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Conserved domains on  [gi|133931048|ref|NP_502327|]
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J domain-containing protein [Caenorhabditis elegans]

Protein Classification

J domain-containing protein( domain architecture ID 1000550)

J domain-containing protein similar to molecular chaperone DnaJ, a protein that plays crucial roles in protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of Hsp70

CATH:  1.10.287.110
Gene Ontology:  GO:0006457
PubMed:  35729039|9644977|8016869|15170475
SCOP:  4000605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DnaJ super family cl33903
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 8-91 4.44e-06

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0484:

Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 45.08  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931048   8 NHYQVLKVRKNATHFEIYNAYMNSMAK----VDPNDPYV---FKkdlAFGLAYSTLSDPGLREEYDRQLDGISRNSRISH 80
Cdd:COG0484    1 DYYEILGVSRDASAEEIKKAYRKLAKKyhpdRNPGDPEAeekFK---EINEAYEVLSDPEKRAAYDRFGHAAELLLATEL 77

                         90
                 ....*....|.
gi 133931048  81 SNRSLDNMRQT 91
Cdd:COG0484   78 AESAAAEAAAA 88
 
Name Accession Description Interval E-value
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 8-91 4.44e-06

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 45.08  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931048   8 NHYQVLKVRKNATHFEIYNAYMNSMAK----VDPNDPYV---FKkdlAFGLAYSTLSDPGLREEYDRQLDGISRNSRISH 80
Cdd:COG0484    1 DYYEILGVSRDASAEEIKKAYRKLAKKyhpdRNPGDPEAeekFK---EINEAYEVLSDPEKRAAYDRFGHAAELLLATEL 77

                         90
                 ....*....|.
gi 133931048  81 SNRSLDNMRQT 91
Cdd:COG0484   78 AESAAAEAAAA 88
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 8-66 1.12e-05

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 41.69  E-value: 1.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 133931048    8 NHYQVLKVRKNATHFEIYNAYMNsMAK-----VDPNDPYVFKKDLAFGLAYSTLSDPGLREEYD 66
Cdd:pfam00226   1 DYYEILGVSPDASDEEIKKAYRK-LALkyhpdKNPGDPEAEEKFKEINEAYEVLSDPEKRAIYD 63
PRK14295 PRK14295
molecular chaperone DnaJ;
1-71 1.38e-04

molecular chaperone DnaJ;


Pssm-ID: 237665 [Multi-domain]  Cd Length: 389  Bit Score: 42.14  E-value: 1.38e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 133931048   1 MSS--FENQNHYQVLKVRKNATHFEIYNAYMNSMAKVDPN----DPYVFKKDLAFGLAYSTLSDPGLREEYD--RQLDG 71
Cdd:PRK14295   1 MSTkdYIEKDYYKVLGVPKDATEAEIKKAYRKLAREYHPDankgDAKAEERFKEISEAYDVLSDEKKRKEYDeaRSLFG 79
 
Name Accession Description Interval E-value
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 8-91 4.44e-06

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 45.08  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133931048   8 NHYQVLKVRKNATHFEIYNAYMNSMAK----VDPNDPYV---FKkdlAFGLAYSTLSDPGLREEYDRQLDGISRNSRISH 80
Cdd:COG0484    1 DYYEILGVSRDASAEEIKKAYRKLAKKyhpdRNPGDPEAeekFK---EINEAYEVLSDPEKRAAYDRFGHAAELLLATEL 77

                         90
                 ....*....|.
gi 133931048  81 SNRSLDNMRQT 91
Cdd:COG0484   78 AESAAAEAAAA 88
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 8-66 1.12e-05

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 41.69  E-value: 1.12e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 133931048    8 NHYQVLKVRKNATHFEIYNAYMNsMAK-----VDPNDPYVFKKDLAFGLAYSTLSDPGLREEYD 66
Cdd:pfam00226   1 DYYEILGVSPDASDEEIKKAYRK-LALkyhpdKNPGDPEAEEKFKEINEAYEVLSDPEKRAIYD 63
PRK14295 PRK14295
molecular chaperone DnaJ;
1-71 1.38e-04

molecular chaperone DnaJ;


Pssm-ID: 237665 [Multi-domain]  Cd Length: 389  Bit Score: 42.14  E-value: 1.38e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 133931048   1 MSS--FENQNHYQVLKVRKNATHFEIYNAYMNSMAKVDPN----DPYVFKKDLAFGLAYSTLSDPGLREEYD--RQLDG 71
Cdd:PRK14295   1 MSTkdYIEKDYYKVLGVPKDATEAEIKKAYRKLAREYHPDankgDAKAEERFKEISEAYDVLSDEKKRKEYDeaRSLFG 79
PRK14299 PRK14299
chaperone protein DnaJ; Provisional
 7-67 2.15e-04

chaperone protein DnaJ; Provisional


Pssm-ID: 237667 [Multi-domain]  Cd Length: 291  Bit Score: 41.46  E-value: 2.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 133931048   7 QNHYQVLKVRKNATHFEIYNAYMNSMAKVDPN---DPYVFKKDLAFGLAYSTLSDPGLREEYDR 67
Cdd:PRK14299   4 KDYYAILGVPKNASQDEIKKAFKKLARKYHPDvnkSPGAEEKFKEINEAYTVLSDPEKRRIYDT 67
PRK14276 PRK14276
chaperone protein DnaJ; Provisional
 5-66 2.74e-04

chaperone protein DnaJ; Provisional


Pssm-ID: 237653 [Multi-domain]  Cd Length: 380  Bit Score: 41.23  E-value: 2.74e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 133931048   5 ENQNHYQVLKVRKNATHFEIYNAYMNSMAKVDPN---DPYVFKKDLAFGLAYSTLSDPGLREEYD 66
Cdd:PRK14276   2 NNTEYYDRLGVSKDASQDEIKKAYRKLSKKYHPDinkEPGAEEKYKEVQEAYETLSDPQKRAAYD 66
PRK14277 PRK14277
chaperone protein DnaJ; Provisional
 7-67 3.78e-04

chaperone protein DnaJ; Provisional


Pssm-ID: 184599 [Multi-domain]  Cd Length: 386  Bit Score: 40.94  E-value: 3.78e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133931048   7 QNHYQVLKVRKNATHFEIYNAYMNsMAK-----VDPNDPYVFKKDLAFGLAYSTLSDPGLREEYDR 67
Cdd:PRK14277   5 KDYYEILGVDRNATEEEIKKAYRR-LAKkyhpdLNPGDKEAEQKFKEINEAYEILSDPQKRAQYDQ 69
PTZ00037 PTZ00037
DnaJ_C chaperone protein; Provisional
 5-66 4.34e-04

DnaJ_C chaperone protein; Provisional


Pssm-ID: 240236 [Multi-domain]  Cd Length: 421  Bit Score: 40.57  E-value: 4.34e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 133931048   5 ENQNHYQVLKVRKNATHFEIYNAYMNSMAKVDPN---DPYVFKKdlaFGLAYSTLSDPGLREEYD 66
Cdd:PTZ00037  26 DNEKLYEVLNLSKDCTTSEIKKAYRKLAIKHHPDkggDPEKFKE---ISRAYEVLSDPEKRKIYD 87
PRK14284 PRK14284
chaperone protein DnaJ; Provisional
 8-67 5.87e-04

chaperone protein DnaJ; Provisional


Pssm-ID: 237658 [Multi-domain]  Cd Length: 391  Bit Score: 40.21  E-value: 5.87e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 133931048   8 NHYQVLKVRKNATHFEIYNAYMNSMAKV----DPNDPYVFKKDLAFGLAYSTLSDPGLREEYDR 67
Cdd:PRK14284   2 DYYTILGVSKTASPEEIKKAYRKLAVKYhpdkNPGDAEAEKRFKEVSEAYEVLSDAQKRESYDR 65
PRK14291 PRK14291
chaperone protein DnaJ; Provisional
 5-66 1.12e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 237661 [Multi-domain]  Cd Length: 382  Bit Score: 39.37  E-value: 1.12e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 133931048   5 ENQNHYQVLKVRKNATHFEIYNAYMNSMAKVDPN---DPYVFKKDLAFGLAYSTLSDPGLREEYD 66
Cdd:PRK14291   1 AKKDYYEILGVSRNATQEEIKKAYRRLARKYHPDfnkNPEAEEKFKEINEAYQVLSDPEKRKLYD 65
PRK14282 PRK14282
chaperone protein DnaJ; Provisional
 5-67 1.60e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 184603 [Multi-domain]  Cd Length: 369  Bit Score: 39.01  E-value: 1.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 133931048   5 ENQNHYQVLKVRKNATHFEIYNAYMNSMAKVDPNDPYVFKKDLAFGL-----AYSTLSDPGLREEYDR 67
Cdd:PRK14282   2 EKKDYYEILGVSRNATQEEIKRAYKRLVKEWHPDRHPENRKEAEQKFkeiqeAYEVLSDPQKRAMYDR 69
PRK14283 PRK14283
chaperone protein DnaJ; Provisional
 5-73 1.74e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 184604 [Multi-domain]  Cd Length: 378  Bit Score: 39.04  E-value: 1.74e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 133931048   5 ENQNHYQVLKVRKNATHFEIYNAYMNSMAKVDPN---DPYVFKKDLAFGLAYSTLSDPGLREEYDR----QLDGIS 73
Cdd:PRK14283   3 EKRDYYEVLGVDRNADKKEIKKAYRKLARKYHPDvseEEGAEEKFKEISEAYAVLSDDEKRQRYDQfghaGMDGFS 78
PRK14279 PRK14279
molecular chaperone DnaJ;
6-66 2.92e-03

molecular chaperone DnaJ;


Pssm-ID: 237655 [Multi-domain]  Cd Length: 392  Bit Score: 38.17  E-value: 2.92e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 133931048   6 NQNHYQVLKVRKNATHFEIYNAYMNSMAKV----DPNDPYVFKKDLAFGLAYSTLSDPGLREEYD 66
Cdd:PRK14279   8 EKDFYKELGVSSDASAEEIKKAYRKLARELhpdaNPGDPAAEERFKAVSEAHDVLSDPAKRKEYD 72
PRK14289 PRK14289
molecular chaperone DnaJ;
5-67 4.07e-03

molecular chaperone DnaJ;


Pssm-ID: 237660 [Multi-domain]  Cd Length: 386  Bit Score: 37.89  E-value: 4.07e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 133931048   5 ENQNHYQVLKVRKNATHFEIYNAYMNSMAKV----DPNDPYVFKKDLAFGLAYSTLSDPGLREEYDR 67
Cdd:PRK14289   3 EKRDYYEVLGVSKTATVDEIKKAYRKKAIQYhpdkNPGDKEAEEKFKEAAEAYDVLSDPDKRSRYDQ 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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