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Conserved domains on  [gi|71985930|ref|NP_501875|]
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Enoyl-CoA Hydratase [Caenorhabditis elegans]

Protein Classification

3-hydroxyacyl-CoA dehydrogenase( domain architecture ID 12804107)

3-hydroxyacyl-CoA dehydrogenase (HCDH) catalyzes the NAD-dependent oxidation of 3-hydroxyacyl-CoA to form 3-oxoacyl-CoA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 38-307 2.52e-89

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 272.37  E-value: 2.52e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  38 DVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNE---QRCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHKLS 114
Cdd:COG1250   1 EIKKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPealERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930 115 NCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSS 194
Cdd:COG1250  81 DADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930 195 QAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEyGYL-PHQIDKIITN-FGFLMGPMTVADMNGFD-- 270
Cdd:COG1250 161 ETVATAVAFARRLGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEE-GVAsPEDIDAAMRLgFGFPMGPFELADLVGLDta 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 71985930 271 --VMEKLKKENG---LEPNPIEKEMWRLKRYGRKTNKGFYKY 307
Cdd:COG1250 240 laVLEVLYEALGdprYRPPPLLKKLVEAGRLGRKTGRGFYDY 281
3HCDH super family cl37630
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 343-397 1.70e-04

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


The actual alignment was detected with superfamily member pfam00725:

Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 40.28  E-value: 1.70e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 71985930   343 VINFMLYPTVNEGYRCIEEGVISNESlIDIMFILGFGWPIhsgGPMRFGKTEGLD 397
Cdd:pfam00725   3 VVNRLLAPYLNEAIRLVEEGVATPED-IDAAMRLGLGLPM---GPFELSDLVGLD 53
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 38-307 2.52e-89

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 272.37  E-value: 2.52e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  38 DVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNE---QRCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHKLS 114
Cdd:COG1250   1 EIKKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPealERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930 115 NCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSS 194
Cdd:COG1250  81 DADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930 195 QAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEyGYL-PHQIDKIITN-FGFLMGPMTVADMNGFD-- 270
Cdd:COG1250 161 ETVATAVAFARRLGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEE-GVAsPEDIDAAMRLgFGFPMGPFELADLVGLDta 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 71985930 271 --VMEKLKKENG---LEPNPIEKEMWRLKRYGRKTNKGFYKY 307
Cdd:COG1250 240 laVLEVLYEALGdprYRPPPLLKKLVEAGRLGRKTGRGFYDY 281
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 41-217 6.61e-64

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 203.54  E-value: 6.61e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930    41 SVAIIGGGTMGKAMAICFGLAGIETFLVVRNE---QRCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHKLSNCD 117
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAGLEVVLVDISEealEKALERIESSLERLVEKGRITEEEVDAALARISFTTDLAAAVDAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   118 LIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSSQAI 197
Cdd:pfam02737  81 LVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETV 160

                         170       180
                  ....*....|....*....|
gi 71985930   198 ATAFQACESIKKLPVLVGNC 217
Cdd:pfam02737 161 ATTVELAKKIGKTPVVVKDT 180
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
35-428 7.60e-59

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 204.71  E-value: 7.60e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   35 EAYDVNSVAIIGGGTMGKAMAICFGLAGIEtflVVRNEQRCKQ-ELEVMYAREKSFKRLNDKRIE-----KINANLKITS 108
Cdd:PRK11730 309 DAKPVKQAAVLGAGIMGGGIAYQSASKGVP---VIMKDINQKAlDLGMTEAAKLLNKQVERGKIDgakmaGVLSSIRPTL 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  109 DFHKLSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIY 188
Cdd:PRK11730 386 DYAGFERVDVVVEAVVENPKVKAAVLAEVEQKVREDTILASNTSTISISLLAKALKRPENFCGMHFFNPVHRMPLVEVIR 465

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  189 GSHTSSQAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEyGYLPHQIDKIITN-FGFLMGPMTVADMN 267
Cdd:PRK11730 466 GEKTSDETIATVVAYASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRD-GADFRQIDKVMEKqFGWPMGPAYLLDVV 544

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  268 GFD-------VM-----EKLKKEnglEPNPIEKeMWRLKRYGRKTNKGFYKYD-DKT--QRKENDTEMEQIIRRVSQNAk 332
Cdd:PRK11730 545 GIDtahhaqaVMaegfpDRMKKD---YRDAIDV-LFEAKRFGQKNGKGFYRYEeDKKgkPKKEVDPAVYELLAPVVQPK- 619

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  333 sniQIINDQDVINFMLYPTVNEGYRCIEEGVISNESLIDIMFILGFGWPIHSGGPMRFGKTEGLDKIANMLVHWSSLEPk 412
Cdd:PRK11730 620 ---REFSDEEIIARMMIPMINEVVRCLEEGIVASPAEADMALVYGLGFPPFRGGAFRYLDTLGVANYVALADKYAHLGP- 695

                        410
                 ....*....|....*...
gi 71985930  413 esAYIVADAL--KTANNK 428
Cdd:PRK11730 696 --LYQVPEGLreMAANGE 711
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 38-428 2.99e-56

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 197.75  E-value: 2.99e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930    38 DVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQ---RCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHKLS 114
Cdd:TIGR02441 334 PVKTLAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAgldRGQQQVFKGLNKKVKRKKITSLERDSILSNLTPTLDYSGFK 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   115 NCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSS 194
Cdd:TIGR02441 414 NADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSK 493

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   195 QAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEyGYLPHQIDKIITNFGFLMGPMTVADMNGFDVMEK 274
Cdd:TIGR02441 494 DTLASAVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQE-GVDPKKLDKLTTKFGFPVGAATLADEVGVDVAEH 572

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   275 LKKENGLEPNP--------IEKEMWRLKRYGRKTNKGFYKYDD--KTQRKENDtEMEQIIRRVSQNAKSNIQiiNDQDVI 344
Cdd:TIGR02441 573 VAEDLGKAFGErfgggsaeLLSELVKAGFLGRKSGKGIFIYQEgkKGSKKVNS-DADEILAQYKLPPKAEVS--SPEDIQ 649

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   345 NFMLYPTVNEGYRCIEEGVISNESLIDIMFILGFGWPIHSGGPMRFGKTEGLDKIANMLVHWSSL--EPKESAYIVADAL 422
Cdd:TIGR02441 650 IRLVSRFVNEAVLCLEEGILASPSEGDIGAVFGLGFPPFLGGPFRFVDLYGADKLVDKMEKYAAAygVQFTPCQLLLDHA 729


                  ....*.
gi 71985930   423 KTANNK 428
Cdd:TIGR02441 730 KSPGKK 735
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 343-397 1.70e-04

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 40.28  E-value: 1.70e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 71985930   343 VINFMLYPTVNEGYRCIEEGVISNESlIDIMFILGFGWPIhsgGPMRFGKTEGLD 397
Cdd:pfam00725   3 VVNRLLAPYLNEAIRLVEEGVATPED-IDAAMRLGLGLPM---GPFELSDLVGLD 53
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 38-307 2.52e-89

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 272.37  E-value: 2.52e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  38 DVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNE---QRCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHKLS 114
Cdd:COG1250   1 EIKKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPealERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930 115 NCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSS 194
Cdd:COG1250  81 DADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930 195 QAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEyGYL-PHQIDKIITN-FGFLMGPMTVADMNGFD-- 270
Cdd:COG1250 161 ETVATAVAFARRLGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEE-GVAsPEDIDAAMRLgFGFPMGPFELADLVGLDta 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 71985930 271 --VMEKLKKENG---LEPNPIEKEMWRLKRYGRKTNKGFYKY 307
Cdd:COG1250 240 laVLEVLYEALGdprYRPPPLLKKLVEAGRLGRKTGRGFYDY 281
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 41-217 6.61e-64

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 203.54  E-value: 6.61e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930    41 SVAIIGGGTMGKAMAICFGLAGIETFLVVRNE---QRCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHKLSNCD 117
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAGLEVVLVDISEealEKALERIESSLERLVEKGRITEEEVDAALARISFTTDLAAAVDAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   118 LIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSSQAI 197
Cdd:pfam02737  81 LVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETV 160

                         170       180
                  ....*....|....*....|
gi 71985930   198 ATAFQACESIKKLPVLVGNC 217
Cdd:pfam02737 161 ATTVELAKKIGKTPVVVKDT 180
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
35-428 7.60e-59

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 204.71  E-value: 7.60e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   35 EAYDVNSVAIIGGGTMGKAMAICFGLAGIEtflVVRNEQRCKQ-ELEVMYAREKSFKRLNDKRIE-----KINANLKITS 108
Cdd:PRK11730 309 DAKPVKQAAVLGAGIMGGGIAYQSASKGVP---VIMKDINQKAlDLGMTEAAKLLNKQVERGKIDgakmaGVLSSIRPTL 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  109 DFHKLSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIY 188
Cdd:PRK11730 386 DYAGFERVDVVVEAVVENPKVKAAVLAEVEQKVREDTILASNTSTISISLLAKALKRPENFCGMHFFNPVHRMPLVEVIR 465

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  189 GSHTSSQAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEyGYLPHQIDKIITN-FGFLMGPMTVADMN 267
Cdd:PRK11730 466 GEKTSDETIATVVAYASKMGKTPIVVNDCPGFFVNRVLFPYFAGFSQLLRD-GADFRQIDKVMEKqFGWPMGPAYLLDVV 544

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  268 GFD-------VM-----EKLKKEnglEPNPIEKeMWRLKRYGRKTNKGFYKYD-DKT--QRKENDTEMEQIIRRVSQNAk 332
Cdd:PRK11730 545 GIDtahhaqaVMaegfpDRMKKD---YRDAIDV-LFEAKRFGQKNGKGFYRYEeDKKgkPKKEVDPAVYELLAPVVQPK- 619

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  333 sniQIINDQDVINFMLYPTVNEGYRCIEEGVISNESLIDIMFILGFGWPIHSGGPMRFGKTEGLDKIANMLVHWSSLEPk 412
Cdd:PRK11730 620 ---REFSDEEIIARMMIPMINEVVRCLEEGIVASPAEADMALVYGLGFPPFRGGAFRYLDTLGVANYVALADKYAHLGP- 695

                        410
                 ....*....|....*...
gi 71985930  413 esAYIVADAL--KTANNK 428
Cdd:PRK11730 696 --LYQVPEGLreMAANGE 711
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 38-428 2.99e-56

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 197.75  E-value: 2.99e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930    38 DVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQ---RCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHKLS 114
Cdd:TIGR02441 334 PVKTLAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAgldRGQQQVFKGLNKKVKRKKITSLERDSILSNLTPTLDYSGFK 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   115 NCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSS 194
Cdd:TIGR02441 414 NADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSK 493

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   195 QAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEyGYLPHQIDKIITNFGFLMGPMTVADMNGFDVMEK 274
Cdd:TIGR02441 494 DTLASAVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQE-GVDPKKLDKLTTKFGFPVGAATLADEVGVDVAEH 572

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   275 LKKENGLEPNP--------IEKEMWRLKRYGRKTNKGFYKYDD--KTQRKENDtEMEQIIRRVSQNAKSNIQiiNDQDVI 344
Cdd:TIGR02441 573 VAEDLGKAFGErfgggsaeLLSELVKAGFLGRKSGKGIFIYQEgkKGSKKVNS-DADEILAQYKLPPKAEVS--SPEDIQ 649

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   345 NFMLYPTVNEGYRCIEEGVISNESLIDIMFILGFGWPIHSGGPMRFGKTEGLDKIANMLVHWSSL--EPKESAYIVADAL 422
Cdd:TIGR02441 650 IRLVSRFVNEAVLCLEEGILASPSEGDIGAVFGLGFPPFLGGPFRFVDLYGADKLVDKMEKYAAAygVQFTPCQLLLDHA 729


                  ....*.
gi 71985930   423 KTANNK 428
Cdd:TIGR02441 730 KSPGKK 735
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 38-307 3.54e-55

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 184.40  E-value: 3.54e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   38 DVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQRCKQELEVMyarEKSFKRLNDKriEKIN--------ANLKITSD 109
Cdd:PRK05808   2 GIQKIGVIGAGTMGNGIAQVCAVAGYDVVMVDISDAAVDRGLATI---TKSLDRLVKK--GKMTeadkeaalARITGTTD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  110 FHKLSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYG 189
Cdd:PRK05808  77 LDDLKDADLVIEAATENMDLKKKIFAQLDEIAKPEAILATNTSSLSITELAAATKRPDKVIGMHFFNPVPVMKLVEIIRG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  190 SHTSSQAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEYGYLPHQID---KIITNFGflMGPMTVADM 266
Cdd:PRK05808 157 LATSDATHEAVEALAKKIGKTPVEVKNAPGFVVNRILIPMINEAIFVLAEGVATAEDIDegmKLGCNHP--IGPLALADL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 71985930  267 NGFD----VMEKLKKENG---LEPNPIEKEMWRLKRYGRKTNKGFYKY 307
Cdd:PRK05808 235 IGLDtclaIMEVLYEGFGdskYRPCPLLRKMVAAGWLGRKTGRGFYDY 282
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
23-408 5.38e-51

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 182.79  E-value: 5.38e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   23 SLPNDRGdhTNSEAYDVNSVAIIGGGTMGKAMA-ICFGLAGIETFLVVRNEQRCKQELEVMYAR-EKSFKRLNDKRIEKI 100
Cdd:PRK11154 295 EMKKDTG--SDAKPRPVNKVGVLGGGLMGGGIAyVTATKAGLPVRIKDINPQGINHALKYSWDLlDKKVKRRHLKPSERD 372

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  101 NANLKI--TSDFHKLSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPA 178
Cdd:PRK11154 373 KQMALIsgTTDYRGFKHADVVIEAVFEDLALKQQMVAEVEQNCAPHTIFASNTSSLPIGQIAAAAARPEQVIGLHYFSPV 452

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  179 NVIRLVEIIYGSHTSSQAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEyGYLPHQIDKIITNFGFLM 258
Cdd:PRK11154 453 EKMPLVEVIPHAKTSAETIATTVALAKKQGKTPIVVRDGAGFYVNRILAPYINEAARLLLE-GEPIEHIDAALVKFGFPV 531

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  259 GPMTVADMNGFDVMEK----LKKENG--LEPNPIEKEMWRLKRYGRKTNKGFYKYDD--KTQRKENDTEMEQIIrRVSQN 330
Cdd:PRK11154 532 GPITLLDEVGIDVGTKiipiLEAALGerFSAPAAFDKLLNDDRKGRKNGRGFYLYGQkgKKSKKQVDESVYPLL-GITPQ 610

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 71985930  331 AKSNIQIINDQDVInfmlyPTVNEGYRCIEEGVISNESLIDIMFILGFGWPIHSGGPMRFGKTEGLDKIANMLVHWSS 408
Cdd:PRK11154 611 SRLSANEIAERCVM-----LMLNEAVRCLDEGIIRSARDGDIGAVFGIGFPPFLGGPFRYMDSLGAGEVVAILERLAA 683
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 37-319 1.44e-50

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 178.50  E-value: 1.44e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   37 YDVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQRCKQelevmyAREKSFKRLnDKRIEK----------INANLKI 106
Cdd:PRK08268   5 PSIATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAA------ARDGIAARL-AKLVEKgkltaeqadaALARLRP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  107 TSDFHKLSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEI 186
Cdd:PRK08268  78 VEALADLADCDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  187 IYGSHTSSQAIATAFQACESIKKLPVlvgNCKS---FVFNRLLHVYFDQSQKLMYEYGYLPHQIDKIITN-FGFLMGPMT 262
Cdd:PRK08268 158 VSGLATDPAVADALYALARAWGKTPV---RAKDtpgFIVNRAARPYYTEALRVLEEGVADPATIDAILREaAGFRMGPFE 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71985930  263 VADMNGFD----VMEKLKK----ENGLEPNPIEKEMWRLKRYGRKTNKGFYKYDDKTQRKENDTE 319
Cdd:PRK08268 235 LMDLIGLDvnhaVMESVYRqfyqEPRFRPSLIQQELVAAGRLGRKSGQGFYRYADGAKQPPAEAA 299
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 38-312 5.83e-48

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 166.06  E-value: 5.83e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   38 DVNSVAIIGGGTMGKAMAICFGLAGIETFL-------VVRNEQRCKQELEVMYAREKSFKRLNDKRIEKInanlKITSDF 110
Cdd:PLN02545   3 EIKKVGVVGAGQMGSGIAQLAAAAGMDVWLldsdpaaLSRGLDSISSSLARLVKKGKMSQEEADATLGRI----RCTTNL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  111 HKLSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGS 190
Cdd:PLN02545  79 EELRDADFIIEAIVESEDLKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQQVIGMHFMNPPPIMKLVEIIRGA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  191 HTSSQAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEYGYLPHQID---KIITNFGflMGPMTVADMN 267
Cdd:PLN02545 159 DTSDEVFDATKALAERFGKTVVCSQDYPGFIVNRILMPMINEAFYALYTGVASKEDIDtgmKLGTNHP--MGPLHLADFI 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 71985930  268 GFDV----MEKLKK---ENGLEPNPIEKEMWRLKRYGRKTNKGFYKYDDKTQ 312
Cdd:PLN02545 237 GLDTclsiMKVLHEglgDSKYRPCPLLVQYVDAGRLGRKSGRGVYHYDGKKR 288
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
39-313 2.71e-43

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 153.41  E-value: 2.71e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   39 VNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQ---RCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHK-LS 114
Cdd:PRK09260   1 IEKLVVVGAGVMGRGIAYVFAVSGFQTTLVDIKQEqleSAQQEIASIFEQGVARGKLTEAARQAALARLSYSLDLKAaVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  115 NCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSS 194
Cdd:PRK09260  81 DADLVIEAVPEKLELKKAVFETADAHAPAECYIATNTSTMSPTEIASFTKRPERVIAMHFFNPVHKMKLVELIRGLETSD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  195 QAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEYGYLPHQIDKIIT-NFGFLMGPMTVADMNGFD--- 270
Cdd:PRK09260 161 ETVQVAKEVAEQMGKETVVVNEFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIRlGLNFPMGPLELGDLVGLDtrl 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 71985930  271 -VMEKLKKENG--LEPNPIEKEMWRLKRYGRKTNKGFYKYDDKTQR 313
Cdd:PRK09260 241 nNLKYLHETLGekYRPAPLLEKYVKAGRLGRKTGRGVYDYTNRENV 286
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 39-314 1.84e-41

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 149.15  E-value: 1.84e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   39 VNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNE---QRCKQELEVmyAREKSFKrlnDKRIEKINANLKITSDFHK-LS 114
Cdd:PRK06130   4 IQNLAIIGAGTMGSGIAALFARKGLQVVLIDVMEgalERARGVIER--ALGVYAP---LGIASAGMGRIRMEAGLAAaVS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  115 NCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSS 194
Cdd:PRK06130  79 GADLVIEAVPEKLELKRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVTRPERFVGTHFFTPADVIPLVEVVRGDKTSP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  195 QAIATAFQACESIKKLPVLVG-NCKSFVFNRLLHVYFDQSQKLMYEYGYLPHQIDKIIT-NFGF---LMGPMTVADMNGF 269
Cdd:PRK06130 159 QTVATTMALLRSIGKRPVLVKkDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKwSLGIrlaLTGPLEQRDMNGL 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 71985930  270 DVMEKLKK------ENGLEPNPIEKEMWRLKRYGRKTNKGFYKYDDKTQRK 314
Cdd:PRK06130 239 DVHLAVASylyqdlENRTTPSPLLEEKVEAGELGAKSGQGFYAWPPERREE 289
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 38-280 1.87e-36

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 135.39  E-value: 1.87e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   38 DVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQRCKQELEVMYAREKSFKRLNDK------RIEKINANLKITSDFH 111
Cdd:PRK06035   2 DIKVIGVVGSGVMGQGIAQVFARTGYDVTIVDVSEEILKNAMELIESGPYGLRNLVEKgkmsedEAKAIMARIRTSTSYE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  112 KLSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSH 191
Cdd:PRK06035  82 SLSDADFIVEAVPEKLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALERKDRFIGMHWFNPAPVMKLIEVVRAAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  192 TSSQAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLmYEYGYLP-HQIDKIIT-NFGFLMGPMTVADMNGF 269
Cdd:PRK06035 162 TSEETFNTTVELSKKIGKIPIEVADVPGFFTTRFIEGWLLEAIRS-FEIGIATiKDIDEMCKlAFGFPMGPFELMDIIGI 240

                        250
                 ....*....|....*
gi 71985930  270 D----VMEKLKKENG 280
Cdd:PRK06035 241 DtvyhIAEYLYEETG 255
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 38-307 3.19e-36

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 134.34  E-value: 3.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   38 DVNSVAIIGGGTMGKAMAICFGLAGIETfLVVRNEQRC----KQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHKL 113
Cdd:PRK07819   4 AIQRVGVVGAGQMGAGIAEVCARAGVDV-LVFETTEELatagRNRIEKSLERAVSRGKLTERERDAALARLRFTTDLGDF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  114 SNCDLIVESVIEDMKLKKELFANLENIC-KSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHT 192
Cdd:PRK07819  83 ADRQLVIEAVVEDEAVKTEIFAELDKVVtDPDAVLASNTSSIPIMKLAAATKRPGRVLGLHFFNPVPVLPLVELVPTLVT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  193 SSQAI--ATAFqACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKlMYEYGY-LPHQIDKIITN-FGFLMGPMTVADMNG 268
Cdd:PRK07819 163 SEATVarAEEF-ASDVLGKQVVRAQDRSGFVVNALLVPYLLSAIR-MVESGFaTAEDIDKAMVLgCAHPMGPLRLSDLVG 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 71985930  269 FDVM----EKLKKENGlEPN----PIEKEMWRLKRYGRKTNKGFYKY 307
Cdd:PRK07819 241 LDTVkaiaDSMYEEFK-EPLyappPLLLRMVEAGLLGKKSGRGFYTY 286
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 36-307 1.55e-33

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 127.43  E-value: 1.55e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   36 AYDVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQRCKQELEVM---YAREKSFKRLNDKRIEKINANLKITSDFHK 112
Cdd:PRK07530   1 MMAIKKVGVIGAGQMGNGIAHVCALAGYDVLLNDVSADRLEAGLATIngnLARQVAKGKISEEARAAALARISTATDLED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  113 LSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHT 192
Cdd:PRK07530  81 LADCDLVIEAATEDETVKRKIFAQLCPVLKPEAILATNTSSISITRLASATDRPERFIGIHFMNPVPVMKLVELIRGIAT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  193 SSQAIATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEYGYLPHQID---KIITNFGflMGPMTVADMNGF 269
Cdd:PRK07530 161 DEATFEAAKEFVTKLGKTITVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDtamKLGANHP--MGPLELADFIGL 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 71985930  270 D----VMEKLkkENGL-----EPNPIekemwrLKRY------GRKTNKGFYKY 307
Cdd:PRK07530 239 DtclsIMQVL--HDGLadskyRPCPL------LVKYveagwlGRKTGRGFYDY 283
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
38-307 1.05e-23

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 100.01  E-value: 1.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   38 DVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNE---QRCKQELEVMYAREKSFKRLNDK-RIEKINANLKITSDFHK- 112
Cdd:PRK08293   2 DIKNVTVAGAGVLGSQIAFQTAFHGFDVTIYDISDealEKAKERIAKLADRYVRDLEATKEaPAEAALNRITLTTDLAEa 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  113 LSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHT 192
Cdd:PRK08293  82 VKDADLVIEAVPEDPEIKGDFYEELAKVAPEKTIFATNSSTLLPSQFAEATGRPEKFLALHFANEIWKNNTAEIMGHPGT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  193 SSQAIATAFQACESIKKLPVLVGNCKS-FVFNRLLHVYFDQSQKLMYEYGYLPHQIDK---IITnfGFLMGPMTVADMNG 268
Cdd:PRK08293 162 DPEVFDTVVAFAKAIGMVPIVLKKEQPgYILNSLLVPFLSAALALWAKGVADPETIDKtwmIAT--GAPMGPFGILDIVG 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 71985930  269 FD----VM----EKLKKENGLEPNPIEKEMWRLKRYGRKTNKGFYKY 307
Cdd:PRK08293 240 LDtaynITsnwaEATDDENAKKAAALLKEYIDKGKLGVATGEGFYNY 286
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 40-267 5.27e-19

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 87.02  E-value: 5.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   40 NSVAIIGGGTMGKAMAICFGLAGIETFLVVRNE---QRCKQELEVMYAREKSFKRLNDKRIEKINANLKITSDFHK-LSN 115
Cdd:PRK06129   3 GSVAIIGAGLIGRAWAIVFARAGHEVRLWDADPaaaAAAPAYIAGRLEDLAAFDLLDGEAPDAVLARIRVTDSLADaVAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  116 CDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSSQ 195
Cdd:PRK06129  83 ADYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71985930  196 AIATAFQACESIKKLPVLVG-NCKSFVFNRLLHVYFDQSQKLmYEYGYL-PHQIDKIITNfGF-----LMGPMTVADMN 267
Cdd:PRK06129 163 TLARAEALYRAAGQSPVRLRrEIDGFVLNRLQGALLREAFRL-VADGVAsVDDIDAVIRD-GLglrwsFMGPFETIDLN 239
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 50-309 6.90e-19

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 87.04  E-value: 6.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   50 MGKAMAICFGLAGIETFLV----------VRNEQRCKQELEVMYAREKSFKRLNDKRIEKINANLKITS---DFHKLSNC 116
Cdd:PRK08269   1 MGQGIALAFAFAGHDVTLIdfkprdaagwRALDAEARAEIERTLAALVALGRIDAAQADAVLARIAVVArdgAADALADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  117 DLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSSQA 196
Cdd:PRK08269  81 DLVFEAVPEVLDAKREALRWLGRHVDADAIIASTTSTFLVTDLQRHVAHPERFLNAHWLNPAYLMPLVEVSPSDATDPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  197 IATAFQACESIKKLPVLVGNCKSFVFNRLLHVYFDQSQKLMYEYGYLPHQIDKII-TNFGF---LMGPMTVADMNGFDV- 271
Cdd:PRK08269 161 VDRLAALLERIGKVPVVCGPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDKAIrTGFGLrfaVLGLLEFIDWGGCDIl 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 71985930  272 ------MEKLKKENGLEPNPIEKEMWRLKRYGRKTNKGFYKYDD 309
Cdd:PRK08269 241 yyasryLAGEIGPDRFAPPAIVVRNMEEGRDGLRTGAGFYDYAG 284
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 220-307 1.76e-14

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 68.78  E-value: 1.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   220 FVFNRLLHVYFDQSQKLMYEYGYLPHQIDKIITN-FGFLMGPMTVADMNGFDV-------MEKLKKENGLEPNPIEKEMW 291
Cdd:pfam00725   2 FVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLgLGLPMGPFELSDLVGLDVgyhilevLAEEFGDRAYRPPPLLEKLV 81

                          90
                  ....*....|....*.
gi 71985930   292 RLKRYGRKTNKGFYKY 307
Cdd:pfam00725  82 EAGRLGRKTGKGFYKY 97
PRK07531 PRK07531
carnitine 3-dehydrogenase;
39-226 4.38e-14

carnitine 3-dehydrogenase;


Pssm-ID: 236044 [Multi-domain]  Cd Length: 495  Bit Score: 74.00  E-value: 4.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   39 VNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQRCKQELEVMYAREKSFKRLNDKRIEKiNANLKITSDFHK-LSNCD 117
Cdd:PRK07531   4 IMKAACIGGGVIGGGWAARFLLAGIDVAVFDPHPEAERIIGEVLANAERAYAMLTDAPLPP-EGRLTFCASLAEaVAGAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  118 LIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHTSSQAI 197
Cdd:PRK07531  83 WIQESVPERLDLKRRVLAEIDAAARPDALIGSSTSGFLPSDLQEGMTHPERLFVAHPYNPVYLLPLVELVGGGKTSPETI 162

                        170       180       190
                 ....*....|....*....|....*....|
gi 71985930  198 ATAFQACESIKKLPVLVGN-CKSFVFNRLL 226
Cdd:PRK07531 163 RRAKEILREIGMKPVHIAKeIDAFVGDRLL 192
PRK07066 PRK07066
L-carnitine dehydrogenase;
113-255 5.79e-08

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 54.07  E-value: 5.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  113 LSNCDLIVESVIEDMKLKKELFANLENICKSTCIFGTNTSSLDLNEISSVLRDPSNLVGIHFFNPANVIRLVEIIYGSHT 192
Cdd:PRK07066  81 VADADFIQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGERT 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71985930  193 SSQAIATAFQACESIKKLPVLV-GNCKSFVFNRLLHVYFDQSQKLMYEYGYLPHQIDKIItNFG 255
Cdd:PRK07066 161 APEAVDAAMGIYRALGMRPLHVrKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAI-RFG 223
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 41-123 5.01e-05

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 45.03  E-value: 5.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  41 SVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQRCkqelEVMYAREKSFKRLNDKrieKINANLKITSDFHK-LSNCDLI 119
Cdd:COG0240   2 KIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVA----EEINETRENPRYLPGV---KLPENLRATSDLEEaLAGADLV 74


                ....
gi 71985930 120 VESV 123
Cdd:COG0240  75 LLAV 78
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
41-123 1.13e-04

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 43.90  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930   41 SVAIIGGGTMGKAMAICFGLAGIETFLVVRNEQRCKQELEvmyareksfKRLNDKRI--EKINANLKITSDFHK-LSNCD 117
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINA---------DRENPRYLpgIKLPDNLRATTDLAEaLADAD 73


                 ....*.
gi 71985930  118 LIVESV 123
Cdd:PRK00094  74 LILVAV 79
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 343-397 1.70e-04

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 40.28  E-value: 1.70e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 71985930   343 VINFMLYPTVNEGYRCIEEGVISNESlIDIMFILGFGWPIhsgGPMRFGKTEGLD 397
Cdd:pfam00725   3 VVNRLLAPYLNEAIRLVEEGVATPED-IDAAMRLGLGLPM---GPFELSDLVGLD 53
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 41-123 1.76e-03

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 38.71  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930    41 SVAIIGGGTMGKAMAICFGLAGIETFLVVRNEqrckQELEVMYAREKSFKRLNDKrieKINANLKITSDF-HKLSNCDLI 119
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNGHEVRLWGRDE----ELIEEINTTHENVRYLPGI---KLPENLKATTDLaEALKGADII 73


                  ....
gi 71985930   120 VESV 123
Cdd:pfam01210  74 VIVV 77
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 42-128 3.08e-03

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 39.45  E-value: 3.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71985930  42 VAIIGGGTMGKAMAICFGLAGIETFLVVRNEQrckqeLEVMyaREKSFkRLNDKRIEKINANLKITSDFHKLSNCDLI-- 119
Cdd:COG1893   3 IAILGAGAIGGLLGARLARAGHDVTLVARGAH-----AEAL--RENGL-RLESPDGDRTTVPVPAVTDPEELGPADLVlv 74

                        90
                ....*....|....*
gi 71985930 120 ------VESVIEDMK 128
Cdd:COG1893  75 avkaydLEAAAEALA 89
PLN00093 PLN00093
geranylgeranyl diphosphate reductase; Provisional
 42-76 5.97e-03

geranylgeranyl diphosphate reductase; Provisional


Pssm-ID: 177713 [Multi-domain]  Cd Length: 450  Bit Score: 38.96  E-value: 5.97e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 71985930   42 VAIIGGGTMGKAMAICFGLAGIETFLVVRNEQRCK 76
Cdd:PLN00093  42 VAVIGGGPAGACAAETLAKGGIETFLIERKLDNAK 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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