PRK09751 81 GIRTGDTPAQerskltrnpPD--ILITTPESLYLMLTsRARETLRGVETVIIDEVHAVAGSKRGahlaLSLERLDALLHT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 262 NIKQAFLSATIPNARQFAQWVASikQQPVNVVytdyRPTPLQHW----IYPVggEGMYEVVNVKGEFREDkfrdamsgla 337
Cdd:PRK09751 159 SAQRIGLSATVRSASDVAAFLGG--DRPVTVV----NPPAMRHPqiriVVPV--ANMDDVSSVASGTGED---------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 338 tagdsagsfnkrrTGGGTQG------DSNVLKIIRSVASNdglncIVFSFSRKECESYAISLKDM---DFNKDHEKGMVK 408
Cdd:PRK09751 221 -------------SHAGREGsiwpyiETGILDEVLRHRST-----IVFTNSRGLAEKLTARLNELyaaRLQRSPSIAVDA 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 409 SVYESAIAQLSPEDQKLPqilnilPLLRRGigvHHSGLMPILKETIEILFGEGLVKVLFATETFSMGLNMPARTVVFTSA 488
Cdd:PRK09751 283 AHFESTSGATSNRVQSSD------VFIARS---HHGSVSKEQRAITEQALKSGELRCVVATSSLELGIDMGAVDLVIQVA 353
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 17542826 489 RKFDgsdnryITSGeyIQMAGRAGRR-GKDDRGTVIL-----MVDSAMSAD 533
Cdd:PRK09751 354 TPLS------VASG--LQRIGRAGHQvGGVSKGLFFPrtrrdLVDSAVIVE 396
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
434-515 |
9.99e-09 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 54.14 E-value: 9.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 434 LLRRGIGV--HHSGLMPILKETIEILFGEGLVKVLFATETFSMGLNMP-ARTVVFtsarkFDGSDNryitSGEYIQMAGR 510
Cdd:pfam00271 34 LEKEGIKVarLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVIN-----YDLPWN----PASYIQRIGR 104
|
....*
gi 17542826 511 AGRRG 515
Cdd:pfam00271 105 AGRAG 109
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
140-279 |
1.92e-08 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 55.84 E-value: 1.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 140 NQSVLVSAHTSAGKTVVAT----YAIAKCLREKQ-------RVIYTSPIKALSNQKYRELEEEFKDVGL----MTGDVTL 204
Cdd:cd18019 33 DENLLLCAPTGAGKTNVALltilREIGKHRNPDGtinldafKIVYIAPMKALVQEMVGNFSKRLAPYGItvaeLTGDQQL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 205 NPD----ASCLVMTTEILRSMLYRGSE--IMKEVGWVVYDEIHYMRDkERGVVWEETIILMSKNIKQAF-------LSAT 271
Cdd:cd18019 113 TKEqiseTQIIVTTPEKWDIITRKSGDrtYTQLVRLIIIDEIHLLHD-DRGPVLESIVARTIRQIEQTQeyvrlvgLSAT 191
|
....*...
gi 17542826 272 IPNARQFA 279
Cdd:cd18019 192 LPNYEDVA 199
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
122-280 |
7.13e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 53.36 E-value: 7.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 122 YPFQLDAFQKqailcIDNNQSVLVSAHTSAGKTVVATYAI-AKCLREKQ-RVIYTSPIKALSN---QKYRELEEEFK--- 193
Cdd:cd17923 2 YSHQAEAIEA-----ARAGRSVVVTTGTASGKSLCYQLPIlEALLRDPGsRALYLYPTKALAQdqlRSLRELLEQLGlgi 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 194 DVGLMTGD--------VTLNPdASCLVMTTEILRSMLYRGSE----IMKEVGWVVYDEIHYMrdkeRGVVWEETIILM-- 259
Cdd:cd17923 77 RVATYDGDtpreerraIIRNP-PRILLTNPDMLHYALLPHHDrwarFLRNLRYVVLDEAHTY----RGVFGSHVALLLrr 151
|
170 180
....*....|....*....|....*....
gi 17542826 260 --------SKNIKQAFLSATIPNARQFAQ 280
Cdd:cd17923 152 lrrlcrryGADPQFILTSATIGNPAEHAR 180
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
119-273 |
5.24e-07 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 50.88 E-value: 5.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 119 AKYYPFQLDAFQKQAI------LCIDNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRVIYTSPIKALSNQKYRELEEEF 192
Cdd:cd17918 9 CKSLPFSLTKDQAQAIkdiekdLHSPEPMDRLLSGDVGSGKTLVALGAALLAYKNGKQVAILVPTEILAHQHYEEARKFL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 193 KD--VGLMTGDVT--LNPDASCLVMTTEILRSmlyrgSEIMKEVGWVVYDEIHYMrdkerGVVWEETIILMSK-NIKQAf 267
Cdd:cd17918 89 PFinVELVTGGTKaqILSGISLLVGTHALLHL-----DVKFKNLDLVIVDEQHRF-----GVAQREALYNLGAtHFLEA- 157
|
....*..
gi 17542826 268 lSAT-IP 273
Cdd:cd17918 158 -TATpIP 163
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
130-293 |
2.04e-06 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 49.51 E-value: 2.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 130 QKQAILCIDNNQSVLVSAHTSAGKTVV-ATYAIAKCLREKQ----RVIYTSPIKALSNQKYREL-----EEEFKdVGLMT 199
Cdd:cd17957 17 QMQAIPILLHGRDLLACAPTGSGKTLAfLIPILQKLGKPRKkkglRALILAPTRELASQIYRELlklskGTGLR-IVLLS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 200 GDVTLNPDAS--------CLVMTTEILRSMLYRGSEIMKEVGWVVYDEIhymrDK--ERGVVwEETIILM----SKNIKQ 265
Cdd:cd17957 96 KSLEAKAKDGpksitkydILVSTPLRLVFLLKQGPIDLSSVEYLVLDEA----DKlfEPGFR-EQTDEILaactNPNLQR 170
|
170 180
....*....|....*....|....*...
gi 17542826 266 AFLSATIPNarQFAQWVASIKQQPVNVV 293
Cdd:cd17957 171 SLFSATIPS--EVEELARSVMKDPIRII 196
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
140-282 |
2.39e-06 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 49.35 E-value: 2.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 140 NQSVLVSAHTSAGKTVVATYAIAKCLREKQR-----------VIYTSPIKALSNQKYRELEEEFKDVGL----MTGDVTL 204
Cdd:cd18020 17 NENMLICAPTGAGKTNIAMLTILHEIRQHVNqggvikkddfkIVYIAPMKALAAEMVEKFSKRLAPLGIkvkeLTGDMQL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 205 NP----DASCLVMTTEILRSMLYRGS---EIMKEVGWVVYDEIHYMRDkERGVVWEETI------ILMSKN-IKQAFLSA 270
Cdd:cd18020 97 TKkeiaETQIIVTTPEKWDVVTRKSSgdvALSQLVRLLIIDEVHLLHD-DRGPVIESLVartlrqVESTQSmIRIVGLSA 175
|
170
....*....|..
gi 17542826 271 TIPNARQFAQWV 282
Cdd:cd18020 176 TLPNYLDVADFL 187
|
|
| DEXQc_Suv3 |
cd17913 |
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ... |
149-252 |
1.58e-05 |
|
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350671 [Multi-domain] Cd Length: 142 Bit Score: 45.63 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 149 TSAGKTvvatYAIAKCLREKQRVIYTSPIKALSNQKYRELEEEFKDVGLMTGD-VTLNPDASCLVMTTEilrsMLYRGSE 227
Cdd:cd17913 10 TNSGKT----YHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQeRREVEGATHVSCTVE----MASISEP 81
|
90 100
....*....|....*....|....*
gi 17542826 228 ImkEVgwVVYDEIHYMRDKERGVVW 252
Cdd:cd17913 82 Y--DV--AVIDEIQMIGDPQRGWAW 102
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
373-526 |
2.88e-05 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 44.94 E-value: 2.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 373 GLNCIVFSFSRKECESYAISLKDMdfnkdhekgmvksvyesaiaqlspedqklpqiLNILPLLRRGIGVHHSGLMPILKE 452
Cdd:cd18797 35 GVKTIVFCRSRKLAELLLRYLKAR--------------------------------LVEEGPLASKVASYRAGYLAEDRR 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17542826 453 TIEILFGEGLVKVLFATETFSMGLNMPARTVVFTSArkFDGSdnryITSgeYIQMAGRAGRRGKDdrgTVILMV 526
Cdd:cd18797 83 EIEAELFNGELLGVVATNALELGIDIGGLDAVVLAG--YPGS----LAS--LWQQAGRAGRRGKD---SLVILV 145
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
464-524 |
3.20e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.38 E-value: 3.20e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17542826 464 KVLFATETFSMGLNMP-ARTVVFTSARkfdgsdnryITSGEYIQMAGRAGrRGKDDRGTVIL 524
Cdd:cd18785 24 EILVATNVLGEGIDVPsLDTVIFFDPP---------SSAASYIQRVGRAG-RGGKDEGEVIL 75
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
143-276 |
1.40e-03 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 40.74 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 143 VLVSAHTSAGKTVVATYAIAKcLREKQ---RVIYTSPIKALSNQKYRELEEEFK------DVGLMTGDVTLNPD------ 207
Cdd:cd17930 4 VILEAPTGSGKTEAALLWALK-LAARGgkrRIIYALPTRATINQMYERIREILGrlddedKVLLLHSKAALELLesdeep 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 208 ------------------ASCLVMTT--EILRSML------YRGSEIMKEVgwVVYDEIH-----YMRDKERGVVWeeti 256
Cdd:cd17930 83 dddpveavdwalllkrswLAPIVVTTidQLLESLLkykhfeRRLHGLANSV--VVLDEVQaydpeYMALLLKALLE---- 156
|
170 180
....*....|....*....|
gi 17542826 257 ILMSKNIKQAFLSATIPNAR 276
Cdd:cd17930 157 LLGELGGPVVLMTATLPALL 176
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
129-281 |
2.76e-03 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 39.83 E-value: 2.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 129 FQKQAILCIDNNQSVLVSAHTSAGKTVVATY-----AIAKCLREKQRVIYTSP--IKALSNQKYRELEE-EFKDVGLMTG 200
Cdd:cd17981 6 MKQEIINMIDNNQVTVISGETGCGKTTQVTQfilddAIERGKGSSCRIVCTQPrrISAISVAERVAAERaESCGLGNSTG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 201 -DVTLNP-----DASCLVMTTEILRSMLyRGSEIMKEVGWVVYDEIHymrdkERGVvweETIILMS---------KNIKQ 265
Cdd:cd17981 86 yQIRLESrkprkQGSILYCTTGIVLQWL-QSDPHLSNVSHLVLDEIH-----ERNL---QSDVLMGivkdllpfrSDLKV 156
|
170
....*....|....*.
gi 17542826 266 AFLSATIpNARQFAQW 281
Cdd:cd17981 157 ILMSATL-NAEKFSDY 171
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
122-241 |
3.35e-03 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 39.94 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542826 122 YPFQLDAFQKqailCIDNNqsVLVSAHTSAGKTVVAT-------YAIAKCLREKQRVIYTSPIKALSNQKYRELEEEFK- 193
Cdd:cd18034 4 RSYQLELFEA----ALKRN--TIVVLPTGSGKTLIAVmlikemgELNRKEKNPKKRAVFLVPTVPLVAQQAEAIRSHTDl 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17542826 194 DVGLMTGDvtLNPDASC-------------LVMTTEILRSMLYRGSEIMKEVGWVVYDEIH 241
Cdd:cd18034 78 KVGEYSGE--MGVDKWTkerwkeelekydvLVMTAQILLDALRHGFLSLSDINLLIFDECH 136
|
|
| DEXHc_priA |
cd17929 |
DEXH-box helicase domain of PriA; PriA, also known as replication factor Y or primosomal ... |
130-198 |
5.35e-03 |
|
DEXH-box helicase domain of PriA; PriA, also known as replication factor Y or primosomal protein N', is a 3'-->5' superfamily 2 DNA helicase that acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. PriA is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350687 [Multi-domain] Cd Length: 178 Bit Score: 39.11 E-value: 5.35e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17542826 130 QKQAILCI----DNNQSVLVSAHTSAGKTVVATYAIAKCLREKQRVIYTSPIKALSNQKYRELEEEF-KDVGLM 198
Cdd:cd17929 1 QRKAYEAIvsslGGFKTFLLHGVTGSGKTEVYIELIEKVLAKGKQVLVLVPEISLTPQLIKRFKKRFgDKVAVL 74
|
|
| |
